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51. 发明申请

WO2004113505A2 SYSTEM AND METHOD FOR SEQUENCE DISTANCE MEASURE FOR PHYLOGENETIC TREE CONSTRUCTION 审中-公开
标题翻译：用于生物树构造的序列距离测量系统和方法
公开(公告)号：WO2004113505A2
公开(公告)日：2004-12-29
申请号：PCT/US2004/019762
申请日：2004-06-21
申请人： BOARD OF REGENTS OF UNIVERSITY OF NEBRASKA , SAYOOD, Khalid , OTU, Hasan, H. , HINRICHS, Steven, H.
发明人： SAYOOD, Khalid , OTU, Hasan, H. , HINRICHS, Steven, H.
IPC分类号： C12N
CPC分类号： G06F19/14 , G06F19/22
摘要： The present invention permits identification of biological materials following recovery of DNA using standard techniques by comparing a mathematical characterization of the unknown sequence with the mathematical characterization of DNA sequences of known genera and species. The clinical identification of infectious organisms is required for accurate diagnosis and selection of antimicrobial therapeutics. The invention allows an ab initio approach with the potential for rapid identification of biological materials of unknown origin. The approach provides for identification and classification of emergent or new organisms without previous phenotypic identification. The technique may also be used in monitoring situations where the need exists for classification of material into broad categories of bacteria which could have an immediate impact on bio-terrorism prevention.
摘要翻译：本发明允许使用标准技术回收DNA后鉴定生物材料，通过比较未知序列的数学表征与已知属和物种的DNA序列的数学表征。传染性生物体的临床鉴定是精确诊断和选择抗菌药物所必需的。本发明允许从头开始的方法具有用于快速鉴定未知来源的生物材料的潜力。该方法提供了对未出现先前表型鉴定的突变体或新生物的鉴定和分类。该技术也可用于监测需要将材料分类为可能对生物恐怖主义预防产生直接影响的大类细菌的情况。

52. 发明申请

WO2004071406A2 CREATINE ESTER ANTI-INFLAMMATORY COMPOUNDS AND FORMULATIONS 审中-公开
标题翻译： CRETINE ESTER抗炎化合物和制剂
公开(公告)号：WO2004071406A2
公开(公告)日：2004-08-26
申请号：PCT/US2004/001481
申请日：2004-01-16
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA , MILLER, Donald, W. , AUGUSTINE, Samuel, C. , WAGNER, Jon, C. , MCDONALD, Thomas, L. , ROBINSON, Dennis, H.
发明人： MILLER, Donald, W. , AUGUSTINE, Samuel, C. , WAGNER, Jon, C. , MCDONALD, Thomas, L. , ROBINSON, Dennis, H.
IPC分类号： A61K
CPC分类号： A61K31/221 , A23K20/142 , A23K40/10 , A23K50/10 , A23K50/40 , A23L33/175 , A61K31/198 , A61K31/22 , A61K31/661
摘要： The present invention provides a creatine ester anti-inflammatory compound which may be received by animals and then metabolized into a biologically active form of creatine. The biologically active creatine inhibits the production of chemical mediators, released during an inflammatory response, which are important components in the inflammatory response and the inflammation and pain resulting from physical or chemical trauma to cells and tissue.
摘要翻译：本发明提供肌酸酯抗炎化合物，其可以被动物接受，然后代谢成生物活性形式的肌酸。生物活性肌酸抑制在炎症反应期间释放的化学介质的产生，其是炎症反应中的重要组成部分以及由对细胞和组织的物理或化学创伤引起的炎症和疼痛。

53. 发明申请

WO2003038109A3 METHOD FOR THE INHIBITION OF METHANOGENESIS 审中-公开
公开(公告)号：WO2003038109A3
公开(公告)日：2003-05-08
申请号：PCT/US2002/029597
申请日：2002-09-18
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人： MINER, Jess, L. , RAGSDALE, Stephen, W. , TAKACS, James, M.
IPC分类号： C12P5/02
摘要： The current invention is directed toward a method for inhibiting methanogenesis and/or the growth of methanogens. The method comprises contacting a methanogenic archaea medium with a methane inhibiting amount and/or a growth inhibiting amount of a compound that specifically inhibits methane formation and inhibits the growth of methanogens. A method to increase feed efficiency in a ruminant is also provided via administering to the animal an effective rumen modifying amount of a compound that specifically inhibits methanogenesis.

54. 发明申请

WO2003001439A1 METHODOLOGY FOR DATA STRUCTURE CHARACTERIZATION, INDEXING, STORAGE AND RETRIEVAL 审中-公开
标题翻译：数据结构表征，索引，存储和检索的方法
公开(公告)号：WO2003001439A1
公开(公告)日：2003-01-03
申请号：PCT/US2001/019759
申请日：2001-06-21
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人： ZHU, Qiuming
IPC分类号： G06K9/32
CPC分类号： G06K9/525 , G06F17/30256
摘要： Disclosed is a method for enabling easy characterization, storage and retrieval of multi-dimensional data structures involving use of a translation, rotation and scaling invariant index (A) which results from concatenating a series of Eigenvalue calculation mediated index elements determined at a plurality of hierarchical data depth levels by characterizing spatial first and second central moment calculations (B), optionally including pre-selection of pixels in data structures which demonstrate significant intensity and/or color gradients with respect to surrounding pixels (C). Preferred characterizing vector(s) consist of typically orthogonally specific frequency integer counts of pre-selected pixels, as well as spatial data structure first central moment value(s), and non-degenerate parameter(s) determined from Eigenvalues derived from second central moments.
摘要翻译：公开了一种使得能够容易地表征，存储和检索涉及使用翻译，旋转和缩放不变索引（A）的多维数据结构的方法，其由连接在多个层级上确定的一系列特征值计算介导的索引元素而产生通过表征空间第一和第二中心矩计算（B）的数据深度级别，可选地包括对围绕像素（C）示出显着的强度和/或颜色梯度的数据结构中的像素的预先选择。优选的特征向量由预选像素的典型的正交特定频率整数计数以及空间数据结构第一中心矩值和从第二中心矩导出的特征值确定的非简并参数组成。

55. 发明申请

WO2002079390A2 $I(PESUDOMONAS) AVR AND HOP PROTEINS, THEIR ENCODING NUCLEIC ACIDS, AND USE THEREOF 审中-公开
标题翻译： DOLLAR I（PESUDOMONAS）AVR和HOP蛋白，其编码核酸及其使用
公开(公告)号：WO2002079390A2
公开(公告)日：2002-10-10
申请号：PCT/US2002/010532
申请日：2002-04-02
申请人： CORNELL RESEARCH FOUNDATION, INC. , UNIVERSITY OF NEBRASKA AT LINCOLN , KANSAS STATE UNIVERSITY RESEARCH FOUNDATION , INSTITUTE FOR GENOMIC RESEARCH , BOYCE THOMPSON INSTITUTE FOR PLANT RESEARCH INC.
发明人： COLLMER, Alan , ALFANO, James, R. , TANG, Xiaoyan , BUELL, C., Robin , MARTIN, Gregory, B.
IPC分类号： C12N
CPC分类号： C12N15/8271 , A61K38/00 , A61K48/00 , C07K14/21 , C12N15/8261 , C12N15/8281 , C12N15/8282 , C12N15/8286 , C12N2799/021 , Y02A40/146 , Y02A40/162
摘要： One aspect of the present invention relates to isolated nucleic acid molecules encoding avirulence proteins or polypeptides of Pseudomonas syringae pv. Syringae DC 3000, or nucleic acid molecules which are complementary thereto. Expression vectors, host cells, and transgenic plants which include the DNA molecules of the present invention are also disclosed. Another aspect relates to the isolated proteins or polypeptides and compositions containing the same. The nucleic acid molecules and proteins of the present invention can be used to impart disease resistance to a plant.
摘要翻译：本发明的一个方面涉及编码无毒素蛋白或丁香假单胞菌pv的多肽的分离的核酸分子。 Syringae DC 3000或与其互补的核酸分子。还公开了包括本发明的DNA分子的表达载体，宿主细胞和转基因植物。另一方面涉及分离的蛋白质或多肽以及含有它们的组合物。本发明的核酸分子和蛋白质可用于赋予植物抗病性。

56. 发明申请

WO2002060274A1 EGGSHELL DERIVED MONOCALCIUM AND DICALCIUM PHOSPHATE 审中-公开
标题翻译： EGGSHELL衍生的单糖和磷酸氢钙
公开(公告)号：WO2002060274A1
公开(公告)日：2002-08-08
申请号：PCT/US2002/001384
申请日：2002-01-16
申请人： BOARD OF REGENTS OF UNIVERSITY OF NEBRASKA
发明人： ASH, Jodi, A. , SCHEIDELER, Sheila, E.
IPC分类号： A23K1/175
CPC分类号： A23K50/10 , A23K10/26 , A23K20/24 , A23K20/26 , A23K40/10 , Y10S426/805 , Y10S426/807
摘要： An eggshell-derived product is utilized as an alternative feed grade calcium and phosphorous source for potential use for all species of livestock. The products is environmentally advantageous and biologically equivalent or superior to currently available commercial products such as feed grade dicalcium phosphate. A method of producing the product elicits monocalcium phosphate and/or dicalcium phosphate from a combination of dried eggshell waste and phosphoric acid, using water as a catalyst.
摘要翻译：使用蛋壳衍生产品作为替代饲料级钙和磷源，可用于所有种类的牲畜。该产品在环境上优于生物等效或优于目前可获得的商业产品，如饲料级磷酸二钙。使用水作为催化剂，产生产物的方法从干蛋壳废物和磷酸的组合引起磷酸一钙和/或磷酸二钙。

57. 发明申请

WO2002059395A3 ELECTROLYTIC DEPOSITION OF COATINGS FOR PROSTHETIC METALS AND ALLOYS 审中-公开
公开(公告)号：WO2002059395A3
公开(公告)日：2002-08-01
申请号：PCT/US2001/049875
申请日：2001-12-27
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人： REDEPENNING, Jody, G.
IPC分类号： C25D9/00
摘要： An article coated with an electrolytically deposited bio-compatible composite layer useful as an internal prosthetic device is disclosed. The bio-compatible composite coating that is electrolytically deposited onto the article comprises hydroxyapatite and chitosan. The introduction of chitosan into the crystal matrix of brushite/hydroxyapatite significantly improves the adhesive and chemical and mechanical stability properties of the coating.

58. 发明申请

WO2002059368A1 SPECIFIC MUCIN EXPRESSION AS A MARKER FOR PANCREATIC CANCER 审中-公开
标题翻译：特异性MUCIN表达作为胰腺癌的标记
公开(公告)号：WO2002059368A1
公开(公告)日：2002-08-01
申请号：PCT/US2001/046887
申请日：2001-12-07
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA , BATRA, Surinder, K. , BRAND, Randall, E. , RINGEL, Joerg , FAULAMNN, Grit , LOHR, Matthias , VARSHENY, Grish, C.
发明人： BATRA, Surinder, K. , BRAND, Randall, E. , RINGEL, Joerg , FAULAMNN, Grit , LOHR, Matthias , VARSHENY, Grish, C.
IPC分类号： C12Q1/68
CPC分类号： C07K16/303 , C07K16/3092 , C12Q1/6886 , C12Q2600/158 , G01N33/57438 , G01N2333/4725
摘要： Methods are provided for the diagnosis of pancreatic cancer
摘要翻译：为诊断胰腺癌提供了方法

59. 发明申请

WO1998020899A1 ATTENUATED SERPULINA HYODYSENTERIAE MUTANT FOR PREVENTION OF SWINE DYSENTERY 审中-公开
标题翻译：用于防止肌肉松解的灭活血清抑制剂
公开(公告)号：WO1998020899A1
公开(公告)日：1998-05-22
申请号：PCT/US1997021199
申请日：1997-11-12
申请人： BOARD OF REGENTS UNIVERSITY OF NEBRASKA LINCOLN , DUHAMEL, Gerald, E. , ELDER, Robert, O.
发明人： BOARD OF REGENTS UNIVERSITY OF NEBRASKA LINCOLN
IPC分类号： A61K39/02
CPC分类号： A61K39/0225 , A61K39/00 , C07K14/20
摘要： Serpulina hyodysenteriae mutants having attenuated virulence are provided by specific disruption of a gene found to be involved in S. hyodysenteriae virulence. The attenuated mutant strains of S. hyodysenteriae thus produced are useful as live attenuated vaccines for increasing the resistance in swine to dysentery infection.
摘要翻译：具有减毒毒力的丝氨酸假单胞菌突变体通过发现参与猪链霉菌毒力的基因的特异性破坏来提供。由此产生的猪痢疾短链霉菌的减毒突变菌株可用作活减毒疫苗，用于增加猪对痢疾感染的抵抗力。

60. 发明申请

WO1998000445A1 NEPHROPATHY-RELATED IMMUNOGLOBULIN G AND ANTIBODIES FOR SAME 审中-公开
标题翻译： NEPHROPATHY相关免疫球蛋白G及其抗体
公开(公告)号：WO1998000445A1
公开(公告)日：1998-01-08
申请号：PCT/US1996011140
申请日：1996-07-01
申请人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA
发明人： BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA , McDONALD, Thomas, L.
IPC分类号： C07K16/42
CPC分类号： C07K16/18 , G01N33/6854 , G01N33/6893 , G01N2800/042 , G01N2800/347
摘要： A novel immunoglobulin-like glycoprotein is described which has been found to occur in high concentrations in the urine of patients with glomerulosclerosis of end-stage renal disease. This nephropathy-related protein is also found at a high frequency in the urine of patients with a high risk of developing kidney disease, as well as in the urine of kidney transplant recipients who are expriencing early signs of organ failure or rejection. Although this glycoprotein has several antigenic epitopes which are identical to those on normal human IgG molecules, two monoclonal antibodies have been developed which bind epitopes which are unique to this nephropathy-related immunoglobulin-like molecule. Immunometric assays have been developed which permit this nephropathy-related protein to serve as an early and specific marker for kidney-related diseases.
摘要翻译：描述了一种新型的免疫球蛋白样糖蛋白，其被发现在终末期肾脏疾病的肾小球硬化患者的尿中以高浓度发生。这种肾病相关蛋白质也发现在高发生肾脏疾病风险的患者的尿液中以及正在发生早期器官衰竭或排斥征象的肾脏移植受者的尿液中。虽然该糖蛋白具有与正常人IgG分子相同的几个抗原表位，但是已经开发了两种单克隆抗体，其结合与该肾病相关免疫球蛋白样分子独特的表位。已经开发了免疫测定法，其允许这种肾病相关蛋白质作为肾脏相关疾病的早期和特异性标记物。

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