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31. 发明申请

WO1996042006A2 MULTI-ANGLE, MULTIWAVELENGTH PARTICLE CHARACTERIZATION SYSTEM AND METHOD 审中-公开
标题翻译：多角度，多波长粒子特征系统及方法
公开(公告)号：WO1996042006A2
公开(公告)日：1996-12-27
申请号：PCT/US1996010342
申请日：1996-06-13
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , GARCIA-RUBIO, Luis, Humberto
IPC分类号： G01N15/02
CPC分类号： G01N15/0211
摘要： A system and method are provided for the characterization of a sample containing a macromolecule in solution. A light source illuminates the sample, generally in the ultraviolet-visible wavelength range, and a plurality of sensors that are radially disposed about the sample at a plurality of observation angles simultaneously sense the light energy emerging from the sample. An intensity spectrum is calculated as a function of wavelength for each observation angle, from which is calculated a particle characteristic such as shape, conformational change, composition, and particle size distribution. Both scattering and absorption data are utilized to provide complementary information.
摘要翻译：提供了一种用于表征溶液中含有大分子的样品的系统和方法。光源通常以紫外 - 可见波长范围照射样品，并且以多个观察角度围绕样品径向设置的多个传感器同时感测从样品出射的光能。对于每个观察角度计算强度谱作为波长的函数，从其计算出诸如形状，构象变化，组成和粒度分布的颗粒特征。利用散射和吸收数据提供补充信息。

32. 发明申请

WO1996033264A1 PURIFIED AND ISOLATED SERTOLI CELL AGGREGATE 审中-公开
标题翻译：纯化和分离的SERTOLI细胞聚集
公开(公告)号：WO1996033264A1
公开(公告)日：1996-10-24
申请号：PCT/US1996005066
申请日：1996-04-12
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , HELLER, Richard , CAMERON, Don, F. , SANBERG, Paul, R. , JAROSZESKI, Mark, J.
IPC分类号： C12N05/00
CPC分类号： C12N5/0683 , A61K35/12 , A61K35/39 , A61K35/48 , A61K38/00 , A61K2035/122 , C12N5/16
摘要： A purified and isolated Sertoli cell aggregate characterized by being a) capable of survival in situ after transplantation; b) able to provide immunoprotection for co-transplanted cells; and c) able to provide a mechanism for prolonged viability and functionality of the transplanted cells.
摘要翻译：一种纯化和分离的Sertoli细胞聚集体，其特征在于a）能够在移植后原位生存; b）能够为共移植细胞提供免疫保护; 和c）能够提供延长移植细胞活力和功能的机制。

33. 发明申请

WO1996029002A1 METHOD OF DIAGNOSING PITUITARY DEPENDENT GROWTH HORMONE DEFICIENCY 审中-公开
标题翻译：诊断依赖性生长激素缺陷的方法
公开(公告)号：WO1996029002A1
公开(公告)日：1996-09-26
申请号：PCT/US1996003607
申请日：1996-03-14
申请人： UNIVERSITY OF SOUTH FLORIDA , BERCU, Barry, B. , WALKER, Richard, F.
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A61B05/00
CPC分类号： C07K14/60 , G01N33/5091 , G01N33/74 , G01N2333/61
摘要： A diagnostic protocol and kit for evaluating pituitary growth hormone (GH) secretory capability as a means to identify the etiology of GH deficiency in children and adults is disclosed. The inventive protocol includes measuring GH secretion, as determined by changes in serum, plasma, or whole blood GH concentrations following administration of the xenobiotic GH releasing hexapeptide (GHRP-6) or any of its peptidyl or non-peptidyl synthetic analogues that release GH by the same cellular mechanism as GHRP-6. The naturally occurring GH releasing compound (GHRC) or its analogues is also administered to children and adults afflicted with disorders related to GH deficiency and GH secretion is measured. After evaluating the effects of independent administration of the GH secretagogues upon changes in blood GH concentrations, the effect of the co-administered GH secretagogues on blood GH concentrations in the child or adult subject is then measured.
摘要翻译：公开了用于评估垂体生长激素（GH）分泌能力作为识别儿童和成人GH缺乏病因的手段的诊断方案和试剂盒。本发明方案包括测量GH分泌，其通过施用异生物GH释放六肽（GHRP-6）或其任何其释放GH的肽基或非肽基合成类似物之后的血清，血浆或全血GH浓度的变化来确定，与GHRP-6相同的细胞机制。天然存在的GH释放化合物（GHRC）或其类似物也被施用于患有与GH缺乏和GH分泌相关的疾病的儿童和成人。在评估GH分泌剂独立施用对血液GH浓度变化的影响后，测定共同施用的GH促分泌素对儿童或成人受试者血液GH浓度的影响。

34. 发明申请

WO1996028030A1 SERTOLI CELLS AS NEURORECOVERY INDUCING CELLS FOR NEURODEGENERATIVE DISORDERS 审中-公开
标题翻译： SERTOLI细胞作为神经元诱导神经细胞增生性疾病的细胞
公开(公告)号：WO1996028030A1
公开(公告)日：1996-09-19
申请号：PCT/US1996003335
申请日：1996-03-12
申请人： UNIVERSITY OF SOUTH FLORIDA , SANBERG, Paul, R. , CAMERON, Don, F. , BORLONGAN, Cesario, V.
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A01N63/00
CPC分类号： A61K35/48
摘要： A method of generating in situ trophic factor production by transplanting Sertoli cells into a tissue in need of trophic factors of a mammal, the cells creating trophic factors in situ.
摘要翻译：通过将Sertoli细胞移植到需要哺乳动物营养因子的组织中的原位营养因子产生的方法，所述细胞在原位产生营养因子。

35. 发明申请

WO1996012834A1 AN IMPROVED LASER HEATED PEDESTAL GROWTH SYSTEM AND PROCESS FOR GROWING CRYSTAL FIBERS 审中-公开
标题翻译：改进的激光加热垫生长系统和用于生长晶体纤维的方法
公开(公告)号：WO1996012834A1
公开(公告)日：1996-05-02
申请号：PCT/US1995013411
申请日：1995-10-19
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , PHOMSAKHA, Vongvilay , CHANG, Robert, S., F. , DJEU, Nicholas, I.
IPC分类号： C30B13/02
CPC分类号： C30B13/22 , C30B13/00 , C30B29/20 , Y10S117/904 , Y10T117/1088
摘要： An improved system and process for growing crystal fibers comprising a means for creating a laser beam (4) having substantially constant intensity profile through its cross-sectional area, means (22 and 24) for directing the laser beam at a portion of solid feed material (16) located within a fiber growth chamber (42) to form molten feed material (18), means (34 and 35) to support a seed fiber (20 and 21) above the molten feed material, means to translate the seed fiber towards and away from the molten feed material so that the seed fiber can make contact with the molten feed material, fuse to the molten feed material and then be withdrawn away from the molten feed material whereby the molten feed material is drawn off in the form of a crystal fiber.
摘要翻译：一种用于生长晶体纤维的改进的系统和方法，包括用于通过其横截面积产生具有基本恒定强度分布的激光束（4）的装置，用于将激光束引导到固体进料的一部分的装置（22和24）（16）位于纤维生长室（42）内以形成熔融进料材料（18），用于在熔融进料上方支撑种子纤维（20和21）的装置（34和35），将种子纤维转向并且远离熔融进料，使得种子纤维可以与熔融进料接触，熔化到熔融进料，然后从熔融进料中取出，从而将熔融进料以水晶纤维。

36. 发明申请

WO1996011012A1 HEMATOPOIETIC CELL L-SELECTIN LIGAND (HLL) AND THERAPEUTICS THEREOF 审中-公开
标题翻译： HEMATOPOIETIC CELL L-SELECTIN LIGAND（HLL）AND THERAPEUTICS THEREOF
公开(公告)号：WO1996011012A1
公开(公告)日：1996-04-18
申请号：PCT/US1995013736
申请日：1995-10-10
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , SACKSTEIN, Robert
IPC分类号： A61K35/12
CPC分类号： A61K35/14 , A61K38/00 , A61K47/6849 , C07K14/705 , C07K16/28
摘要： An isolated and purified glycoprotein and functional analogs are disclosed. The glycoproteins are characterized by being expressed on at least primitive hematopoietic cells, and being a ligand for L-selectin. The binding of ligand to L-selectin is not inhibitied by anti-CD34 antibodies nor by MECA 79 monoclonal antibody.
摘要翻译：公开了分离和纯化的糖蛋白和功能类似物。糖蛋白的特征在于至少在原始造血细胞上表达，并且是L-选择素的配体。配体与L-选择蛋白的结合不受抗CD34抗体和MECA 79单克隆抗体的抑制。

37. 发明申请

WO1995014769A1 TRANSGENIC MOUSE PREPARED USING YEAST ARTIFICIAL CHROMOSOMES (YACs) AND HOMOLOGOUS RECOMBINATION 审中-公开
标题翻译：使用YEAST人造色素（YAC）和同种异体重组制备的转基因小鼠
公开(公告)号：WO1995014769A1
公开(公告)日：1995-06-01
申请号：PCT/US1994013604
申请日：1994-11-22
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , HARDY, John , DUFF, Karen
IPC分类号： C12N05/00
CPC分类号： A01K67/0275 , A01K2217/05 , C07K14/4711 , C12N15/902
摘要： A method of producing a mouse that expresses human mutant protein sequences by: a) obtaining a partial or whole gene contained within a yeast artificial chromosome; b) introducing a predetermined mutant DNA sequence into the yeast artificial chromosome by homologous recombination; c) utilizing transgenics to insert the mutant gene into embryonic stem cells; and d) injecting the stem cells into blastocysts to derive a transgenic mouse that expresses the mutant protein sequences. A transgenic mouse made by the above process and mutant yeast artificial chromosomes made by the above process are also disclosed.
摘要翻译：一种生产表达人突变型蛋白质序列的小鼠的方法，其通过以下步骤：a）获得酵母人造染色体中所含的部分或全部基因; b）通过同源重组将预定突变体DNA序列引入酵母人造染色体; c）利用转基因将突变基因插入胚胎干细胞; 和d）将干细胞注入胚泡以产生表达突变蛋白序列的转基因小鼠。还公开了通过上述方法制备的转基因小鼠和通过上述方法制备的突变体酵母人造染色体。

38. 发明申请

WO1994016070A1 LEUKOCYTE DERIVED GROWTH FACTORS 审中-公开
标题翻译： LEUKOCYTE衍生生长因子
公开(公告)号：WO1994016070A1
公开(公告)日：1994-07-21
申请号：PCT/US1994000300
申请日：1994-01-07
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , GROTENDORST, Gary, R. , IIDA, Naoko
IPC分类号： C12N15/12
CPC分类号： C07K14/52 , A61K38/00
摘要： A protein, Leukocyte Derived Growth Factor 2 (hereinafter LDGF2) having PDGF-like activity is described. LDGF2 reacts with PDGF receptors and processes mitogenic and/or chemotactic activity for avarious cell types, particularly connective tissue cells. LDGF2 may be used as the active ingredient in therapeutic compositions, e.g. wound healing compositions, or even further may be used as an additive to cell culture media for the purpose of stimulating cell growth. The protein has a molecular weight of about 7000 daltons determined by SDS gel electrophoresis and is about 61 amino acids in length.
摘要翻译：描述了具有PDGF样活性的蛋白质，白细胞衍生生长因子2（以下称为LDGF2）。 LDGF2与PDGF受体反应，并且对贪心细胞类型，特别是结缔组织细胞进行有丝分裂和/或趋化活性。 LDGF2可以用作治疗组合物中的活性成分，例如，伤口愈合组合物，或甚至可以用作细胞培养基的添加剂，以刺激细胞生长。蛋白质通过SDS凝胶电泳测定的分子量约为7000道尔顿，长度约为61个氨基酸。

39. 发明申请

WO1993003548A1 METHOD AND APPARATUS FOR THE COMPRESSION AND DECOMPRESSION OF DATA USING LEMPEL-ZIV BASED TECHNIQUES 审中-公开
标题翻译：使用基于点的ZIV技术对数据进行压缩和分解的方法和装置
公开(公告)号：WO1993003548A1
公开(公告)日：1993-02-18
申请号：PCT/US1992006332
申请日：1992-07-30
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , RANGANATHAN, N. , HENRIQUES, Selwyn
IPC分类号： H03M07/38
CPC分类号： H03M7/3086
摘要： Method for compressing a variable number of data symbols to form fixed-length codewords. Symbols are shifted into the first half of a buffer (18), while uncompressed data is shifted into the buffer's second half (19). A systolic processor array (28) compares each data symbol in the second half with each in the first half. Each processor (28a-28d) compares symbol pairs, selectively passing them to an adjacent processor. Output is provided indicating length and starting point of the longest substring in the buffer's first half matching a substring from the second half. Matched symboles in the second half, and the data symbol immediately following these matched symbols, are then shifted into the first half; uncompressed data are shifted in the second half. A shifted register (36) indicates the symbol following the last match. Length, starting point, and last symbol information are assembled to form a stored codeword, which can be decompressed to provide original data.

40. 发明申请

WO1989010690A1 METHOD FOR ELECTROFUSING BIOLOGICAL PARTICLES TO TISSUES 审中-公开
标题翻译：电组织生物颗粒的方法
公开(公告)号：WO1989010690A1
公开(公告)日：1989-11-16
申请号：PCT/US1989001774
申请日：1989-04-27
申请人： UNIVERSITY OF SOUTH FLORIDA , GRASSO, Robert, J.
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A01K45/00
CPC分类号： C12N13/00 , C12N5/12
摘要： This invention relates to methods for electrofusing biological particles to cells of animal or plant tissues in vitro, in situ, or vivo. Selected biological particles are placed in contact with cells of a selected tissue and fused to cells in the tissue by means of an electric field. The method of this invention may be used to produce animals and plants characterized by features and properties that differ from those typically displayed by the native species. One embodiment of the methods of this invention has been used to produce an animal model for ocular gonorrhea by electrofusing human cells with functional receptors for the human bacterial pathogen Neisseria Gonorrhoeae to epithelial cells in the histologically intact superficial corneal tissue of living rabbits. The methods of this invention may be used to produce other animal or plant models for the study of receptor-mediated processes, including infectivity studies required for the development of vaccines effective to protect against or lessen the severity of infections caused by microbial pathogens. This is achieved by electrofusing cells with membrane receptors for a pathogen to cells of tissues of plants or animals that are normally not susceptible to infection by that pathogen. Other applications are disclosed.
摘要翻译：本发明涉及在体外，原位或体内将生物颗粒电气化到动物或植物组织细胞的方法。将选定的生物颗粒置于与选定组织的细胞接触并通过电场与组织中的细胞融合。本发明的方法可以用于产生特征在于与天然物种通常显示的特征和性质不同的特征和特征的动物和植物。本发明方法的一个实施方案已经用于通过将人细胞与人细菌性病原体淋病奈瑟氏球菌的功能受体电融合到活的兔的组织学上完整的表浅角膜组织中的上皮细胞上来产生眼淋病动物模型。本发明的方法可用于产生用于研究受体介导的过程的其它动物或植物模型，包括开发有效防止或减轻由微生物病原体引起的感染的严重性的疫苗所需的感染性研究。这通过将具有病原体的膜受体的细胞与通常不易被该病原体感染的植物或动物的组织细胞电融合而实现。公开了其他应用。

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