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51. 发明申请

WO1996037233A1 POLYMYXIN CONJUGATES 审中-公开
标题翻译：聚甲基丙烯酸
公开(公告)号：WO1996037233A1
公开(公告)日：1996-11-28
申请号：PCT/EP1996002256
申请日：1996-05-24
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , KAPA, Prasad, Koteswara , KARDASH, Gleb , KUCEROVY, Andrew , LAKE, Philip , MATTNER, Paul, Gerard , PETTER, Russell, C. , PRASHAD, Mahavir , SHARMA, Sushill
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： A61K47/48
CPC分类号： A61K47/61
摘要： Water-soluble polymyxin B/dextran conjugates (or salts thereof) having anti-endotoxin activity greater than unconjugated polymyxin B. They can be prepared by reacting polymyxin B or a salt thereof with dextran in an aqueous medium at a pH of from about 9.3 to about 10 and a temperature of from about 30 DEG to about 35 DEG C.
摘要翻译：具有大于未缀合的多粘菌素B的抗内毒素活性的水溶性多粘菌素B /葡聚糖缀合物（或其盐）。它们可以通过使多粘菌素B或其盐与葡聚糖在水性介质中反应制备，pH为约9.3〜约10℃，温度为约30℃至约35℃。

52. 发明申请

WO1996020927A1 DIBENZ[cd,f]INDOLE DERIVATIVES 审中-公开
标题翻译： DIBENZ [cd，f] INDOLE DERIVATIVES
公开(公告)号：WO1996020927A1
公开(公告)日：1996-07-11
申请号：PCT/EP1995005167
申请日：1995-12-29
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , GIGER, Rudolf, Karl, Andreas
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D209/56
CPC分类号： C07D209/80
摘要： 1-Alkyl-9,10-dihydroxy-4,5,5a,6-tetrahydro-dibenz[cd,f]indoles of formula (I) may be used in the treatment of Morbus Parkinson, alcohol abuse and drug dependency. In said formula, R1, R2 and R3 are independently (C1-4)alkyl, in free or acid addition salt form.
摘要翻译：式（I）的1-烷基-9,10-二羟基-4,5,5a，6-四氢 - 二苯并[cd，f]吲哚可用于治疗Morbus帕金森氏症，酒精滥用和药物依赖性。在所述式中，R 1，R 2和R 3独立地为（C 1-4）烷基，为游离或酸加成盐形式。

53. 发明申请

WO1996017843A2 NOVEL PYRIMIDINYLOXY- AND PYRIMIDINYLAMINO-ETHYLPHENYL-DIOXOLANE DERIVATIVES 审中-公开
标题翻译：新型吡咯烷酮和吡咯烷基氨基 - 乙基苯基二氧化物衍生物
公开(公告)号：WO1996017843A2
公开(公告)日：1996-06-13
申请号：PCT/EP1995004795
申请日：1995-12-06
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , LAMBERTH, Clemens , SCHAUB, Fritz
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D405/12
CPC分类号： C07D405/12 , A01N43/54 , C07C69/78 , C07D317/20 , C07D317/22 , C07D317/24 , C07D317/28 , C07D495/04
摘要： The invention discloses 2-[4-(2-(pyrimidin-4-yloxy- and -4-ylamino)-ethyl-phenyl]-dioxolanes of formula (I) wherein R1 is hydrogen, C1-4alkyl, C1-4haloalkyl or C3-6cycloalkyl, R2 is hydrogen, C1-10alkyl, C1-8alkoxy-C1-4alkyl, C3-8alkenyloxy-C1-4alkyl, C3-8haloalkenyloxy-C1-4alkyl, C3-8alkynyloxy-C1-4alkyl, C1-8haloalkoxy-C1-4alkyl, C1-8alkylthio-C1-4alkyl, aryl, aryloxy-C1-4alkyl, aryl-C1-4alkoxy-C1-4-alkyl, heteroaryloxy-C1-4alkyl, C1-4alkoxy-C1-4alkoxy-C1-4alkyl or aryl-C1-8alkyl, R3 and R4 independently are halogen, C1-4alkyl, C1-4alkoxy, C1-4alkoxy-C1-4alkyl, C1-4alkoxycarbonyl-C1-4alkyl, C1-4alkoxycarbonyl, cyano-C1-4alkyl, cyano, or -COOH, or R3 and R4 together form a bridge member selected from 1,4-butylene, 1,4-butadienylene, or -S-CH=CH-, each optionally substituted by one or two radicals selected from halogen or C1-4alkyl, and Z is NH or oxygen; the use of such compounds for the control of undesired acarinae, fungi, and insects, compositions for facilitating such use, and the preparation of the compounds of formula I.
摘要翻译：本发明公开了式（I）的2- [4-（2-（嘧啶-4-基氧基 - 和-4-基氨基） - 乙基 - 苯基] - 二氧杂环戊烷，其中R 1是氢，C 1-4烷基，C 1-4卤代烷基或C 3 -6-环烷基，R 2是氢，C 1-10烷基，C 1-8烷氧基-C 1-4烷基，C 3-8烯烃氧基-C 1-4烷基，C 3-8卤代烯氧基-C 1-4烷基，C 3-8炔氧基-C 1-4烷基，C 1-8卤代烷氧基-C 1-4烷基，C 1-8烷硫基-C 1-4烷基，芳基，芳氧基-C 1-4烷基，芳基-C 1-4烷氧基-C 1-4 - 烷基，杂芳氧基-C 1-4烷基，C 1-4烷氧基-C 1-4烷氧基-C 1-4烷基或芳基-C1 烷基，R 3和R 4独立地是卤素，C 1-4烷基，C 1-4烷氧基，C 1-4烷氧基-C 1-4烷基，C 1-4烷氧基羰基-C 1-4烷基，C 1-4烷氧基羰基，氰基-C 1-4烷基，氰基或-COOH，或R 3和R 4一起形成选自1,4-亚丁基，1,4-丁二烯基或-S-CH = CH-的桥连体，每个任选被一个或两个选自卤素或C 1-4烷基的基团取代，Z 是NH或氧;使用这些化合物来控制不希望的螨虫，真菌和昆虫，用于促进这种使用的组合物，以及制备式Ⅰ化合物。

54. 发明申请

WO1996005150A1 CEMENT ACCELERATING ADMIXTURE 审中-公开
标题翻译：水泥加速粘合剂
公开(公告)号：WO1996005150A1
公开(公告)日：1996-02-22
申请号：PCT/EP1995003132
申请日：1995-08-07
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , LEIKAUF, Bernhard
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C04B28/02
CPC分类号： C04B28/02 , C04B2103/10 , C04B2111/00146 , C04B14/303 , C04B22/082 , C04B22/124 , C04B24/2641 , C04B40/0039 , C04B22/148 , C04B24/122
摘要： An accelerating admixture for use with sprayable cementitious compositions such as shotcrete comprises a mixture of (a) amorphous aluminium hydroxide and/or aluminium hydroxysulphate, and (b) at least one amine, preferably an alkanolamine. In a preferred embodiment, the admixture also comprises an aqueous dispersion of at least one polymer which comprises pendant carboxylic moieties.
摘要翻译：与喷雾混凝土可喷涂水泥质组合物一起使用的加速混合物包括（a）无定形氢氧化铝和/或羟基硫酸铝的混合物，和（b）至少一种胺，优选链烷醇胺。在优选的实施方案中，混合物还包含至少一种包含羧酸部分的聚合物的水性分散体。

55. 发明申请

WO1996004785A1 LONG TERM XENOGENEIC MYELOID AND LYMPHOID CELL PRODUCTION IN CHIMERIC IMMUNOCOMPROMISED ANIMALS 审中-公开
标题翻译：长期免疫免疫动物中的长期XENOGENEIC MYELOID和LYMPHOID细胞生产
公开(公告)号：WO1996004785A1
公开(公告)日：1996-02-22
申请号：PCT/EP1995003198
申请日：1995-08-11
申请人： SANDOZ LTD. , SYSTEMIX INC. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
发明人： SANDOZ LTD. , SYSTEMIX INC. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , CHEN, Benjamin, P. , FRASER, Christopher, C.
IPC分类号： A01K67/027
CPC分类号： G01N33/56977 , A01K67/0271
摘要： Immunocompromised mammalian hosts are subcutaneously implanted with a combination of human fetal bone and spleen. The chimeric animals can produce human B-cells, myeloid cells and T-cells for up to 9 months in vivo when supplied with an allogeneic human fetal thymic fragment at the same site. Grafts contain cell populations expressing CD4 and CD8, CD19 or CD33, CD14 and CD15, all of which also express the HLA type of the fetal bone/spleen. T-cells derived from progenitors in the fetal bone/spleen contain both mature single positive CD4+CD8-, CD8+CD4- as well as a high percentage of immature double positive CD4+CD8+ populations.
摘要翻译：将免疫受损的哺乳动物宿主皮下植入人胎儿骨与脾的组合。当在同一位点提供同种异体的人胎儿胸腺胸腺片段时，嵌合动物可以在体内产生人B细胞，骨髓细胞和T细胞长达9个月。移植物包含表达CD4和CD8，CD19或CD33，CD14和CD15的细胞群体，所有这些细胞群体也表达胎儿骨/脾脏的HLA型。来自胎儿骨/脾脏祖细胞的T细胞既含有成熟的单一阳性CD4 + CD8-，CD8 + CD4-以及高比例的未成熟双阳性CD4 + CD8 +群体。

56. 发明申请

WO1995019346A1 QUINAZOLINE-2,4-DIONES 审中-公开
标题翻译：喹唑啉-2,4-二酮
公开(公告)号：WO1995019346A1
公开(公告)日：1995-07-20
申请号：PCT/EP1995000136
申请日：1995-01-13
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , KOLLER, Manuel
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D239/96
CPC分类号： C07D239/96
摘要： Quinazoline-2,4-diones of formula (I) wherein R, R1 and R2 are as defined in the description, are useful as pharmaceuticals.
摘要翻译：式（I）的喹唑啉-2,4-二酮其中R，R 1和R 2如说明书中所定义，可用作药物。

57. 发明申请

WO1995016691A1 RAPAMYCIN DERIVATIVES USEFUL AS IMMUNOSUPPRESSANTS 审中-公开
标题翻译： RAPAMYCIN衍生物作为免疫抑制剂有用
公开(公告)号：WO1995016691A1
公开(公告)日：1995-06-22
申请号：PCT/EP1994004191
申请日：1994-12-16
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , COTTENS, Sylvain , SEDRANI, Richard
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C07D498/18
CPC分类号： C07D498/18 , C07F7/1804
摘要： Novel demethoxy derivatives of rapamycin of formula (I) are found to have pharmaceutical utility, particularly as an immunosuppressants. In formula (I) R2 = formula (II) or formula (III), X, Y, R1, R3, R3, R4, R5 are as defined in the application.
摘要翻译：发现式（I）的雷帕霉素的新型甲氧基衍生物具有药物效用，特别是作为免疫抑制剂。在式（I）中，R 2 =式（II）或式（III）中，X，Y，R 1，R 3，R 3，R 4，R 5如本申请中所定义。

58. 发明申请

WO1995011967A1 VIABLE ZYGOTE 审中-公开
标题翻译：可变的ZYGOTE
公开(公告)号：WO1995011967A1
公开(公告)日：1995-05-04
申请号：PCT/EP1994003485
申请日：1994-10-24
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , BUCHTER-LARSEN, Aksel , PEDERSEN, Hans, Christian
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H.
IPC分类号： C12N15/00
CPC分类号： C12N15/8241 , C12N5/04 , C12N15/00 , C12N15/8206
摘要： The present invention provides a viable zygote in which chromosomal DNA from one of the parental gametes has been substantially degraded. The invention also provides: organisms, particularly plants, resulting from cell division of the zygote; and a method of producing a viable zygote having an altered chromosome complement when compared with the wild type - comprising fertilizing a maternal gamete with a paternal gamete - characterized in that in the zygote, chromosomal DNA from one of the gametes is substantially degraded. The paternal gamete is preferably treated with a DNA intercalating agent in the dark, fertilization of the maternal gamete takes place in the dark, and the zygote is subjected to visible and/or ultra-violet light before or after its first mitotic division.
摘要翻译：本发明提供了一种可行的受精卵，其中来自亲本配子之一的染色体DNA已经被大大降解。本发明还提供：由受精卵的细胞分裂产生的生物体，特别是植物; 以及当与野生型相比时产生具有改变的染色体补体的可活受精卵的方法 - 包括用母本配子施用母本配子 - 其特征在于，在受精卵中，来自其中一个配子的染色体DNA被大大降解。父系配子优选在黑暗中用DNA插入剂处理，母体配子的受精发生在黑暗中，受精卵在其第一次有丝分裂分裂之前或之后经受可见和/或紫外光。

59. 发明申请

WO1995011306A1 ANTI-MICROBIAL PROTEINS 审中-公开
标题翻译：抗微生物蛋白
公开(公告)号：WO1995011306A1
公开(公告)日：1995-04-27
申请号：PCT/EP1994003449
申请日：1994-10-20
申请人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH , KRAGH, Karsten, Matthias , MIKKELSEN, Jorn, Dalgaard , NIELSEN, Klaus, Kristian
发明人： SANDOZ LTD. , SANDOZ-PATENT-GMBH , SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT MBH
IPC分类号： C12N15/82
CPC分类号： C12N15/8282 , A01N65/08 , C07K14/415
摘要： An anti-microbial protein comprising a peptide having the amino acid sequence: AA1-AA2-AA3-Cys-AA5-AA6-AA7-AA8-AA9-Cys-AA11-AA12-AA13-AA14-Cys-Cys-AA17-AA18-AA19-AA20-AA21-Cys-AA23-AA24-AA25-AA26-AA27-AA28-Cys-AA30. An anti-microbial protein having the sequence depicted in any one of SEQ ID Nos. 1-3. Recombinant DNA encoding such proteins. A vector comprising such DNA which is expressible in plants and which is linked to a plant operable promoter and terminator. Plants transformed with such recombinant DNA; the progeny of such plants which contain the DNA stably incorporated and hereditable in a Mendelian manner, and/or the seeds of such plants or such progeny.
摘要翻译：包含具有氨基酸序列的肽的抗微生物蛋白质：AA1-AA2-AA3-Cys-AA5-AA6-AA7-AA8-AA9-Cys-AA11-AA12-AA13-AA14-Cys-Cys-AA17-AA18- AA19-AA20-AA21-CYS-AA23-AA24-AA25-AA26-AA27-AA28-CYS-AA30。具有SEQ ID No.3-1中任一项所示序列的抗微生物蛋白质。编码这种蛋白质的重组DNA。包含这样的DNA的载体，其在植物中可表达并与植物可操作的启动子和终止子连接。用这种重组DNA转化的植物; 这些植物的后代含有以孟德尔方式稳定掺入和遗传的DNA，和/或这种植物或其后代的种子。

60. 发明申请

WO1994029464A1 VIRUS RESISTANT PLANTS 审中-公开
标题翻译：抗病植物
公开(公告)号：WO1994029464A1
公开(公告)日：1994-12-22
申请号：PCT/EP1994001817
申请日：1994-06-03
申请人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD. , DE HAAN, Petrus, Theodorus
发明人： SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. , SANDOZ-PATENT-GMBH , SANDOZ LTD.
IPC分类号： C12N15/82
CPC分类号： C12N15/8283
摘要： DNA constructs encoding an RNA molecule capable of interacting with an RNA dependent RNA polymerase encoded for by a virus when invading a plant such that either an eliciting element or a plus sense RNA is produced as a consequence of the interaction with the RNA dependent RNA polymerase encoded by the said invading virus, whereby any produced plus sense RNA molecule is capable of encoding for an eliciting element, plants containing such constructs and processes for obtaining such plants.
摘要翻译：编码能够与入侵植物编码的RNA依赖性RNA聚合酶相互作用的RNA分子的DNA构建体，以便作为与编码的RNA依赖性RNA聚合酶相互作用的结果产生引发元件或正义RNA 通过所述入侵病毒，由此任何产生的正义RNA分子能够编码引发元件，含有这种构建体的植物和获得这种植物的方法。

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