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31. 发明申请

WO2007031621B1 METRONIDAZOLE-BASED DERMATOLOGICAL FOAM AND EMULSIONS FOR THE PRODUCTION THEREOF 审中-公开
标题翻译：基于甲基咪唑的皮肤病学泡沫和用于其生产的乳液
公开(公告)号：WO2007031621B1
公开(公告)日：2007-06-21
申请号：PCT/FR2006002038
申请日：2006-09-05
申请人： GALDERMA SA , TAMARKIN DOV , FRIEDMAN DORON
发明人： TAMARKIN DOV , FRIEDMAN DORON
IPC分类号： A61K9/12 , A61K9/107 , A61K31/40 , A61P17/00
CPC分类号： A61K9/0014 , A61K9/107 , A61K9/122
摘要： The invention relates to emulsions comprising the following components expressed in mass percentage with respect to the total mass of the composition thereof: (a) 72-76 mass % water, (b) 0.1-5 mass % gelling agent of the emulsion aqueous phase, (c) 0.75-2 mass % metronidazole, (d) 5-10 mass % mineral oil, (e) 0.5-10 mass % surfactant agent, (f) 0.5-5 mass % fatty acid, (g) 0-4 mass % metronidazole (c) absorption promoter and (h) 0.1-5 mass % preservative agent selected from a group consisting of methylparabene, propylparabene, phenoxyethanol and the mixture thereof. A metronidazole-based foams obtainable from said emulsions and the use thereof are also disclosed.
摘要翻译：（a）72-76质量％的水，（b）乳液含水相的0.1-5质量％胶凝剂，以及（b）（c）0.75-2质量％甲硝唑，（d）5-10质量％矿物油，（e）0.5-10质量％表面活性剂，（f）0.5-5质量％脂肪酸，（g）0-4质量％甲硝唑（c）吸收促进剂和（h）0.1-5质量％防腐剂，其选自甲基对苯二甲酸，丙基对苯二甲酸，苯氧基乙醇及其混合物。还公开了由所述乳液得到的基于甲硝唑的泡沫及其用途。

32. 发明申请

WO2012023142A3 FUNCTIONAL FOOD COMPOSITIONS AND METHODS 审中-公开
标题翻译：功能性食品组合物和方法
公开(公告)号：WO2012023142A3
公开(公告)日：2012-05-31
申请号：PCT/IL2011000676
申请日：2011-08-18
申请人： CLEARFARMA IND LTD , FRIEDMAN DORON , STRASSMANN GIDEON , SHMULEWITZ ASCHER
发明人： FRIEDMAN DORON , STRASSMANN GIDEON , SHMULEWITZ ASCHER
IPC分类号： A61K9/16 , A61K9/50
CPC分类号： A23L33/12 , A23L21/25 , A23L29/10 , A23L33/105 , A23P10/30 , A23P10/35
摘要： A functional food and a method of producing same are provide. The functional food is produced by mixing a lipid solvent including a bioactive agent with a semi-solid or liquid food base carrier until formation of an emulsion that includes solid lipid particles loaded with the bioactive agent.
摘要翻译：提供功能性食品及其制造方法。功能性食品通过将包含生物活性剂的脂质溶剂与半固体或液体食品基料载体混合直至形成包含装载有生物活性剂的固体脂质颗粒的乳液。

33. 发明申请

WO2007034482A3 A METHOD AND SYSTEM FOR MANAGING DATA AND ORGANIZATIONAL CONSTRAINTS 审中-公开
标题翻译：一种用于管理数据和组织约束的方法和系统
公开(公告)号：WO2007034482A3
公开(公告)日：2007-11-01
申请号：PCT/IL2006001104
申请日：2006-09-20
申请人： FRIEND CONNECTION LTD , CHODOROV AMIR , SCHAPP BOAZ , FRIEDMAN DORON
发明人： CHODOROV AMIR , SCHAPP BOAZ , FRIEDMAN DORON
IPC分类号： G06F9/44
CPC分类号： G06Q10/10
摘要： A method and system for managing data and organizational constraints is provided. Data is collected and stored as records in a database and multi-dimensional matrices known as parameters are associated with each of the sets of records. The parameters are then processed using various formulae and functions and the results of the processing are kept separate from the parameters themselves allowing for a flexible and fast response to any change in any of the parameters. The dimensions of each parameter are defined to include zero or more properties configured to access the multi-dimensional matrices and each parameter is defined in relation to each of the dimensions of the parameter. The set of dependencies among the parameters form part of a large constraint propagation network so that any change to a value of one of the parameters will be propagated throughout the network.
摘要翻译：提供了一种用于管理数据和组织约束的方法和系统。数据被收集并作为记录存储在数据库中，并且称为参数的多维矩阵与记录集合中的每一个相关联。然后使用各种公式和功能处理参数，并且处理结果与参数本身保持分离，从而允许对任何参数的任何改变的灵活和快速的响应。每个参数的尺寸被定义为包括被配置为访问多维矩阵的零个或多个属性，并且每个参数相对于参数的每个维来定义。这些参数之间的依赖关系构成了大型约束传播网络的一部分，因此对整个网络中传播参数之一的值的任何改变都将被传播。

34. 发明申请

WO2005065652A9 NON-AQUEOUS COMPOSITION FOR ORAL DELIVERY OF INSOLUBLE BIOACTIVE AGENTS 审中-公开
标题翻译：用于口服递送不溶性生物剂的非水性组合物
公开(公告)号：WO2005065652A9
公开(公告)日：2006-08-03
申请号：PCT/IL2004001144
申请日：2004-12-19
申请人： FRIEDMAN DORON
发明人： FRIEDMAN DORON
IPC分类号： A61K9/107 , A61K9/48
CPC分类号： A61K9/4866 , A61K9/1075 , A61K9/4858
摘要： The present invention provides a composition of low water solubility drug, dissolved or dispersed in a non crystalline or low crystalline form in an emulsion type composition of internal oily-solvent and external non-hydrous and water soluble solvent, whereas 1) emulsifying stabilizer comprises low fraction of the composition, and 2) emulsions of mean droplets size below one micron is obtained upon dilution with physiological fluids, and 3) facilitated dispersion of biologically active agents in body fluids is obtained, and more particularly to facilitating biological availability or improving clinical performance.
摘要翻译：本发明提供了一种低溶解性药物的组合物，其溶解或分散在非结晶或低结晶形式的内部油性溶剂和外部非水和水溶性溶剂的乳液型组合物中，而1）乳化稳定剂包含低组合物的分数，和2）当用生理流体稀释时获得平均液滴尺寸低于1微米的乳液，和3）促进生物活性剂在体液中的分散，更具体地说是促进生物利用度或改善临床表现。

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