专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

31. 发明申请

WO2005033629A3 MULTI-CAMERA INSPECTION OF UNDERWATER STRUCTURES 审中-公开
标题翻译：水下结构的多摄像机检测
公开(公告)号：WO2005033629A3
公开(公告)日：2006-04-27
申请号：PCT/US2004030162
申请日：2004-09-15
申请人： UNIV MIAMI
发明人： SHAHRIAR NEGAHDARIPOUR , PEZHMAN FIROOZFAM
IPC分类号： G06K9/00 , G01C20060101 , G01S15/00 , H04N7/18
CPC分类号： G06K9/0063 , G06K9/209 , G06K2009/2045 , G06T7/593 , G06T7/74
摘要： A method, system and apparatus for viewing and imaging an underwater structure from a submersible platform, navigating along the structure and constructing a map of the structure in the forms of a photomosaic and a 3-D structural map. The system can include a submersible platform, at least two cameras coupled to the submersible platform, and stereovision matching logic programmed to simulate a frontal view of a target underwater structure from a fixed distance based upon an oblique view of the target underwater structure obtained by the cameras from a variable distance. The cameras can be forward or side mounted to the submersible platform and can include optical cameras, acoustical cameras or both. Preferably, the submersible platform can be a remotely operated vehicle (ROV), or an autonomous underwater vehicle (AUV). Finally, the system further can include absolute positioning sensors.
摘要翻译：一种用于从潜水平台观察和成像水下结构的方法，系统和装置，沿着结构进行导航并且以光马赛克和3-D结构图的形式构造该结构的地图。该系统可以包括潜水平台，耦合到潜水平台的至少两个摄像机以及被编程为基于由目标水下结构获得的目标水下结构的斜视图从固定距离模拟目标水下结构的正视图的立体视觉匹配逻辑摄像机从可变距离。相机可以向前或侧面安装到潜水平台，并且可以包括光学相机，声学相机或两者。优选地，潜水平台可以是遥控车辆（ROV）或自主水下航行器（AUV）。最后，系统还可以包括绝对定位传感器。

32. 发明申请

WO2005095987A3 SALIVARY SOLUBLE CD44: A MOLECULAR MARKER FOR HEAD AND NECK CANCER 审中-公开
标题翻译： SALIVARY SOLUBLE CD44：分子标记为头和鼻癌
公开(公告)号：WO2005095987A3
公开(公告)日：2006-03-23
申请号：PCT/US2005010463
申请日：2005-03-28
申请人： UNIV MIAMI , FRANZMANN ELIZABETH J , LOKESHWAR VINATA B , REATEGUI ERIKA P
发明人： FRANZMANN ELIZABETH J , LOKESHWAR VINATA B , REATEGUI ERIKA P
IPC分类号： C12Q1/68 , G01N33/574 , G01N33/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/158 , G01N33/57407 , G01N33/57488 , G01N33/6872 , G01N2333/70585 , G01N2800/52
摘要： A method of diagnosing head and neck squamous cell carcinoma (HNSCC) includes obtaining a sample form a subject and measuring soluble CD44 (solCD44). The sample may be a body fluid such as saliva. An elevated level of solCD44 in the sample relative to baseline from a normal population of subjects is indicative of the presence of HNSCC. The degree of elevation can be indicative of the severity of disease. The HNSCC can be detected in an early stage and also as a recurrence of the disease.
摘要翻译：诊断头颈鳞状细胞癌（HNSCC）的方法包括从受试者获得样品并测量可溶性CD44（solCD44）。样品可以是诸如唾液的体液。相对于正常人群的基线，样本中solCD44的水平升高表明HNSCC的存在。升高程度可以指示疾病的严重程度。 HNSCC可以在早期发现，也可以作为疾病的复发。

33. 发明申请

WO0229808A3 AUXILIARY CHANNEL MASKING IN AN AUDIO SIGNAL 审中-公开
标题翻译： AUXILIARY CHANNEL MASKING IN AUDIO SIGNAL
公开(公告)号：WO0229808A3
公开(公告)日：2002-09-06
申请号：PCT/US0131214
申请日：2001-10-05
申请人： UNIV MIAMI
发明人： ILIEV ALEXANDER I , SCORDILIS MICHAEL S
IPC分类号： G10L11/00 , C02F1/28 , C02F1/42 , C02F1/463 , C02F1/48 , C02F1/66 , G10L19/00 , G11B20/00 , H04H20/31 , H04H1/00
CPC分类号： H04H20/31 , C02F1/283 , C02F1/42 , C02F1/463 , C02F1/48 , C02F1/66 , C02F2101/20 , C02F2103/10 , G10L19/018 , G11B20/00086 , G11B20/00891
摘要： A method is provided for embedding data into an audio signal and determing data embedded into an audio signal. In the method for embedding data into an audio signal, the audio signal is based on a first set of data and includes a phase component. The method modifies at least a portion of the phase component of the audio signal to embed a second set of data into the audio signal. The modified audio signal can be made to differ with respect to the audio signal in a manner at least one of (i) substantially imperceptible and (ii) imperceptible to a listener of the first set of data depending on the extent that the phase component of the audio signal is modified. In the method for determining data embedded into an audio signal, the audio signal is based on a first set of data of an original audio signal and includes a phase component. The method determines a second set of data embedded into the audio signal based on the phase component of the audio signal. The audio signal differs with respect to the original audio signal in a manner that is at least one of (i) substantially imperceptible and (ii) imperceptible to a listener of the first set of data.
摘要翻译：提供了一种用于将数据嵌入音频信号并确定嵌入到音频信号中的数据的方法。在将数据嵌入音频信号的方法中，音频信号基于第一组数据并且包括相位分量。该方法修改音频信号的相位分量的至少一部分以将第二组数据嵌入到音频信号中。修改后的音频信号可以以下述至少一种方式相对于音频信号而不同：（i）基本上不可察觉的和（ii）第一组数据的收听者不可察觉的取决于第一组数据的收听者的程度，音频信号被修改。在用于确定嵌入到音频信号中的数据的方法中，音频信号基于原始音频信号的第一组数据，并且包括相位分量。该方法基于音频信号的相位分量来确定嵌入到音频信号中的第二组数据。音频信号相对于原始音频信号的不同之处在于（i）基本上不可察觉的和（ii）第一组数据的收听者不能察觉的至少之一。

34. 发明申请

WO0194610A3 BINARY HYBRID MUTATIONAL VECTORS 审中-公开
标题翻译：二进制混合样本矢量
公开(公告)号：WO0194610A3
公开(公告)日：2002-04-04
申请号：PCT/US0118320
申请日：2001-06-05
申请人： UNIV JEFFERSON , UNIV MIAMI , GAMPER HOWARD B , KIMIEC ERIC , BARTLETT RICHARD J
发明人： GAMPER HOWARD B , KIMIEC ERIC , BARTLETT RICHARD J
IPC分类号： A01K67/027 , A61K48/00 , C12N15/82 , C12N15/90 , C12N15/00 , A01N43/04 , C07H21/00 , C12N15/11 , C12N15/87
CPC分类号： A01K67/0275 , A01K2217/05 , A01K2217/075 , A61K48/00 , C12N15/8213 , C12N15/902
摘要： The invention concerns novel compounds used to make specific genetic alterations in the genome of target eukaryotic and prokaryotic cells, methods of their production and use, and kits containing the compounds. The compounds are two-strand duplex oligonucleobase compounds termed binary Hybrid Mutational Vectors bHMV. A bHMV preferably contains a deoxyribo-type oligonucleobase mutator strand and a ribo-type oligonucleobase targeting strand. A bHMV is constructed to effect changes in a target gene via a combination of gene targeting and mismatch repair between the bHMV and the target gene.
摘要翻译：本发明涉及用于在靶真核和原核细胞的基因组中进行特异性遗传改变的新化合物，其生产和使用方法，以及含有该化合物的试剂盒。该化合物是称为二元杂交突变载体bHMV的双链双链寡核苷酸化合物。 bHMV优选含有脱氧核糖型寡核苷酸变异体链和核型寡核苷酸靶向链。构建bHMV以通过bHMV和靶基因之间的基因靶向和错配修复的组合来实现靶基因的变化。

35. 发明申请

WO0148187A2 A MOLECULAR SWITCH FOR REGULATING MAMMALIAN GENE EXPRESSION 审中-公开
标题翻译：用于调节MAMMALIAN基因表达的分子开关
公开(公告)号：WO0148187A2
公开(公告)日：2001-07-05
申请号：PCT/US0033269
申请日：2000-12-15
申请人： UNIV MIAMI
发明人： WEBSTER KEITH A
IPC分类号： C12N15/09 , A61K35/76 , A61K48/00 , A61P9/00 , A61P9/10 , A61P31/00 , A61P35/00 , A61P37/02 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/63 , C12N15/85 , C12N15/00
CPC分类号： C12N15/85 , C12N15/63 , C12N2830/001 , C12N2830/002 , C12N2830/008 , C12N2830/85
摘要： Expression vectors are disclosed that are comprised of (a) one or more silencer elements and conditionally inducible elements to form silencer-inducible regions and (b) promoters in operative linkage upstream of at least one expressed region. The expression vector thereby regulates expression of at least one downstream region by conditional silencing in which an expressed DNA region of a gene is transcribed to produce RNA transcripts, which may or may not be translated to produce polypeptides. Genetically engineered mammalian cells and non-human mammals can be made using such expression vectors through transfection and transgenesis techniques. Moreover, processes of making and using the aforementioned products are disclosed (e.g., the expression vector may be used diagnostically, therapeutically, or prophylactically).
摘要翻译：公开了表达载体，其包含（a）一种或多种消音元件和条件诱导型元件以形成消音诱导区，和（b）在至少一个表达区域的上游具有可操作连接的启动子。因此，表达载体通过条件沉默来调节至少一个下游区域的表达，其中基因的表达的DNA区域被转录以产生RNA转录物，其可以被翻译以产生多肽。基因工程哺乳动物细胞和非人哺乳动物可以使用这种表达载体通过转染和转基因技术制备。此外，公开了制备和使用上述产物的方法（例如，表达载体可以在诊断，治疗或预防中使用）。

36. 发明申请

WO2015085121A9 COMPOSITIONS AND METHODS FOR REDUCING INTRAOCULAR PRESSURE 审中-公开
标题翻译：用于减少内压的组合物和方法
公开(公告)号：WO2015085121A9
公开(公告)日：2016-07-21
申请号：PCT/US2014068671
申请日：2014-12-04
申请人： UNIV MIAMI
发明人： LEE RICHARD K , BHATTACHARYA SANJOY K
IPC分类号： A61K31/683 , A61K31/685 , A61K31/688
CPC分类号： A61K31/675 , A61K9/0048 , A61K31/557 , A61K31/661 , A61K31/683 , A61K31/685 , A61K31/688 , A61K45/06 , A61K47/10 , A61K47/20 , A61K47/22 , A61K47/24 , A61K2300/00
摘要： Compositions, kits, and methods for reducing intraocular pressure (IOP) in a subject (e.g., human) include at least one naturally occurring or synthesized version or analog thereof of a lipid (e.g., a phosphoserine, a phosphocholine, a psychosine or other glycolipid) that is endogenous to non-glaucomatous aqueous humor in a subject and that lowers IOP in the subject, in a therapeutically effective amount for promoting aqueous outflow through TM in at least one eye of the subject and reducing IOP in the subject. The compositions can be used for, e.g., treating glaucomas, including, for example, primary open angle glaucoma (POAG) and normal tension glaucoma (NTG).
摘要翻译：用于降低受试者（例如人）中的眼内压（IOP）的组合物，试剂盒和方法包括至少一种脂质的天然存在或合成的版本或类似物（例如，磷酸丝氨酸，磷酸胆碱，精神病或其他糖脂），其以受试者体内的非青光眼性房水是内源性的，并且以治疗有效量降低受试者的至少一只眼睛中的TM的水流出，并减少受试者的IOP。组合物可用于例如治疗青光眼，包括例如原发性开角型青光眼（POAG）和正常张力性青光眼（NTG）。

37. 发明申请

WO2015116568A3 MUSCLE CELL-TARGETING NANOPARTICLES FOR VACCINATION AND NUCLEIC ACID DELIVERY, AND METHODS OF PRODUCTION AND USE THEREOF 审中-公开
标题翻译：用于接种和核酸递送的肌肉细胞靶向纳米颗粒及其生产和使用方法
公开(公告)号：WO2015116568A3
公开(公告)日：2015-11-12
申请号：PCT/US2015013024
申请日：2015-01-27
申请人： UNIV MIAMI
发明人： DAFTARIAN PIROUZ , DAUNERT SYLVIA , DEO SAPNA , DIKICI EMRE , KAIFER ANGEL , JATIVA SAMUEL
IPC分类号： A61K9/14 , A61K47/48
CPC分类号： C12N15/88 , A61K39/385 , A61K39/39 , A61K48/0041 , A61K2039/53 , A61K2039/55516 , A61K2039/55555 , A61K2039/6031 , A61K2039/6093
摘要： Described herein are conjugates (e.g., nanoparticles), compositions (e.g., nanoparticle-based compositions), kits, methods and platforms for muscle-specific targeting of vaccines and gene therapies. The nanoparticles are composed of charged polymers or charged particles (e.g., polyamidoamide dendrimers) surface-modified with a muscle cell ligand (a targeting moiety) and an anionic enhancer (e.g. a phospholipid) resulting in a multinucleotide-carrying conjugate for introducing vaccines or genes into skeletal muscle cells of a subject (e.g., human and other mammals). The novel compositions described herein find use in muscle-targeted vaccination and gene therapy delivery (e.g., delivery of gene-based vaccines) for the prevention and treatment of disease (e.g., skeletal muscle atrophy, cancer, autoimmune disease, infection).
摘要翻译：本文描述了用于疫苗和基因治疗的肌肉特异性靶向的缀合物（例如纳米颗粒），组合物（例如纳米颗粒基组合物），试剂盒，方法和平台。纳米粒子由用肌肉细胞配体（靶向部分）和阴离子增强剂（例如磷脂）表面修饰的带电聚合物或带电粒子（例如聚酰胺酰胺树状聚体）组成，导致用于引入疫苗或基因的携带多核苷酸的缀合物转移到受试者（例如人类和其他哺乳动物）的骨骼肌细胞中。本文所述的新型组合物可用于预防和治疗疾病（例如骨骼肌萎缩，癌症，自身免疫性疾病，感染）的肌肉靶向疫苗接种和基因治疗递送（例如，递送基于基因的疫苗）。

38. 发明申请

WO2014100816A3 GHRH AGONISTS FOR ISLET CELL TRANSPLANTATION AND FUNCTION AND THE TREATMENT OF DIABETES 审中-公开
标题翻译：用于胰岛细胞移植和功能的GHRH激素和糖尿病的治疗
公开(公告)号：WO2014100816A3
公开(公告)日：2014-10-09
申请号：PCT/US2013077514
申请日：2013-12-23
申请人： UNIV MIAMI , U S A REPRESENTED BY THE DEPT OF VETERANS AFFAIRS , DRESDEN UNIVERSITY OF TECHNOLOGY
发明人： SCHALLY ANDREW V , BLOCK NORMAN L , BORNSTEIN STEFAN , LUDWIG BARBARA
IPC分类号： C07K14/60
CPC分类号： A61K35/39 , A61K35/28 , A61K38/25 , C07K14/60 , A61K2300/00
摘要： Disclosed herein are compositions of GHRH agonists and peptides, and methods to treat diabetes. In one embodiment, a method of promoting survival of grafted cells and/or tissues may involve exposing the cells and/or tissues to an effective amount of at least one agonist of GHRH. In some embodiments, the grafted cells and/or tissues may be pancreatic cells. In some embodiments, the grafted cells may be islet cells co-cultured with non-pancreatic cells. In a further embodiment, a method of treating a patient diagnosed with diabetes involves transplanting and/or grafting the islet cells and/or tissues comprising islet cells into a patient, and administering a therapeutically effective amount of at least one agonist of GHRH to the patient.
摘要翻译：本文公开了GHRH激动剂和肽的组合物以及治疗糖尿病的方法。在一个实施方案中，促进移植细胞和/或组织的存活的方法可包括将细胞和/或组织暴露于有效量的至少一种GHRH激动剂。在一些实施方案中，接枝的细胞和/或组织可以是胰腺细胞。在一些实施方案中，接枝的细胞可以是与非胰腺细胞共培养的胰岛细胞。在另一个实施方案中，治疗诊断患有糖尿病的患者的方法包括将包含胰岛细胞的胰岛细胞和/或组织移植和/或移植到患者体内，以及向患者施用治疗有效量的至少一种GHRH激动剂。

39. 发明申请

WO2012177481A3 FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITION FOR THE TREATMENT OF DISEASE 审中-公开
标题翻译： FIBROBLAST生长因子受体抑制疾病的治疗
公开(公告)号：WO2012177481A3
公开(公告)日：2014-05-08
申请号：PCT/US2012042449
申请日：2012-06-14
申请人： UNIV MIAMI , FAUL CHRISTIAN , WOLF MYLES
发明人： FAUL CHRISTIAN , WOLF MYLES
IPC分类号： C12N15/113 , A61K39/395 , C12P21/00
CPC分类号： A61K39/3955 , A61K38/179 , C07K14/71 , C07K16/2863 , C07K2319/31 , C07K2319/32 , C12N15/1138 , C12Q1/6876 , G01N33/53
摘要： Methods of inhibiting fibroblast growth factor mediated activation of fibroblast growth factor receptors for the treatment of chronic kidney disease, diabetes, and cardiac diseases are enclosed. Pharmaceutical compositions for the treatment of such diseases using the methods are also disclosed as are methods of determining whether a subject would benefit from the methods of treatment and pharmaceutical compositions.
摘要翻译：包封抑制成纤维细胞生长因子介导的成纤维细胞生长因子受体激活治疗慢性肾脏疾病，糖尿病和心脏病的方法。还公开了用于使用这些方法治疗这些疾病的药物组合物，是确定受试者是否将受益于治疗方法和药物组合物的方法。

40. 发明申请

WO2014004934A3 COMPOSITIONS AND METHODS OF TREATING ALZHEIMER'S DISEASE 审中-公开
标题翻译：治疗阿尔茨海默病的组合物和方法
公开(公告)号：WO2014004934A3
公开(公告)日：2014-05-01
申请号：PCT/US2013048381
申请日：2013-06-27
申请人： UNIV MIAMI , US OF AMERICA REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
发明人： SCHALLY ANDREW V , JASBERENYI MIKLOS , BLOCK NORMAN L
IPC分类号： A61P35/00 , A61K38/16 , C07K14/00
CPC分类号： C07K14/47 , A61K38/17 , A61K38/1709 , A61K45/06
摘要： Disclosed herein are compositions of GHRH peptide antagonists, and methods to treat Alzheimer's disease and other neurodegenerative disorders. Such compounds are useful for therapeutics, for protecting neuronal cells from cell-death and for promoting neuronal cell viability.
摘要翻译：本文公开了GHRH肽拮抗剂的组合物，以及治疗阿尔茨海默病和其它神经变性疾病的方法。这些化合物可用于治疗，用于保护神经元细胞免于细胞死亡和促进神经细胞活力。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式