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41. 发明申请

WO2017051402A3 A METHOD EFFECTIVE TO MODULATE EXPRESSION OF T-BOX PROTEIN 4 (TBX4) FOR REDUCING PROGRESSION OF LUNG FIBROSIS AFTER A LUNG INJURY 审中-公开
公开(公告)号：WO2017051402A3
公开(公告)日：2017-03-30
申请号：PCT/IB2016/056575
申请日：2016-11-01
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： NOBLE, Paul , JIANG, Dianhua , XIE, Ting , LIANG, Carol Jiurong
IPC分类号： A61K48/00 , C12N15/11 , C12Q1/68 , G01N33/53
摘要： The described invention provides a method for reducing progression of lung fibrosis after a lung injury comprising administering a therapeutic amount of a therapeutic agent, wherein the therapeutic amount is effective: (a) to modulate expression of a T-box transcription factor in a population of cells in lung; and (b) to reduce proliferation of the population of cells in lung expressing the T-box transcription factor. According to some embodiments the T-box transcription factor is Tbx4.

42. 发明申请

WO2017040546A1 BREATH GAS ANALYSIS 审中-公开
标题翻译：气道气体分析
公开(公告)号：WO2017040546A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/049528
申请日：2016-08-30
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GUPTA, Kapil , PIMENTEL, Mark , REZAIE, Ali
IPC分类号： G01N33/497
CPC分类号： G01N33/497
摘要： Systems and methods have been developed for implementation of a portable SIBO testing system for convenient sampling of intestinal gases exhaled from a patient's breath. These devices may be in the form of a hand held meter that would integrate with a smartphone or other device with an application that can record data relating to food consumed by a user. Various technologies may be utilized to measure the levels of gases exhaled by a user, which may include (1) sorbent based technology and (2) membrane based technology. In some examples, the system will determine an indication of whether a patient has SIBO by adjusting a change in exhaled hydrogen concentration by a methane level exhaled by a patient.
摘要翻译：已经开发了用于实施便携式SIBO测试系统的系统和方法，用于方便地从患者呼吸中呼出的肠道气体取样。这些设备可以是手持式仪表的形式，其将与智能电话或其他设备集成，其具有可以记录与用户消费的食物相关的数据的应用。可以使用各种技术来测量用户呼出的气体水平，其可以包括（1）基于吸附剂的技术和（2）基于膜的技术。在一些实例中，系统将通过调节由呼吸的氢浓度变化由患者呼出的甲烷水平来确定患者是否患有SIBO。

43. 发明申请

WO2016044707A1 COMPOSITIONS AND METHODS FOR TREATING FIBROSIS 审中-公开
标题翻译：治疗纤维化的组合物和方法
公开(公告)号：WO2016044707A1
公开(公告)日：2016-03-24
申请号：PCT/US2015/050906
申请日：2015-09-18
申请人： CEDARS-SINAI MEDICAL CENTER , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
发明人： MURALI, Ramachandran , HABTEZION, Aida , PANDOL, Stephen J.
IPC分类号： C07K16/28 , C07K14/54 , A61P35/00
CPC分类号： A61K38/10 , A61N5/1001 , C07K14/5406 , C07K14/5437
摘要： The invention provides methods for treating fibrosis and/or cancer in a subject in need thereof. The methods include providing a composition comprising an inhibitor of IL-4/IL-13 receptor function and administering an effective amount of the composition to the subject to treat fibrosis and/or cancer.
摘要翻译：本发明提供了在有需要的受试者中治疗纤维化和/或癌症的方法。所述方法包括提供包含IL-4 / IL-13受体功能抑制剂的组合物，并向受试者施用有效量的组合物以治疗纤维化和/或癌症。

44. 发明申请

WO2015187994A1 METHOD FOR NON SURGICAL REPAIR OF VERTEBRAL COMPRESSION FRACTURES 审中-公开
标题翻译： VERTEBRAL压缩骨折非手术修复方法
公开(公告)号：WO2015187994A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/034275
申请日：2015-06-04
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GAZIT, Dan , SCHWARZ, Edward, M. , BAE, Hyun , PELLED, Gadi , GAZIT, Zulma , SHEYN, Dmitriy , TAWACKOLI, Wafa
IPC分类号： A61K38/00 , A61P19/10 , A01N63/00
CPC分类号： A61K35/28 , A61K9/0019 , A61K38/1875 , A61K38/29 , A61K2300/00
摘要： Described herein are methods and compositions using PTH and mesenchymal stem cells (MSCs) for treatment of osteoporosis, bone fractures, and related conditions. Administration of both PTH and MSCs leads to increased homing of MSCs to sites of vertebral bone and rib fracture. The described methods and compositions provide therapeutic approaches that rely, in-part, on stem cell capacity for regeneration and repair. The potential for enhanced bone formation and fracture repair may allow for both preventative and palliative treatments in osteoporotic patients, with combined PTH + MSC therapy producing bone regeneration capacity that is significantly superior to either treatment alone.
摘要翻译：本文描述了使用PTH和间充质干细胞（MSC）治疗骨质疏松症，骨折和相关病症的方法和组合物。管理PTH和MSCs导致MSC的归巢增加到椎骨和肋骨骨折部位。所描述的方法和组合物提供了部分依赖于干细胞再生和修复能力的治疗方法。增强骨形成和骨折修复的潜力可能允许骨质疏松患者的预防和姑息治疗，组合的PTH + MSC治疗产生的骨再生能力明显优于单独治疗。

45. 发明申请

WO2015131070A1 SURGICAL DRAPE 审中-公开
标题翻译：外科皮肤病
公开(公告)号：WO2015131070A1
公开(公告)日：2015-09-03
申请号：PCT/US2015/018056
申请日：2015-02-27
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： SMITH, Frederick
IPC分类号： A61B19/08 , A61B19/10
CPC分类号： A61B46/20 , A61B46/00 , A61B46/10 , A61B90/39 , A61B2017/00902 , A61B2046/205 , A61B2090/3983
摘要： Some embodiments of the invention include a device for creating a sterile environment when using an o-shaped or a c-shaped multidimensional surgical imaging system. The device may comprise a drape configured to drape over a patient, a cover removably attached to the drape, and an adhesive seam configured to pull apart to disassemble the drape after. The drape may have a puncture configured to engage with a spine reference clamp, a reference frame, each of the puncture and the reference frame positioned along a center line of the drape, and the cover may be removably attached to the drape to cover the puncture and the reference frame.
摘要翻译：本发明的一些实施例包括用于在使用o形或c形多维手术成像系统时产生无菌环境的装置。该装置可以包括构造成悬挂在患者身上的覆盖物，可移除地附接到盖布的盖子以及被配置成拉开以分解后盖的粘合缝。悬垂布可以具有穿刺构造成与脊柱参考夹，参考框架接合，每个穿刺和参考框架沿着盖布的中心线定位，并且盖可以可移除地附接到盖布以覆盖穿刺和参考框架。

46. 发明申请

WO2015095598A1 SYSTEMS AND METHODS FOR PROGNOSTICATING BRAIN TUMORS 审中-公开
标题翻译：用于预防脑肿瘤的系统和方法
公开(公告)号：WO2015095598A1
公开(公告)日：2015-06-25
申请号：PCT/US2014/071282
申请日：2014-12-18
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： YU, John S. , EDWARDS, Lincoln A.
IPC分类号： A61P35/00
CPC分类号： G01N33/57407 , A61K31/404 , A61K31/4188 , A61K31/436 , A61K31/44 , A61K31/506 , A61K45/06 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N2333/904 , G01N2800/52 , A61K2300/00
摘要： The present invention describes methods of prognosticating patient survival based on an analysis of the ZEB1 gene or gene product. The present invention also describes methods of selecting and/or selecting various therapies based on the analysis of ZEB1, PTEN, MGMT and/or RET. Further describes are systems for analyzing ZEB1, PTEN, MGMT and/or RET as well as selecting and/or selecting the therapies.
摘要翻译：本发明基于ZEB1基因或基因产物的分析描述了预测患者存活的方法。本发明还描述了基于ZEB1，PTEN，MGMT和/或RET的分析来选择和/或选择各种疗法的方法。还描述了用于分析ZEB1，PTEN，MGMT和/或RET以及选择和/或选择治疗的系统。

47. 发明申请

WO2014186665A3 DISTINCT EFFECTS OF IFN-GAMMA AND IL-17 ON TL1A MODULATED INFLAMMATION AND FIBROSIS 审中-公开
公开(公告)号：WO2014186665A3
公开(公告)日：2014-11-20
申请号：PCT/US2014/038333
申请日：2014-05-16
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： SHIH, David, Q. , TARGAN, Stephan, R. , BILSBOROUGH, Janine
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
摘要： Described herein are methods and compositions related to Inflammatory Bowel Disease. Specifically TL1A drives regional intestinal inflammation and fibrosis and is differentially modulated by IFN gamma and IL-17a. In one embodiment, the present invention is a method of diagnosing a condition in a subject by determining the presence or absence of IFN gamma and/or IL-17 and diagnosing the subject.

48. 发明申请

WO2014182868A1 TARGETING CORROLES FOR TUMOR TOXICITY AND MRI 审中-公开
标题翻译：针对肿瘤毒性和核磁共振成像
公开(公告)号：WO2014182868A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/037234
申请日：2014-05-08
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： MEDINA-KAUWE, Lali, K.
IPC分类号： A01N55/02
CPC分类号： A61K49/106 , A61K9/16 , A61K9/5115 , A61K31/555 , A61K33/24 , A61K33/26 , A61K33/32 , A61K47/48269 , A61K49/1818
摘要： Disclosed herein are compositions comprising a targeted corrole nanoparticle; and an acceptable excipient. Also disclosed are compositions comprising a targeted corrole nanoparticle; and an acceptable carrier. Further, disclosed herein are methods of imaging a condition in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; administering an effective amount of the targeted corrole nanoparticle to the subject; and imaging the condition in the subject. In addition, disclosed herein are methods of treating cancer in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; and administering a therapeutically effective dosage of the targeted corrole nanoparticle to the subject.
摘要翻译：本文公开了包含目标钌纳米颗粒的组合物; 和可接受的赋形剂。还公开了包含目标钌纳米颗粒的组合物; 和可接受的载体。此外，本文公开了对受试者中的病症进行成像的方法，其包括提供包含靶向的cor纳纳米颗粒的组合物; 向受试者施用有效量的目标cor纳米颗粒; 并对受试者的状况进行成像。此外，本文公开了治疗受试者中的癌症的方法，其包括提供包含目标cor纳米颗粒的组合物; 以及向所述受试者施用治疗有效剂量的目标cor纳米颗粒。

49. 发明申请

WO2014172390A2 METHODS FOR DETECTING CANCER METASTASIS 审中-公开
标题翻译：检测癌症转移的方法
公开(公告)号：WO2014172390A2
公开(公告)日：2014-10-23
申请号：PCT/US2014/034245
申请日：2014-04-15
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： DI VIZIO, Dolores , FREEMAN, Michael R. , MORELLO, Matteo , MINCIACCHI, Valentina R.
IPC分类号： C12Q1/68
CPC分类号： G01N33/57484 , A61K45/06 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/178 , G01N2800/56
摘要： The invention provides methods for isolating large oncosomes and determining cancer metastasis based on the presence of large oncosomes in a subject in need thereof.
摘要翻译：本发明提供了在有需要的受试者中基于存在大肿瘤体来分离大肿瘤体并确定癌症转移的方法。

50. 发明申请

WO2014152754A2 METHODS OF DIAGNOSIS, SELECTION, AND TREATMENT OF DISEASES AND CONDITIONS CAUSED BY OR ASSOCIATED WITH METHANOGENS 审中-公开
标题翻译：诊断，选择和治疗由甲状腺引起或与甲状腺相关的疾病和病症的方法
公开(公告)号：WO2014152754A2
公开(公告)日：2014-09-25
申请号：PCT/US2014/027697
申请日：2014-03-14
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： PIMENTEL, Mark , MATHUR, Ruchi , CHANG, Christopher
IPC分类号： A61K31/4164 , C12Q1/68 , A61K31/7028 , A61K31/437 , A61K31/155 , A61K35/74
CPC分类号： A61K38/10 , A61K31/137 , A61K31/155 , A61K31/22 , A61K31/337 , A61K31/352 , A61K31/357 , A61K31/366 , A61K31/40 , A61K31/4045 , A61K31/405 , A61K31/4164 , A61K31/426 , A61K31/437 , A61K31/4525 , A61K31/454 , A61K31/47 , A61K31/505 , A61K31/55 , A61K31/7028 , A61K38/14 , A61K38/26 , A61K38/28 , C12Q1/689 , C12Q2600/106 , A61K2300/00
摘要： The invention described herein provides for methods and systems for determining, selecting, and/or treating diseases and conditions caused by or associated with high quantities of methanogens in a subject, or diseases and conditions caused by or associated with low quantities of methanogens in a subject. In various embodiments, a therapy to inhibit the growth of methanogens or to promote the growth of methanogens are selected and/or administered to a subject in need thereof.
摘要翻译：本文描述的发明提供了用于确定，选择和/或治疗由受试者或由受试者中的少量产甲烷菌引起或与之相关的疾病和病症引起的或与其相关的疾病和病症的方法和系统。在各种实施方案中，选择和/或施用抑制产甲烷菌生长或促进产甲烷菌生长的治疗方法。

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