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51. 发明申请

WO2009100048A1 REGULATION OF FIBROBLASTIC GROWTH FACTOR-2 (FGF-2) GENE EXPRESSION IN LIVING CELLS WITH THE APPLICATION OF SPECIFIC AND SELECTIVE ELECTRIC AN ELECTROMAGNETIC FIELDS 审中-公开
标题翻译：使用特定电选电气领域调节生殖细胞中纤维生长因子-2（FGF-2）基因表达
公开(公告)号：WO2009100048A1
公开(公告)日：2009-08-13
申请号：PCT/US2009/032925
申请日：2009-02-03
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , BRIGHTON, Carl, T.
发明人： BRIGHTON, Carl, T.
IPC分类号： C12M3/00 , A61N1/00
CPC分类号： A61N1/326 , A61N1/40 , C12N13/00
摘要： Methods and devices are described for the regulation of Fibroblastic Growth Factor-2 mRNA and/or FGF-2 protein in bone cells and other tissues via capacitive coupling or inductive coupling of specific and selective electric and/or electromagnetic fields to the bone cells or other tissues, where the specific and selective fields are generated by application of -specific and selective signals to electrodes or one or more coils or other field generating device disposed with respect to the bone cells or other tissues so as to facilitate the treatment of diseased or injured bone and other tissues. By gene expression is meant the up-regulation or down-regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased bone and other tissue that include generating specific and selective signals that generate electric and/or electromagnetic fields in the target tissue optimized for increase of FGF-2 protein gene expression and exposing bone and other tissue to the fields generated by specific and selective signals so as to regulate FGF-2 protein gene expression in such tissue. The resulting methods and devices are useful for the targeted treatment of osteoporosis, osteopenia, osteonecrosis, fresh bone fractures, fractures at risk, nonunion, bone defects, spine fusion, and/or other conditions in which FGF-2 protein has been implicated.
摘要翻译：描述了用于通过电容耦合或特定和选择性电和/或电磁场对骨细胞或其他物质的电感耦合或调节骨细胞和其他组织中成纤维细胞生长因子-2mRNA和/或FGF-2蛋白的方法和装置组织，其中通过将特定和选择性信号施加到相对于骨细胞或其他组织设置的电极或一个或多个线圈或其它场发生装置来产生特定和选择性场，以便于治疗患病或受伤骨和其他组织。基因表达是指将基因组（DNA）的特定部分（基因）转录成mRNA并随后转化为蛋白质的过程的上调或下调。提供了用于靶向治疗受损或患病骨骼和其他组织的方法和装置，所述组织包括产生特异性和选择性信号，所述特异性和选择性信号在针对增加FGF-2蛋白基因表达和暴露骨骼的优化的靶组织中产生电和/或电磁场通过特异性和选择性信号产生的场的其他组织，从而调节这种组织中的FGF-2蛋白基因表达。所得到的方法和装置可用于骨质疏松症，骨质减少症，骨坏死，新鲜骨折，风险骨折，不愈合，骨缺损，脊柱融合和/或其中涉及FGF-2蛋白的其它病症的靶向治疗。

52. 发明申请

WO2009086043A3 PARTICLE ANALYSIS IN AN ACOUSTIC CYTOMETER 审中-公开
公开(公告)号：WO2009086043A3
公开(公告)日：2009-07-09
申请号：PCT/US2008/087579
申请日：2008-12-19
申请人： LOS ALAMOS NATIONAL SECURITY, LLC , KADUCHAK, Gregory , WARD, Michael, D.
发明人： KADUCHAK, Gregory , WARD, Michael, D.
IPC分类号： G01J3/00
摘要： Provided herein are methods for separating particles by size, the methods comprising: flowing particles in a flow stream; directing radial acoustic radiation pressure to the flow stream; and acoustically separating the particles by size. Devices for carrying out these methods are also disclosed.

53. 发明申请

WO2009048682A2 PLASMA DISCHARGE SELF-CLEANING FILTRATION SYSTEM 审中-公开
标题翻译：等离子体放电自清洁过滤系统
公开(公告)号：WO2009048682A2
公开(公告)日：2009-04-16
申请号：PCT/US2008/072502
申请日：2008-08-07
申请人： DREXEL UNIVERSITY , CHO, Young, I. , FRIDMAN, Alexander , GUTSOL, Alexander, F. , YANG, Yong
发明人： CHO, Young, I. , FRIDMAN, Alexander , GUTSOL, Alexander, F. , YANG, Yong
CPC分类号： B01D35/06 , B01D29/62 , B01D29/72
摘要： The present invention is directed to a novel method for cleaning a filter surface using a plasma discharge self-cleaning filtration system. The method involves utilizing plasma discharges to induce short electric pulses of nanoseconds duration at high voltages. These electrical pulses generate strong Shockwaves that disintegrate and dislodge particulate matter located on the surface of the filter.
摘要翻译：本发明涉及一种使用等离子体放电自清洁过滤系统清洁过滤器表面的新方法。该方法涉及利用等离子体放电在高电压下诱导纳秒持续时间的短电脉冲。这些电脉冲产生强烈的冲击波，分解和清除位于过滤器表面的颗粒物质。

54. 发明申请

WO2009045879A2 ELECTROCATALYSTS FOR FUEL CELLS 审中-公开
标题翻译：燃料电池电磁炉
公开(公告)号：WO2009045879A2
公开(公告)日：2009-04-09
申请号：PCT/US2008/077804
申请日：2008-09-26
申请人： DREXEL UNIVERSITY , ELABD, Youssef, A. , GOGOTSI, Yury , EIRICH, Benjamin , SHAY, Daniel
发明人： ELABD, Youssef, A. , GOGOTSI, Yury , EIRICH, Benjamin , SHAY, Daniel
IPC分类号： B01J23/42
CPC分类号： H01M4/9083 , H01M4/8828 , H01M4/8842 , H01M4/92 , H01M4/926 , Y10T428/2982
摘要： Disclosed are metallized carbonaceous materials, processes for forming such materials, and electrodes and fuel cells comprising the disclosed materials.
摘要翻译：公开了金属化碳质材料，用于形成这种材料的方法，以及包括所公开的材料的电极和燃料电池。

55. 发明申请

WO2009045436A1 VEHICULAR TRANSMISSION PARTS 审中-公开
标题翻译：车辆传动部件
公开(公告)号：WO2009045436A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011363
申请日：2008-10-01
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , MORPH TECHNOLOGIES, INC. , ELIA, Andri, E. , DAY, Michael, R. , MCCREA, Jonathan , STEED, Glenn , WANG, Andrew
发明人： ELIA, Andri, E. , DAY, Michael, R. , MCCREA, Jonathan , STEED, Glenn , WANG, Andrew
IPC分类号： F16H55/06
CPC分类号： F16H55/06 , Y10T74/19 , Y10T74/1987 , Y10T74/20 , Y10T74/2186 , Y10T428/12569 , Y10T428/12882 , Y10T428/1355 , Y10T428/24942 , Y10T428/269 , Y10T428/31678 , Y10T428/31681
摘要： Metal coated organic polymer compositions are useful as vehicular transmission parts. Such parts may have lighter weight, and/or superior corrosion resistance, and/or be more easily fabricated than similar conventional transmission parts.
摘要翻译：金属涂覆的有机聚合物组合物可用作车辆传动部件。与类似的常规传动部件相比，这样的部件可以具有更轻的重量和/或优异的耐腐蚀性，和/或更容易制造。

56. 发明申请

WO2009045425A8 VEHICULAR OIL PANS 审中-公开
公开(公告)号：WO2009045425A8
公开(公告)日：2009-04-09
申请号：PCT/US2008/011351
申请日：2008-10-01
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , MORPH TECHNOLOGIES INC. , ELIA, Andri, E. , DAY, Michael, R. , STEED, Glenn , ESPEY, Robert , McCREA, Jonathan
发明人： ELIA, Andri, E. , DAY, Michael, R. , STEED, Glenn , ESPEY, Robert , McCREA, Jonathan
IPC分类号： B65D90/04
摘要： Metal plated organic polymer compositions are useful as vehicular engine oil pans. Such oil pans may have lighter weight, and/or superior corrosion resistance, than conventional metal oil pans.

57. 发明申请

WO2009038824A1 CURRENT/VOLTAGE MODE IMAGE SENSOR WITH SWITCHLESS ACTIVE PIXELS 审中-公开
标题翻译：具有可切换主动像素的电流/电压模式图像传感器
公开(公告)号：WO2009038824A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/064699
申请日：2008-05-23
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , GRUEV, Viktor , YANG, Zheng , VAN DER SPIEGEL, Jan
发明人： GRUEV, Viktor , YANG, Zheng , VAN DER SPIEGEL, Jan
IPC分类号： H04N5/335
CPC分类号： H04N5/37457 , H04N5/3658 , H04N5/3741 , H04N5/378
摘要： A voltage and current mode active pixel sensor for high resolution imaging is presented. The photo pixel is composed of a photodiode and two transistors: reset and transconductance amplifier transistor. The switch transistor is moved outside the pixel, allowing for lower pixel pitch and increased linearity of the output photocurrent. The reset and amplifier (readout) transistors may also be shared among adjacent pixels by the introduction of transfer switches between the photodiodes and the source of the reset transistor and the gate of the readout transistor. The switch transistor outside the pixels provides biasing voltages or currents to the readout transistors to selectively turn them on when readout of the corresponding photodiode is desired and turns the readout transistor off when the corresponding photodiode is not to be read out.
摘要翻译：提出了一种用于高分辨率成像的电压和电流模式有源像素传感器。照片像素由光电二极管和两个晶体管组成：复位和跨导放大晶体管。开关晶体管移动到像素外部，允许较低的像素间距和增加的输出光电流的线性度。复位和放大器（读出）晶体管也可以通过在光电二极管与复位晶体管的源极和读出晶体管的栅极之间引入转换开关而在相邻像素之间共享。像素外部的开关晶体管向读出晶体管提供偏置电压或电流，以在需要读出相应的光电二极管时选择性地将其导通，并且当不读出对应的光电二极管时，使读出晶体管截止。

58. 发明申请

WO2009012435A1 CONFORMATIONAL ENTROPY IN MOLECULAR RECOGNITION 审中-公开
标题翻译：分子识别中的一致性熵
公开(公告)号：WO2009012435A1
公开(公告)日：2009-01-22
申请号：PCT/US2008/070436
申请日：2008-07-18
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , VALENTINE, Kathleen, G. , MARLOW, Michael , WAND, Andrew, J. , FREDERICK, Kendra, K.
发明人： VALENTINE, Kathleen, G. , MARLOW, Michael , WAND, Andrew, J. , FREDERICK, Kendra, K.
IPC分类号： G06F19/00 , G01N33/48
CPC分类号： G01N33/6803 , G01N24/088 , G01R33/465 , G06F19/16 , G06F19/18
摘要： The present invention provides methods for the determination of the degree of molecular recognition of a protein with a ligand, including a first protein with a second protein. The methods may comprise determining the squared generalized order parameter (hereinafter, O ) for at least one intramolecular bond of the first protein. The protein is then formed into a complex with a ligand. The value or values of O2 for the said at least one bond of the protein is then determined while the protein and the ligand are in the complex. The O value or values determined for the protein while the protein and the ligand are in a complex are compared or related to the O value or values determined for the uncomplexed protein.
摘要翻译：本发明提供了用配体（包括具有第二种蛋白质的第一种蛋白质）测定蛋白质的分子程度的方法。所述方法可以包括确定第一蛋白质的至少一个分子内键的平方广义序参数（以下称为O）。然后将蛋白质与配体形成复合物。然后在蛋白质和配体在复合物中时确定蛋白质的所述至少一个键的O 2的值或值。将蛋白质和配体在复合物中确定的O值或值与对于未复合蛋白质确定的O值或值进行比较或相关。

59. 发明申请

WO2009006184A1 DISCODERMOLIDE ANALOGUES AND METHODS OF THEIR USE 审中-公开
标题翻译：异恶草酮类似物及其使用方法
公开(公告)号：WO2009006184A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/068288
申请日：2008-06-26
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , KOSAN BIOSCIENCES, INC. , SMITH, Amos, B. , SHAW, Simon, J. , MYLES, David, C.
发明人： SMITH, Amos, B. , SHAW, Simon, J. , MYLES, David, C.
IPC分类号： A01N43/42 , A61K31/47
CPC分类号： C07D311/16 , C07D215/227 , C07D265/36
摘要： 6- and 7-substituted coumarin and related 6- and 7-substituted l H -quinolin-2-one compounds, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the 7-substituted coumarin and related 7-substituted l H -quinolin-2-one compounds mimic or exceed the high level of pharmacological activity of discodermolide. In other embodiments, their preparation involves more readily available materials, higher yield processes and/or simpler synthetic sequences. In yet other embodiments, the compounds of the invention represent structurally simpler, therapeutically active analogues of discodermolide than heretofore known and may be useful as microtubule stabilizers and, inter alia , for treating and/or preventing cancer and other diseases, disorders, and/or conditions mediated by the stabilization of microtubules.
摘要翻译： 6-和7-取代的香豆素及相关的6-和7-取代的1H-喹啉-2-酮化合物，含有这些化合物的药物组合物及其药物用途的方法。在某些实施方案中，7-取代的香豆素和相关的7-取代的1H-喹啉-2-酮化合物模拟或超过discodermolide的高水平的药理活性。在其他实施方案中，它们的制备涉及更容易获得的材料，更高的产率过程和/或更简单的合成序列。在其它实施方案中，本发明的化合物表示比迄今已知的结构上更简单的治疗活性的discodermolide类似物，并且可用作微管稳定剂，尤其用于治疗和/或预防癌症和其它疾病，障碍和/或由微管稳定介导的病症。

60. 发明申请

WO2009002866A1 FLUORESCENT LABELING OF TRANSFER RNA AND STUDY OF PROTEIN SYNTHESIS 审中-公开
标题翻译：转染RNA的荧光标记和蛋白质合成研究
公开(公告)号：WO2009002866A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/067735
申请日：2008-06-20
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , COOPERMAN, Barry, S. , SMILANSKY, Zeev , GOLDMAN, Yale, E. , PAN, Dongli
发明人： COOPERMAN, Barry, S. , SMILANSKY, Zeev , GOLDMAN, Yale, E. , PAN, Dongli
IPC分类号： C07H21/02 , C12P19/34
CPC分类号： G01N33/582 , C12P19/34 , C12P21/02 , C12Q1/6806 , G01N33/5308 , G01N33/6803
摘要： Provided are methods for labeling transfer RNA comprising replacing the uracil component of a dihydrouridine of said transfer RNA with a fluorophore. The disclosed methods may comprise fluorescent labeling of natural tRNAs (i.e., tRNAs that have been synthesized in a cell, for example, in a bacterium, a yeast cell, or a vertebrate cell) at dihydrouridine (D) positions, or fluorescent labeling of synthetic tRNAs. In another aspect, the present invention provides methods for assessing protein synthesis in a translation system comprise providing a tRNA having a fluorophore substitution for the uracil component of a dihydrouridine in a D loop of the tRNA; introducing the labeled tRNA into the translation system; irradiating the translation system with electromagnetic radiation, thereby generating a fluorescence signal from the fluorophore; detecting the fluorescence signal; and, correlating the fluorescence signal to one or more characteristics of the protein synthesis in the translation system. The disclosed methods are useful in single molecule as well as in ensemble settings.
摘要翻译：提供用于标记转移RNA的方法，包括用荧光团替代所述转移RNA的二氢尿苷的尿嘧啶组分。所公开的方法可以包括在二氢尿苷（D）位置处天然tRNA（即在细胞中例如细菌，酵母细胞或脊椎动物细胞中合成的tRNA）的荧光标记，或合成的荧光标记 tRNA的。另一方面，本发明提供了用于评估翻译系统中的蛋白质合成的方法，包括在tRNA的D环中提供具有二氢尿苷的尿嘧啶组分的荧光团取代的tRNA; 将标记的tRNA引入翻译系统; 用电磁辐射照射翻译系统，从而产生来自荧光团的荧光信号; 检测荧光信号; 并将荧光信号与翻译系统中蛋白质合成的一个或多个特征相关联。所公开的方法在单分子以及整体设置中是有用的。

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