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31. 发明申请

WO2002029032A3 WHOLE CELL ENGINEERING BY MUTAGENIZING A SUBSTANTIAL PORTION OF A STARTING GENOME, COMBINING MUTATIONS, AND OPTIONALLY REPEATING 审中-公开
公开(公告)号：WO2002029032A3
公开(公告)日：2002-04-11
申请号：PCT/US2001/031004
申请日：2001-10-01
申请人： DIVERSA CORPORATION , SHORT, Jay, M. , FU, Pengcheng , LATTERICH, Martin , WEI, Jing , LEVIN, Michael
发明人： SHORT, Jay, M. , FU, Pengcheng , LATTERICH, Martin , WEI, Jing , LEVIN, Michael
IPC分类号： G01N33/68
摘要： An invention comprising cellular transformation, directed evolution, and screening methods for creating novel transgenic organisms having desirable properties. In one embodiment, this invention provides a method of generating a transgenic organism, such as a microbe or a plant, having a plurality of traits that are differentially activatable. This invention also provides a method of retooling genes and gene pathways by the introduction of regulatory sequences, such as promoters, that are operable in an intended host, this conferring operability to a novel gene pathway when it is introduced into an intended host. For example a novel man-made gene pathway, generated based on microbially-derived progenitor templates, that is operable in a plant cell. This invention also provides a method of generating novel host organisms having increased expression of desirable traits, recombinant genes, and gene products. This invention provides novel methods for determining polypeptide profiles, and protein expression variations, which methods are applicable to all sample types disclosed herein. The present invention provides methods of simultaneously identifying and quantifying individual proteins in complex protein mixtures. Additionally this invention provides methods for cellular and metabolic engineering of new and modified phenotypes by using "on-line" or "real-time" metabolic flux analysis.

32. 发明申请

WO2003060084A3 METHODS FOR MAKING POLYNUCLEOTIDES AND PURIFYING DOUBLE-STRANDED POLYNUCLEOTIDES 审中-公开
公开(公告)号：WO2003060084A3
公开(公告)日：2003-07-24
申请号：PCT/US2003/001189
申请日：2003-01-14
申请人： DIVERSA CORPORATION , FREY, Gerhard , SHORT, Jay, M. , PARRA-GESSERT, Lilian
发明人： FREY, Gerhard , SHORT, Jay, M. , PARRA-GESSERT, Lilian
IPC分类号： C12Q1/68
摘要： The invention provides methods for identifying and purifying double-stranded polynucleotides lacking base pair mismatches, insertion/deletion loops and/or nucleotide gaps. The invention provides libraries of nucleic acid building blocks and methods for generating any nucleic acid sequence, including synthetic genes, antisense constructs and polypeptide coding sequences. The invention provides chimeric antigen binding molecules and the nucleic acids that encode them.

33. 发明申请

WO2003000840A2 NITRILASES 审中-公开
标题翻译：腈
公开(公告)号：WO2003000840A2
公开(公告)日：2003-01-03
申请号：PCT/US2002/015983
申请日：2002-05-15
申请人： DIVERSA CORPORATION , MADDEN, Darcy , DESANTIS, Grace , CHAPLIN, Jennifer, Ann , WEINER, David, Paul , MILAN, Aileen , CHI, Ellen , SHORT, Jay, M. , BURK, Mark
发明人： DESANTIS, Grace , CHAPLIN, Jennifer, Ann , WEINER, David, Paul , MILAN, Aileen , CHI, Ellen , SHORT, Jay, M. , BURK, Mark
IPC分类号： C12N
CPC分类号： C12P13/004 , C12N9/78 , C12P7/42 , C12P13/04 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译：本发明涉及腈水解酶和编码腈水解酶的核酸。另外还提供了设计新腈水解酶的方法及其使用方法。在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。

34. 发明申请

WO2002092780A2 NOVEL ANTIGEN BINDING MOLECULES FOR THERAPEUTIC, DIAGNOSTIC, PROPHYLACTIC, ENZYMATIC, INDUSTRIAL, AND AGRICULTURAL APPLICATIONS, AND METHODS FOR GENERATING AND SCREENING THEREOF 审中-公开
标题翻译：用于治疗，诊断，预防，食用，工业和农业应用的新型抗原结合分子及其产生和筛选的方法
公开(公告)号：WO2002092780A2
公开(公告)日：2002-11-21
申请号：PCT/US2002/015767
申请日：2002-05-17
申请人： DIVERSA CORPORATION , SHORT, Jay, M.
发明人： SHORT, Jay, M.
IPC分类号： C12N
CPC分类号： C12N15/1093 , C12N15/102 , C12N15/1027 , C12N15/66
摘要： The invention is directed to methods for generating sets, or libraries, of nucleic acids encoding antigen-binding sites, such as antibodies, antibody domains or other fragments, including single and double stranded antibodies, major histocompatibility complex (MHC) molecules, T cell receptors (TCRs), and the like. This invention provides methods for generating variant antigen binding sites, e.g., antibodies and specific domains or fragments of antibodies (e.g., Fab or Fc domains), by altering template nucleic acids including by saturation mutagenesis, synthetic ligation reassembly, or a combination thereof. In one aspect, the invention provides methods for generating all human or humanized antibodies and evolving them to achieve optimized properties related to stability, duration, expression, production, enzymatic activity, affinity, avidity, localization, and other immunological properties. Polypeptides generated by these methods can be analyzed using a novel capillary array platform, which provides unprecedented ultra-high throughput screening.
摘要翻译：本发明涉及用于产生编码抗原结合位点的核酸（例如抗体，抗体结构域或其它片段，包括单链和双链抗体，主要组织相容性复合体（MHC）分子，T细胞受体（TCR）等。本发明提供了通过改变模板核酸，包括饱和诱变，合成连接重组或其组合来产生变体抗原结合位点，例如抗体和抗体的特异结构域或片段（例如，Fab或Fc结构域）的方法。一方面，本发明提供了产生所有人源化或人源化抗体并进化出来以实现与稳定性，持续时间，表达，产生，酶活性，亲和力，亲合力，定位和其他免疫学性质相关的优化性质的方法。通过这些方法产生的多肽可以使用新颖的毛细管阵列平台进行分析，提供前所未有的超高通量筛选。

35. 发明申请

WO2013163630A1 MODIFIED ANTIBODY REGIONS AND USES THEREOF 审中-公开
标题翻译：改良抗体区及其用途
公开(公告)号：WO2013163630A1
公开(公告)日：2013-10-31
申请号：PCT/US2013/038538
申请日：2013-04-26
申请人： BIOATLA LLC. , FREY, Gerhard , SHORT, Jay, M. , CHANG, Hwai, Wen
发明人： FREY, Gerhard , SHORT, Jay, M. , CHANG, Hwai, Wen
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/00 , A61K2039/505 , C07K2317/52 , C07K2317/94
摘要： The present invention relates to modified Fc regions of antibodies, and uses thereof, such as in antibodies that contain an Fc region of the present invention.
摘要翻译：本发明涉及抗体的修饰的Fc区及其用途，例如含有本发明的Fc区的抗体。

36. 发明申请

WO2012092376A2 COMPREHENSIVE MONOCLONAL ANTIBODY GENERATION 审中-公开
标题翻译：综合性单克隆抗体的产生
公开(公告)号：WO2012092376A2
公开(公告)日：2012-07-05
申请号：PCT/US2011/067596
申请日：2011-12-28
申请人： SHORT, Jay, M.
发明人： SHORT, Jay, M.
IPC分类号： G01N33/53 , C12Q1/68 , C07K16/00 , C12Q1/02 , C12N5/0781 , C12N15/12
CPC分类号： G01N33/6857 , C07K16/00 , C07K16/005 , C07K2317/56 , G01N33/5052 , G01N33/577
摘要： The present invention relates to methods for efficiently generating recombinant monoclonal antibodies derived from B cells of a non-human host which has been immunochallenged with one or more target antigens. The methods comprise the steps of identifying and isolating B cell that bind to the antigen by FACS, and recombining and enriching for thousands of cells to create a B cell library. Related products and methods, such as methods of producing expression libraries, are also disclosed.
摘要翻译：本发明涉及用于有效产生来自用一种或多种靶抗原免疫攻击的非人宿主的B细胞的重组单克隆抗体的方法。该方法包括以下步骤：通过FACS鉴定和分离与抗原结合的B细胞，并重组和富集数千个细胞以产生B细胞文库。还公开了相关产品和方法，例如生产表达文库的方法。

37. 发明申请

WO2010104821A1 MIRAC PROTEINS 审中-公开
标题翻译： MIRAC蛋白
公开(公告)号：WO2010104821A1
公开(公告)日：2010-09-16
申请号：PCT/US2010/026611
申请日：2010-03-09
申请人： BIOATLA, LLC , SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
发明人： SHORT, Jay, M. , CHANG, Hwai, Wen , FREY, Gerhard
IPC分类号： C12Q1/68 , C12P21/00 , C07K14/00 , A61K38/17
CPC分类号： C12N15/102 , A61K38/00 , C07K7/06 , C07K14/3153 , C07K14/47 , C07K14/575 , C07K14/57545 , C07K14/57563 , C12N9/16 , C12N9/50 , C12N9/6435 , C12N9/6459 , C12N9/6462 , C12N15/1058 , C12Y302/01035 , C12Y304/21007 , C12Y304/21069 , C12Y304/21073 , C12Y304/23015 , C12Y304/24029 , G01N33/54306 , G01N33/573 , G01N33/6845 , G01N33/6854 , Y02A50/473
摘要： This disclosure relates to a method of generating conditionally active biologic proteins from wild type proteins, in particular therapeutic proteins, which are reversibly or irreversibly inactivated at the wild type normal physiological conditions. For example, evolved proteins are virtually inactive at body temperature, but are active at lower temperatures.
摘要翻译：本公开涉及从野生型正常生理条件下可逆地或不可逆地灭活的野生型蛋白质，特别是治疗性蛋白质产生条件活性生物蛋白质的方法。例如，进化蛋白质在体温实际上是无活性的，但在较低温度下是活性的。

38. 发明申请

WO2013177465A1 PHENOTYPIC INTEGRATED SOCIAL SEARCH DATABASE AND METHOD 审中-公开
标题翻译： PHENOTYPIC综合社会搜索数据库和方法
公开(公告)号：WO2013177465A1
公开(公告)日：2013-11-28
申请号：PCT/US2013/042527
申请日：2013-05-23
申请人： CAPIA IP , SHORT, Jay, M. , BRIGGS, Steve
发明人： SHORT, Jay, M. , BRIGGS, Steve
IPC分类号： G06F19/10 , G01N33/48 , C12Q1/68
CPC分类号： G06F17/30867 , C12Q1/6883 , C12Q2600/158 , G06F19/00 , G06F19/24 , G06F19/28 , G06Q30/02 , G06Q30/0251 , G06Q50/22 , G16H10/20
摘要： The present invention provides methods, databases and devices for establishing the first integration of social behavior with biological phenotypic measurements. In one embodiment, a method for correlating data from a sample database and a survey database is provided. The method comprises obtaining a sample comprising biological molecules from an individual, simultaneously obtaining survey data from the individual, storing the survey data in the survey database, analyzing the sample of biological molecules to determine the composition of biological molecules, storing the data from the composition in the sample database, and correlating the data from the sample database to the data from the survey database.
摘要翻译：本发明提供用于建立社会行为与生物表型测量的第一次整合的方法，数据库和装置。在一个实施例中，提供了用于将来自样本数据库和调查数据库的数据相关联的方法。该方法包括获得包含来自个体的生物分子的样品，同时从个体获得调查数据，将调查数据存储在调查数据库中，分析生物分子样品以确定生物分子的组成，存储来自组合物的数据在样本数据库中，并将来自样本数据库的数据与调查数据库的数据相关联。

39. 发明申请

WO2013170168A1 MULTI-SPECIFIC MONOCLONAL ANTIBODIES 审中-公开
标题翻译：多特异性单克隆抗体
公开(公告)号：WO2013170168A1
公开(公告)日：2013-11-14
申请号：PCT/US2013/040575
申请日：2013-05-10
申请人： BIOATLA LLC , FREY, Gernard , CHANG, Hwai, Wen , SHORT, Jay, M.
发明人： FREY, Gernard , CHANG, Hwai, Wen , SHORT, Jay, M.
IPC分类号： C07K16/46 , C07K16/18 , G01N33/53 , C12N15/13
CPC分类号： C07K16/468 , A01K2267/03 , C07K16/005 , C07K2317/14 , C07K2317/21 , C07K2317/31 , C07K2317/92 , C07K2317/94 , C12N15/1034 , G01N33/6854
摘要： The present invention is relevant to the generation of multi-specific antibodies, antibodies that are distinguished by their ability to bind to multiple antigens with specificity and with affinity. In particular, the present invention is related to bi-specific antibodies.
摘要翻译：本发明与多特异性抗体的产生相关，抗体的特异性是通过其特异性和亲和性与多种抗原结合的能力来区分。特别地，本发明涉及双特异性抗体。

40. 发明申请

WO2012092374A2 EXPRESS HUMANIZATION OF ANTIBODIES 审中-公开
标题翻译：抗体的表达人源化
公开(公告)号：WO2012092374A2
公开(公告)日：2012-07-05
申请号：PCT/US2011/067589
申请日：2011-12-28
申请人： SHORT, Jay, M.
发明人： SHORT, Jay, M.
IPC分类号： C12N15/09 , C12N15/10 , C12N15/63 , C12P21/08 , C12N15/12 , C07K16/18
CPC分类号： C07K16/461 , C07K16/248 , C07K16/464 , C07K2317/14 , C07K2317/24 , C07K2317/51 , C07K2317/515 , C07K2317/92
摘要： The disclosure provides a method for generation of humanized full length antibodies in mammalian cells. A library of humanized variants is provided with high, validated human framework diversity without requiring back-mutations to retain original affinity. Synthetic CDR encoding fragment libraries derived from a template antibody are ligated to human framework region encoding fragments from a human framework pool limited only to germline sequences from a functionally expressed antibodies. The vector comprises a nucleic acid sequence encoding HC framework region 4. No CDR grafting or phage display is required.
摘要翻译：本公开内容提供了用于在哺乳动物细胞中产生人源化全长抗体的方法。提供人源化变体文库，其具有高的，经验证的人框架多样性，而不需要回复突变来保持原始亲和力。衍生自模板抗体的合成CDR编码片段文库连接至编码来自仅限于来自功能性表达抗体的种系序列的人框架库的片段的人框架区。载体包含编码HC构架区4的核酸序列。不需要CDR移植或噬菌体展示。

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