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41. 发明申请

WO2011022656A2 RECOMBINANT AVIAN PARAMYXOVIRUS VACCINE AND METHOD FOR MAKING AND USING THEREOF 审中-公开
标题翻译：重组禽类副粘病毒疫苗及其制备和使用方法
公开(公告)号：WO2011022656A2
公开(公告)日：2011-02-24
申请号：PCT/US2010046179
申请日：2010-08-20
申请人： MERIAL LTD , UNIV GEORGIA , BUBLOT MICHEL , MEBATSION TESHOME , PRITCHARD JOYCE , MUNDT EGBERT
发明人： BUBLOT MICHEL , MEBATSION TESHOME , PRITCHARD JOYCE , MUNDT EGBERT
IPC分类号： A61K39/155
CPC分类号： C12N7/00 , A61K39/00 , A61K39/12 , A61K39/155 , A61K2039/525 , A61K2039/5256 , A61K2039/545 , A61K2039/552 , C07K14/005 , C12N15/86 , C12N2760/16134 , C12N2760/18121 , C12N2760/18122 , C12N2760/18134 , C12N2760/18143 , C12N2760/18152 , C12N2999/007
摘要： The present invention encompasses engineered APMV compositions or vaccines. The vaccine or composition may be a recombinant APMV composition or vaccine. The present invention encompasses methods for modifying the genome of APMV to produce recombinant APMV; modified APMV prepared by such methods; DNA and protein sequences; and methods for infecting cells and host animals with such recombinant APMV.
摘要翻译：本发明包括工程APMV组合物或疫苗。疫苗或组合物可以是重组APMV组合物或疫苗。本发明包括修饰APMV的基因组以产生重组APMV的方法; 通过这些方法制备的修饰的APMV; DNA和蛋白质序列; 以及用这种重组APMV感染细胞和宿主动物的方法。

42. 发明申请

WO2010087927A2 ANTIBODIES AGAINST AND METHODS FOR PRODUCING VACCINES FOR RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：抗生素抗生素和生产呼吸道感染病毒疫苗的方法
公开(公告)号：WO2010087927A2
公开(公告)日：2010-08-05
申请号：PCT/US2009/069406
申请日：2009-12-23
申请人： MEDIMMUNE, LLC , MCAULIFFE, Josephine , PALMER-HILL, Frances , ZHU, Qing , SUZICH, Joann
发明人： MCAULIFFE, Josephine , PALMER-HILL, Frances , ZHU, Qing , SUZICH, Joann
IPC分类号： A61K39/155
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C12N7/00 , C12N2760/18522 , C12N2760/18534 , C12N2760/18551 , G01N33/6854

43. 发明申请

WO2010009277A3 IMMUNOGENIC AMPHIPATHIC PEPTIDE COMPOSITIONS 审中-公开
标题翻译：免疫抑制肽组成
公开(公告)号：WO2010009277A3
公开(公告)日：2010-07-22
申请号：PCT/US2009050764
申请日：2009-07-15
申请人： NOVARTIS AG , O'HAGAN DEREK T , GEALL ANDREW , DORMITZER PHILIP
发明人： O'HAGAN DEREK T , GEALL ANDREW , DORMITZER PHILIP
IPC分类号： A61K9/127 , A61K31/16 , A61K39/145 , A61K39/155 , A61K39/385 , A61K39/39
CPC分类号： C07K14/005 , A61K9/1272 , A61K9/1275 , A61K39/00 , A61K39/12 , A61K39/145 , A61K39/155 , A61K2039/55516 , A61K2039/55555 , A61K2039/64 , C07K2319/03 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , C12N2760/18522
摘要： The present application pertains to a composition, comprising (a) amphipathic peptides; (b) lipids and (c) at least one immunogenic species. Respective compositions are suitable for immunogenic species transport and delivery, for example for systemic or local delivery to a mammal. Also provided are pharmaceutical compositions, comprising respective compositions. Methods of forming the foregoing are also provided.
摘要翻译：本申请涉及组合物，其包含（a）两亲肽; （b）脂质和（c）至少一种免疫原性物质。各种组合物适用于免疫原性物质的运输和递送，例如用于向哺乳动物全身或局部递送。还提供了包含相应组合物的药物组合物。还提供了形成前述的方法。

44. 发明申请

WO2010075491A3 RECOMBINANT EXPRESSION OF SELF-FOLDING NEUTRALIZING EPITOPE-BEARING SUBDOMAINS OF THE RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT AND FUSION PROTEINS 审中-公开
公开(公告)号：WO2010075491A3
公开(公告)日：2010-07-01
申请号：PCT/US2009/069364
申请日：2009-12-23
申请人： UNIVERSITY OF ROCHESTER , MURATA, Yoshihiko , WALSH, Edward, E.
发明人： MURATA, Yoshihiko , WALSH, Edward, E.
IPC分类号： A61K39/155 , A61K39/12
摘要： The present invention is directed to self-folding, soluble, stable RSV G and F polypeptides that contain a neutralizing epitope. Fusion proteins and immunogenic conjugates containing the RSV G and F polypeptides, along with recombinant transgenes and vectors, and host cells suitable for expression of such genetic constructs are also disclosed. Use of the RSV G and F polypeptides, fusion proteins, immunogenic conjugates, or a pharmaceutical composition containing the same, is contemplated for inducing a protective immune response against RSV.

45. 发明申请

WO2010048572A1 A NOVEL ANTI-VIRAL METHOD 审中-公开
标题翻译：一种新的反虚方法
公开(公告)号：WO2010048572A1
公开(公告)日：2010-04-29
申请号：PCT/US2009/061940
申请日：2009-10-23
申请人： CORNELL UNIVERSITY , MOSCONA, Anne , POROTTO, Matteo , LAVAN, David , YI, Feng
发明人： MOSCONA, Anne , POROTTO, Matteo , LAVAN, David , YI, Feng
IPC分类号： C12N7/04 , A61K39/155
CPC分类号： C12N7/00 , C12N2760/18261
摘要： The invention provides a method of reducing viral infectivity in a sample compnsing contacting the sample with a earner matrix wherein lipids are attached to the carrier matrix, and wherein at least one virus-specific agent is attached to the lipids The virus-specific agent is capable of binding to at least one viral component The virus specific agent may be a receptor The earner matrix may be a silica particle, which may be coated with a lipid bilayer The invention further provides a method of inactivating a virus comprising contacting the virus with a earner matrix wherein lipids are attached to the earner matrix, and wherein at least one receptor is attached to the lipids, binding the receptor to at least one viral receptor-binding protein, and activating at least one viral fusion protein, wherein activation inactivates the virus, and releases the virus from the earner matrix
摘要翻译：本发明提供了一种降低样品中病毒感染性的方法，其使样品与载体基质接触，其中脂质连接到载体基质上，并且其中至少一种病毒特异性试剂连接至脂质。病毒特异性试剂是能够与至少一种病毒组分结合病毒特异性试剂可以是受体。载体基质可以是可以用脂质双层包被的二氧化硅颗粒。本发明进一步提供灭活病毒的方法，包括使病毒与载体接触基质，其中脂质连接到载体基质上，并且其中至少一种受体连接到脂质上，将受体结合至至少一种病毒受体结合蛋白，以及激活至少一种病毒融合蛋白，其中活化使病毒失活，并从载体矩阵中释放病毒

46. 发明申请

WO2010039224A2 RESPIRATORY SYNCYTIAL VIRUS (RSV) SEQUENCES FOR PROTEIN EXPRESSION AND VACCINES 审中-公开
标题翻译：呼吸道合胞病毒（RSV）序列蛋白表达和疫苗
公开(公告)号：WO2010039224A2
公开(公告)日：2010-04-08
申请号：PCT/US2009005383
申请日：2009-09-30
申请人： UNIV MASSACHUSETTS MEDICAL , MORRISON TRUDY G
发明人： MORRISON TRUDY G
IPC分类号： C07K14/135 , A61K39/155 , C07K19/00 , C12N15/45 , C12N15/62 , G01N33/569
CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C12N7/00 , C12N2760/18122 , C12N2760/18522 , C12N2760/18523 , C12N2760/18534 , G01N2333/135
摘要： The invention provides RSV fusion (F) protein ectodomain polypeptide sequences and nucleotide sequences encoding them, as well as cells containing the invention's polypeptide and nucleotide sequences. The invention further provides VLPs that contain the invention's polypeptides, and methods for using the VLPs for protein expression and vaccine formulation. Also provided are methods for distinguishing between subjects immunized with the invention's compositions and subjects infected with RSV.
摘要翻译：本发明提供了RSV融合（F）蛋白胞外域多肽序列和编码它们的核苷酸序列，以及含有本发明的多肽和核苷酸序列的细胞。本发明进一步提供了含有本发明多肽的VLP，以及使用VLP进行蛋白质表达和疫苗制剂的方法。还提供了用于区分用本发明的组合物免疫的受试者和感染RSV的受试者的方法。

47. 发明申请

WO2009079796A1 RECOMBINANT RSV ANTIGENS 审中-公开
标题翻译：重组RSV抗原
公开(公告)号：WO2009079796A1
公开(公告)日：2009-07-02
申请号：PCT/CA2008/002277
申请日：2008-12-23
申请人： ID BIOMEDICAL CORPORATION OF QUEBEC , GlaxoSmithKline Biologicals s.a. , BAUDOUX, Jean-Pierre , BLAIS, Normand , RHEAULT, Patrick , RUELLE, Jean-Louis
发明人： BAUDOUX, Jean-Pierre , BLAIS, Normand , RHEAULT, Patrick , RUELLE, Jean-Louis
IPC分类号： C07K19/00 , A61K39/00 , A61K39/155 , A61K39/295 , A61K9/107 , A61K9/127 , A61P31/14 , A61P37/04 , C07K14/135 , C12N15/45 , C12N15/62
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/55505 , A61K2039/55572 , A61K2039/55577 , C07K16/1027 , C07K2317/21 , C07K2317/76 , C07K2319/73 , C12N2760/18522 , C12N2760/18534 , Y02A50/466
摘要： This disclosure provides recombinant respiratory syncytial virus (RSV) antigens and methods for making and using them, including immunogenic compositions ( e.g ., vaccines) for the treatment and/or prevention of RSV infection.
摘要翻译：本公开提供重组呼吸道合胞病毒（RSV）抗原及其制备和使用它们的方法，包括用于治疗和/或预防RSV感染的免疫原性组合物（例如疫苗）。

48. 发明申请

WO2008133663A3 CODON MODIFIED IMMUNOGENIC COMPOSITIONS AND METHODS OF USE 审中-公开
标题翻译：密码子修饰的免疫原性组合物和使用方法
公开(公告)号：WO2008133663A3
公开(公告)日：2009-03-19
申请号：PCT/US2007024625
申请日：2007-11-30
申请人： US GOV HEALTH & HUMAN SERV , GRAHAM BARNEY S , JOHNSON TERESA
发明人： GRAHAM BARNEY S , JOHNSON TERESA
IPC分类号： A61K39/155 , C12N15/09 , C12N15/45 , C12N15/86
CPC分类号： C07K14/005 , A61K39/12 , A61K39/155 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C12N2710/10343 , C12N2710/24143 , C12N2760/18522 , C12N2760/18534 , C12N2770/36143
摘要： The present invention features immunogenic compositions comprising codon modified genes that encode viral proteins and/or glycoproteins or fragments. The immunogenic compositions of the invention are useful in various methods of treatment, such as preventing or treating viral infection. Also provided in the present invention are kits and instructions for use.
摘要翻译：本发明的特征在于包含编码病毒蛋白和/或糖蛋白或片段的密码子修饰的基因的免疫原性组合物。本发明的免疫原性组合物可用于各种治疗方法，例如预防或治疗病毒感染。本发明还提供了试剂盒和使用说明书。

49. 发明申请

WO2008084294A3 METHODS OF VACCINE ADMINISTRATION 审中-公开
标题翻译：疫苗管理方法
公开(公告)号：WO2008084294A3
公开(公告)日：2008-12-31
申请号：PCT/IB2007003666
申请日：2007-11-23
申请人： PFIZER PROD INC , TUCKER CASSIUS MCALLISTER , HAWORTH JOHN DAVID
发明人： TUCKER CASSIUS MCALLISTER , HAWORTH JOHN DAVID
IPC分类号： A61K39/02 , A61K39/10 , A61K39/12 , A61K39/155 , A61K39/175 , A61K39/23 , A61K39/295
CPC分类号： A61K39/235 , A61K39/00 , A61K39/0225 , A61K39/099 , A61K39/12 , A61K39/155 , A61K39/175 , A61K39/23 , A61K2039/525 , A61K2039/5254 , A61K2039/542 , A61K2039/545 , A61K2039/552 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/10034 , C12N2710/10071 , C12N2710/10334 , C12N2750/14034 , C12N2750/14071 , C12N2750/14334 , C12N2760/18034 , C12N2760/18071 , C12N2760/18434 , C12N2760/18471 , C12N2770/20022
摘要： This invention relates to a method of treating a dog for canine diseases comprising administering to the dog therapeutically effective amounts of a vaccine, wherein the vaccine comprises viral antigens, a bacterin, or both, and wherein the vaccine is administered subcutaneously or orally according to the schedules provided herein.
摘要翻译：本发明涉及一种治疗狗疾病的方法，其包括给狗施用治疗有效量的疫苗，其中该疫苗包含病毒抗原，菌苗或两者，并且其中该疫苗根据本发明的皮下或口服施用在此提供的时间表。

50. 发明申请

WO2008148170A1 HUMAN METAPNEUMOVIRUS IMMUNOGENIC PEPTIDES, COMPOSITIONS, AND METHODS OF USE 审中-公开
标题翻译：人类METATNEUMOVIRUS免疫球蛋白，组合物和使用方法
公开(公告)号：WO2008148170A1
公开(公告)日：2008-12-11
申请号：PCT/AU2008/000821
申请日：2008-06-06
申请人： THE UNIVERSITY OF QUEENSLAND , TINDLE, Robert
发明人： TINDLE, Robert
IPC分类号： C07K4/02 , C07K7/06 , C12N15/45 , C12N15/62 , A61K38/08 , A61K38/16 , A61K39/155 , A61K39/295 , A61P31/14 , C07K16/10
CPC分类号： A61K39/155 , A61K39/12 , A61K39/385 , C07K14/005 , C07K2319/735 , C12N2730/10122 , C12N2760/18322 , C12N2760/18334 , C12N2760/18522 , C12N2760/18622 , G01N2333/115 , G01N2333/135
摘要： Isolated immunogenic peptides of eight to ten contiguous amino acids of a hMPV protein and a variants thereof are provided herein. Typically, the isolated immunogenic peptides are T cell epitopes. Also provided are isolated proteins comprising at least one of the isolated immunogenic peptides of the invention for example, a chimeric protein comprising an amino acid sequence of an isolated immunogenic peptide and an amino sequence derived from an heterologous protein. Also provided are expression constructs, VLPs, compositions, vaccines and methods of treatment that may be useful in the prophylactic and/or therapeutic treatment of hMPV-associated diseases, disorders or conditions.
摘要翻译：本文提供了hMPV蛋白的8至10个连续氨基酸及其变体的分离的免疫原性肽。通常，分离的免疫原性肽是T细胞表位。还提供了分离的蛋白质，其包含本发明的分离的免疫原性肽中的至少一种，例如包含分离的免疫原性肽的氨基酸序列和源自异源蛋白质的氨基序列的嵌合蛋白。还提供了可用于预防和/或治疗与hMPV相关的疾病，病症或病症的治疗的表达构建体，VLP，组合物，疫苗和治疗方法。

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