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41. 发明申请

WO2011163423A2 METHODS AND COMPOSITIONS FOR CELL PERMEABLE STAT3 INHIBITOR 审中-公开
标题翻译：细胞渗透性STAT3抑制剂的方法和组合物
公开(公告)号：WO2011163423A2
公开(公告)日：2011-12-29
申请号：PCT/US2011/041537
申请日：2011-06-22
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , TURKSON, James
发明人： TURKSON, James
IPC分类号： G01N33/574
CPC分类号： C07K14/435 , A61K38/00 , A61K2039/505 , C07K14/4703 , C07K14/4705 , C07K16/18 , C07K16/3015 , G01N33/564 , G01N33/574 , G01N33/6893 , G01N2800/24 , G01N2800/44 , G01N2800/56
摘要： Disclosed herein are compositions for inhibition of Stat, particularly Stat3. Disclosed herein are compositions comprising cell permeable Stat3 inhibitors. Compositions may comprise peptides, polypeptides, antibodies, nucleic acids, vectors, and host cells for making, using, assaying, and evaluating Stat3 inhibitors. Disclosed herein are methods for making and using the disclosed compositions.
摘要翻译：本文公开了抑制Stat的组合物，特别是Stat3。本文公开了包含细胞渗透性Stat3抑制剂的组合物。组合物可以包括肽，多肽，抗体，核酸，载体和用于制备，使用，测定和评价Stat3抑制剂的宿主细胞。本文公开了制备和使用所公开的组合物的方法。

42. 发明申请

WO2011109746A2 CONTROLLERS FOR BATTERY CHARGERS AND BATTERY CHARGERS THEREFROM 审中-公开
标题翻译：电池充电器的控制器和电池充电器
公开(公告)号：WO2011109746A2
公开(公告)日：2011-09-09
申请号：PCT/US2011/027257
申请日：2011-03-04
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , ADVANCED POWER ELECTRONICS CORPORATION (APECOR CORP.) , ELMES, John , KERSTEN, Rene , PEPPER, Michael
发明人： ELMES, John , KERSTEN, Rene , PEPPER, Michael
CPC分类号： H02J7/022 , H02J7/0072 , H02J7/0091 , H02J7/0093 , H02J7/35 , H02J2007/0059 , Y02E10/58
摘要： A controller for a battery charger that includes a power converter has parametric sensors for providing a sensed Vin signal, a sensed Vout signal and a sensed lout signal. A battery current regulator (BCR) is coupled to receive the sensed lout signal and an lout reference, and outputs a first duty cycle control signal. An input voltage regulator (IVR) receives the sensed Vin signal and a Vin reference. The IVR provides a second duty cycle control signal. A processor receives the sensed lout signal and utilizes a Maximum Power Point Tracking (MPPT) algorithm, and provides the Vin reference to the IVR. A selection block forwards one of the first and second duty cycle control signals as a duty cycle control signal to the power converter. Dynamic switching between the first and second duty cycle control signals maximizes the power delivered to the battery.
摘要翻译：用于包括电力转换器的电池充电器的控制器具有用于提供感测的Vin信号，感测的Vout信号和感测的Iout信号的参数传感器。电池电流调节器（BCR）被耦合以接收感测的Iout信号和Iout参考，并且输出第一占空比控制信号。输入电压调节器（IVR）接收感测的Vin信号和Vin参考。 IVR提供第二个占空比控制信号。处理器接收检测到的Iout信号并利用最大功率点跟踪（MPPT）算法，并将IV参考值提供给IVR。选择块将第一和第二占空比控制信号中的一个作为占空比控制信号转发给功率转换器。第一和第二工作循环控制信号之间的动态切换使传送给电池的功率最大化。

43. 发明申请

WO2010117438A2 COMPOUNDS THAT SUPPRESS CANCER CELLS AND EXHIBIT ANTITUMOR ACTIVITY 审中-公开
标题翻译：抑制癌细胞和展示抗肿瘤活性的化合物
公开(公告)号：WO2010117438A2
公开(公告)日：2010-10-14
申请号：PCT/US2010/001021
申请日：2010-04-05
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , UNIVERSITY OF TORONTO MISSISSAUGA , TURKSON, James , GUNNING, Patrick
发明人： TURKSON, James , GUNNING, Patrick
IPC分类号： C07D211/14
CPC分类号： A61K31/451 , A61K31/196 , C07C311/19 , C07C2601/14 , C07D211/26
摘要： The present invention provides compounds S3I-201.1066 (Formula 1) and S3I-201.2096 (Formula 2) as selective Stat3 binding agents that block Stat3 association with cognate receptor pTyr motifs, Stat3 phosphorylation and nuclear translocation, Stat3 transcriptional function, and consequently induced Stat3-specific antitumor cell effects in vitr o and antitumor response in vivo .
摘要翻译：本发明提供了作为选择性Stat3结合剂的化合物S3I-201.1066（式1）和S3I-201.2096（式2），其阻断Stat3与同源受体pTyr基序，Stat3磷酸化和核易位Stat3转录功能的关联，并因此诱导Stat3- 体外特异性抗肿瘤细胞效应和体内抗肿瘤反应。

44. 发明申请

WO2008070697A4 STAT3 INHIBITOR HAVING ANTI-CANCER ACTIVITY AND ASSOCIATED METHODS 审中-公开
公开(公告)号：WO2008070697A4
公开(公告)日：2008-06-12
申请号：PCT/US2007/086453
申请日：2007-12-05
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , TURKSON, James , HAMILTON, Andrew, D. , JOVE, Richard , SEBTI, Said, M.
发明人： TURKSON, James , HAMILTON, Andrew, D. , JOVE, Richard , SEBTI, Said, M.
IPC分类号： A61K31/535 , C07D211/00
摘要： A small-molecule Stat3 dimerization inhibitor, S3I-M2001. is described and the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 chemical probe inhibitor are elucidated. S3I-M2001 is a newly-identified oxazole-based peptidomimetic of the Stat3 Src Homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently-activated Stat3 were inhibited by S3I-M2001. S3I-M2001 inhibited Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL. The disclosed compound is useful as a new potential treatment for certain cancers.

45. 发明申请

WO2007053182A2 PLANT PRODUCED VACCINE FOR AMEBIASIS 审中-公开
标题翻译：植物生产AMEBIASIS的疫苗
公开(公告)号：WO2007053182A2
公开(公告)日：2007-05-10
申请号：PCT/US2006/021020
申请日：2006-05-30
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , DANIELL, Henry
发明人： DANIELL, Henry
IPC分类号： A01H1/00
CPC分类号： A61K39/002 , A01H5/10 , A01H5/12 , A61K2039/517 , C07K14/44 , C12N15/8214 , C12N15/8258 , C12N15/8281 , C12N15/8282 , Y02A50/486 , Y02A50/487
摘要： Disclosed herein are methods of making a vaccine against Entamoeba histolytica and methods of immunizing a subject using such vaccine. Specifically exemplified are plants expressing a LecA polypeptide and plant material obtained from such plant being used as a basis for vaccination.
摘要翻译：本文公开了制备针对溶组织内阿米巴的疫苗的方法和使用这种疫苗免疫受试者的方法。具体举例说明的是表达LecA多肽的植物和从这种植物获得的植物材料被用作疫苗接种的基础。

46. 发明申请

WO2006118954A2 INHIBITION OF REACTIVE OXYGEN SPECIES AND PROTECTION OF MAMMALIAN CELLS 审中-公开
标题翻译：对活性氧物质的抑制作用及其保护作用
公开(公告)号：WO2006118954A2
公开(公告)日：2006-11-09
申请号：PCT/US2006/016050
申请日：2006-04-27
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , UNIVERSITY OF OKLAHOMA, CORP.
发明人： SEAL, Sudipta
IPC分类号： A61K33/24
CPC分类号： A61K33/24
摘要： Methods and compositions useful for neuronal protection in retinal cells in vitro and the protection of mammalian cells from reactive oxygen species in vivo are provided. UltrafÊne nano-size cerium oxide particles, less than 10 nanometers in diameter, have been provided to decrease reactive oxygen species (ROS) in retina tissue that generates large amounts of ROS. These reactive oxygen species (ROS) are involved in light- induced retina degeneration and age-related macular degeneration (AMD). Cerium oxide nanoparticles have been used to promote the lifespan of retinal neurons and protect the neurons from apoptosis induced by hydrogen peroxide in vitro and in vivo. The neuronal protection in retinal cells is achieved by decreasing generation of intracellular reactive oxygen species (ROS). Thus, cerium oxide particles are used to promote the longevity of retinal neurons in vitro and mammalian cells in vivo.
摘要翻译：提供了可用于体外视网膜细胞中神经元保护的方法和组合，并且在体内保护哺乳动物细胞免受活性氧的影响。已经提供了直径小于10纳米的超细纳米尺寸氧化铈颗粒，以减少产生大量ROS的视网膜组织中的活性氧（ROS）。这些活性氧（ROS）参与光诱导的视网膜变性和年龄相关性黄斑变性（AMD）。已经使用氧化铈纳米粒子来促进视网膜神经元的寿命，并保护神经元免受体外和体内过氧化氢诱导的细胞凋亡。通过减少细胞内活性氧（ROS）的产生来实现视网膜细胞中的神经元保护。因此，氧化铈颗粒用于体外促进视网膜神经元在体外和哺乳动物细胞的寿命。

47. 发明申请

WO2022187744A1 CHAPERONIN-CONTAINING TCP-1 INHIBITORS FOR THE TREATMENT OF CANCER 审中-公开
公开(公告)号：WO2022187744A1
公开(公告)日：2022-09-09
申请号：PCT/US2022/019165
申请日：2022-03-07
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： KHALED, Annette
IPC分类号： A61K38/10 , A61P35/00 , C07K7/08 , C12Q1/6886
摘要： Disclosed herein are compositions and uses thereof for treating cancers.

48. 发明申请

WO2022184062A1 OPTICAL DISPLAY SYSTEM AND ELECTRONICS APPARATUS 审中-公开
公开(公告)号：WO2022184062A1
公开(公告)日：2022-09-09
申请号：PCT/CN2022/078657
申请日：2022-03-01
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. , GOERTEK INC.
发明人： YIN, Kun , HE, Ziqian , WU, Shin-Tson , LI, Kun
IPC分类号： G09G3/00
摘要： An optical display system and an electronics apparatus are disclosed. The optical display system comprises: a display unit, which generate a first image light and a second image light, wherein the first image light is in a first polarization state and the second image light is in a second polarization state and the first image light and the second image light are generated by a same display panel; a resolution enhancement optic unit, which enhances the resolution of the first image light with respect to the second image light; and a magnifying optic unit, which magnify the first and second image lights from the resolution enhancement optic unit.

49. 发明申请

WO2022177570A1 HYBRID ANALOG AND DIGITAL COMPUTATIONAL SYSTEM 审中-公开
公开(公告)号：WO2022177570A1
公开(公告)日：2022-08-25
申请号：PCT/US2021/018709
申请日：2021-02-19
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： PANG, Shuo , LI, Guifang , ZHU, Zheyuan
IPC分类号： G01B11/30 , G06F7/38 , H04L9/00
摘要： A hybrid analog and digital computational system is created by receiving equations in which a set of solution values is unknown. A residual iterative algorithm is implemented to solve the set of solution values for the equations. The residual iterative algorithm includes an outer update loop computed using a digital computing device with a set of residue values initially set to a first initial value and a set of solution update values set to a second initial value. The residual iterative algorithm includes an inner residual loop, which is iteratively computed using an analog accelerator until one or more inner residual loop stopping criteria is met and returning the set of solution update values. Next, the set of solution updates are used to update the set of residue values and a range of a next set of solution update values, thereby adjusting a computational precision of the inner residual loop.

50. 发明申请

WO2021236805A1 COLOR-CHANGING FABRIC AND APPLICATIONS 审中-公开
公开(公告)号：WO2021236805A1
公开(公告)日：2021-11-25
申请号：PCT/US2021/033216
申请日：2021-05-19
申请人： UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC.
发明人： ABOURADDY, Ayman , KAUFMAN, Joshua , TAN, Felix , MONROE, Morgan
IPC分类号： D01F1/00 , C09B5/26 , C09B67/08 , G02F1/163 , G02F1/167
摘要： A color-changing product includes a fabric and a color-changing fiber embroidered into a portion of the fabric. The color-changing fiber includes an electrically conductive core and a coating disposed around the electrically conductive core. The coating includes a thermochromic pigment. A method for manufacturing a color-changing product includes embroidering the first color-changing fiber into a first portion of the fabric; embroidering the second color-changing fiber into a second portion of the fabric; and electrically connecting the electrically conductive core of the first color-changing fiber and the second color-changing fiber to a power source.

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