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51. 发明申请

WO2017019536A1 SURFACE MODIFICATION OF POLYMER FOAMS USING PLASMA 审中-公开
标题翻译：使用等离子体的聚合物表面改性
公开(公告)号：WO2017019536A1
公开(公告)日：2017-02-02
申请号：PCT/US2016/043657
申请日：2016-07-22
申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC , THE TEXAS A&M UNIVERSITY SYSTEM
发明人： NASH, Landon D. , MAITLAND, Duncan J. , RIVERA, Nicole , WILSON, Thomas S. , SMALL, IV, Ward , ORTEGA, Jason
IPC分类号： C08J9/224 , B29C59/14 , C08J9/34 , A61L31/14 , B32B5/18 , B32B27/06
CPC分类号： A61L31/14 , A61L31/06 , A61L31/146 , A61L2400/16 , A61L2430/36 , B29C44/5663 , B29C59/14 , B29K2033/04 , B29K2069/00 , B29K2075/00 , B29K2077/00 , B29K2995/0093 , B32B5/18 , B32B27/06 , C08J9/36 , C08J9/365 , C08J2201/026 , C08J2375/04 , C08L75/04
摘要： An embodiment includes a system comprising: a monolithic shape memory polymer (SMP) foam having first and second states; wherein the SMP foam includes: (a) polyurethane, (b) an inner half portion having inner reticulated cells defined by inner struts, (c) an outer half portion, having outer reticulated cells defined by outer struts, surrounding the inner portion in a plane that provides a cross-section of the SMP foam, (d) hydroxyl groups chemically bound to outer surfaces of both the inner and outer struts. Other embodiments are discussed herein.
摘要翻译：一个实施方案包括一种系统，包括：具有第一和第二状态的整体形状记忆聚合物（SMP）泡沫; 其中所述SMP泡沫包括：（a）聚氨酯，（b）具有由内支柱限定的内网孔的内半部分，（c）具有由外支柱限定的外网孔的外半部分，提供SMP泡沫的横截面的平面，（d）与内部和外部支柱的外表面化学结合的羟基。本文讨论了其它实施例。

52. 发明申请

WO2017011778A1 SELF-EXPANDING HEART ASSIST DEVICE 审中-公开
标题翻译：自扩张心脏辅助装置
公开(公告)号：WO2017011778A1
公开(公告)日：2017-01-19
申请号：PCT/US2016/042578
申请日：2016-07-15
申请人： THE TEXAS A&M UNIVERSITY SYSTEM , CORINNOVA INCORPORATED
发明人： CRISCIONE, John, C. , BOLCH, Christina, M. , LESCHINSKY, Boris
IPC分类号： A61F2/00
CPC分类号： A61F2/2481 , A61F2002/2484 , A61M1/1008 , A61M1/106 , A61M1/1068 , A61M1/12
摘要： The present invention includes a device and method for a self-expanding framework device adapted to facilitate the deployment of an extra-cardiac device. The device includes a deployment tube and a self-expanding wire framework having a structure that results in the self-expanding wire framework circumferential flaring motion and bending outwardly to advance around the heart.
摘要翻译：本发明包括一种用于自扩张框架装置的装置和方法，其适于促进心脏外装置的部署。该装置包括展开管和自膨胀线框架，其具有导致自扩张线框架圆周扩张运动并向外弯曲以在心脏周围前进的结构。

53. 发明申请

WO2016191492A1 SHAPE MEMORY POLYMER NANOCOMPOSITES AND USES THEREOF 审中-公开
标题翻译：形状记忆聚合物纳米复合物及其用途
公开(公告)号：WO2016191492A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/034160
申请日：2016-05-25
申请人： THE TEXAS A&M UNIVERSITY SYSTEM , LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
发明人： HASAN, Sayyeda, Marziya , RODRIGUEZ, Jennifer, Nicole , SINGHAL, Pooja , WILSON, Thomas, Stephen , MAITLAND, Duncan, J.
IPC分类号： A61M29/02 , A61M29/00
CPC分类号： A61B17/12113 , A61B17/12131 , A61B17/1219 , A61B2017/00526 , A61B2017/00871 , A61B2090/3966 , A61L31/128 , A61L31/14 , A61L31/146 , A61L31/18 , A61L2400/12 , A61L2400/16 , A61M31/002 , C08L2201/12
摘要： The invention relates to radiopaque shape memory foam compositions and methods of using the compositions. In certain embodiments, the compositions are used in neurovascular occlusion applications.
摘要翻译：本发明涉及不透射线形状记忆泡沫组合物和使用该组合物的方法。在某些实施方案中，组合物用于神经血管闭塞应用。

54. 发明申请

WO2016176500A1 SCALABLE PRODUCTION OF STANDARDIZED EXTRACELLULAR VESICLES, EXTRACELLULAR VESICLE PREPARATIONS AND USES THEREOF 审中-公开
标题翻译：标准制造的细胞外细菌，细胞外制剂及其用途的可生产
公开(公告)号：WO2016176500A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/029874
申请日：2016-04-28
申请人： THE TEXAS A&M UNIVERSITY SYSTEM
发明人： PROCKOP, Darwin, J. , KIM, Dong-ki , NISHIDA, Hidetaka , SHETTY, Askok, K.
IPC分类号： A61K35/28 , A61K35/12 , A61P29/00 , A61P25/28
CPC分类号： A61K35/12 , A61K35/28 , C12N5/0663 , C12N2500/95
摘要： Preparations comprising an enriched population of extracellular vesicles (nEVs) having a negatively charged surface, and that are CD81+ and CD9-, are provided. Improved processes and methods for producing an enriched population of nEVs from non-murine cells, especially human origin cells and/or tissues, are disclosed. Therapeutic methods for using the preparations, including for reducing brain inflammation and treatment of various pathologies associated with brain inflammation, such as by intravenous or intranasal administration, are also described. Methods and preparations for reducing brain inflammation associated with traumatic brain injury (TBI) are also disclosed. A method for treating a patient having suffered a mild traumatic injury (mTMI), or concussion, such as a sports-related head injury, is also disclosed. The nEVs are also demonstrated to reduce the expression level of IL-Ιβ in brain tissue of an animal having had traumatic brain injury. Methods for improving cognitive function and performance in animals after a traumatic brain injury is also demonstrated using the preparations of nEVs disclosed herein.
摘要翻译：提供了包含具有带负电表面的富集的胞外囊泡（nEV）的制剂，并且是CD81 +和CD9-。公开了用于从非鼠细胞，特别是人源细胞和/或组织产生富集的nEVs群体的改进的方法和方法。还描述了使用制剂的治疗方法，包括用于减少脑炎症和治疗与脑炎症相关的各种病症，例如静脉内或鼻内给药。还公开了减少与创伤性脑损伤（TBI）相关的脑炎症的方法和制剂。还公开了治疗患有轻度创伤性损伤（mTMI）的患者或脑震荡等运动性头部损伤的方法。还证明，nEVs可降低具有创伤性脑损伤的动物的脑组织中IL-1β的表达水平。创伤性脑损伤后改善动物认知功能和表现的方法也使用本文公开的nEVs的制备来证明。

55. 发明申请

WO2016149070A1 HEMORRHAGE MANAGEMENT SYSTEM 审中-公开
标题翻译： HEMORRHAGE管理系统
公开(公告)号：WO2016149070A1
公开(公告)日：2016-09-22
申请号：PCT/US2016/021938
申请日：2016-03-11
申请人： LAWRENCE LIVERMORE NATIONAL SECURITY, LLC , THE TEXAS A&M UNIVERSITY SYSTEM
发明人： MAITLAND, Duncan J. , LANDSMAN, Todd L. , TOUCHET, Tyler J. , COSGRIFF-HERNANDEZ, Elizabeth , WILSON, Thomas S.
IPC分类号： A61L15/26 , A61L15/46 , A61L15/12 , A61L15/14
CPC分类号： A61L15/18 , A61F13/00017 , A61L15/26 , A61L15/425 , A61L15/46 , A61L24/0015 , A61L24/0036 , A61L24/0094 , A61L2300/106 , A61L2300/404 , A61L2400/16 , C08L75/04
摘要： An embodiment includes a wound dressing comprising: a shape memory polymer (SMP) foam, including open cells, having first and second states; and a hydrogel (HG) included within the cells; wherein (a) in a first position a composite, including the SMP foam and the HG, is configured to be located proximate a hemorrhagic tissue with the SMP foam in the first state; (b) in a second position the composite is configured to be expanded to the second state against the hemorrhagic tissue when the SMP foam is plasticized at 37° C depressing a glass transition temperature (T g ) of the SMP foam to below 25° C. Other embodiments are described herein.
摘要翻译：实施方案包括伤口敷料，其包括：具有第一和第二状态的形状记忆聚合物（SMP）泡沫，包括开孔; 和包含在细胞内的水凝胶（HG）; 其中（a）在第一位置，包括所述SMP泡沫和HG的复合材料构造成位于所述SMP泡沫处于第一状态的出血组织附近; （b）在第二位置，当SMP泡沫在37℃下塑化以将SMP泡沫的玻璃化转变温度（Tg）降至25℃以下时，复合材料被构造成针对出血组织膨胀至第二状态。本文描述了其它实施例。

56. 发明申请

WO2016118538A1 FUNCTIONALIZED PROTEIN-BASED MATERIALS AND THEIR USES 审中-公开
标题翻译：功能性蛋白质的材料及其用途
公开(公告)号：WO2016118538A1
公开(公告)日：2016-07-28
申请号：PCT/US2016/013977
申请日：2016-01-20
申请人： THE TEXAS A&M UNIVERSITY SYSTEM , WILLIAM MARSH RICE UNIVERSITY
发明人： BONDOS, Sarah , BAYLESS, Kayla , MATTHEWS, Kathleen , PATTERSON, Jan , ABBEY, Colette , HOWELL, David , HSIAO, Hao-Ching , CHURION, Kelly , TSAI, Shang-Pu , RAMASAMY, Sandhya , PORTERPAN, Dustin , NORTHERN, Kiera
IPC分类号： A61K38/18 , A61K9/00 , A61F13/00 , A61K48/00 , C07K14/00
CPC分类号： A61K38/195 , A61K38/08 , A61K38/16 , A61K38/1825 , A61K38/1866 , C07K14/43581 , A61K2300/00
摘要： Embodiments of the invention are directed to Ubx-fusion molecules that maintain their mechanical strength and properties even after being fused with Ubx. Ubx fusions with VEGF and other growth factors, cell signaling proteins, and cell binding proteins can be used to induce angiogenesis. Ubx fibers and mesh, embedded within a tissue engineering scaffold, induce formation of vasculature within the scaffold. The presence of vasculature is necessary to provide oxygen and nutrients to other cells growing within the scaffold.
摘要翻译：本发明的实施方案涉及即使在与Ubx融合后也保持其机械强度和性质的Ubx-融合分子。与VEGF和其他生长因子的Ubx融合，细胞信号蛋白和细胞结合蛋白可用于诱导血管生成。嵌入组织工程支架内的Ubx纤维和网状物在支架内诱导脉管系统的形成。脉管系统的存在对于在脚手架内生长的其他细胞提供氧气和营养是必需的。

57. 发明申请

WO2016099818A1 SPRAY FORMATION OF IMPERMEABLE BARRIER 审中-公开
标题翻译：喷雾形成不可阻挡的障碍物
公开(公告)号：WO2016099818A1
公开(公告)日：2016-06-23
申请号：PCT/US2015/062224
申请日：2015-11-23
申请人： COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELIN , MICHELIN RECHERCHE ET TECHNIQUE S.A. , THE TEXAS A&M UNIVERSITY SYSTEM
发明人： WEN, Charlie , WINSTON, Paul , MCHUGH, John , GRUNLAN, Jamie C.
IPC分类号： B05B13/06 , B05C9/12 , B29D30/06
CPC分类号： B29D30/0061 , B05B13/0645 , B05D1/002 , B05D1/02 , B05D5/00 , B05D7/02 , B05D7/22 , B05D7/24 , B29D30/0662 , B29D30/0685 , B29D2030/0663
摘要： A method is provided for forming an impermeable barrier layer on an inner tire surface of a tire. An assembly is also provided along with a kit for forming an impermeable barrier layer on an inner tire surface of a tire accordingly.
摘要翻译：提供了一种在轮胎的内轮胎表面上形成不可渗透的阻挡层的方法。还提供了一种组件以及用于在轮胎的内轮胎表面上形成不可渗透阻隔层的套件。

58. 发明申请

WO2016094521A1 MOBILE POLARIZED-IMAGING PLATFORM FOR POINT-OF-CARE DIAGNOSTICS 审中-公开
标题翻译：点对点诊断的移动极化成像平台
公开(公告)号：WO2016094521A1
公开(公告)日：2016-06-16
申请号：PCT/US2015/064712
申请日：2015-12-09
申请人： THE TEXAS A&M UNIVERSITY SYSTEM
发明人： PIRNSTILL, Casey, W. , COTÉ, Gerard, L.
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/444
摘要： A mobile imaging system and method includes a mount for a mobile device and a sampling module. The mount includes an attachment point that permits different sampling modules to be attached to the mobile-imaging device to permit both transmissive and reflective imaging analysis to be performed. The transmissive analysis may be performed in conjunction with a standard blood smear on a slide or with a microfluidic sample cartridge. The reflective analysis may be performed on, for example, a patient's skin.
摘要翻译：移动成像系统和方法包括用于移动设备的安装件和采样模块。安装座包括附接点，其允许不同的采样模块附接到移动成像装置，以允许执行透射和反射成像分析。透射分析可以与载玻片上的标准血液涂片或微流体样品盒一起进行。反射分析可以在例如患者的皮肤上进行。

59. 发明申请

WO2016073212A1 SINGLE ANCHOR TERMINAL 审中-公开
标题翻译：单锚栓
公开(公告)号：WO2016073212A1
公开(公告)日：2016-05-12
申请号：PCT/US2015/056879
申请日：2015-10-22
申请人： THE TEXAS A&M UNIVERSITY SYSTEM
发明人： BRACKIN, Michael, S. , ALBERSON, Dean, C. , BLIGH, Roger, P. , BULLARD, D., Lance
IPC分类号： E01F11/00
CPC分类号： E01F15/06
摘要： A single anchor terminal is provided for a roadside wire rope barrier. The single anchor terminal includes a release post, a brace, and an anchor base. The brace supports the release post in an upright position and extends from the release post to the anchor base. The brace has a first portion attached to the release post and a second portion coupled to the first portion with a release component. The anchor base includes a main post that supports the release post and a brace anchor that is coupled to the main post.
摘要翻译：为路边钢丝绳屏障提供单个锚定终端。单个锚定终端包括释放柱，支架和锚固基座。支架将支柱支撑在直立位置，并从释放柱延伸到锚基座。支架具有附接到释放柱的第一部分和与释放部件联接到第一部分的第二部分。锚固基座包括支撑释放柱的主柱和耦合到主柱的支撑锚。

60. 发明申请

WO2015196106A1 VARIANTS OF PHOSPHOTRIESTERASE FOR THE HYDROLYSIS AND DETOXIFICATION OF NERVE AGENTS 审中-公开
标题翻译：磷酸酯酶对神经病毒水解和脱氧作用的变化
公开(公告)号：WO2015196106A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036745
申请日：2015-06-19
申请人： RAUSHEL, Frank M. , BIGLEY, Andrew N. , THE TEXAS A&M UNIVERSITY SYSTEM
发明人： RAUSHEL, Frank M. , BIGLEY, Andrew N.
IPC分类号： C12N9/16 , C12N15/55 , C12N15/00 , C12N15/63
CPC分类号： C12N9/16 , A62D3/02 , A62D2101/02 , A62D2101/26 , C12Y301/03008 , C12Y301/08001
摘要： Variants of phosphotriesterase have been created that exhibit enhanced hydrolysis of V-type and G-type nerve agents over wild-type phosphotriesterase. V- and G-type nerve agents have an SP and RP enantiomer. The SP enantiomers are more toxic. V-type nerve agents are among the most toxic substances known. Variants of phosphotriesterase can prefer to hydrolyze one enantiomer of VX over the other enantiomer.
摘要翻译：已经产生了磷酸三酯酶的变体，其表现出V型和G型神经药剂与野生型磷酸三酯酶的水解增强。 V型和G型神经毒素具有SP和RP对映异构体。 SP对映体毒性更大。 V型神经毒素是已知的最毒性物质之一。磷酸三酯酶的变体可以优选地将VX的一种对映异构体水解成另一种对映异构体。

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