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31. 发明申请

WO2021081404A INDICATOR COMPOUNDS, DEVICES COMPRISING INDICATOR COMPOUNDS, AND METHODS OF MAKING AND USING THE SAME 审中-公开
公开(公告)号：WO2021081404A
公开(公告)日：2021-04-29
申请号：PCT/US2020/057164
申请日：2020-10-23
申请人： CERCACOR LABORATORIES, INC. [US]/[US]
发明人： KRISHNAMANI, Venkatramanan , BALASHOV, Sergei Petrovich , PAULEY, Kevin Hughes , LONG, Ruiqi , VO, Hung The
IPC分类号： G01N33/52 , G01N33/533 , G01N33/543 , G01N33/566 , C07K19/00 , A61B5/145
摘要： Some embodiments disclosed herein pertain to indicator compounds used to detect the presence of and/or an amount of an analyte. In some embodiments, the indicator compounds are fusion proteins. In some embodiments, when the analyte binds to the indicator compound, the indicator compound undergoes a conformational change. In some embodiments, the conformational change results in a luminescent signal that allows quantification of the amount of analyte present.

32. 发明申请

WO2021081063A1 FENTANYL ANALOGUE DETECTION METHODS AND KITS THEREOF 审中-公开
公开(公告)号：WO2021081063A1
公开(公告)日：2021-04-29
申请号：PCT/US2020/056613
申请日：2020-10-21
申请人： VERITEQUE USA, INC.
发明人： LOANE, Christian
IPC分类号： G01N21/78 , G01N21/77 , G01N21/79 , G01N31/22 , G01N33/50 , G01N33/52
摘要： A portable detection kit for identifying the presence of narcotic compounds (NCs) includes at least one chemical dye, a catalytic reagent, at least one solvent, and a least one surfactant. The at least one dry chemical dye is configured to undergo physic-chemical interaction with at least one predetermined NC to produce a color visible change. The at least one predetermined NC is selected from the group consisting of fentanyl analogues (FAs) and narcotics containing nitrogen heterocyclic moiety.

33. 发明申请

WO2021068060A1 INCUBATOR IMAGING SYSTEM 审中-公开
公开(公告)号：WO2021068060A1
公开(公告)日：2021-04-15
申请号：PCT/CA2020/051336
申请日：2020-10-06
申请人： INCUVERS INC.
发明人： HADJIANTONIOU, Sebastian , SEAN, David
IPC分类号： G01N15/10 , C12M1/34 , C12M1/36 , G01N33/52 , G02B21/36
摘要： An incubator imaging system for live cell imaging having an incubation chamber for maintaining an internal environment, an environmental controller for controlling the internal environment in the incubation chamber, an environmental sensor for detecting an environmental condition in the incubation chamber, and a microscopy device with a illumination matrix having a plurality of light sources. The incubator imaging system can capture images of cells in a variety of illumination conditions during cell growth by varying the image capture conditions.

34. 发明申请

WO2021049527A1 キットおよび方法审中-公开
公开(公告)号：WO2021049527A1
公开(公告)日：2021-03-18
申请号：PCT/JP2020/034107
申请日：2020-09-09
申请人：デンカ株式会社
发明人：伊藤　康樹 , 佐藤　謙亨
IPC分类号： C12Q1/60 , G01N33/52 , G01N33/92
摘要：試料中のｓｄＬＤＬ－Ｃの分別に用いられるキットであって、コレステロールエステラーゼ活性、コレステロールオキシダーゼ活性およびスフィンゴミエリナーゼ活性からなる群から選択される１または２以上の活性を有する第１試薬組成物と、ｓｄＬＤＬ－Ｃを定量するための第２試薬組成物と、を含み、第１試薬組成物を３７℃にて２週間保存した後の吸収スペクトルにおいて、ＡＢＳ４００／ＡＢＳ４５０で表される比Ｒ１が０．９０以上３．００以下であり、第２試薬組成物を３７℃にて２週間保存した後の吸収スペクトルにおいて、ＡＢＳ４００／ＡＢＳ４５０で表される比Ｒ１が０．９０以上８．００以下である、キット。

35. 发明申请

WO2021045475A1 비색법 진단 패드, 이를 이용한 검출 대상물질 정량화 시스템 및 방법 审中-公开
公开(公告)号：WO2021045475A1
公开(公告)日：2021-03-11
申请号：PCT/KR2020/011683
申请日：2020-09-01
申请人： 주식회사 필메디
发明人： 이병환
IPC分类号： G01N21/76 , G01N33/53 , G01N33/52 , H04N5/335 , G06F17/10 , G01N21/77
摘要： 비색법 진단 패드 및 이를 이용한 검출 대상물질 정량화 시스템 및 방법을 개시한다. 상기 비색법 진단 패드는 제1 가이드 영역(110)이 표시된 기판(100) 및 상기 제1 가이드 영역(110) 내부에 위치하고 기재(210)와 상기 기재 상에 위치하는 검출영역(220)을 구비한 비색법 진단 스트립(200)을 포함할 수 있다. 본 발명의 검출 대상물질 정량화 시스템 및 방법은 별도의 장치를 사용하지 않고, 스마트폰에 내장된 플래쉬 라이트를 사용하여 촬영해 주변 광원의 영향을 감소시킬 수 있는 효과가 있다. 또한 스마트폰과 비색법 진단 패드의 가이드를 일치시켜 촬영하여 스마트폰과 비색법 진단 패드 사이의 거리 및 각도를 일정하게 유지할 수 있고, 스마트폰의 가이드 조절을 통해 일정한 휘도 조건에서 촬영하여 스마트폰 간의 편차를 줄일 수 있는 효과가 있다. 또한 플래쉬 라이트의 직접광을 피해서 촬영하므로 진단 스트립의 액체가 마르지 않아도 액체에 플래쉬 라이트의 광원이 반사되는 것을 방지할 수 있고, 진단 스트립 구성 시 실링테이프, 플라스틱 하우징 등 플래쉬 라이트의 광원이 반사될 수 있는 구성품이 사용된 진단 스트립도 촬영이 가능하다.

36. 发明申请

WO2021019529A1 METHODS AND KITS FOR IDENTIFYING THROMBUS ORIGIN AND OPTIMIZING POST-ISCHEMIC EVENT TREATMENT 审中-公开
公开(公告)号：WO2021019529A1
公开(公告)日：2021-02-04
申请号：PCT/IL2020/050816
申请日：2020-07-23
申请人： TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
发明人： ORION, David , ITSEKSON-HAYOSH, Zeev , SHAVIT-STEIN, Efrat , CHAPMAN, Joab
IPC分类号： G01N33/86 , C12Q1/56 , G01N33/52
摘要： Provided herein are method and kits for identifying thrombus origin based on temporal thrombin activity assay, and use thereof for optimizing post-ischemic event treatment, and further preventing recurrence of secondary ischemic events.

37. 发明申请

WO2020234728A1 COMPENSATION SYSTEM AND METHOD FOR THERMISTOR SENSING IN AN ANALYTE BIOSENSOR 审中-公开
公开(公告)号：WO2020234728A1
公开(公告)日：2020-11-26
申请号：PCT/IB2020/054643
申请日：2020-05-15
申请人： ASCENSIA DIABETES CARE HOLDINGS AG
发明人： HARRISON, Bern, Everett
IPC分类号： A61B5/145 , G01N27/327 , G01N33/487 , G01N33/52
摘要： An analyte concentration sensor system is disclosed that selects a temperature for input to an analyte concentration estimation algorithm. The analyte concentration estimation algorithm is executed by an analyte meter that analyzes a sample in a test sensor. A thermistor based temperature sensor is configured to measure temperature. An estimated temperature is obtained via a temperature estimation algorithm. The difference between the estimated temperature and the measured temperature is determined. One of the estimated temperature or the measured temperature is selected based on the estimated temperature, the measured temperature and the absolute difference between the estimated temperature and the measured temperature. In addition, a malfunction in the test sensor may be determined based on the estimated temperature, the measured temperature and the absolute difference between the estimated temperature and the measured temperature.

38. 发明申请

WO2020188596A1 A METHOD FOR DETECTION OF PROTEIN ACTIVATION USING PHOSPHOBRET IMAGING SENSOR AND METHODS THEREOF 审中-公开
公开(公告)号：WO2020188596A1
公开(公告)日：2020-09-24
申请号：PCT/IN2020/050237
申请日：2020-03-16
申请人： ADVANCED CENTRE FOR TREATMENT, RESEARCH AND EDUCATION IN CANCER, TATA MEMORIAL CENTRE
发明人： DE, Abhijit , RAY, Pritha , DIMRI, Shalini , BISHNU, Aniketh
IPC分类号： G01N33/52
摘要： A fusion construct comprising sequence encoding Nanoluciferase and a flurophore selected from list of TurboFP635, TagRFP and mOrange to form a bioluminescence resonance energy transfer (BRET) sensor-based donor-acceptor pair is provided. The system and methods to detect phosphorylation of STAT3 and AKT protein is provided.

39. 发明申请

WO2020182633A1 Staining Agent Solutions For Use In Fluorescence Microscopy 审中-公开
公开(公告)号：WO2020182633A1
公开(公告)日：2020-09-17
申请号：PCT/EP2020/055941
申请日：2020-03-05
申请人： SAMANTREE MEDICAL SA
发明人： SHAFFER, Etienne , HORISBERGER, Aurèle Timothée , SCHMITT, Frédéric , RACHET, Bastien
IPC分类号： G01N33/52 , G01N1/30 , G02B21/34
摘要： Disclosed herein are staining agent solutions for use in fluorescence microscopy. One example of fluorescence microscopy in which the stainingagent solutions are useful is intraoperative confocal microscopy. Intraoperative confocal microscopy can be used, for example, to assess margins of resected cancerous tissue. Example staining agent solutions include acridine orange,where the pH of the solutionis from6 to8, for example from6.8 to 7.4. The solutionmay include a phosphate-buffered saline (PBS). The solutionmay be isotonic. The solutionmay comprise one or more of potassiumdihydrogenphosphate, disodium hydrogenphosphate, and sodium chloride. In some embodiments, the staining agent solution does not comprise acetic acid (e.g., an acetate buffer). Staining agent solutions disclosed herein may reduce adverse impacts to tissue resulting from staining. Staining agent solutions disclosed herein may preserve normal appearance of tissue. Staining agent solutions disclosed herein may have negligible or reduced odor.

40. 发明申请

WO2020148593A1 MULTI-TEST KIT 审中-公开
公开(公告)号：WO2020148593A1
公开(公告)日：2020-07-23
申请号：PCT/IB2019/061468
申请日：2019-12-31
申请人： RUSSAK, Ze'ev
发明人： RUSSAK, Ze'ev
IPC分类号： C12Q1/02 , C12Q1/04 , C12Q1/68 , C12Q1/70 , C12M1/34 , G01N21/75 , G01N21/78 , G01N33/50 , G01N33/52 , G01N33/53
摘要： A prefabricated multi-test kit, the kit that comprises a plurality of reaction cells, each one of at least two of the reaction cells holding reagents of a respective, different set of at least two tests selected from a group consisting of a plurality of different tests, the tests being distributed among the reaction cells in a manner that leaves reagents of each different one of the tests of the group in a respective different sub-combination of the reaction cells, and allows any sub-combination of the reaction cells to be indicative of a sub-group comprising all positive tests of the group when each reaction cell of the sub-combination that is indicative of the sub-group, contains an at least one positive test and none of the remaining reaction cells contain a positive test.

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