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51. 发明申请

WO2020028565A1 TRICYCLIC HETERARYL COMPOUNDS AS STING ACTIVATORS 审中-公开
公开(公告)号：WO2020028565A1
公开(公告)日：2020-02-06
申请号：PCT/US2019/044499
申请日：2019-07-31
申请人： INCYTE CORPORATION
发明人： WU, Liangxing , YE, Yingda , YAO, Wenqing
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P31/00 , A61P7/00
摘要： The present application provides tricyclic heteroaryl compounds of formula (la) that activate the STING pathway to produce interferons which are useful in the treatment of various diseases including infectious diseases and cancer.

52. 发明申请

WO2018165623A1 USES OF FLUORINATED EPOXIDES AND NOVEL MIXTURES THEREOF 审中-公开
公开(公告)号：WO2018165623A1
公开(公告)日：2018-09-13
申请号：PCT/US2018/021864
申请日：2018-03-09
申请人： THE CHEMOURS COMPANY FC, LLC , PETROV, Viacheslav A. , BRANDT, Drew Richard , MINOR, Barbara Haviland , KONTOMARIS, Konstantinos , ROBIN, Mark L. , WYSONG, Ernest Bryon , MUSYIMI, Harrison K. , GLATT, Christine M.
发明人： PETROV, Viacheslav A. , BRANDT, Drew Richard , MINOR, Barbara Haviland , KONTOMARIS, Konstantinos , ROBIN, Mark L. , WYSONG, Ernest Bryon , MUSYIMI, Harrison K. , GLATT, Christine M.
IPC分类号： H01B3/56 , A61K31/336 , C09K3/30 , C09K5/04 , C09K5/10 , C08J9/14 , A61P23/02 , A62D1/00 , B01F17/00 , H01B3/24 , B01D12/00 , C11D7/28 , C11D7/50 , C11D11/00
CPC分类号： H01B3/56 , A61K31/336 , A61P23/02 , A62D1/00 , A62D1/0057 , A62D1/0085 , B01D12/00 , B01F17/0035 , C08J9/143 , C08J2201/022 , C08J2201/03 , C08J2203/146 , C08J2323/04 , C08J2323/10 , C08J2325/04 , C08J2375/04 , C09K3/30 , C09K5/045 , C11D7/28 , C11D7/5018 , C11D11/0005 , C11D11/0064 , H01B3/24
摘要： This application relates to compositions comprising one or more partially fluorinated epoxides and/or one or more perfluorinated epoxides which may be useful in applications including refrigerants, air conditioning, heat transfer media, high-temperature heat pumps, organic Rankine cycles, fire extinguishing/fire suppression, propellants, foam blowing, solvents, dielectrics, and/or cleaning fluids.

53. 发明申请

WO2018165608A1 PROCESSES FOR PREPARING PARTIALLY FLUORINATED EPOXIDES AND PERFLUORINATED EPOXIDES AND COMPOSITIONS RELATED THERETO 审中-公开
公开(公告)号：WO2018165608A1
公开(公告)日：2018-09-13
申请号：PCT/US2018/021841
申请日：2018-03-09
申请人： THE CHEMOURS COMPANY FC, LLC , PETROV, Viacheslav A. , BRANDT, Drew Richard
发明人： PETROV, Viacheslav A. , BRANDT, Drew Richard
IPC分类号： C07D301/03 , C07D303/48
摘要： This application relates to the preparation of partially fluorinated epoxides and perfluorinated epoxides which may be useful in various applications including refrigerants, heat transfer media, high-temperature heat pumps, organic Rankine cycles, fire extinguishing/fire suppression, propellants, foam blowing, solvents, gaseous dielectrics, and/or cleaning fluids. Compositions comprising the fluorinated epoxide compounds are also provided.

54. 发明申请

WO2018147894A1 NANOPROBE-METAL CHELATOR COMPLEXES 审中-公开
公开(公告)号：WO2018147894A1
公开(公告)日：2018-08-16
申请号：PCT/US2017/039888
申请日：2017-06-29
申请人： THE GENERAL HOSPITAL CORPORATION , NORTHEASTERN UNIVERSITY , CHOI, Hak Soo , KIM, Jonghan , EL FAKHRI, Georges
发明人： CHOI, Hak Soo , KIM, Jonghan , EL FAKHRI, Georges
IPC分类号： C09B23/04 , A61L17/12 , C09B23/10
摘要： Provided herein are compounds that are able to bind metal ions ( e.g. , free metal ions or metal ions bound to low affinity ligands) in a sample or subject. Also provided herein are methods of using the compounds for chelating metal ions and for the treatment of diseases associated with abnormal levels of metal ions. Methods of preparing the compounds and pharmaceutical compositions are also provided.

55. 发明申请

WO2018126183A3 HER3 PEPTIDES FOR IMAGING AND RADIOTHERAPY 审中-公开
公开(公告)号：WO2018126183A3
公开(公告)日：2018-07-05
申请号：PCT/US2017/069031
申请日：2017-12-29
申请人： THE GENERAL HOSPITAL CORPORATION , MAHMOOD, Umar , LARIMER, Benjamin
发明人： MAHMOOD, Umar , LARIMER, Benjamin
IPC分类号： C07K7/00 , C07K7/04 , C07K14/00 , C07K14/435 , C07K14/47 , C07K14/82
摘要： Provided herein are compositions useful for imaging HER3. An exemplary composition provided herein is useful as a radiotracer for position emission tomography (PET) imaging. Methods of imaging HER3 and combination therapies comprising the HER3 imaging agents are also provided.

56. 发明申请

WO2017214367A1 INHIBITORS OF THE MENIN-MLL INTERACTION 审中-公开
公开(公告)号：WO2017214367A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036506
申请日：2017-06-08
申请人： VITAE PHARMACEUTICALS, INC.
发明人： CACATIAN, Salvacion , CLAREMON, David, A. , DILLARD, Lawrence, Wayne , DONG, Chengguo , FAN, Yi , JIA, Lanqi , LOTESTA, Stephen, D. , MARCUS, Andrew , MORALES-RAMOS, Angel , SINGH, Suresh, B. , VENKATRAMAN, Shankar , YUAN, Jing , ZHENG, Yajun , ZHUANG, Linghang , PARENT, Stephan, D. , HOUSTON, Travis, L.
IPC分类号： C07D405/14 , C07D403/04 , C07D403/14 , C07D471/10 , C07D487/10 , C07D491/10 , A61K31/407 , A61P35/00 , A61P3/10
CPC分类号： C07D487/10 , A61P35/02 , C07B2200/13 , C07D403/04 , C07D403/14 , C07D405/14 , C07D471/10 , C07D491/10 , C07D491/107 , C07F9/6561
摘要： The present invention is directed to inhibitors of the interaction of menin with MLL and MLL fusion proteins, pharmaceutical compositions containing the same, and their use in the treatment of cancer and other diseases mediated by the menin-MLL interaction.

57. 发明申请

WO2017147400A1 USE OF PERFLUOROHEPTENES IN POWER CYCLE SYSTEMS 审中-公开
标题翻译：全氟戊烷在电力循环系统中的应用
公开(公告)号：WO2017147400A1
公开(公告)日：2017-08-31
申请号：PCT/US2017/019323
申请日：2017-02-24
申请人： THE CHEMOURS COMPANY FC, LLC
发明人： KONTOMARIS, Konstantinos , SIMONI, Luke David
IPC分类号： F01K25/08
CPC分类号： F01K25/08
摘要： A process is provided for converting heat energy from a heat source to mechanical work or electricity by utilizing a working fluid comprising perfluoroheptene. The process comprises heating a working fluid using heat supplied from the heat source; and expanding the heated working fluid to generate mechanical work. Also provided is an organic Rankine power cycle system utilizing a working fluid comprising perfluoroheptene. Further provided is a method of replacing the working fluid of an Organic Rankine Power Cycle System designed and configured to utilize a working fluid comprising HFC-245fa with a working fluid comprising of a perfluoroheptene.
摘要翻译：提供了一种通过利用包含全氟庚烯的工作流体将来自热源的热能转化为机械功或电力的方法。该方法包括使用从热源提供的热量来加热工作流体; 并且使被加热的工作流体膨胀以产生机械功。还提供了使用包含全氟庚烯的工作流体的有机朗肯动力循环系统。进一步提供了一种替换设计和构造成利用包含HFC-245fa的工作流体与包含全氟庚烯的工作流体的有机朗肯动力循环系统的工作流体的方法。

58. 发明申请

WO2017070680A1 METHODS FOR TREATING ANGELMAN SYNDROME AND RELATED DISORDERS 审中-公开
标题翻译：治疗安赫曼综合征及相关疾病的方法
公开(公告)号：WO2017070680A1
公开(公告)日：2017-04-27
申请号：PCT/US2016/058487
申请日：2016-10-24
申请人： CAVION LLC
发明人： MARICICH, Yuri
IPC分类号： A61K38/00 , A61K31/00 , A61K33/24 , A61K39/00 , A61K45/00
CPC分类号： A61K31/713 , A61K31/4184 , A61K31/4412
摘要： Provided herein are methods of treating Angelman Syndrome and/or Prader-Willi syndrome, that include administering an effective amount of a T-type calcium channel antagonist to a subject in need of the treatment.
摘要翻译：本文提供治疗Angelman综合征和/或Prader-Willi综合征的方法，其包括将有效量的T型钙通道拮抗剂施用于需要治疗的受试者。 >

59. 发明申请

WO2016172545A1 CASTRATION-RESISTANT PROSTATE CANCER 审中-公开
标题翻译：耐药前列腺癌
公开(公告)号：WO2016172545A1
公开(公告)日：2016-10-27
申请号：PCT/US2016/028936
申请日：2016-04-22
申请人： NUTECH VENTURES , SIMPSON, Melanie, A. , BARYCKI, Joseph
发明人： SIMPSON, Melanie, A. , BARYCKI, Joseph
IPC分类号： C12Q1/32 , A61P13/08 , A61P35/00 , G01N33/574
CPC分类号： A61K33/24 , A61K31/075 , A61K31/09 , A61K31/122 , A61K31/136 , A61K31/145 , A61K31/165 , A61K31/17 , A61K31/192 , A61K31/198 , A61K31/277 , A61K31/282 , A61K31/305 , A61K31/341 , A61K31/352 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4045 , A61K31/409 , A61K31/41 , A61K31/415 , A61K31/416 , A61K31/4184 , A61K31/421 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/433 , A61K31/4365 , A61K31/444 , A61K31/47 , A61K31/4709 , A61K31/50 , A61K31/5025 , A61K31/519 , A61K31/5377 , A61K31/7034 , A61K45/06 , C12Q1/32
摘要： This invention relates to inhibitors of UDP-glucose dehydrogenase, and more particularly to UDP-glucose dehydrogenase inhibitors that are useful in the treatment of prostate cancer. Methods of inhibiting UDP-glucose dehydrogenase and improving the efficacy of additional prostate cancer therapies are also provided.
摘要翻译：本发明涉及UDP-葡萄糖脱氢酶的抑制剂，更具体地涉及可用于治疗前列腺癌的UDP-葡萄糖脱氢酶抑制剂。还提供了抑制UDP-葡萄糖脱氢酶并提高其他前列腺癌疗法的功效的方法。

60. 发明申请

WO2016168704A1 KSR ANTAGONISTS 审中-公开
公开(公告)号：WO2016168704A1
公开(公告)日：2016-10-20
申请号：PCT/US2016/027899
申请日：2016-04-15
申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
发明人： DAR, Arvin , DHAWAN, Neil , SCOPTON, Alex P.
IPC分类号： C07D239/94 , A61K31/517 , A61P35/00 , C07D239/86
CPC分类号： A61K31/517 , A61K31/519 , A61P35/00 , C07D239/74 , C07D239/88 , C07D239/93 , C07D239/94
摘要： This invention relates to antagonists of Kinase Suppressor of Ras (KSR). Pharmaceutical compositions comprising KSR inhibitors and methods of treating cancer are also provided.
摘要翻译：本发明涉及Ras（KSR）激酶抑制因子的拮抗剂。还提供了包含KSR抑制剂的药物组合物和治疗癌症的方法。

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