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31. 发明申请

WO2003078960A2 ANALYSIS OF SULFATED POLYSACCHARIDES 审中-公开
标题翻译：硫化多糖的分析
公开(公告)号：WO2003078960A2
公开(公告)日：2003-09-25
申请号：PCT/US2003/007208
申请日：2003-03-11
申请人： MOMENTA PHARMACEUTICALS, INC. , VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Malikarjun , SHRIVER, Zachary , QI, Yi-Wei
发明人： VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Malikarjun , SHRIVER, Zachary , QI, Yi-Wei
IPC分类号： G01N
CPC分类号： G01N33/66 , G01N33/86 , G01N2400/10 , G01N2400/40 , Y10T436/143333 , Y10T436/17 , Y10T436/24
摘要： The invention relates to methods and products associated with analyzing and monitoring heterogeneous populations of sulfated polysaccharides. In particular therapeutic heparin products including low molecular weight heparin products and methods of analyzing and monitoring these products are described.
摘要翻译：本发明涉及与分析和监测硫酸多糖的异质种群相关的方法和产品。特别是包括低分子量肝素产品的治疗性肝素产品以及分析和监测这些产品的方法被描述。

32. 发明申请

WO2018071822A2 ANTIBODIES THAT BIND ZIKA VIRUS ENVELOPE PROTEIN AND USES THEREOF 审中-公开
标题翻译：结合ZIKA病毒包膜蛋白的抗体及其用途
公开(公告)号：WO2018071822A2
公开(公告)日：2018-04-19
申请号：PCT/US2017/056596
申请日：2017-10-13
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , NATIONAL UNIVERSITY OF SINGAPORE
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan , CHAN, Kuan, Rong , WATANABE, Satoru , VASUDEVAN, Subhash, G. , OOI, Eng, Eong
IPC分类号： A61K39/12
摘要： Isolated monoclonal antibodies which bind to Zika virus envelope protein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
摘要翻译：公开了与寨卡病毒包膜蛋白和相关的基于抗体的组合物和分子结合的分离的单克隆抗体。还公开了使用抗体的治疗和诊断方法。

33. 发明申请

WO2017117179A1 BISPECIFIC ANTIBODIES HAVING CONSTANT REGION MUTATIONS AND USES THEREFOR 审中-公开
标题翻译：具有恒定区域突变的双特异性抗体及其用途
公开(公告)号：WO2017117179A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/068808
申请日：2016-12-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan , SUBRAMANIAN, Vidya , FLEISCHER, Eduardo , HATAS, Andrew, Peter
IPC分类号： C07K16/46 , C07K16/32 , C07K16/28 , C07K16/22
CPC分类号： C07K16/468 , C07K16/22 , C07K16/2818 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/526 , C07K2317/92
摘要： Described herein are mutations in the CHl/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
摘要翻译：本文描述了促进异二聚化的双特异性抗体的CH1 / CL界面和CH3恒定区中的突变以及有效产生双特异性抗体的方法。还公开了使用抗体的治疗和诊断方法。

34. 发明申请

WO2015123362A1 NOVEL FULL SPECTRUM ANTI-DENGUE ANTIBODY 审中-公开
标题翻译：全新的抗体抗体抗体
公开(公告)号：WO2015123362A1
公开(公告)日：2015-08-20
申请号：PCT/US2015/015510
申请日：2015-02-11
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan
IPC分类号： A61K39/395 , A61K39/42 , C12P21/08 , C07K16/00
CPC分类号： C07K16/10 , A61K39/42 , A61K45/06 , C07K16/1081 , C07K2317/92
摘要： The present invention provides, among other things, antibody agents (e.g., antibodies, and/or antigen-binding fragments thereof) that bind to DV epitopes, as well as compositions containing them and methods of designing, providing, formulating, using, identifying and/or characterizing them. In some embodiments, provided antibody agents show significant binding to a plurality of DV serotypes. In some embodiments, provided antibody agents show significant binding to all four DV serotypes. Such antibody agents are useful, for example, in the prophylaxis, treatment, diagnosis, and/or study of DV.
摘要翻译：本发明尤其提供了与DV表位结合的抗体试剂（例如，抗体和/或其抗原结合片段），以及含有它们的组合物以及设计，提供，制定，使用，鉴定和 /或表征他们。在一些实施方案中，所提供的抗体试剂显示与多种DV血清型的显着结合。在一些实施方案中，所提供的抗体试剂显示与所有四种DV血清型的显着结合。这样的抗体试剂可用于例如DV的预防，治疗，诊断和/或研究。

35. 发明申请

WO2002023190A8 METHODS AND PRODUCTS RELATED TO LOW MOLECULAR WEIGHT HEPARIN 审中-公开
公开(公告)号：WO2002023190A8
公开(公告)日：2002-03-21
申请号：PCT/US2001/028457
申请日：2001-09-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SUNDARAM, Mallikarjun , VENKATARAMAN, Ganesh , SHRIVER, Zachary , LIU, Dongfang , QI, Yi, Wei , SASISEKHARAN, Ram
IPC分类号： A61K31/727 , G01N33/86
摘要： The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminoglycans such as heparin are also described.

36. 发明申请

WO2004066808A2 GLYCAN MARKERS FOR DIAGNOSING AND MONITORING DISEASE 审中-公开
标题翻译：用于诊断和监测疾病的GLYCAN标记
公开(公告)号：WO2004066808A2
公开(公告)日：2004-08-12
申请号：PCT/US2003/040547
申请日：2003-12-19
申请人： MOMENTA PHARMACEUTICALS, INC. , SHRIVER, Zachary , VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Mallikarjun
发明人： SHRIVER, Zachary , VENKATARAMAN, Ganesh , SASISEKHARAN, Ram , SUNDARAM, Mallikarjun
IPC分类号： A61B
CPC分类号： G01N33/574 , G01N33/57473 , G01N33/57476 , G01N2400/10 , G06F19/28
摘要： The present invention provides ultra-sensitive methods for detecting changes in glycosylation that are correlated with pre-cancerous or early cancerous states. Because the chance of complete recovery is increased with earlier detection of cancer, the present invention provides therapeutically useful methods of early detection, diagnosis, staging and prognostication.
摘要翻译：本发明提供了用于检测与癌前或早期癌症状态相关的糖基化变化的超灵敏方法。因为随着癌症的早期检测，完全恢复的机会增加，本发明提供治疗有用的早期检测，诊断，分期和预后的方法。

37. 发明申请

WO2003025133A2 METHODS OF MAKING GLYCOLMOLECULES WITH ENHANCED ACTIVITIES AND USES THEREOF 审中-公开
标题翻译：制备具有增强活性的甘油分子的方法及其用途
公开(公告)号：WO2003025133A2
公开(公告)日：2003-03-27
申请号：PCT/US2002/029285
申请日：2002-09-16
申请人： MIMEON, INC. , VENKATARAMAN, Ganesh , SHRIVER, Zachary , SASISEKHARAN, Ram
发明人： VENKATARAMAN, Ganesh , SHRIVER, Zachary , SASISEKHARAN, Ram
IPC分类号： C12N
CPC分类号： C08B37/00 , C12P21/005 , G01N2400/00
摘要： Methods to rapidly produce and identify polysaccharides, and other sugar structures, having enhanced activities, have been developed. The methods include producing a molecule, e.g., a therapeutic molecule, which includes a first, non-saccharide moiety (e.g., a protein, polypeptide, peptide, amino acid or lipid) and a second, polysaccharide, moiety. The method includes: determining the chemical composition and structure of all or a portion of the second moiety, modifying the structure of the second moiety to provide a modified second moiety, and evaluating or screening the molecule having the modified second moiety, e.g., for a biological activity or other chemical or physical property. In some embodiments, the step of determining the chemical structure and composition of the second moiety includes a comparison of one or more properties of the second moiety with a database, e.g., a database which correlates such one or more properties with structure or function of a polysaccharide.
摘要翻译：已经开发了快速产生和鉴定具有增强活性的多糖和其他糖结构的方法。所述方法包括产生分子，例如包括第一非糖部分（例如蛋白质，多肽，肽，氨基酸或脂质）和第二多糖部分的治疗分子。该方法包括：确定第二部分的全部或部分的化学组成和结构，修饰第二部分的结构以提供修饰的第二部分，以及评估或筛选具有修饰的第二部分的分子，例如，用于生物活性或其他化学或物理性质。在一些实施方案中，确定第二部分的化学结构和组成的步骤包括将第二部分的一种或多种性质与数据库进行比较，数据库例如将这样的一种或多种性质与结构或功能相关联的数据库多糖。

38. 发明申请

WO2017117179A8 BISPECIFIC ANTIBODIES HAVING CONSTANT REGION MUTATIONS AND USES THEREFOR 审中-公开
公开(公告)号：WO2017117179A8
公开(公告)日：2017-07-06
申请号：PCT/US2016/068808
申请日：2016-12-28
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan , SUBRAMANIAN, Vidya , FLEISCHER, Eduardo , HATAS, Andrew, Peter
IPC分类号： C07K16/46 , C07K16/32 , C07K16/28 , C07K16/22
摘要： Described herein are mutations in the CH1/CL interface and CH3 constant regions of a bispecific antibody which facilitate heterodimerization and methods for the efficient production of bispecific antibodies. Also disclosed are therapeutic and diagnostic methods for using the antibodies.

39. 发明申请

WO2016054598A3 ANTIBODIES THAT BIND EBOLA GLYCOPROTEIN AND USES THEREOF 审中-公开
标题翻译：结合埃博拉糖蛋白及其用途的抗体
公开(公告)号：WO2016054598A3
公开(公告)日：2016-04-07
申请号：PCT/US2015/053871
申请日：2015-10-02
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： SASISEKHARAN, Ram , THARAKARAMAN, Kannan , QUINLAN, Devin , SUBRAMANIAN, Vidya
IPC分类号： C07K16/10
摘要： Isolated monoclonal antibodies which bind to Ebola virus glycoprotein and related antibody-based compositions and molecules are disclosed. Also disclosed are therapeutic and diagnostic methods for using the antibodies.
摘要翻译：公开了与埃博拉病毒糖蛋白和相关的基于抗体的组合物和分子结合的分离的单克隆抗体。还公开了使用抗体的治疗和诊断方法。

40. 发明申请

WO2014197723A2 HUMAN ADAPTATION OF H7 HA 审中-公开
标题翻译：人类适应H7 HA
公开(公告)号：WO2014197723A2
公开(公告)日：2014-12-11
申请号：PCT/US2014/041149
申请日：2014-06-05
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： THARAKARAMAN, Kannan , RAMAN, Rahul , JAYARAMAN, Akila , STEBBINS, Nathan , SASISEKHARAN, Ram
IPC分类号： C12Q1/70
CPC分类号： C07K14/005 , A61K39/00 , C07K16/1018 , C07K2317/33 , C07K2317/76 , C12N7/00 , C12N2760/16122 , C12N2760/16134 , C12Q1/701 , G01N33/56983 , G01N33/68 , G01N2333/11 , G01N2469/10
摘要： The present invention provides, among other things, systems (e.g., comprising compositions and/or methods) for diagnosis, prophylaxis, treatment, prevention, and/or characterization of influenza transmission and/or infection. The present invention also provides methods for monitoring influenza variants for their potential to present a pandemic risk to humans.
摘要翻译：本发明尤其提供用于诊断，预防，治疗，预防和/或表征流感传播和/或感染的系统（例如，包括组合物和/或方法）。本发明还提供了用于监测流感变体潜在地为人类引起大流行风险的方法。

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