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31. 发明申请

WO2005014037A2 POLYSACCHARIDE-PROTEIN CONJUGATE VACCINES 审中-公开
标题翻译：多糖 - 蛋白质结合疫苗
公开(公告)号：WO2005014037A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/025477
申请日：2004-08-06
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , LEE, Che-Hung, Robert , FRASCH, Carl, E.
发明人： LEE, Che-Hung, Robert , FRASCH, Carl, E.
IPC分类号： A61K39/02
CPC分类号： A61K39/095 , A61K39/09 , A61K39/385 , A61K47/646 , A61K2039/6037 , A61K2039/62 , Y02A50/484
摘要： Abstract of the Disclosure Methods for synthesis and manufacture of polysaccharide-protein conjugate vaccines at high yield are provided. The methods involve reaction of a hydrazide group on one reactant with an aldehyde or cyanate ester group on the other reactant. The reaction proceeds rapidly with a high conjugation efficiency, such that a simplified purification process can be employed to separate the conjugate product from the unconjugated protein and polysaccharide and other small molecule by-products.
摘要翻译：摘要提供了以高产率合成和制造多糖 - 蛋白质结合疫苗的方法。该方法包括将一个反应物上的酰肼基团与另一反应物上的醛或氰酸酯基团反应。该反应以高共轭效率快速进行，从而可以采用简化的纯化方法将共轭产物与未结合的蛋白质和多糖等小分子副产物分离。

32. 发明申请

WO1992019267A1 IMMUNOSTIMULATING AND IMMUNOPOTENTIATING RECONSTITUTED INFLUENZA VIROSOMES AND VACCINES CONTAINING THEM 审中-公开
标题翻译：免疫调节和免疫重建的流感病毒和包含它们的疫苗
公开(公告)号：WO1992019267A1
公开(公告)日：1992-11-12
申请号：PCT/EP1992001014
申请日：1992-05-08
申请人： SCHWEIZ. SERUM- & IMPFINSTITUT BERN , GLÜCK, Reinhard , MISCHLER, Robert
发明人： SCHWEIZ. SERUM- & IMPFINSTITUT BERN
IPC分类号： A61K39/145
CPC分类号： A61K39/29 , A61K9/1271 , A61K39/12 , A61K39/385 , A61K39/39 , A61K2039/5252 , A61K2039/5258 , A61K2039/55555 , A61K2039/6075 , A61K2039/62 , A61K2039/622 , C12N7/00 , C12N2770/24234 , C12N2770/32434 , Y02A50/464
摘要： Disclosed are immunostimulating reconstituted influenza virosomes (IRIVs) comprising the following components: (a) a mixture of phospholipids; (b) essentially reconstituted functional virus envelopes; (c) an influenza hemagglutinin protein (HA) or a derivative thereof which is biologically active and capable of inducing the fusion of said IRIV with cellular membranes and of inducing the lysis of said IRIV after endocytosis by antigen presenting cells, preferably macrophages or B cells; and (d) an antigen, and vaccines containing these IRIVs.
摘要翻译：公开了免疫刺激重构的流感病毒体（IRIV），其包含以下组分：（a）磷脂的混合物; （b）基本上重建的功能性病毒信封; （c）具有生物活性且能够诱导所述IRIV与细胞膜融合的流感血凝素蛋白（HA）或其衍生物，并且在抗原呈递细胞（优选巨噬细胞或B细胞）内吞后诱导所述IRIV的裂解 ; 和（d）抗原和含有这些IRIV的疫苗。

33. 发明申请

WO2015179270A2 COMBINATORIAL PLATFORM FOR THE DISPLAY OF SURFACE ADJUVANTS AND ANTIGENS 审中-公开
标题翻译：用于显示表面调节物和抗原的组合平台
公开(公告)号：WO2015179270A2
公开(公告)日：2015-11-26
申请号：PCT/US2015/031325
申请日：2015-05-18
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
发明人： TRENT, M. Stephen , BOLL, Joseph M.
IPC分类号： A61K39/295 , C12N1/20
CPC分类号： A61K39/145 , A61K39/107 , A61K39/12 , A61K2039/522 , A61K2039/5252 , A61K2039/55572 , A61K2039/55583 , A61K2039/575 , A61K2039/6006 , A61K2039/6087 , A61K2039/62 , A61K2039/70 , C07K14/005 , C07K14/195 , C07K2319/03 , C07K2319/21 , C07K2319/42 , C07K2319/91 , C12N7/00 , C12N9/1081 , C12N15/52 , C12N2760/16022 , C12N2760/16034 , C12N2760/16071 , C12N2760/16134 , C12Y204/99019 , Y02A50/407 , Y02A50/466 , Y02A50/472 , Y02A50/484
摘要： Engineered bacteria are provided that produce modified lipid A and a polypeptide or polysaccharide antigens. In some aspects, immunogenic compositions are provided comprising a modified a lipid A and a polypeptide or polysaccharide antigen.
摘要翻译：提供了产生经修饰的脂质A和多肽或多糖抗原的工程细菌。在一些方面，提供包含修饰的脂质A和多肽或多糖抗原的免疫原性组合物。

34. 发明申请

WO2013116656A1 IMMUNOSTIMULATORY COMPOSITIONS, PARTICLES, AND USES RELATED THERETO 审中-公开
标题翻译：免疫组化，颗粒和相关用途
公开(公告)号：WO2013116656A1
公开(公告)日：2013-08-08
申请号：PCT/US2013/024355
申请日：2013-02-01
申请人： EMORY UNIVERSITY
发明人： SELVARAJ, Periasamy
IPC分类号： A61K39/00 , A61K39/12 , A61P35/00 , A61P31/12
CPC分类号： A61K39/385 , A61K39/0011 , A61K39/39 , A61K2039/515 , A61K2039/5152 , A61K2039/5258 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55533 , A61K2039/55538 , A61K2039/55561 , A61K2039/55572 , A61K2039/6018 , A61K2039/62 , A61K2039/627
摘要： In some embodiments, described herein is a method of tumor treatment or tumor vaccination. The method generally comprises applying to a human being in need thereof a tumor therapeutic composition or tumor vaccine defined herein. The tumor therapeutic composition or tumor vaccine can be produced by protein transfer of glycosyl-phosphatidylinositol (GPI)-anchored immunostimulatory or costimulatory molecules.
摘要翻译：在一些实施方案中，本文所述是肿瘤治疗或肿瘤疫苗接种的方法。该方法通常包括向有需要的人施用本文定义的肿瘤治疗组合物或肿瘤疫苗。肿瘤治疗组合物或肿瘤疫苗可以通过蛋白质转移糖基 - 磷脂酰肌醇（GPI） - 免疫刺激或共刺激分子来产生。

35. 发明申请

WO2011110531A2 CONJUGATION PROCESS 审中-公开
标题翻译：衔接流程
公开(公告)号：WO2011110531A2
公开(公告)日：2011-09-15
申请号：PCT/EP2011/053400
申请日：2011-03-07
申请人： GLAXOSMITHKLINE BIOLOGICALS S.A. , BIEMANS, Ralph Leon , DUVIVIER, Pierre , GAVARD, Ollivier Francis Nicolas
发明人： BIEMANS, Ralph Leon , DUVIVIER, Pierre , GAVARD, Ollivier Francis Nicolas
CPC分类号： A61K47/48261 , A61K39/092 , A61K47/61 , A61K47/6415 , A61K47/646 , A61K2039/6037 , A61K2039/62
摘要： Process for conjugation of bacterial saccharides including Streptococcus pneumoniae and Haemophilus influenzae saccharides by reductive amination are provided herein.
摘要翻译：本文提供了通过还原胺化将包括肺炎链球菌和流感嗜血杆菌糖在内的细菌糖共轭的方法。

36. 发明申请

WO2011085231A2 SYNTHETIC VIRUS-LIKE PARTICLES CONJUGATED TO HUMAN PAPILLOMAVIRUS CAPSID PEPTIDES FOR USE AS VACCINES 审中-公开
标题翻译：合成病毒颗粒与人类斑马鱼胶囊一起用作疫苗
公开(公告)号：WO2011085231A2
公开(公告)日：2011-07-14
申请号：PCT/US2011/020557
申请日：2011-01-07
申请人： SELECTA BIOSCIENCES, INC. , PITTET, Lynnelle, Ann McNamee , GAO, Yun , ZEPP, Charles , LIPFORD, Grayson, B.
发明人： PITTET, Lynnelle, Ann McNamee , GAO, Yun , ZEPP, Charles , LIPFORD, Grayson, B.
IPC分类号： A61K39/385 , C07K17/00 , A61K38/16 , C07K14/00 , C07K14/025 , A61P31/12 , A61P37/04 , C12N7/00
CPC分类号： A61K39/12 , A61K39/385 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/6935 , A61K2039/5258 , A61K2039/6093 , A61K2039/62 , A61K2039/70 , C07K14/005 , C12N7/00 , C12N2710/20022 , C12N2710/20023 , C12N2710/20034 , G01N33/54346
摘要： Disclosed are compositions and related methods that involve a synthetic nanocarrier that includes at least one peptide obtained from Human papillomavirus L1 or L2 capsid protein; wherein the peptide is coupled to an external surface of the synthetic nanocarrier.
摘要翻译：公开了涉及包含从人乳头瘤病毒L1或L2衣壳蛋白获得的至少一种肽的合成纳米载体的组合物和相关方法; 其中所述肽与所述合成纳米载体的外表面偶联。

37. 发明申请

WO2010138194A3 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS 审中-公开
标题翻译：免疫组化试剂 - 聚合物
公开(公告)号：WO2010138194A3
公开(公告)日：2011-06-30
申请号：PCT/US2010001561
申请日：2010-05-26
申请人： SELECTA BIOSCIENCES INC , ZEPP CHARLES , LIPFORD GRAYSON B , GAO YUN , JOHNSTON LLOYD , FU FEN-NI , KEEGAN MARK J , BALDWIN SAM
发明人： ZEPP CHARLES , LIPFORD GRAYSON B , GAO YUN , JOHNSTON LLOYD , FU FEN-NI , KEEGAN MARK J , BALDWIN SAM
IPC分类号： A61K47/48 , A61K9/16 , A61K39/385 , A61K39/39 , A61P37/04
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译：本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

38. 发明申请

WO2010123798A3 COMPOSITIONS FOR TRANSFECTION OF BIOMOLECULES INTO CELLS 审中-公开
标题翻译：生物分子转染细胞的组合物
公开(公告)号：WO2010123798A3
公开(公告)日：2011-03-10
申请号：PCT/US2010031559
申请日：2010-04-19
申请人： GALENBIO INC , GRANDICS PETER , SZATHMARY SUSAN
发明人： GRANDICS PETER , SZATHMARY SUSAN
IPC分类号： C12N5/00
CPC分类号： A61K47/02 , A61K39/0241 , A61K2039/552 , A61K2039/6087 , A61K2039/62
摘要： The present invention is directed to new compositions that are described for the simultaneous, controlled dose delivery of a variety of biomolecules into phagocytic cells. Such a composition is a biologically active composition comprising: (1) at least one of the following biologically active components: (a) a nucleic acid or a derivative thereof; (b) a nucleoside, nucleotide, or a derivative of a nucleoside or nucleotide; (c) a peptide, protein, or a derivative of a peptide or protein; (d) a lipopolysaccharide or a derivative thereof; (e) a peptidoglycan or a derivative thereof; (f) a carbohydrate or a derivative thereof; (g) a lipid or a derivative thereof; (h) a lipopeptide or a derivative thereof; (i) a metal ion; (j) a thiol; (k) an antibiotic or a derivative thereof; (I) a vitamin or a derivative thereof; (m) a bioflavonoid or a derivative thereof; (n) an antioxidant or a derivative thereof; (o) an immune response modifier; (p) an antibody; (q) a biologically active nonmetal; (r) histamine or an antihistamine; and (s) a kinase inhibitor; and (2) at least one carrier effective to deliver the composition to a phagocytic cell such that the biologically active component is taken up by the phagocytic cell and influences its biological activity.
摘要翻译：本发明涉及用于将多种生物分子同时受控剂量递送至吞噬细胞的新组合物。这种组合物是生物活性组合物，其包含：（1）至少一种以下生物活性成分：（a）核酸或其衍生物; （b）核苷或核苷酸的核苷酸或衍生物; （c）肽或蛋白质的肽，蛋白质或衍生物; （d）脂多糖或其衍生物; （e）肽聚糖或其衍生物; （f）碳水化合物或其衍生物; （g）脂质或其衍生物; （h）脂肽或其衍生物; （i）金属离子; （j）硫醇; （k）抗生素或其衍生物; （I）维生素或其衍生物; （m）生物类黄酮或其衍生物; （n）抗氧化剂或其衍生物; （o）免疫反应调节剂; （p）抗体; （q）生物活性非金属; （r）组胺或抗组胺药; 和（s）激酶抑制剂; 和（2）至少一种有效将组合物递送至吞噬细胞的载体，使得生物活性成分被吞噬细胞吸收并影响其生物活性。

39. 发明申请

WO2010138194A2 IMMUNOMODULATORY AGENT-POLYMERIC COMPOUNDS 审中-公开
标题翻译：免疫组化试剂 - 聚合物
公开(公告)号：WO2010138194A2
公开(公告)日：2010-12-02
申请号：PCT/US2010/001561
申请日：2010-05-26
申请人： SELECTA BIOSCIENCES, INC. , ZEPP, Charles , LIPFORD, Grayson, B. , GAO, Yun , JOHNSTON, Lloyd , FU, Fen-ni , KEEGAN, Mark, J. , BALDWIN, Sam
发明人： ZEPP, Charles , LIPFORD, Grayson, B. , GAO, Yun , JOHNSTON, Lloyd , FU, Fen-ni , KEEGAN, Mark, J. , BALDWIN, Sam
IPC分类号： A61K47/48
CPC分类号： A61K39/385 , A61K9/5138 , A61K39/0013 , A61K39/39 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/64 , A61K47/6925 , A61K47/6935 , A61K47/6937 , A61K2039/55511 , A61K2039/55544 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/62 , A61K2039/627 , B82Y5/00 , C07D471/04 , C07D473/34 , C08G63/06 , C08G63/08 , C08G63/912 , C08G64/42 , C08J3/24 , C08J2367/04
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of immunomodulatory agents and polymers or unit(s) thereof. The conjugates may be contained within synthetic nanocarriers, and the immunomodulatory agents may be released from the synthetic nanocarriers in a pH sensitive manner.
摘要翻译：本发明涉及免疫调节剂和聚合物或其单元的缀合物的组合物及相关化合物和方法。缀合物可以包含在合成纳米载体内，并且免疫调节剂可以以pH敏感的方式从合成纳米载体中释放。

40. 发明申请

WO2010006753A3 SILICON DIOXIDE NANOPARTICLES AND THEIR USE FOR VACCINATION 审中-公开
标题翻译：二氧化硅纳米粒子及其用途接种
公开(公告)号：WO2010006753A3
公开(公告)日：2010-04-29
申请号：PCT/EP2009005078
申请日：2009-07-13
申请人： MERCK PATENT GMBH , WEIGANDT MARKUS , HANEFELD ANDREA , KUEBELBECK ARMIN , LARBIG GREGOR
发明人： WEIGANDT MARKUS , HANEFELD ANDREA , KUEBELBECK ARMIN , LARBIG GREGOR
IPC分类号： A61K9/16
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/10 , A61K9/143 , A61K9/5115 , A61K39/0005 , A61K47/52 , A61K47/54 , A61K47/643 , A61K47/6923 , A61K2039/55505 , A61K2039/62 , B82Y5/00 , Y10T428/2982
摘要： The invention relates to ultra-small, monodisperse nanoparticles of silicon dioxide with at least one antigen attached to their surface. The nanoparticles can be used for the immunoprophylaxis or immunotherapy of cancer. The invention also provides a method of targeting antigens at antigen-presenting cells and of activating the immune system, the efficiency of targeting and/or immune activation being adjusted via the particle characteristics. The invention also relates to methods of active and passive immunization of a mammal.
摘要翻译：本发明涉及一种二氧化硅的超小，单分散的纳米颗粒，在其表面上的至少一种抗原连接。所述纳米颗粒可用于免疫预防或免疫治疗癌症。本发明还提供了用于抗原靶向抗原呈递细胞和免疫系统的激活，由此定位和/或免疫激活的效率经由粒子特性来设定的方法。本发明还涉及一种用于哺乳动物的主动和被动免疫的方法。

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