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1. 发明申请

WO2015187994A1 METHOD FOR NON SURGICAL REPAIR OF VERTEBRAL COMPRESSION FRACTURES 审中-公开
标题翻译： VERTEBRAL压缩骨折非手术修复方法
公开(公告)号：WO2015187994A1
公开(公告)日：2015-12-10
申请号：PCT/US2015/034275
申请日：2015-06-04
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GAZIT, Dan , SCHWARZ, Edward, M. , BAE, Hyun , PELLED, Gadi , GAZIT, Zulma , SHEYN, Dmitriy , TAWACKOLI, Wafa
IPC分类号： A61K38/00 , A61P19/10 , A01N63/00
CPC分类号： A61K35/28 , A61K9/0019 , A61K38/1875 , A61K38/29 , A61K2300/00
摘要： Described herein are methods and compositions using PTH and mesenchymal stem cells (MSCs) for treatment of osteoporosis, bone fractures, and related conditions. Administration of both PTH and MSCs leads to increased homing of MSCs to sites of vertebral bone and rib fracture. The described methods and compositions provide therapeutic approaches that rely, in-part, on stem cell capacity for regeneration and repair. The potential for enhanced bone formation and fracture repair may allow for both preventative and palliative treatments in osteoporotic patients, with combined PTH + MSC therapy producing bone regeneration capacity that is significantly superior to either treatment alone.
摘要翻译：本文描述了使用PTH和间充质干细胞（MSC）治疗骨质疏松症，骨折和相关病症的方法和组合物。管理PTH和MSCs导致MSC的归巢增加到椎骨和肋骨骨折部位。所描述的方法和组合物提供了部分依赖于干细胞再生和修复能力的治疗方法。增强骨形成和骨折修复的潜力可能允许骨质疏松患者的预防和姑息治疗，组合的PTH + MSC治疗产生的骨再生能力明显优于单独治疗。

2. 发明申请

WO2017214439A1 NON-INVASIVE PH-DEPENDENT IMAGING USING QUANTITATIVE CHEMICAL EXCHANGE SATURATION TRANSFER (QCEST) 审中-公开
标题翻译：利用定量化学交换饱和转移（QCEST）进行非侵入性PH相关成像
公开(公告)号：WO2017214439A1
公开(公告)日：2017-12-14
申请号：PCT/US2017/036617
申请日：2017-06-08
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GAZIT, Dan , LI, Debiao , PELLED, Gadi , GAZIT, Zulma , ZHOU, Zhengwei
IPC分类号： A61B5/00 , A61B5/05 , A61B5/055
摘要： In various embodiments, the invention teaches systems and methods for magnetic resonance imaging. In some embodiments, the invention teaches systems and methods for determining the source of pain in intervertebral discs by measuring one or more physiological biomarkers associated with disc pain and/or disc degeneration.
摘要翻译：在各种实施例中，本发明教导了用于磁共振成像的系统和方法。在一些实施方案中，本发明教导了通过测量与椎间盘疼痛和/或椎间盘退变相关的一种或多种生理生物标志物来确定椎间盘中疼痛源的系统和方法。

3. 发明申请

WO2017151674A1 METHOD OF ENDOGENOUS STEM CELL ACTIVATION FOR TENDON/LIGAMENT OSSEOINTEGRATION 审中-公开
标题翻译：内皮干细胞活化的肌腱/韧带内固定方法
公开(公告)号：WO2017151674A1
公开(公告)日：2017-09-08
申请号：PCT/US2017/020033
申请日：2017-02-28
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GAZIT, Dan , PELLED, Gadi , KREMEN, Thomas
IPC分类号： A61L27/54 , A61L27/24
摘要： Tendon and ligament injuries are common in orthopaedic clinical practice and cause substantial morbidity in sports and in routine daily activities. While surgical reconstruction is effective, the majority of patients suffer from a prolonged period of recovery because of limited regeneration capacity of the tendon-bone interface. Here, the Inventors have established an approach for promoting tendon/ligament integration. By first recruiting endogenous stem cells to the site of injury, bone morphogenic proteins (BMPs), are then delivered in vivo to promote repair. Significant acceleration of healing via the above methods and compositions leads to fast recovery and return to normal activities, thereby providing new therapeutic avenues for treatment of injuries involving the tendon-bone interface.
摘要翻译：肌腱和韧带损伤在整形外科临床实践中很常见，并且在体育运动和日常日常活动中导致严重的发病。虽然手术重建是有效的，但由于肌腱 - 骨界面的再生能力有限，大多数患者长时间恢复。在这里，发明人已经建立了促进肌腱/韧带整合的方法。首先将内源性干细胞募集到损伤部位，然后在体内递送骨形态发生蛋白（BMP），以促进修复。通过上述方法和组合物显着加速愈合导致快速恢复并恢复正常活动，从而为涉及肌腱 - 骨界面的损伤的治疗提供新的治疗途径。

4. 发明申请

WO2016209987A1 A METHOD FOR REGENERATING THE INTERVERTERBRAL DISC WITH NOTOCHORDAL CELLS 审中-公开
标题翻译：用于再生带状细胞的椎间盘的方法
公开(公告)号：WO2016209987A1
公开(公告)日：2016-12-29
申请号：PCT/US2016/038799
申请日：2016-06-22
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GAZIT, Zulma , SHEYN, Dmitriy , PELLED, Gadi , GAZIT, Dan
IPC分类号： C12N5/0797 , C12N5/079 , C12N5/074 , C12N5/0735 , A61P19/08
CPC分类号： C12N5/0668 , A61L27/3895 , A61L27/52 , A61L2300/62 , A61L2300/64 , A61L2430/38 , C12N5/0619 , C12N5/0655 , C12N2501/727 , C12N2501/999 , C12N2506/45
摘要： Described herein are compositions and methods related to derivation of human notochordal cells differentiated from induced pluripotent stem cells (iPSCs). The inventors have developed a two-step process for generating these iPSC-derived notochordal cells (iNCs), which can provide a renewable source of therapeutic material for use in degenerative disc disease (DDD). As iNCs are capable of reversing DDD and supporting regeneration of invertebral disc (IVD) tissue based on the understanding that NC cells maintain homeostasis and repair of other IVD cell types such as nuclear pulposus (NP).
摘要翻译：本文描述了与诱导的多能干细胞（iPSC）分化的人脊髓细胞的衍生相关的组合物和方法。发明人已经开发了用于产生这些iPSC衍生的脊髓细胞（iNC）的两步法，其可以提供用于退行性椎间盘疾病（DDD）的治疗材料的可再生源。由于iNC能够逆转DDD并支持椎间盘（IVD）组织的再生，因为NC细胞维持体内平衡和其他IVD细胞类型如核髓（NP）的修复。

5. 发明申请

WO2014172682A1 IMAGING BIOMARKERS FOR DIAGNOSIS OF BACK PAIN 审中-公开
标题翻译：成像生物标志物用于诊断背痛
公开(公告)号：WO2014172682A1
公开(公告)日：2014-10-23
申请号：PCT/US2014/034720
申请日：2014-04-18
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GAZIT, Dan , LI, Debiao , BAE, Hyun , PELLED, Gadi , GAZIT, Zulma , LIU, Qi , TAWACKOLI, Wafa
IPC分类号： A61B5/05 , A61B5/055 , G01N33/48
CPC分类号： A61B5/055 , A61B5/004 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/407 , A61B5/4566 , A61B5/4824 , A61B5/7282
摘要： The present invention teaches novel methods of diagnosing and prognosing conditions associated with tissue degeneration and/or pain, including intervertebral disc degeneration, discogenic pain, osteoarthritis, rheumatoid arthritis, and articular cartilage injury. Using the inventive noninvasive imaging methods, the diagnosis and prognosis of back pain and related conditions can be quickly and accurately determined by detecting one or more biomarkers disclosed herein.
摘要翻译：本发明教导了诊断和预后与组织退化和/或疼痛有关的病症的新方法，包括椎间盘退变，椎间盘突出症，骨关节炎，类风湿性关节炎和关节软骨损伤。使用本发明的无创成像方法，通过检测本文公开的一种或多种生物标志物可以快速和准确地确定背痛和相关病症的诊断和预后。

6. 发明申请

WO2018098091A1 A NOVEL TRANSFECTION AND DRUG DELIVERY DEVICE 审中-公开
公开(公告)号：WO2018098091A1
公开(公告)日：2018-05-31
申请号：PCT/US2017/062640
申请日：2017-11-20
申请人： CEDARS-SINAI MEDICAL CENTER , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： GAZIT, Dan , PELLED, Gadi , FERRARA, Katherine W. , STEPHENS, Douglas N.
IPC分类号： A61B5/05 , A61B8/00 , G01N29/24 , G01S15/89
摘要： An ultrasound transmitter device for treating a patient is provided. The ultrasound transmitter device includes an imaging probe; an imaging array; and a therapeutic ultrasound device, wherein the imaging probe is configured to guide the therapeutic ultrasound device to the patients treatment site by use of ultrasound imaging with the imaging array, wherein the therapeutic ultrasound device is configured to produce a controlled intensity of ultrasound energy for treating the patients treatment site, and wherein the imaging probe and the therapeutic ultrasound device are configured to work in conjunction with one another to apply therapeutic ultrasound to tissue or bone graft sites in the patient.

7. 发明申请

WO2017123806A1 A METHOD OF NON DESTRUCTIVE MONITORING OF BIOLOGICAL PROCESSES IN MICROFLUIDIC TISSUE CULTURE SYSTEMS 审中-公开
标题翻译：微流体组织培养系统中生物过程无损监测的一种方法
公开(公告)号：WO2017123806A1
公开(公告)日：2017-07-20
申请号：PCT/US2017/013250
申请日：2017-01-12
申请人： CEDARS-SINAI MEDICAL CENTER
发明人： GAZIT, Dan , PELLED, Gadi , GAZIT, Zulma , SHEYN, Dmitriy
IPC分类号： C12N5/0735 , C12N5/074 , C12N5/079 , C12N5/0797
CPC分类号： C12N5/0075 , G01N33/5038
摘要： Microfluidic "organ-on-a-chip" devices have been developed with the aim to replicate human tissues in vitro . However, there is no option to quantitatively monitor biological processes that take place within the chip, over time. Destructive methods in order to analyze, tissue formation, gene expression, protein secretion etc. require the harvest of the "tissue" at a certain time point. Described herein are methods and compositions for non-destructive molecular imaging methods and systems in order to quantitatively monitor specific biological processes, over time, within the chip, without the need to harvest.
摘要翻译：微流体“片上器官”（organ-on-a-chip）已经开发了旨在体外复制人体组织的装置。然而，随着时间的推移，没有办法定量监测芯片内发生的生物过程。为了分析，组织形成，基因表达，蛋白质分泌等的破坏性方法需要收集“组织” 在某个时间点。本文描述了用于无损分子成像方法和系统的方法和组合物，以便随时间定量监测芯片内的特定生物过程，而不需要收获。

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