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31. 发明申请

WO2010142423A2 USE OF AN ANTI-TAU PS422 ANTIBODY FOR THE TREATMENT OF BRAIN DISEASES 审中-公开
标题翻译：使用抗谷氨酸PS422抗体治疗脑疾病
公开(公告)号：WO2010142423A2
公开(公告)日：2010-12-16
申请号：PCT/EP2010/003437
申请日：2010-06-08
申请人： F. HOFFMANN-LA ROCHE AG , BOHRMANN, Bernd , GOEPFERT, Ulrich , GRUENINGER, Fiona , HUBER, Walter , KRELL, Hans-Willi , LIFKE, Valeria , MUNDIGL, Olaf , OFFNER, Sonja , OZMEN, Laurence , SCHRAEML, Michael
发明人： BOHRMANN, Bernd , GOEPFERT, Ulrich , GRUENINGER, Fiona , HUBER, Walter , KRELL, Hans-Willi , LIFKE, Valeria , MUNDIGL, Olaf , OFFNER, Sonja , OZMEN, Laurence , SCHRAEML, Michael
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/4711 , C07K16/3053 , C07K2317/622 , C07K2317/92 , C07K2317/94 , C07K2319/40 , C07K2319/55
摘要： An antibody binding to Tau, phosphorylated at serine 422 (pS422), characterized in specifically binding to phosphorylated Tau fragment of SEQ ID NO: 9 and to Tau pS422, but not binding to Tau and to phosphorylated MCAK fragment of SEQ ID NO: 17 is useful in the treatment of a Tauopathy.
摘要翻译：特异性结合SEQ ID NO：9的磷酸化Tau片段和Tau pS422，但不结合Tau和SEQ ID NO：17的磷酸化MCAK片段的以丝氨酸422（pS422）磷酸化的抗体结合Tau的抗体是可用于治疗Tauopathy。

32. 发明申请

WO2010022910A1 METHOD TO SCREEN HIGH AFFINITY ANTIBODY 审中-公开
标题翻译：筛选高亲和力抗体的方法
公开(公告)号：WO2010022910A1
公开(公告)日：2010-03-04
申请号：PCT/EP2009/006136
申请日：2009-08-25
申请人： F. HOFFMANN-LA ROCHE AG , SCHRAEML, Michael , VON PROFF, Leopold
发明人： SCHRAEML, Michael , VON PROFF, Leopold
IPC分类号： G01N21/55
CPC分类号： G01N33/6854 , C07K16/26 , G01N21/553
摘要： The current invention reports a method for producing an antibody comprising the steps of a) providing a plurality of hybridoma cells each expressing an antibody, b) determining the time dependent amount of said antibody bound to the respective antigen by surface plasmon resonance at different temperatures and different antibody concentrations, c) calculating with the time dependent amount determined in b) based on equations (II) to (XIII) at least the thermodynamic parameters (i) standard association binding entropy formula (A), (ii) standard dissociation binding entropy formula (B), (iii) standard binding entropy (ΔS°), (iv) free standard binding enthalpy (ΔG°), (v) standard dissociation free binding enthalpy formula (C), (vi) standard association free binding enthalpy formula (D), (vii) -TΔS°, (viii) dissociation rate constant k d , (ix) equilibrium binding constant K D , and (x) association rate constant k a , d) selecting a hybridoma cell producing an antibody with at least two of the following: i) a standard association binding entropy of less than 10 J/K*mol, ii) an absolute standard dissociation binding entropy of 100 J/mol*K or more, iii) an absolute standard binding entropy of 100 J/mol*K or more, e) producing an antibody by cultivating said selected cell under conditions suitable for the expression of said antibody and recovering said antibody from the cells or/and the cultivation medium.
摘要翻译：本发明报告了一种制备抗体的方法，包括以下步骤：a）提供多个表达抗体的杂交瘤细胞，b）通过在不同温度下的表面等离振子共振测定与相应抗原结合的所述抗体的时间依赖性量，不同的抗体浓度，c）基于等式（II）至（XIII），至少在热力学参数（i）标准关联结合熵公式（A），（ii）标准解离结合熵式（B），（iii）标准结合熵（ΔS°），（iv）游离标准结合焓（ΔG°），（v）标准无离子结合焓式（C），（vi）焓公式（D），（vii）-T≤S°，（viii）解离速率常数kd，（ix）平衡结合常数KD和（x）缔合速率常数ka，d）选择产生抗体的杂交瘤细胞至少有两个以下：i）小于10J / K * mol的标准缔合结合熵，ii）100J / mol * K以上的绝对标准解离结合熵，iii）绝对标准结合熵为100J / mol * K以上，e）通过在适于表达所述抗体的条件下培养所述选择的细胞并从细胞或培养基中回收所述抗体来产生抗体。

33. 发明申请

WO2023012321A1 CHIMERIC IGG-FC-BINDING LIGAND POLYPEPTIDE AND USES THEREOF FOR IGG AFFINITY PURIFICATION 审中-公开
公开(公告)号：WO2023012321A1
公开(公告)日：2023-02-09
申请号：PCT/EP2022/072045
申请日：2022-08-05
申请人： ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC. , F. HOFFMANN-LA ROCHE AG
发明人： EISENHAUER, Romina , KRONER, Frank , PATEL, Jigar , SCHRAEML, Michael , STRAUSS, Martin , TAEUBER, Simone
IPC分类号： C07K14/195 , C07K16/06
摘要： The present invention relates to a chimeric IgG-Fc-binding ligand polypeptide, comprising a protein fragment of SlyD, wherein the IF domain thereof is replaced by the affinity peptide Fc-III-4C or an Fc-III-XC variant thereof, as well as related uses for IgG affinity purification.

34. 发明申请

WO2022090455A1 SARS-COV-2 NUCLEOCAPSID ANTIBODIES 审中-公开
公开(公告)号：WO2022090455A1
公开(公告)日：2022-05-05
申请号：PCT/EP2021/080106
申请日：2021-10-29
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： GERG, Michael , JUCKNISCHKE, Ute , KURTKAYA, Ulrike , MOCK, Thomas , SCHRAEML, Michael , STIEGLER, Sandrine Carolina
IPC分类号： C07K16/10 , G01N33/569 , G01N33/577
摘要： The present invention relates to monoclonal antibodies binding to the nucleocapsid protein of SARS-CoV-2 virus, nucleic acids encoding said antibody, host cells producing the same, compositions and kits comprising said antibodies, as well as method od detecting SARS-CoV-2 virus in a sample comprising using said antibodies.

35. 发明申请

WO2020245377A1 HYBRIDIZING ALL-LNA OLIGONUCLEOTIDES 审中-公开
公开(公告)号：WO2020245377A1
公开(公告)日：2020-12-10
申请号：PCT/EP2020/065654
申请日：2020-06-05
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： BERGMANN, Frank , HEINDL, Dieter , SCHRAEML, Michael , STOECKEL, Johannes
IPC分类号： C12Q1/6804 , G01N33/543
摘要： The present report relates to hybridizing single-stranded (ss-) oligonucleotides which entirely consist of locked nucleic acid (LNA) monomers. The present document shows hybridization experiments with pairs of entirely complementary ss- oligonucleotides which fail to form a duplex within a given time interval. The present report provides methods to identify such incompatible oligonucleotide pairs. In another aspect, the present report provides pairs of complementary ss- oligonucleotides which are capable of rapid duplex formation. The present report also provides methods to identify and select compatible oligonucleotide pairs. In yet another aspect the present report provides use of compatible oligonucleotide pairs as binding partners in binding assays, e.g. receptor-based assays.

36. 发明申请

WO2018083237A1 NOVEL ANTI-PY520-DDR1 ANTIBODIES 审中-公开
标题翻译：新型抗PY520-DDR1抗体
公开(公告)号：WO2018083237A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/078183
申请日：2017-11-03
申请人： ROCHE DIAGNOSTICS OPERATIONS INC. , ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人： GERG, Michael , SCHRAEML, Michael , HILLRINGHAUS, Lars
IPC分类号： C07K16/28
CPC分类号： C07K16/2851 , C07K2317/34 , C07K2317/92
摘要： The present invention relates to an antibody as characterized in the appended claims, wherein the antibody specifically binds to the discoidin domain receptor 1 (DDR1) which is phosphorylated at the tyrosine in position 520 of the DDR1 sequence represented in SEQ ID NO:58. The present invention further relates to nucleic acid molecules encoding the light chain variable region or the heavy chain variable region of the antibody of the invention, as well as vectors comprising said nucleic acid molecules. The invention further relates to a host cell or non-human host comprising the vector(s) of the invention, as well as to a method for the production of an antibody according to the invention comprising culturing the host cell of the invention under suitable conditions and isolating the antibody produced. Furthermore, the present invention relates to an antibody obtainable by the method of the invention, to a composition comprising at least one of the antibody of the invention, the nucleic acid molecule of the invention, the vector of the invention, the host cell of the invention or the antibody produced by the method of the invention. The present invention also relates to the use of the antibody of the invention for determining phosphorylation of DDR1 at the tyrosine in position 520 of the DDR1 sequence represented in SEQ ID NO:58 as well as to a method of determining phosphorylation of DDR1 at the tyrosine in position 520 of the DDR sequence represented in SEQ ID NO:58.
摘要翻译：本发明涉及如所附权利要求中所表征的抗体，其中所述抗体特异性结合在所代表的DDR1序列的520位的酪氨酸处被磷酸化的盘基蛋白结构域受体1（DDR1）在SEQ ID NO：58中。本发明进一步涉及编码本发明抗体的轻链可变区或重链可变区的核酸分子，以及包含所述核酸分子的载体。本发明进一步涉及包含本发明载体的宿主细胞或非人宿主，以及用于产生根据本发明的抗体的方法，所述方法包括在合适的条件下培养本发明的宿主细胞并分离产生的抗体。此外，本发明涉及可通过本发明的方法获得的抗体，包含本发明的抗体，本发明的核酸分子，本发明的载体，发明或由本发明的方法产生的抗体。本发明还涉及本发明的抗体用于测定DDR1在SEQ ID NO：58所示的DDR1序列的520位的酪氨酸磷酸化的用途，以及测定DDR1在酪氨酸处的磷酸化的方法在SEQ ID NO：58中所示的DDR序列的520位中。

37. 发明申请

WO2018083235A1 NOVEL ANTI-PY513-DDR1 ANTIBODIES 审中-公开
标题翻译：新型抗PY513-DDR1抗体
公开(公告)号：WO2018083235A1
公开(公告)日：2018-05-11
申请号：PCT/EP2017/078180
申请日：2017-11-03
申请人： ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS INC. , F. HOFFMANN-LA ROCHE AG , CHUGAI SEIYAKU KABUSHIKI KAISHA
发明人： GERG, Michael , SCHRAEML, Michael , HILLRINGHAUS, Lars
IPC分类号： C07K16/40
CPC分类号： C07K16/40
摘要： The present invention relates to an antibody as characterized in the appended claims, wherein the antibody specifically binds to the discoidin domain receptor 1 (DDR1) which is phosphorylated at the tyrosine in position 513 of the DDR1 sequence represented in SEQ ID NO:55. The present invention further relates to nucleic acid molecules encoding the light chain variable region or the heavy chain variable region of the antibody of the invention, as well as vectors comprising said nucleic acid molecules. The invention further relates to a host cell or non-human host comprising the vector(s) of the invention, as well as to a method for the production of an antibody according to the invention comprising culturing the host cell of the invention under suitable conditions and isolating the antibody produced. Furthermore, the present invention relates to an antibody obtainable by the method of the invention, to a composition comprising at least one of the antibody of the invention, the nucleic acid molecule of the invention, the vector of the invention, the host cell of the invention or the antibody produced by the method of the invention. The present invention also relates to the use of the antibody of the invention for determining phosphorylation of DDR1 at the tyrosine in position 13 of the DDR1 sequence represented in SEQ ID NO:55 as well as to a method of determining phosphorylation of DDR1 at the tyrosine in position 513 of the DDR1 sequence represented in SEQ ID NO:55.
摘要翻译：本发明涉及如所附权利要求中所表征的抗体，其中抗体特异性结合盘基蛋白结构域受体1（DDR1），其在所代表的DDR1序列的513位的酪氨酸处被磷酸化在SEQ ID NO：55中。本发明进一步涉及编码本发明抗体的轻链可变区或重链可变区的核酸分子，以及包含所述核酸分子的载体。本发明进一步涉及包含本发明载体的宿主细胞或非人宿主，以及用于产生根据本发明的抗体的方法，所述方法包括在合适的条件下培养本发明的宿主细胞并分离产生的抗体。此外，本发明涉及可通过本发明的方法获得的抗体，包含本发明的抗体，本发明的核酸分子，本发明的载体，发明或由本发明的方法产生的抗体。本发明还涉及本发明的抗体用于确定DDR1在SEQ ID NO：55所示的DDR1序列的13位酪氨酸处的磷酸化的用途以及测定DDR1在酪氨酸处的磷酸化的方法位于SEQ ID NO：55所示的DDR1序列的513位。

38. 发明申请

WO2017102759A1 FKBP DOMAIN WITH TRANSGLUTAMINASE RECOGNITION SITE 审中-公开
标题翻译：具有谷氨酰胺识别位点的FKBP结构域
公开(公告)号：WO2017102759A1
公开(公告)日：2017-06-22
申请号：PCT/EP2016/080847
申请日：2016-12-13
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： SCHRAEML, Michael , STEFFEN, Wojtek
IPC分类号： C07K1/13 , C12N9/90 , G01N33/532 , G01N33/58 , G01N33/68
CPC分类号： A61K47/65 , C07K1/13 , C07K2319/21 , C07K2319/35 , C12N9/90 , C12N2740/14022 , G01N33/532
摘要： The present invention relates to a recombinant transglutaminase (TG) substrate comprising an amino acid sequence of the FKBP domain of an FKBP polypeptide, wherein the "insert-in-flap" (IF) domain thereof is, at least in part, replaced by an amino acid sequence ("Q-tag") of 5 to 20 amino acids comprising a sequence having at least 80% sequence identity to the YRYRQ portion of the peptide sequence X -YRYRQ-X 2 (SEQ ID NO. 1), and wherein said TG substrate is a substrate for the TG function of the Kutzneria albida TG. The present invention furthermore relatesuses of said substrate.
摘要翻译：本发明涉及包含FKBP多肽的FKBP结构域的氨基酸序列的重组转谷氨酰胺酶（TG）底物，其中“插入翼片” （IF）结构域至少部分被5-20个氨基酸的氨基酸序列（“Q-标签”）置换，所述氨基酸序列包含与肽序列的YRYRQ部分具有至少80％序列同一性的序列 X-YRYRQ-X 2（SEQ ID NO.1），并且其中所述TG底物是Kutzneria albida TG的TG功能的底物。本发明还涉及所述基材的用途。

39. 发明申请

WO2015067547A1 A METHOD FOR DETERMINING THE TOTAL AMOUNT AND/OR CONCENTRATION OF AN ANALYTE IN THE PRESENCE OF A BINDING MOLECULE AS WELL AS KITS, COMPOSITIONS AND USES RELATING THERETO 审中-公开
标题翻译：一种用于确定分析人员在绑定分子存在下的总量和/或浓度的方法，如作为工具，组合物和与之相关的用途
公开(公告)号：WO2015067547A1
公开(公告)日：2015-05-14
申请号：PCT/EP2014/073523
申请日：2014-11-03
申请人： ROCHE DIAGNOSTICS GMBH , F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： SCHRAEML, Michael , ROESSLER, Markus , GERG, Michael
IPC分类号： G01N33/53 , G01N33/536
CPC分类号： G01N33/543 , G01N33/53
摘要： The present invention relates to a method for determining the total amount and/or concentration of an analyte in the presence of a binding molecule as well as kits, compositions and uses relating thereto.
摘要翻译：本发明涉及用于在结合分子存在下测定分析物的总量和/或浓度的方法以及与其相关的试剂盒，组合物和用途。

40. 发明申请

WO2015044083A1 THERMUS THERMOPHILUS SLYD FKBP DOMAIN SPECIFIC ANTIBODIES 审中-公开
标题翻译： THERMUS THERMOPHILUS SLYD FKBP域特异性抗体
公开(公告)号：WO2015044083A1
公开(公告)日：2015-04-02
申请号：PCT/EP2014/070123
申请日：2014-09-22
申请人： F. HOFFMANN-LA ROCHE AG , ROCHE DIAGNOSTICS GMBH , ROCHE DIAGNOSTICS OPERATIONS, INC.
发明人： SCHRAEML, Michael , CASAGOLDA VALLRIBERA, David , KRONER, Frank
IPC分类号： C07K16/12
CPC分类号： C07K16/1203 , C07K2317/34 , C07K2317/56 , C07K2317/92 , G01N33/577
摘要： The present description relates to anti- Thermus thermophilus SlyD FKBP domain antibodies and methods of using the same.
摘要翻译：本说明书涉及抗栖热菌嗜热链球菌SlyD FKBP结构域抗体及其使用方法。

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