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51. 发明申请

WO2005031346A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN COUPLED RECEPTOR ADIPOR1 (ADIPOR1) 审中-公开
标题翻译：与G蛋白偶联受体ADIPOR1相关的疾病诊断和治疗（ADIPOR1）
公开(公告)号：WO2005031346A2
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010384
申请日：2004-09-16
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/50
CPC分类号： G01N33/6893 , G01N33/74 , G01N2800/32
摘要： The invention provides a human AdipoR1 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, inflammation, respiratory diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，炎症，呼吸系统疾病，神经系统疾病和泌尿系疾病相关的人AdipoR1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，胃肠疾病，癌症，血液疾病，炎症，呼吸系统疾病，神经疾病和泌尿疾病的化合物的测定。本发明还具有结合和/或活化或抑制AdipoR1活性的化合物以及包含这些化合物的药物组合物。

52. 发明申请

WO2005031345A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN COUPLED RECEPTOR ADIPOR2 (ADIPOR2) 审中-公开
公开(公告)号：WO2005031345A3
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010383
申请日：2004-09-16
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/50
摘要： The invention provides a human AdipoR2 which is associated with the cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, gastroenterological diseases, cancer, hematological diseases, respiratory diseases, inflammation, neurological diseases, urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of AdipoR2 as well as pharmaceutical compositions comprising such compounds.

53. 发明申请

WO2005030946A1 ACYLGLYCEROL ACYLTRANSFERASE-LIKE PROTEIN MGAT-X2 AND USES THEREOF 审中-公开
标题翻译： ACYLGLYCEROL ACYLTRANSFERASE-like蛋白MGAT-X2及其用途
公开(公告)号：WO2005030946A1
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010390
申请日：2004-09-16
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C12N9/10
CPC分类号： C12N9/1029
摘要： The present invention is directed to a polynucleotide and polypeptide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X2. The invention also provides the human MGAT-X2 associated with the cardiovascular diseases, metabolic diseases, muscle-skeleton disorders or dermatological diseases. The invention also provides assays for the identification of compounds useful for the modulation of cardiovascular diseases, dermatological diseases, metabolic diseases or muscle-skeleton disorders for treating of cardiovascular diseases, metabolic diseases, muscle-skeleton disorders or dermatological diseases associated with expression of the MGAT-X2. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明涉及新型酰基甘油酰基转移酶样蛋白MGAT-X2的多核苷酸和多肽序列。本发明还提供了与心血管疾病，代谢疾病，肌肉骨骼疾病或皮肤病学疾病相关的人MGAT-X2。本发明还提供了用于鉴定可用于调节心血管疾病，皮肤病学疾病，代谢疾病或用于治疗心血管疾病的肌肉骨骼疾病，代谢疾病，肌肉骨骼疾病或与MGAT表达相关的皮肤病学疾病的化合物的测定 -X2。本发明还涉及结合和/或活化或抑制MGAT-X2的活性的化合物以及包含这些化合物的药物组合物。

54. 发明申请

WO2005030945A1 NEW ACYLGLYCEROL ACYLTRANSFERASE-LIKE PROTEIN MGAT-X1 AND USES THEREOF 审中-公开
标题翻译：新型ACYLGLYCEROL ACYLTRANSFERASE-like蛋白MGAT-X1及其用途
公开(公告)号：WO2005030945A1
公开(公告)日：2005-04-07
申请号：PCT/EP2004/010386
申请日：2004-09-16
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , WEINGÄRTNER, Bernhard , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , WEINGÄRTNER, Bernhard , GEERTS, Andreas
IPC分类号： C12N9/10
CPC分类号： C07K16/40 , C12N9/1029
摘要： The present invention is directed to a polynucleotide sequence of a novel acylglycerol acyltransferase-like protein MGAT-X1. The invention also provides the human MGAT-X1 associated with the dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases. The invention also provides assays for the identification of compounds useful for the modulation of dermatological diseases, urological diseases, muscle-skeleton disorders, hematological diseases, cancer, reproduction disorders, neurological diseases, metabolic diseases, cardiovascular diseases or gastroenterological diseases for treating of such diseases associated with expression of the MGAT-X1. The invention also features compounds which bind to and/or activate or inhibit the activity of MGAT-X1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明涉及新的酰基甘油酰基转移酶样蛋白MGAT-X1的多核苷酸序列。本发明还提供了与皮肤病，泌尿疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经系统疾病，代谢疾病，心血管疾病或胃肠疾病有关的人MGAT-X1。本发明还提供了用于鉴定可用于调节皮肤病，泌尿系统疾病，肌肉骨骼疾病，血液疾病，癌症，繁殖障碍，神经系统疾病，代谢疾病，心血管疾病或用于治疗这些疾病的胃肠病学疾病的化合物的测定与MGAT-X1的表达相关。本发明还涉及结合和/或活化或抑制MGAT-X1的活性的化合物以及包含这些化合物的药物组合物。

55. 发明申请

WO2005029086A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH ORGANIC CATION TRANSPORTER SLC22A10 (UST3-LIKE2) (SLC22A10) 审中-公开
标题翻译：与有机运输机SLC22A10（UST3-LIKE2）（SLC22A10）有关的疾病诊断和治疗方法
公开(公告)号：WO2005029086A2
公开(公告)日：2005-03-31
申请号：PCT/EP2004/010113
申请日：2004-09-10
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/68
CPC分类号： G01N33/6893 , C07K14/705 , G01N33/6896 , G01N2500/00
摘要： The invention provides a human SLC22A10 which is associated with the gastroenterological diseases, cancer, cardiovascular diseases, metabolic diseases, neurological diseases, respiratory diseases, reproduction disorders and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of gastroenterological diseases, cancer, cardiovascular diseases, metabolic diseases, neurological diseases, respiratory diseases, reproduction disorders and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of SLC22A10 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与胃肠疾病，癌症，心血管疾病，代谢疾病，神经疾病，呼吸系统疾病，繁殖障碍和泌尿系疾病相关的人SLC22A10。本发明还提供了用于鉴定可用于治疗或预防胃肠疾病，癌症，心血管疾病，代谢疾病，神经疾病，呼吸系统疾病，繁殖障碍和泌尿系疾病的化合物的测定。本发明还涉及结合和/或活化或抑制SLC22A10的活性的化合物以及包含这些化合物的药物组合物。

56. 发明申请

WO2005026726A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH ORGANIC CATION TRANSPORTER SLC22A7 (SLC22A7) 审中-公开
标题翻译：与有机运输机相关的疾病诊断与治疗SLC22A7（SLC22A7）
公开(公告)号：WO2005026726A1
公开(公告)日：2005-03-24
申请号：PCT/EP2004/009935
申请日：2004-09-07
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/50
CPC分类号： G01N33/57407 , G01N33/57415 , G01N33/57438 , G01N33/57442 , G01N33/57446 , G01N33/57449 , G01N33/6872 , G01N2800/06 , G01N2800/085 , G01N2800/2821
摘要： The invention provides a human SLC22A7 which is associated with the cardiovascular diseases, gastroenterological diseases, cancer, metabolic diseases, hematological diseases, neurological diseases and urological diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, gastroenterological diseases, cancer, metabolic diseases, hematological diseases, neurological diseases and urological diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of SLC22A7 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠疾病，癌症，代谢疾病，血液疾病，神经系统疾病和泌尿系疾病相关的人SLC22A7。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠疾病，癌症，代谢疾病，血液疾病，神经疾病和泌尿疾病的化合物的测定。本发明还涉及结合和/或活化或抑制SLC22A7活性的化合物以及包含这些化合物的药物组合物。

57. 发明申请

WO2005005478A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED OPIOID RECEPTOR; DELTA 1 (OPRD1) 审中-公开
标题翻译： G蛋白偶联阿片受体相关疾病的诊断和治疗; DELTA 1（OPRD1）
公开(公告)号：WO2005005478A2
公开(公告)日：2005-01-20
申请号：PCT/EP2004/006671
申请日：2004-06-21
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C07K14/705
CPC分类号： G01N33/9486 , G01N2500/00
摘要： The invention provides a human OPRD1 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, inflammatory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, respiratory diseases, inflammatory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of OPRD1 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，血液疾病，呼吸系统疾病，炎性疾病，神经系统疾病和泌尿系统疾病相关的人OPRD1。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，血液疾病，呼吸系统疾病，炎性疾病，神经系统疾病和泌尿系统疾病的化合物的测定法。本发明还涉及结合和/或激活或抑制OPRD1活性的化合物以及包含这些化合物的药物组合物。

58. 发明申请

WO2005003762A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH SENSORY NEURON-SPECIFIC G PROTEIN-COUPLED RECEPTOR 2 (SNSR2) 审中-公开
标题翻译：与感觉神经元特异性G蛋白偶联受体2（SNSR2）相关的疾病的诊断和治疗
公开(公告)号：WO2005003762A2
公开(公告)日：2005-01-13
申请号：PCT/EP2004/006059
申请日：2004-06-04
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , SUMMER, Holger
IPC分类号： G01N33/48
CPC分类号： G01N33/74 , G01N2500/00
摘要： The invention provides a human SNSR2 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, cancer disorders, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of SNSR2 as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，癌症疾病，炎性疾病，血液疾病，呼吸系统疾病，神经系统疾病和泌尿系统疾病相关的人类SNSR2。本发明还提供了用于鉴定可用于治疗或预防心血管病症，胃肠和肝脏疾病，癌症病症，炎性疾病，血液病症，呼吸系统疾病，神经病症和泌尿系统病症的化合物的测定法。本发明的特征还在于结合和/或激活或抑制SNSR2活性的化合物以及包含此类化合物的药物组合物。

59. 发明申请

WO2004101813A1 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH KELL BLOOD GROUP ANTIGEN (KEL) 审中-公开
标题翻译：与细胞血液组织抗原（KEL）相关的疾病诊断和治疗
公开(公告)号：WO2004101813A1
公开(公告)日：2004-11-25
申请号：PCT/EP2004/004837
申请日：2004-05-06
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： C12Q1/37
CPC分类号： G01N33/6893
摘要： The invention provides a human KEL which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, inflammatory diseases, neurological disorders, reproduction disorders and urological disorders. The invention also provides essays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, hematological disorders, inflammatory diseases, neurological disorders, reproduction disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of KEL as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，胃肠和肝脏疾病，血液学疾病，炎性疾病，神经障碍，繁殖障碍和泌尿系统疾病相关的人类KEL。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，胃肠和肝脏疾病，血液学疾病，炎性疾病，神经障碍，繁殖障碍和泌尿系统疾病的化合物的论文。本发明还涉及结合和/或活化或抑制KEL活性的化合物以及包含这些化合物的药物组合物。

60. 发明申请

WO2004097405A3 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G-PROTEIN-COUPLED RECEPTOR H7TBA62 (H7TBA62) 审中-公开
公开(公告)号：WO2004097405A3
公开(公告)日：2004-11-11
申请号：PCT/EP2004/004166
申请日：2004-04-20
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , SUMMER, Holger
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , SUMMER, Holger
IPC分类号： G01N33/48
摘要： The invention provides a human H7TBA62 which is associated with the cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular disorders, gastrointestinal and liver diseases, inflammatory diseases, hematological disorders, respiratory diseases, neurological disorders and urological disorders. The invention also features compounds which bind to and/or activate or inhibit the activity of H7TBA62 as well as pharmaceutical compositions comprising such compounds.

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