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41. 发明申请

WO0192296A3 REGULATION OF HUMAN ISOTOCIN-LIKE G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类等轴蛋白G蛋白偶联受体的调控
公开(公告)号：WO0192296A3
公开(公告)日：2002-05-30
申请号：PCT/EP0105965
申请日：2001-05-25
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , C07K14/705 , C12N15/12 , A61K31/7088 , A61K38/17 , C07K14/72 , C12N1/21 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00
摘要： Reagents which regulate human isotocin G protein-coupled receptor (isotocin-like GPCR) and reagents which bind to human isotocin-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity and diseases related to obesity, cancer, diabetes, osteoporosis, anxiety, depression, hypertension, migraine, compulsive disorders, schizophrenia, autism, neurodegenerative disorders, such as Alzheimer's disease, Parkinsonism, and Huntington's chorea, and cancer chemotherapy-induced vomiting.
摘要翻译：调节人类isotocin G蛋白偶联受体（类雄性样GPCR）的试剂和与人类异鸟毒样GPCR基因产物结合的试剂可以在预防，改善或纠正功能障碍或疾病中发挥作用，包括但不限于肥胖以及与肥胖症，癌症，糖尿病，骨质疏松症，焦虑症，抑郁症，高血压，偏头痛，强迫症，精神分裂症，孤独症，神经变性疾病如阿尔茨海默氏病，帕金森综合征和亨廷顿氏舞蹈病有关的疾病以及癌症化学诱导的呕吐。

42. 发明申请

WO0168702A3 REGULATION OF HUMAN G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类G蛋白偶联受体的调控
公开(公告)号：WO0168702A3
公开(公告)日：2002-05-30
申请号：PCT/EP0103016
申请日：2001-03-16
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , C07K14/705 , A61K48/00 , C12N15/63 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/705 , A61K38/00
摘要： Reagents which regulate human G protein-coupled receptor and reagents which bind to human GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, Parkinson's diseases, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
摘要翻译：调节人G蛋白偶联受体的试剂和与人GPCR基因产物结合的试剂可以在预防，改善或纠正功能障碍或疾病中发挥作用，包括但不限于细菌，真菌，原生动物和病毒等感染感染，特别是由艾滋病病毒，疼痛，癌症，厌食症，贪食症，哮喘，帕金森病，急性心力衰竭，低血压，高血压，尿潴留，骨质疏松症，心绞痛，心肌梗死，溃疡，哮喘，过敏，多发性硬化，良性前列腺肥大，以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆，几种智力低下和运动障碍，如亨廷顿氏病和图雷特综合征。

43. 发明申请

WO0170814A3 REGULATION OF HUMAN RTA-LIKE G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类RTA样蛋白联合受体的调控
公开(公告)号：WO0170814A3
公开(公告)日：2002-04-11
申请号：PCT/EP0103336
申请日：2001-03-23
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , G01N33/74 , C12N15/63 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/74 , A61K38/00 , A61K48/00 , C07K14/705 , G01N2333/726
摘要： Reagents which regulate human RTA-like G protein-coupled receptor treat can be used to infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, Parkinson's diseases, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
摘要翻译：调节人类RTA样G蛋白偶联受体治疗的试剂可用于感染，如细菌，真菌，原生动物和病毒感染，特别是由HIV病毒，疼痛，癌症，厌食症，贪食症，哮喘，帕金森病引起的感染，急性心力衰竭，低血压，高血压，尿潴留，骨质疏松症，心绞痛，心肌梗塞，溃疡，哮喘，过敏，多发性硬化，良性前列腺肥大，精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，几种精神发育迟滞和运动障碍，如亨廷顿病和图雷特综合征。

44. 发明申请

WO0168844A3 REGULATION OF HUMAN LEUKOTRIENE B4-LIKE G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类白介素B4样肽G蛋白偶联受体的调控
公开(公告)号：WO0168844A3
公开(公告)日：2002-01-24
申请号：PCT/EP0103011
申请日：2001-03-16
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： C07K14/705 , C12N15/12 , A61K31/711 , A61K38/00 , C12N5/10 , C12N15/85 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/705
摘要： Reagents which regulate human leukotriene B4-like G protein-coupled receptor and reagents which bind to human leukotriene B4-like receptor gene products can be used to treat conditions which involve inflammatory processes, such as multiple sclerosis, arthritis, skin disorders, respiratory disorders, intestinal diseases, and reperfusion injuries, as well as neoplasia and viral infections.
摘要翻译：调节人白三烯B4样G蛋白偶联受体的试剂和结合人白三烯B4样受体基因产物的试剂可用于治疗涉及炎性过程的病症，例如多发性硬化，关节炎，皮肤病，呼吸系统疾病，肠道疾病和再灌注损伤，以及瘤形成和病毒感染。

45. 发明申请

WO0170813A3 REGULATION OF HUMAN GluR5-LIKE RECEPTOR 审中-公开
标题翻译：人类GluR5样受体的调控
公开(公告)号：WO0170813A3
公开(公告)日：2002-01-10
申请号：PCT/EP0103335
申请日：2001-03-23
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , A61P25/00 , C07K14/705 , C12N15/12 , A61K38/17 , C12N15/11 , C12N15/66 , C12Q1/68
CPC分类号： C07K14/705 , A61K38/00
摘要： Reagents and methods for regulating the high affinity binding of GluR5-like receptor (GR5LR) to kainate are provided. Such reagents and methods can be used inter alia , to treat or prevent urinary incontinence, epilepsy, schizophrenia and other mood disorders, neurodegenerative diseases such as Huntington's disease and Alzheimer's disease, ischemia, and pain.
摘要翻译：提供了用于调节GluR5样受体（GR5LR）与红藻氨酸盐的高亲和力结合的试剂和方法。这些试剂和方法可以特别用于治疗或预防尿失禁，癫痫，精神分裂症和其他情绪障碍，神经变性疾病如亨廷顿病和阿尔茨海默病，局部缺血和疼痛。

46. 发明申请

WO0170967A3 REGULATION OF HUMAN SEROTONIN-LIKE G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类蛋白样G蛋白偶联受体的调控
公开(公告)号：WO0170967A3
公开(公告)日：2001-12-27
申请号：PCT/EP0103117
申请日：2001-03-19
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , A61P25/00 , C07K14/705 , C12N15/12 , A61K38/17 , C12N5/10 , C12N15/63 , C12P21/00 , C12Q1/68
CPC分类号： C07K14/70571 , A61K38/00
摘要： Reagents which regulate human serotonin-like G protein-coupled receptor (5-HT-GPCR) and reagents which bind to human 5-HT-GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to disorders of both the central and the peripheral nervous system, for example in primary and secondary disorders after brain injury, disorders of mood, anxiety disorders, disorders of thought and volition, disorders of sleep and wakefulness, diseases of the motor unit like neurogenic and myopathic disorders, neurodegenerative disorders like Alzheimer's and Parkinson's disease, disorders leading to peripheral and chronic pain.
摘要翻译：调节人类5-羟色胺样G蛋白偶联受体（5-HT-GPCR）的试剂和与人5-HT-GPCR基因产物结合的试剂可以在预防，改善或矫正功能障碍或疾病中发挥作用，包括但不限于限于中枢和周围神经系统的疾病，例如脑损伤后的原发性和继发性障碍，情绪障碍，焦虑障碍，思维障碍，睡眠和觉醒障碍，运动单位疾病如神经源性肌病，神经变性疾病如阿尔茨海默病和帕金森病，导致周围和慢性疼痛的疾病。

47. 发明申请

WO0168839A2 REGULATION OF HUMAN LIPOXIN A4 RECEPTOR-LIKE PROTEIN 审中-公开
标题翻译：人类LIPOXIN A4受体样蛋白的调控
公开(公告)号：WO0168839A2
公开(公告)日：2001-09-20
申请号：PCT/EP0102729
申请日：2001-03-12
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , A61P9/00 , A61P37/08 , C07K14/705 , C12N15/12 , G01N33/566 , G01N33/88 , A61K38/17 , C12N5/10 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/566 , A61K38/00 , C07K14/705 , G01N33/88 , G01N2333/726 , G01N2500/10
摘要： Reagents which regulate human lipoxin A4 receptor-like protein and reagents which bind to human lipoxin A4 receptor-like gene products can be used to affect hemostasis, vascular reactivity, especially vasoconstriction, and inflammatory processes, including anaphylactic and other allergic reactions.
摘要翻译：调节人脂氧素A4受体样蛋白质的试剂和与人类脂氧素A4受体样基因产物结合的试剂可用于影响止血，血管反应性，特别是血管收缩以及炎性过程，包括过敏性和其他过敏反应。

48. 发明申请

WO0229047A3 REGULATION OF HUMAN GPCR-LIKE PROTEIN 审中-公开
标题翻译：人类GPCR样蛋白的调控
公开(公告)号：WO0229047A3
公开(公告)日：2003-02-27
申请号：PCT/EP0111309
申请日：2001-10-01
申请人： BAYER AG , SMITH TIMOTHY J , RAMAKRISHNAN SHYAM , CARUSO ANTHONY
发明人： SMITH TIMOTHY J , RAMAKRISHNAN SHYAM , CARUSO ANTHONY
IPC分类号： A61K38/00 , A61K48/00 , C07K14/705 , C12N15/12 , A61K31/7088 , A61K39/395 , C07K14/72 , C07K16/28 , C12N15/62 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/705 , A61K38/00 , A61K48/00
摘要： Reagents which regulate human GPCR-like protein and reagents which bind to human GPCR-like protein gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, diabetes and hematological disorders.
摘要翻译：调节人类GPCR样蛋白质的试剂和与人GPCR样蛋白质基因产物结合的试剂可以在预防，改善或矫正功能障碍或疾病中发挥作用，包括但不限于糖尿病和血液学疾病。

49. 发明申请

WO0172833A3 HUMAN EPHRIN-LIKE RECEPTOR 审中-公开
标题翻译：人类类似受体
公开(公告)号：WO0172833A3
公开(公告)日：2003-01-16
申请号：PCT/EP0103339
申请日：2001-03-23
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , A61K48/00 , C07K14/715
CPC分类号： C07K14/715 , A61K38/00 , A61K48/00
摘要： Reagents which regulate human ephrin-like receptor and reagents which bind to human ephrin-like receptor gene products can play a role in preventing, ameliorating, or correcting neurodegenerative disorders, including but not limited to, Alzheimer's disease, Parkinson's disease, Huntington's chorea, and amyotrophic lateral sclerosis, and other neuropathies, including regeneration of neurons or in survival of neurons after trauma or stroke. Regulation of human ephrin-like receptor function also can be used to increase or decrease cell proliferation, for example to treat cancer or other hyperproliferative diseases.
摘要翻译：调节人类ephrin样受体的试剂和与人类ephrin样受体基因产物结合的试剂可以在预防，改善或矫正神经变性疾病中发挥作用，所述神经变性疾病包括但不限于阿尔茨海默病，帕金森病，亨廷顿氏舞蹈病和肌萎缩性侧索硬化和其他神经病变，包括神经元的再生或创伤或中风后神经元的存活。人类ephrin样受体功能的调节也可用于增加或减少细胞增殖，例如治疗癌症或其他过度增生性疾病。

50. 发明申请

WO0170969A3 REGULATION OF HUMAN LATROPHILIN-LIKE G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类赖氨酸样G蛋白偶联受体的调控
公开(公告)号：WO0170969A3
公开(公告)日：2002-09-26
申请号：PCT/EP0103223
申请日：2001-03-21
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K48/00 , A61P5/00 , A61P25/00 , C07K14/705 , C07K14/72 , C12N15/12 , C12Q1/68 , G01N33/50 , G01N33/68
CPC分类号： C07K14/705 , A61K48/00 , C07K14/723
摘要： Reagents which regulate human latrophilin-like G protein-coupled receptor (LT-GPCR) protein and reagents which bind to human LT-GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases associated with aberrant exocytosis in both the endocrine system and the nervous system.
摘要翻译：调节人类赖氨酸样蛋白偶联受体（LT-GPCR）蛋白的试剂和与人LT-GPCR基因产物结合的试剂可以在预防，改善或纠正与异常胞吐作用相关的功能障碍或疾病方面发挥作用内分泌系统和神经系统。

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