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51. 发明申请

WO1995032941A1 PROCESS FOR THE PREPARATION OF UNSATURATED AMINO COMPOUNDS 审中-公开
标题翻译：制备不饱和氨基化合物的方法
公开(公告)号：WO1995032941A1
公开(公告)日：1995-12-07
申请号：PCT/EP1995001847
申请日：1995-05-16
申请人： CIBA-GEIGY AG , SIEGRIST, Urs , BAUMEISTER, Peter
发明人： CIBA-GEIGY AG
IPC分类号： C07C227/04
CPC分类号： C07C213/02 , B01J23/56 , B01J23/628 , C07C227/04 , C07C231/12 , C07C253/30
摘要： The present invention relates to a process for the preparation of aromatic amino compounds which are substituted by at least one group comprising at least one unsaturated carbon-carbon bond, by catalytic hydrogenation of corresponding aromatic nitro compounds in the presence of a modified noble metal catalyst, wherein the noble metal catalyst used is platinum modified with a metal selected from the group consisting of lead, mercury, bismuth, germanium, cadmium, arsenic, antimony, silver and gold, and to novel noble metal catalysts for use in this process.
摘要翻译：本发明涉及在改性贵金属催化剂存在下，通过相应的芳族硝基化合物的催化氢化，制备芳香族氨基化合物的方法，该方法被至少一个包含至少一个不饱和碳 - 碳键的基团取代，其中所用的贵金属催化剂是用选自铅，汞，铋，锗，镉，砷，锑，银和金的金属进行铂改性的铂金，以及用于该方法的新型贵金属催化剂。

52. 发明申请

WO1995028144A1 TEMPORALLY CONTROLLED DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：临时控制的药物输送系统
公开(公告)号：WO1995028144A1
公开(公告)日：1995-10-26
申请号：PCT/IB1995000223
申请日：1995-04-03
申请人： CIBA-GEIGY AG , GIANNOS, Steven, Andrew , MINH DINH, Steven , BERNER, Bret
发明人： CIBA-GEIGY AG
IPC分类号： A61K09/00
CPC分类号： A61K9/7084 , A61K9/0002
摘要： A delivery mechanism and device for the passive periodic release of a drug or an active ingredient which avoids the need for external power sources and/or electronic controllers. By taking advantage of oscillating chemical systems, one can change the pH of a solution, a drug, enhancer or solubilizer resulting in oscillating the ability of an active ingredient to be delivered transdermally. The pH of a solution can be oscillated over a range of pH values from 2 to 10 by the reduction and oxidation (redox) reactions of salts, such as permanganates, iodates, sulfates, chlorates, or bromates. Upon activation, the delivery system conditions begin to oscillate and with it, the delivery of the active agent oscillates.
摘要翻译：用于药物或活性成分的被动定期释放的递送机制和装置，其避免需要外部电源和/或电子控制器。通过利用振荡化学系统，可以改变溶液，药物，增强剂或增溶剂的pH，导致活性成分经皮递送的能力的振荡。通过盐，如高锰酸盐，碘酸盐，硫酸盐，氯酸盐或溴酸盐的还原和氧化（氧化还原）反应，溶液的pH可以在2至10的pH范围内振荡。在激活时，递送系统条件开始振荡并且随之而起，活性剂的递送振荡。

53. 发明申请

WO1995025767A1 PROCESS FOR THE STABILIZATION OF HDPE 审中-公开
标题翻译： HDPE稳定化方法
公开(公告)号：WO1995025767A1
公开(公告)日：1995-09-28
申请号：PCT/EP1995000897
申请日：1995-03-10
申请人： CIBA-GEIGY AG , HOFFMANN, Kurt , HERBST, Heinz , PFAENDNER, Rudolf
发明人： CIBA-GEIGY AG
IPC分类号： C08L23/06
CPC分类号： C08K5/524 , C08K3/22 , C08K5/5393 , C08L23/04
摘要： High-density polyethylene (HDPE) which experiences a reduction in molecular weight during processing and is obtainable by means of catalysts of the Ziegler-Natta type can be stabilized against thermo-oxidative degradation by addition of a combination of a sterically hindered phenol and an organic phosphite or phosphonite and calcium oxide.
摘要翻译：在加工过程中经历分子量降低并可通过齐格勒 - 纳塔型催化剂获得的高密度聚乙烯（HDPE）可以通过加入空间位阻酚和有机物的组合来稳定，防止热氧化降解亚磷酸盐或亚膦酸盐和氧化钙。

54. 发明申请

WO1995021879A1 URETHANE MODIFIED EPOXY RESIN COMPOSITIONS 审中-公开
标题翻译： URETHANE改性环氧树脂组合物
公开(公告)号：WO1995021879A1
公开(公告)日：1995-08-17
申请号：PCT/EP1994000389
申请日：1994-02-11
申请人： CIBA-GEIGY AG , UCHIDA, Hiroshi
发明人： CIBA-GEIGY AG
IPC分类号： C08G59/26
CPC分类号： C08G59/26 , C08G18/003 , C08K3/16 , C08L63/00
摘要： An epoxy resin composition comprising (A) an epoxy resin containing an oxazolidone ring and (B) 0.01 - 50 ppm of an alkali metal salt and/or of an alkaline earth metal salt and/or of a hydroxide of an alkali metal and/or of an alkaline earth metal based on said epoxy resin, has excellent heat resistance and curing properties and can be used advantageously as civil engineering and building materials, PCM coating materials, laminate materials, sealing materials, casting materials, adhesives and composite materials.
摘要翻译：一种环氧树脂组合物，其包含（A）含有恶唑烷酮环的环氧树脂和（B）0.01-50ppm的碱金属盐和/或碱土金属盐和/或碱金属的氢氧化物和/或的基于所述环氧树脂的碱土金属具有优异的耐热性和固化性，并且可以有利地用作土木工程和建筑材料，PCM涂料，层压材料，密封材料，浇铸材料，粘合剂和复合材料。

55. 发明申请

WO1995021151A1 PROCESS FOR THE HYDROGENATION OF IMINES 审中-公开
标题翻译：加氢方法
公开(公告)号：WO1995021151A1
公开(公告)日：1995-08-10
申请号：PCT/EP1995000221
申请日：1995-01-21
申请人： CIBA-GEIGY AG , JALETT, Hans-Peter , SPINDLER, Felix , BLASER, Hans-Ulrich , HANREICH, Reinhard, Georg
发明人： CIBA-GEIGY AG
IPC分类号： C07C209/52
CPC分类号： B01J31/2404 , B01J31/04 , B01J31/2291 , B01J31/2295 , B01J31/24 , B01J31/2409 , B01J31/2452 , B01J31/2457 , B01J31/2476 , B01J31/248 , B01J31/26 , B01J2231/643 , B01J2531/0205 , B01J2531/0266 , B01J2531/827 , B01J2531/842 , C07C209/26 , C07C209/52 , C07C213/02 , C07C233/02 , C07D333/36
摘要： A process for the hydrogenation of imines with hydrogen under elevated pressure in the presence of iridium catalysts and with or without an inert solvent, wherein the reaction mixture contains an ammonium or metal chloride, bromide or iodide and additionally an acid.
摘要翻译：在铱催化剂和惰性溶剂存在下，在高压下用氢氢化亚胺的方法，其中反应混合物含有铵或金属氯化物，溴化物或碘化物，另外是酸。

56. 发明申请

WO1995018859A1 SYNERGISTIC ANTIFUNGAL PROTEIN AND COMPOSITIONS CONTAINING SAME 审中-公开
标题翻译：协同抗菌蛋白及其组合物
公开(公告)号：WO1995018859A1
公开(公告)日：1995-07-13
申请号：PCT/US1995000432
申请日：1995-01-09
申请人： CIBA-GEIGY AG , UNIVERSITY RESEARCH CORPORATION , ROBERTS, Walden, K. , SELITRENNIKOFF, Claude, P. , LAUE, Bridget, E. , POTTER, Sharon, L.
发明人： CIBA-GEIGY AG , UNIVERSITY RESEARCH CORPORATION
IPC分类号： C12N15/29
CPC分类号： A61K36/899 , A01N65/44 , A61K38/168 , C07K14/415 , C12N15/8282 , A61K2300/00
摘要： Novel plant proteins (SAFPs) which synergize the activity of antifungal antibiotics are identified. SAFPs are demonstrated to synergize antifungal antibiotics, such as nikkomycins, polyoxins and amphotericins. SAFPs alone also display antifungal activity against several species of fungi, including strains of Candida, Trichoderma, Neurospora and strains of the plant pathogens Fusarium, Rhizoctonia, and Chaetomium. Synergistic antifungal compositions containing SAFP and antifungal antibiotics are provided. In particular, synergistic compositions of corn-SAFP (zeamatin), sorghum-SAFP (sormatin) or oat-SAFP (avematin) and nikkomycin are found to be effective as antifungal compositions, especially against the opportunistic human pathogen Candida albicans. Method for employing SAFPs and synergistic compositions containing them for the inhibition of fungi are provided. In addition, a method for purifying SAFP from grain meal is provided.
摘要翻译：鉴定了协同抗真菌抗生素活性的新型植物蛋白（SAFP）。 SAFPs被证明可以协同抗真菌抗生素，如尼科霉素，多氧菌素和两性霉素。单独的SAFP也显示针对几种真菌的抗真菌活性，包括假丝酵母属，木霉属，脉孢菌属和植物病原体镰刀菌，丝核菌属和毛壳菌属的菌株。提供含有SAFP和抗真菌抗生素的协同抗真菌组合物。特别地，发现玉米-SFP（玉米淀粉），高粱-SGFP（sormatin）或燕麦-SFP（avematin）和尼科霉素的协同组合物作为抗真菌组合物是有效的，特别是抗机会性人类病原体白色念珠菌。提供了使用SAFP和含有它们的协同组合物来抑制真菌的方法。另外，提供了从谷物粉中提纯SAFP的方法。

57. 发明申请

WO1995016715A1 PROCESS FOR FLAME-PROOFING ORGANIC POLYMERIC MATERIALS 审中-公开
标题翻译：用于防火有机聚合材料的方法
公开(公告)号：WO1995016715A1
公开(公告)日：1995-06-22
申请号：PCT/EP1994004029
申请日：1994-12-03
申请人： CIBA-GEIGY AG , BAUER, Michael , REMBOLD, Manfred
发明人： CIBA-GEIGY AG
IPC分类号： C08F30/02
CPC分类号： B05D1/62 , D06M10/08 , D06M14/20 , D06M14/26
摘要： A process is described for flame-proofing organic polymeric materials by means of a low temperature plasma treatment in the presence of at least one volatile, low-molecular compound. The process comprises subjecting a volatile compound, selected from a halogen-free phosphorus compound, to the low temperature plasma, such that a homogeneous polymeric structure forms on the organic material. A very wide range of organic materials can be effectively flame-proofed with the process of this invention without adversely affecting their other properties such as mechanical properties or photochemical stability.
摘要翻译：描述了在至少一种挥发性低分子化合物的存在下通过低温等离子体处理来阻止有机聚合物材料的方法。该方法包括使选自无卤素磷化合物的挥发性化合物经受低温等离子体，从而在有机材料上形成均匀的聚合物结构。通过本发明的方法可以有效地阻燃非常宽范围的有机材料，而不会不利地影响其它性能如机械性能或光化学稳定性。

58. 发明申请

WO1995016663A1 N,N'-BIS(2-HYDROXYBENZYL)ETHYLENEDIAMINE-N,N'-DIACETIC ACID DERIVATIVES AS CHELATING AGENTS 审中-公开
标题翻译： N，N'-BIS（2-羟基苄基）乙烯二胺-N，N'-二酸衍生物作为螯合剂
公开(公告)号：WO1995016663A1
公开(公告)日：1995-06-22
申请号：PCT/IB1994000388
申请日：1994-12-05
申请人： CIBA-GEIGY AG , GASPARINI, Fabrizio , LEUTERT, Thomas , FARLEY, David, L.
发明人： CIBA-GEIGY AG
IPC分类号： C07C229/16
CPC分类号： C07D295/185 , C07C229/16 , C07C235/06 , C07D317/40
摘要： [N,N'-bis(2-hydroxybenzyl)ethylenediamine N,N'-diacetic acid] derivatives of formula (I) in which R represents -(CO)-R1, -O-(CO)-R2, -O-(CO)-O-R3 or (a) wherein R1 is -NR4R5 or (III); whereby R4 and R5 are independent of each other C1-C3 alkyl or C3-C7 cycloalkyl or form together the group -(CH2)n-, n is an integer from 3 to 6; R2 is C1-C6 alkyl, unsubstituted phenyl or phenyl substituted by one to four substituents selected from the group consisting of halogen and hydroxy; R3 is C1-C6 alkyl or C3-C7 cycloalkyl; R4 is C1-C3 alkyl; and salts thereof form chelate-type metal complexes with trivalent metal ions, especially iron (III), and can be used, for example, for the treatment of pathological conditions in warm-blooded animals that are associated with an excess of trivalent metal ions in the body.
摘要翻译：式（I）的[N，N'-双（2-羟基苄基）乙二胺N，N'-二乙酸]衍生物，其中R表示 - （CO）-R1，-O-（CO）-R2，-O- （CO）-O-R3或（a）其中R1是-NR4R5或（III）; 其中R 4和R 5彼此独立地为C 1 -C 3烷基或C 3 -C 7环烷基或一起形成 - （CH 2）n - ，n为3至6的整数; R2是C1-C6烷基，未取代的苯基或被一至四个选自卤素和羟基的取代基取代的苯基; R3是C1-C6烷基或C3-C7环烷基; R4是C1-C3烷基; 其盐与三价金属离子特别是铁（III）形成螯合型金属络合物，并且可用于例如治疗与过量三价金属离子相关的温血动物的病理状况身体。

59. 发明申请

WO1995016033A1 C5a RECEPTOR ANTAGONISTS HAVING SUBSTANTIALLY NO AGONIST ACTIVITY 审中-公开
标题翻译： C5a受体拮抗剂具有主要的无激素活性
公开(公告)号：WO1995016033A1
公开(公告)日：1995-06-15
申请号：PCT/IB1994000359
申请日：1994-11-16
申请人： CIBA-GEIGY AG , VAN OOSTRUM, Jan , BOYAR, William, C. , GALAKATOS, Nicholas, G. , PEPPARD, Jane, V.
发明人： CIBA-GEIGY AG
IPC分类号： C12N15/12
CPC分类号： C07K14/472 , A61K38/00 , C07K16/18 , C07K2319/00
摘要： Disclosed are polypeptide analogues of human C5a which are C5a receptor antagonists that exhibit substantially no analphylatoxin or agonist activity, and derivatives of the analogues, and dimeric forms of the analogues or derivatives. DNA molecules encoding the polypeptides and methods of making the analogues are also provided. Pharmaceutical formulations containing a C5a analogue are used therapeutically in the treatment of C5a-mediated diseases and inflammatory conditions in mammals, and prophylactically to prevent or reduce inflammation caused by an event which causes inflammation or aggravates an existing inflammatory condition, respectively. Further disclosed are antibodies specific to the C5a analogues, derivatives thereof, and dimers of the analogues and derivatives which exhibit substantially no cross-reactivity with human C5a. The antibodies are used to detect or quantify circulating C5a analogue or derivative, as well as to modify, e.g., neutralize, the activity of the C5a receptor antagonist in vivo.
摘要翻译：公开了人C5a的多肽类似物，其是显示基本上没有分泌毒素或激动剂活性的C5a受体拮抗剂，以及类似物的衍生物和类似物或衍生物的二聚体形式。还提供了编码多肽的DNA分子和制备类似物的方法。含有C5a类似物的药物制剂治疗性地用于治疗哺乳动物中C5a介导的疾病和炎性病症，并预防性地预防或减少由引起炎症或加剧现有炎性病症的事件引起的炎症。进一步公开的是对C5a类似物，其衍生物和类似物和衍生物的二聚体特异的抗体，其表现出与人C5a基本上没有交叉反应性。所述抗体用于检测或定量循环C5a类似物或衍生物，以及修饰，例如中和体内C5a受体拮抗剂的活性。

60. 发明申请

WO1995014686A1 NOVEL SUBSTITUED THIOSEMICARBAZONETHIONES 审中-公开
标题翻译：新的替代硫代磷酸盐
公开(公告)号：WO1995014686A1
公开(公告)日：1995-06-01
申请号：PCT/EP1994003778
申请日：1994-11-15
申请人： CIBA-GEIGY AG , MISSBACH, Martin
发明人： CIBA-GEIGY AG
IPC分类号： C07D279/06
CPC分类号： C07D279/06
摘要： The present invention relates to novel substituted thiosemicarbazonethiones containing 6-ring members of formula (I) wherein R1 is lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, or aryl-lower alkyl, R2 is hydrogen, lower alkyl, lower alk-2-en-1-yl, lower alk-2-yn-1-yl, aryl, aryl-lower alkyl, unsaturated or saturated heterocyclyl-lower alkyl, lower alkoxycarbonyl-lower alkyl or a group -C(=O)-R3 or -C(=S)-R3, wherein R3 is lower alkyl, aryl, aryl-lower alkyl, aryl-lower alkenyl, heteroaryl (hetaryl), aryloxy, aryl-lower alkoxy or lower alk-2-en-1-yloxy, and the salts thereof, to a process for the preparation of said compounds, to pharmaceutical compositions containing them, and to the use thereof as medicaments.
摘要翻译：本发明涉及含有式（I）的6-环成员的新型取代的缩氨基硫脲，其中R1是低级烷基，低级烯-2-烯-1-基，低级烯-2-炔-1-基或芳基低级烷基，R 2是氢，低级烷基，低级烯-2-烯-1-基，低级烷-2-炔-1-基，芳基，芳基 - 低级烷基，不饱和或饱和的杂环基 - 低级烷基，低级烷氧基羰基 - 低级烷基或基团-C（= O）-R 3或-C（= S）-R 3，其中R 3是低级烷基，芳基，芳基 - 低级烷基，芳基 - 低级烯基，杂芳基（杂芳基），芳氧基，烷氧基或低级烯-2-烯-1-基氧基及其盐与制备所述化合物的方法，含有它们的药物组合物及其作为药物的用途。

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