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    • 42. 发明申请
    • GENERATION OF A MULTICOLOUR IMAGE OF AN UNSTAINED BIOLOGICAL SPECIMEN
    • 不稳定生物样本的多维图像的生成
    • WO2010061319A1
    • 2010-06-03
    • PCT/IB2009/055159
    • 2009-11-19
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.Van LEEUWEN, Marinus B.KUIPER, Stein
    • Van LEEUWEN, Marinus B.KUIPER, Stein
    • G06T5/50G06T7/40G06T11/00
    • A63B43/02G06T5/50G06T7/90G06T11/001G06T2207/10056G06T2207/10152G06T2207/30024
    • At least two chemically different substances of interest of an unstained biological specimen (12). For each of a substance image (24, 26) is generated, indicating for every region of the image an amount of the substance. A multicolour image is generated on the basis of the substance images. In a related aspect, a data carrier carries instructions for instructing a computer to control or to perform the method. In another related aspect, a system (10) an unstained biological specimen (12) comprises an optical system for exposing to ultraviolet light (18) of a selected frequency and for measuring for various regions of the specimen the intensity of transmitted ultraviolet light (20) and for repeating the steps of exposing and of measuring for different ultraviolet frequencies, thus generating for each frequency an ultra violet image; a computer for generating substance images on the basis of the ultraviolet images and for generating the multicolour image on the basis of the substance images.
    • 至少两种化学上不同的未染色生物样本物质(12)。 对于物质图像(24,26)中的每一个,生成图像的每个区域的物质的量。 基于物质图像生成多色图像。 在相关方面,数据载体携带用于指示计算机控制或执行该方法的指令。 在另一相关方面,一种未染色生物样本(12)的系统(10)包括用于暴露于所选频率的紫外线(18)的光学系统,并且用于测量所述样本的各个区域的透射紫外光的强度(20 ),并重复曝光和测量不同紫外线频率的步骤,从而为每个频率产生紫外线图像; 用于基于紫外线图像产生物质图像并基于物质图像生成多色图像的计算机。
    • 43. 发明申请
    • ADJUSTABLE LENS SYSTEM FOR REAL-TIME APPLICATIONS
    • 可调镜头系统实时应用
    • WO2009077939A1
    • 2009-06-25
    • PCT/IB2008/055205
    • 2008-12-10
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.SUIJVER, Jan, F.HALL, Christopher, S.FERNANDEZ, Anna, T.KUIPER, SteinSHI, Yan, S.
    • SUIJVER, Jan, F.HALL, Christopher, S.FERNANDEZ, Anna, T.KUIPER, SteinSHI, Yan, S.
    • G02B3/14
    • G02B3/14
    • An adjustable fluid type lens system is provided that allows e.g. ultrasound imaging through the lens during adjustment of the lens. The lens includes a container enclosing two immiscible fluids, e.g. water and oil, being in contact with each other at an interface. Incoming waves are then refracted at this interface. The shape of the interface, and thereby the refraction property, is adjustable by adjusting a voltage applied to the lens. The two fluids are selected such that they together exhibit a mechanical damping which is critical or near critical. A control circuit generates the electric voltage for adjusting the refraction from one value to another, the control circuit being arranged to change the electric voltage such that a rate of voltage change is limited to avoid oscillation of the interface, thereby adjusting refraction of incoming waves at the interface in a continuous manner. This makes it possible to use the lens while it is during adjustment from one refraction value to another, since the interface shape will at all time during the adjustment have a controlled shape. The voltage can be either a continuous voltage or a discrete stepwise (digital) voltage which is just controlled with respect to step size and temporal extension of the steps. The lens system has a number of applications e.g. within the medical field, e.g. for 'on the fly' high speed ultrasound imaging, or for ultrasound ablation applications where ablation can be performed during adjustment of the lens to follow a pre-defined trajectory.
    • 提供了一种可调节流体型透镜系统, 超声波成像通过透镜在调整镜片期间。 透镜包括容纳两个不混溶流体的容器,例如 水和油在界面处彼此接触。 然后在这个界面折射出来的波。 通过调节施加到透镜上的电压来调节界面的形状以及由此的折射特性。 选择两种流体使得它们一起显示出关键或近临界的机械阻尼。 控制电路产生用于将折射率从一个值调整到另一个值的电压,控制电路被布置成改变电压,使得电压变化率被限制以避免界面的振荡,由此调节入射波的折射 界面以连续的方式。 这使得可以在从一个折射值到另一个折射值的调整期间使用透镜,因为在调节期间的所有时间的界面形状都具有受控的形状。 电压可以是连续电压或离散的逐步(数字)电压,其仅仅相对于步长的步长和时间延长而被控制。 透镜系统具有许多应用,例如, 在医疗领域内。 用于“飞行”高速超声成像,或用于超声消融应用,其中可以在镜片调整期间执行消融以遵循预定轨迹。
    • 45. 发明申请
    • VARIABLE FLUID LENS HAVING TWO MENISCI
    • 具有两个MENISCI的可变流体镜
    • WO2006131882A1
    • 2006-12-14
    • PCT/IB2006/051800
    • 2006-06-06
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.HENDRIKS, Bernardus, H., W.KUIPER, Stein
    • HENDRIKS, Bernardus, H., W.KUIPER, Stein
    • G02B3/14
    • G02B3/14G02B21/025G02B23/00G02B26/005G02B27/0025G11B7/1378G11B7/13925
    • A variable lens and a method of operation of a variable lens are described. The variable lens has an optical axis (19) . The lens includes a first and a second lens element. The first lens element includes two fluids in contact over a first meniscus (132) extending transverse the optical axis, the fluids being non-misσible and having different indices of refraction. A second lens element includes two fluids in contact over a second meniscus (134) extending transverse the optical axis, the fluids being non-miscible and having different indices of refraction. A meniscus controller is arranged to control the shape of each meniscus. The meniscus controller (110) is arranged to control the shapes of the menisci such that the amount of spherical aberration produced by the first meniscus is substantially compensated by the amount of spherical aberration produced by the second meniscus for radiation of at least a predetermined wavelength. Such a variable lens can be incorporated in a variety of apparatus, including an optical scanning device, a camera, a microscope or a telescope .
    • 描述可变透镜和可变透镜的操作方法。 可变透镜具有光轴(19)。 透镜包括第一和第二透镜元件。 第一透镜元件包括在横向于光轴延伸的第一弯液面(132)上接触的两种流体,流体是非错误的且具有不同的折射率。 第二透镜元件包括在横向于光轴延伸的第二弯液面(134)上接触的两种流体,所述流体是不可混溶的并且具有不同的折射率。 弯液面控制器被布置成控制每个弯液面的形状。 弯液面控制器(110)布置成控制半月板的形状,使得由第一弯液面产生的球面像差的量基本上被由用于至少预定波长的辐射的第二弯液面产生的球面像差的量补偿。 这种可变透镜可以结合在各种装置中,包括光学扫描装置,照相机,显微镜或望远镜。
    • 47. 发明申请
    • LIQUID CRYSTAL BASED LIGHT CONTROL ELEMENT
    • 液晶基光控元件
    • WO2006072868A1
    • 2006-07-13
    • PCT/IB2005/054424
    • 2005-12-29
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.KUIPER, SteinVERSTEGEN, Emile, J., K.HENDRIKS, Bernardus, H., W.
    • KUIPER, SteinVERSTEGEN, Emile, J., K.HENDRIKS, Bernardus, H., W.
    • G02F1/1347G02F1/1333G03B9/02
    • G03B9/02G02F1/133371G02F1/13475
    • A light control element (100) is disclosed having a first chamber (110) encapsulating a first liquid crystal based light absorbing material (112; 114) being switchable from a first orientation in which said material (112; 114) predominantly absorbs light having a first polarization direction to a second orientation in which said material (112; 114) is substantially transparent and that further has a second chamber (120) encapsulating a second liquid crystal based light absorbing material (122; 124) being switchable from a first further orientation in which said material (122; 124) predominantly absorbs light having a polarization direction substantially perpendicular to the first polarization direction to a second further orientation in which said material (122; 124) is substantially transparent. A plurality of electrodes is present for switching the orientations of the first and second light absorbing materials. Consequently, a polarization independent light control element (100) is obtained.
    • 公开了一种光控制元件(100),其具有封装第一液晶基光吸收材料(112; 114)的第一腔室(110),所述第一腔室可从第一取向切换,其中所述材料(112; 114)主要吸收具有 第一偏振方向到第二取向,其中所述材料(112; 114)基本上是透明的,并且还具有封装第二液晶基光吸收材料(122; 124)的第二腔室(120),所述第二腔室可从第一另外的取向 其中所述材料(122; 124)主要将具有基本上垂直于第一偏振方向的偏振方向的光吸收到第二另外的取向,其中所述材料(122; 124)基本上是透明的。 存在多个电极用于切换第一和第二光吸收材料的取向。 因此,获得了偏振无关的光控制元件(100)。
    • 48. 发明申请
    • SWITCHABLE OPTICAL ELEMENT
    • 可切换光学元件
    • WO2006056922A1
    • 2006-06-01
    • PCT/IB2005/053828
    • 2005-11-21
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.TUKKER, Teunis, W.HENDRIKS, Bernardus, H., W.KUIPER, SteinVREHEN, Joris, J.JUTTE, Petrus, T.
    • TUKKER, Teunis, W.HENDRIKS, Bernardus, H., W.KUIPER, SteinVREHEN, Joris, J.JUTTE, Petrus, T.
    • G02B3/14
    • G02B26/005G02B3/14
    • A switchable optical element having an optical path (OP) for a radiation beam and having a first state and a second state, the element comprising: a first fluid (12) and a second, different, fluid (14) which are immiscible and which are separated from each other by a fluid meniscus (16); a first, transparent, wall part and a second, transparent, wall part spaced from each other along the optical path; and a fluid switching system which is arranged to apply forces to the first and/or the second fluid in order to switch the element between the first and the second state. The first wall part includes a non-planar wavefront modifier (28), and wherein the fluid switching system is arranged to apply the forces so that when the element is in the first state, the first wall part is covered by the first fluid (12); and when the element is in the second state, the first wall part is covered by the second fluid (14). The switchable optical element is characterised in that the fluid switching system is arranged to switch between the first state and the second state such that when the element is in the first state the second wall part is covered by the second fluid, and when the element is in the second state the second wall part is covered by the first fluid. When the element is in both the first state and the second state, at least part of the fluid meniscus (16) is located on the optical path.
    • 一种具有用于辐射束的光路(OP)并具有第一状态和第二状态的可切换光学元件,所述元件包括:第一流体(12)和第二不同流体(14),其不混溶,并且其中 通过流体弯液面(16)彼此分离; 第一,透明的壁部分和第二透明壁部分,沿着光路彼此间隔开; 以及布置成向第一和/或第二流体施加力以便在第一和第二状态之间切换元件的流体切换系统。 第一壁部分包括非平面波前修正器(28),并且其中流体切换系统被布置成施加力,使得当元件处于第一状态时,第一壁部分被第一流体(12 ); 并且当元件处于第二状态时,第一壁部分被第二流体(14)覆盖。 可切换光学元件的特征在于,流体切换系统布置成在第一状态和第二状态之间切换,使得当元件处于第一状态时,第二壁部被第二流体覆盖,并且当元件为 在第二状态下,第二壁部被第一流体覆盖。 当元件处于第一状态和第二状态时,流体弯液面(16)的至少一部分位于光路上。
    • 50. 发明申请
    • VARIABLE FOCUS LENS
    • 可变聚焦镜头
    • WO2005116697A1
    • 2005-12-08
    • PCT/IB2005/051614
    • 2005-05-18
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.HENDRIKS, Bernardus, H., W.KUIPER, Stein
    • HENDRIKS, Bernardus, H., W.KUIPER, Stein
    • G02B3/14
    • G02B3/14G02B26/005
    • Disclosed is a variable focus lens, having an optical axis, comprising: a fluid chamber, the fluid chamber comprising a first fluid and an axially displaced second fluid, the fluids being non-miscible, in contact over a meniscus and having different indices of refraction; a fluid contact layer arranged on the inside of the chamber wall; a first electrode separated from the first fluid and second electrode by the fluid contact layer; a second electrode acting on the second fluid; the fluid contact layer having a wettability by the second fluid which varies under the application of a voltage between the first electrode and the second electrode, such that the shape of the meniscus varies in dependence on said voltage; wherein the fluid chamber is shaped such that an angle formed between the wall of the chamber and the optical axis decreases along the length of the optical axis.
    • 公开了一种具有光轴的可变焦距透镜,包括:流体室,所述流体室包括第一流体和轴向移动的第二流体,所述流体不可混溶,在弯液面上接触并具有不同的折射率 ; 布置在室壁内侧的流体接触层; 通过流体接触层与第一流体和第二电极分离的第一电极; 作用在第二流体上的第二电极; 所述流体接触层具有在所述第一电极和所述第二电极之间的电压施加下变化的所述第二流体的润湿性,使得所述弯液面的形状根据所述电压而变化; 其中所述流体室被成形为使得在所述室的壁和所述光轴之间形成的角度沿着所述光轴的长度减小。