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31. 发明申请

WO2005101001A2 DIAGNOSTICS AND THERAPEUTICS FOR DISEASES ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR, FAMILY C, GROUP 5, MEMBER C (GPRC5C) 审中-公开
标题翻译：与G蛋白偶联受体，家族C，组5，成员C（GPRC5C）相关的疾病的诊断和治疗
公开(公告)号：WO2005101001A2
公开(公告)日：2005-10-27
申请号：PCT/EP2005/003411
申请日：2005-04-01
申请人： BAYER HEALTHCARE AG , GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
发明人： GOLZ, Stefan , BRÜGGEMEIER, Ulf , GEERTS, Andreas
IPC分类号： G01N33/579
CPC分类号： G01N33/574 , G01N33/6884 , G01N33/6893 , G01N33/74
摘要： The invention provides a human GPRC5C which is associated with the cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, muscle skeleton disorders, neurological diseases, urological diseases and respiratory diseases. The invention also provides assays for the identification of compounds useful in the treatment or prevention of cardiovascular diseases, dermatological diseases, endocrinological diseases, metabolic diseases, cancer, inflammation, gastroenterological diseases, hematological diseases, muscle skeleton disorders, neurological diseases, urological diseases and respiratory diseases. The invention also features compounds which bind to and/or activate or inhibit the activity of GPRC5C as well as pharmaceutical compositions comprising such compounds.
摘要翻译：本发明提供了与心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，肠胃病，血液疾病，肌肉骨骼疾病，神经系统疾病，泌尿科疾病和呼吸系统疾病有关的人GPRC5C。本发明还提供了用于鉴定可用于治疗或预防心血管疾病，皮肤病，内分泌疾病，代谢疾病，癌症，炎症，胃肠疾病，血液疾病，肌肉骨骼疾病，神经系统疾病，泌尿科疾病和呼吸道疾病的化合物的测定疾病。本发明还涉及结合和/或活化或抑制GPRC5C的活性的化合物以及包含这些化合物的药物组合物。

32. 发明申请

WO2005015236A2 A METHOD FOR PREDICTING THE PROGRESSION OF ADENOCARCINOMA 审中-公开
标题翻译：一种预测腺癌进展的方法
公开(公告)号：WO2005015236A2
公开(公告)日：2005-02-17
申请号：PCT/EP2004/007936
申请日：2004-07-16
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , RUEGER, Ruediger , AUER, Johannes , PORSTMANN, Baerbel , WERNER, Martin , WIESE, Anja
发明人： RUEGER, Ruediger , AUER, Johannes , PORSTMANN, Baerbel , WERNER, Martin , WIESE, Anja
IPC分类号： G01N33/579
CPC分类号： G01N33/57419 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136 , C12Q2600/178 , G01N33/57484 , G01N2500/00
摘要： The present invention is related to a method for predicting the progression of adenocarcinoma, in particular colorectal cancer, after surgery whereby the level of expression of one or several gene markers is compared to a sample serving as control. Another method according to the invention is related to identifying an agent which will inhibit the progression of adenocarcinoma. The invention is further related to kits and arrays comprising the marker genes according to the invention.
摘要翻译：本发明涉及一种用于预测手术后腺癌，特别是结肠直肠癌进展的方法，其中将一个或多个基因标记物的表达水平与作为对照的样品进行比较。根据本发明的另一种方法涉及鉴定将抑制腺癌进展的药剂。本发明进一步涉及包含根据本发明的标记基因的试剂盒和阵列。

33. 发明申请

WO2004001418A2 METHOD FOR IDENTIFYING AND EXTRACTING ENDOTOXIN 审中-公开
标题翻译：检测方法的内毒素的去除
公开(公告)号：WO2004001418A2
公开(公告)日：2003-12-31
申请号：PCT/DE0302096
申请日：2003-06-24
申请人： PROFOS AG , SCHUETZ MICHAEL , MEYER ROMAN , GRALLERT HOLGER , MILLER STEFAN
发明人： SCHUETZ MICHAEL , MEYER ROMAN , GRALLERT HOLGER , MILLER STEFAN
IPC分类号： G01N33/579 , B01J20/24 , B01J20/34 , C07K14/005 , G01N33/483 , G01N33/53 , G01N33/543 , G01N33/547 , G01N33/566 , G01N33/569 , G01N33/92
CPC分类号： G01N33/569 , G01N33/566
摘要： The invention relates to a method for identifying endotoxins in and eliminating them from a sample.
摘要翻译：本发明涉及一种用于检测和减少内毒素的从样品中的方法。

34. 发明申请

WO99019355A1 FACTOR G REDUCED AMEBOCYTE LYSATES FOR DETECTION OF BACTERIAL ENDOTOXINS 审中-公开
标题翻译：因子G减少用于检测细菌内毒素的AMEBOCYTE LYSATE
公开(公告)号：WO99019355A1
公开(公告)日：1999-04-22
申请号：PCT/US1998/020823
申请日：1998-10-02
IPC分类号： G01N33/579 , C07K14/745
CPC分类号： G01N33/579 , Y10S435/962
摘要： The invention provides methods and compositions for the detection and/or quantification of bacterial endotoxins. In particular, provided herein is an inexpensive and reproducible method for producing an improved amebocyte lysate preparation having reduced Factor G activity. Provided also is an endotoxin-specific amebocyte lysate preparation produced by such a method. In addition, the invention provides methods and compositions for enhancing the sensitivity to endotoxins of amebocyte lysate preparations having reducing Factor G activity. In particular, the sensitivity of such amebocyte lysate preparations to endotoxins can be enhanced by the addition of exogenous (1}3) beta -D-glucan.
摘要翻译：本发明提供用于检测和/或定量细菌内毒素的方法和组合物。特别地，本文提供了一种廉价且可重现的方法，用于生产具有降低的因子G活性的改良的血小板裂解物制剂。还提供了通过这种方法制备的内毒素特异性的单核细胞裂解物制剂。此外，本发明提供用于增强具有降低因子G活性的微血管细胞裂解物制剂对内毒素敏感性的方法和组合物。特别地，通过加入外源（1）3）β-D-葡聚糖，可以增强这种细胞裂解物制剂对内毒素的敏感性。

35. 发明申请

WO9906440A8 NOVEL SYNTHETIC PEPTIDES WITH ANTIMICROBIAL AND ENDOTOXIN NEUTRALIZING PROPERTIES FOR MANAGEMENT OF THE SEPSIS SYNDROME 审中-公开
标题翻译：具有抗肠毒素和内毒素中和性质的新型合成肽，用于管理食欲综合征
公开(公告)号：WO9906440A8
公开(公告)日：1999-04-15
申请号：PCT/NL9700449
申请日：1997-07-31
申请人： AZ UNIV AMSTERDAM , APPELMELK BERNARD J , ABRAHAM PHILIP R , DEVENTER SANDER J H VAN
发明人： ABRAHAM PHILIP RICHARD , APPELMELK BERNARD JAN , VAN DEVENTER SANDER JAN HENDRI
IPC分类号： G01N33/53 , A61K38/00 , A61P31/00 , C07K1/00 , C07K7/08 , C07K14/00 , C07K14/47 , C07K17/00 , G01N33/566 , G01N33/579 , A61K38/10 , A61K38/16 , G01N33/68
CPC分类号： G01N33/579 , A61K38/00 , C07K14/4723 , C07K14/4742
摘要： A peptide with an amino acid composition such that the peptide is amphipathic, cationic and forms a stable alpha -helix and has the following structure comprising at least 12 amino acids: R1-R2-A1-B1-(A2-B2-C1-A3)m-(C2)n-R3, wherein A = an amino acid selected from the basic amino acids Lys, Arg or His; B = an amino acid selected from the aromatic amino acids Phe, Trp or Tyr; C = an amino acid selected from the group comprising the hydrophobic amino acids Leu, Ile, Val or Ala; and said peptide has either the orientation according to the formula or the retro orientation thereof, wherein at least 0-n of the repetitive sequence motifs (A2-B2-C1-A3) have the retro orientation and the remaining repetitive motifs (A2-B2-C1-A3) have the orientation as presented in the formula and wherein, R1-R2- and R3 are a number of amino acids, said number ranging from 0-15 for each of the combination of R1 and R2 and for R3 and wherein m=1-10, preferably 2-8, more preferably 2-5 and n=1-3, a pharmaceutical composition comprising such a peptide application thereof in treatment or diagnosis related to i.a. parasite infection topical and systemic tumors and septic shock.
摘要翻译：具有氨基酸组成的肽，使得肽是两亲性的，阳离子的并形成稳定的α-螺旋，并具有包含至少12个氨基酸的以下结构：R1-R2-A1-B1-（A2-B2-C1-A3 ）m-（C 2）n -R 3，其中A =选自碱性氨基酸Lys，Arg或His的氨基酸; B =选自芳族氨基酸Phe，Trp或Tyr的氨基酸; C =选自疏水性氨基酸Leu，Ile，Val或Ala的氨基酸; 并且所述肽具有根据式的取向或其反向取向，其中至少0-n个重复序列基序（A2-B2-C1-A3）具有复制取向和剩余的重复基序（A2-B2 -C1-A3）具有式中所示的取向，并且其中R1-R2-和R3是多个氨基酸，对于R 1和R 2以及R 3的组合中的每一个，所述数目为0-15，并且其中 m = 1-10，优选2-8，更优选2-5和n = 1-3，药物组合物包含其在治疗或诊断中与ia相关的这种肽应用寄生虫感染局部和全身肿瘤和败血性休克。

36. 发明申请

WO1995014932A1 METHOD OF ASSAYING LIMULUS REAGENT-REACTIVE SUBSTANCE 审中-公开
标题翻译：测定极限试剂反应物质的方法
公开(公告)号：WO1995014932A1
公开(公告)日：1995-06-01
申请号：PCT/JP1994001974
申请日：1994-11-22
申请人： SEIKAGAKU CORPORATION , TAMURA, Hiroshi , ODA, Toshio , TANAKA, Shigenori
发明人： SEIKAGAKU CORPORATION
IPC分类号： G01N33/579
CPC分类号： G01N33/579
摘要： A method of assaying a Limulus reagent-reactive substance (endotoxin or (1}3)- beta -D-glucan) in a specimen by the turbidimetric Limulus test without being affected by any interfering substance with high sensitivity and high accuracy, which method comprises treating a specimen solution with a Limulus reagent to cause gelation, irradiating the resulting solution with the rays of light having a measurement wavelength of 460-550 nm and the other rays of light having a reference wavelength of 650-800 nm to detect a change in the absorbance of the transmitted light on the basis of the rise of the solution turbidity caused by the gelation, and establishing a relationship between the concentration of the Limulus reagent-reactive substance and the difference in absorbance between the two rays of light.
摘要翻译：通过比浊鲎试验测定样品中的鲎试剂反应物质（内毒素或（1）3）-β-D-葡聚糖）的方法，不受高灵敏度和高精度的任何干扰物质的影响，该方法包括用鲎试剂处理样品溶液引起凝胶化，用测量波长为460-550nm的光线照射所得到的溶液，并且使用参考波长为650-800nm的其他光线来检测变化基于由凝胶化引起的溶液浊度的升高引起的透射光的吸光度，并且确定鲎试剂反应物质的浓度与两束光线之间的吸光度差之间的关系。

37. 发明申请

WO1991006867A1 ECHINODERM AGGLUTININ AND METHOD OF EXTRACTION 审中-公开
标题翻译： ECHINODERM AGGLUTININ和提取方法
公开(公告)号：WO1991006867A1
公开(公告)日：1991-05-16
申请号：PCT/CA1990000371
申请日：1990-10-29
申请人： WARDLAW, Alastair , MOSELEY, Max
IPC分类号： G01N33/579
CPC分类号： C07K14/435 , G01N33/56916 , G01N33/579 , G01N2400/50
摘要： A method is disclosed for extracting an endotoxin-detecting agglutinin from the coelomic fluid of Echinoderms of the Subclass Regularia. The product is useful in detecting Gram-negative bacteria, endotoxins and endotoxin contamination of injectable and intravenous fluid and medical devices. The product is an alternative to the expensive Limulus Amoebocyte Lysate reagent.
摘要翻译：公开了一种从普通法子类棘皮动物的肠液中提取内毒素检测凝集素的方法。该产品可用于检测注射液和静脉内液体和医疗器械中的革兰氏阴性细菌，内毒素和内毒素污染。该产品是昂贵的鲎变形细胞裂解液试剂的替代品。

38. 发明申请

WO1988009507A1 A METHOD OF DETERMINING THE PRESENCE OF ENDOTOXIN IN A SAMPLE 审中-公开
标题翻译：确定样品中内毒素存在的方法
公开(公告)号：WO1988009507A1
公开(公告)日：1988-12-01
申请号：PCT/DK1988000081
申请日：1988-05-19
申请人： BAEK, Leif , KOCH, Claus
IPC分类号： G01N33/579
CPC分类号： G01N33/579 , G01N33/56916
摘要： In a method of determining the presence of an endotoxin or endotoxin-like material in a sample, a) a sample is incubated with a component of horseshoe crab amoebocytes lysate or haemolymph or a synthetic analogue thereof, b) the incubated mixture of the sample and the component or analogue resulting from step a) is reacted with an antibody raised against the component or analogue or against a reaction product of the incubation of step a), and c) the presence of endotoxin or endotoxin-like material in the sample is determined by detecting any bound antibody in the reaction mixture of step b). In the method either the component or analogue or the antibody or the endotoxin or endotoxin-like material is coupled to a solid support.
摘要翻译：在测定样品中存在内毒素或内毒素样物质的方法中，a）将样品与马蹄蟹变形细胞裂解物或血淋巴或其合成类似物的组分一起温育，b）将样品和由步骤a）得到的组分或类似物与针对组分或类似物产生的抗体或与步骤a）的培养反应产物反应，和c）测定样品中内毒素或内毒素样物质的存在通过检测步骤b）的反应混合物中的任何结合的抗体。在该方法中，组分或类似物或抗体或内毒素或内毒素样物质偶联至固体支持物。

39. 发明申请

WO2022174082A1 HYBRID AMEBOCYTE LYSATE AND USES THEREOF 审中-公开
公开(公告)号：WO2022174082A1
公开(公告)日：2022-08-18
申请号：PCT/US2022/016185
申请日：2022-02-11
申请人： CHARLES RIVER LABORATORIES, INC.
发明人： WAINWRIGHT, Norman, R. , TSUCHIYA, Masakazu , DUBCZAK, John , JORDAN, Foster, T.
IPC分类号： C12N9/64 , C12Q1/34 , G01N33/579
摘要： The invention relates generally to hybrid amebocyte lysate compositions (including both native and recombinant components) and their use in detecting and/or quantifying endotoxin in a sample.

40. 发明申请

WO2021100367A1 検査装置审中-公开
公开(公告)号：WO2021100367A1
公开(公告)日：2021-05-27
申请号：PCT/JP2020/038808
申请日：2020-10-14
申请人：富士フイルム株式会社
发明人：入澤　覚 , 瀬戸　義弘 , 清水　仁 , 宮戸　崇裕
IPC分类号： C12M1/34 , G01N21/01 , G01N21/49 , G01N21/83 , G01N33/579
摘要：複数の試験体を保持し、小型であって、複数の検査方法でエンドトキシンまたは（１→３)－β－Ｄ－グルカンの検査を精度良く実施し得る検査装置を提供する。検査装置１０は、検査対象１３を収容する断面円形の試験体２１と、複数の試験体２１を１列に保持する試験体保持部２２と、複数の試験体２１のうち、隣接する２つの試験体２１に光を入射する発光素子６２，６３と、発光素子６２，６３が発光した光を導光する第１導光路４６と、第１導光路４６よりも細径に形成され、第１導光路４６から試験体２１に、発光素子６２，６３が発光した光を導光する第２導光路４７と、を備える。

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