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31. 发明申请

WO2020163243A1 AUTOMATED MICROSCOPY SCANNING SYSTEMS AND METHODS 审中-公开
公开(公告)号：WO2020163243A1
公开(公告)日：2020-08-13
申请号：PCT/US2020/016436
申请日：2020-02-03
申请人： TOKITAE LLC
发明人： HORNING, Matthew P. , HU, Liming , MCGUIRE, Shawn , MEHANIAN, Courosh
IPC分类号： G02B21/36 , B01L9/00
摘要： Techniques and technologies for automated microscopy scanning systems are disclosed wherein a microscopy system performs "hunt mode" operations at coarsely-spaced locations throughout a scanning window until an acceptable quality scan result is achieved. The system then performs detailed scans at all fields of view within a grid cell that includes the location having the acceptable scan result. The system performs another evaluation of the scan results for the entire grid cell, and if the scan results for the grid cell are collectively acceptable, then the system proceeds to perform "scan mode" operations. The scan mode operations include scanning and evaluating all of the fields of view within one or more grid cells adjacent to the acceptable grid cell from the hunt mode operations. The system may successively perform hunt mode operations and scan mode operations, compiling information regarding one or more aspects of the scanning process, until one or more termination criteria are satisfied.

32. 发明申请

WO2019241342A1 METHODS AND SYSTEMS FOR CONCENTRATION OF SAMPLES FOR LATERAL FLOW ASSAYS 审中-公开
公开(公告)号：WO2019241342A1
公开(公告)日：2019-12-19
申请号：PCT/US2019/036705
申请日：2019-06-12
申请人： TOKITAE LLC
发明人： CONNELLY, John Thomas , DANTZLER, Jeffrey L. , GLUKHOVA, Veronika A. , GRANT, Benjamin David , HARSTON, Stephen Paul , IVEZIC, Vedrana , WEIGL, Bernhard Hans , YILDIRIM, Ozgur Emek
IPC分类号： G01N33/543 , G01N1/40 , B01D15/34 , B01L3/00
摘要： Methods and systems for capture concentration of analytes using lectins and other capture ligands are described. For example, stationary phase media functionalized with lectins are used for capture concentration and cleaning of TB lipoarabinomannan (TB LAM) prior to assay on a lateral flow assay (LFA) device, and filtration devices suitable for particulate or bulk capture media are described. Size-exclusion filtration is used to separate particles with captured analyte during washing and concentration steps. Captured analyte can be eluted from stationary phase media prior to application to a LFA or eluted directly onto a customized LFA device that includes a size-selective filter. In various aspects, a size-selective filter on a LFA is used to transfer particulate capture media on a LFA device.

33. 发明申请

WO2018226504A1 SEROLOGY ASSAY FOR RECENT MALARIA INFECTION 审中-公开
公开(公告)号：WO2018226504A1
公开(公告)日：2018-12-13
申请号：PCT/US2018/035380
申请日：2018-05-31
申请人： TOKITAE LLC , LONDON SCHOOL OF HYGIENE & TROPICAL MEDICINE
发明人： CATE, David Michael , DRAKELEY, Christopher John , GREENHOUSE, Bryan Ross , NICHOLS, Kevin Paul Flood , RODRIGUEZ-BARRAQUER, Isabel , TETTEH, Kevin Kweku Adjei , WEIGL, Bernhard Hans
IPC分类号： G01N33/569 , G01N33/558 , G01N33/68
摘要： In some embodiments, an immunoassay device for detection of recent malaria infection includes: a sample pad positioned adjacent to a first end of a conjugate pad, wherein either the sample pad or the first end of the conjugate pad include a detection complex able to bind anti-ETRAMP5 antibodies; wherein a second end of the conjugate pad includes one or more areas impregnated with a construct protein including ETRAMP5 protein fragments. In some embodiments, the detection complex for anti-ETRAMP5 antibodies includes a capture particle complexed with anti-IgG antibodies. In some embodiments, the detection complex for anti-ETRAMP5 antibodies includes a detection particle complexed with a complex molecule including ETRAMP5 protein fragments.

34. 发明申请

WO2018152157A1 IMAGE ANALYSIS SYSTEMS AND RELATED METHODS 审中-公开
公开(公告)号：WO2018152157A1
公开(公告)日：2018-08-23
申请号：PCT/US2018/018113
申请日：2018-02-14
申请人： TOKITAE LLC
发明人： CHAMPLIN, Cary Richard , DELAHUNT, Charles , HORNING, Matthew P. , HU, Liming , MCGUIRE, Shawn Keith , MEHANIAN, Courosh , THOMPSON, Clay Matthew , WILSON, Benjamin K.
IPC分类号： G06K9/00 , G06K9/46 , G06K9/40 , G01N33/49 , G02B21/36
摘要： Embodiments disclosed herein are directed to systems and methods for determining a presence and an amount of an analyte in a biological sample. The systems and methods for determining the presence of an analyte utilize a plurality of images of a sample slide including multiple fields-of-view having multiple focal planes therein. The systems and methods utilize algorithms configured to balance the color and grayscale intensity of the plurality of images and based thereon determine if the plurality of images contain the analyte therein.

35. 发明申请

WO2017155883A1 TEMPERATURE STABILIZED CULTURE INCUBATOR 审中-公开
标题翻译：温度稳定培养培养箱
公开(公告)号：WO2017155883A1
公开(公告)日：2017-09-14
申请号：PCT/US2017/020951
申请日：2017-03-06
申请人： TOKITAE LLC
发明人： CALDERON, Ryan , FRIEND, Michael , GHIONEA, Simon Jeffrey , MILLER, Andrew Kuehl , NORTON, Bryan
IPC分类号： C12M1/00 , C12M1/02 , G01N29/07 , G01N29/34
摘要： Described embodiments include a culture incubator, method, and sensor circuit. A culture incubator includes an accessible incubation compartment configured to contain a culture item at a specified incubation temperature; a phase change material having a phase transition temperature over the specified incubation temperature; and a heat transfer element in thermal communication with the phase change material and configured to transfer heat to the phase change material. A sensor circuit is configured to acquire data indicative of a phase composition state of the phase change material. A manager circuit is configured to determine a difference between the phase composition state and a target phase composition state for the phase change material. A controller circuit is configured to transfer heat to the phase change material in an amount estimated to change the phase composition state of the phase change material to the target phase composition state.
摘要翻译：所描述的实施例包括培养培养箱，方法和传感器电路。培养培养箱包括可接近的培养室，其被配置为在指定的培养温度下容纳培养物品; 相变温度超过规定温育温度的相变材料; 以及传热元件，其与相变材料热连通并被配置成将热传递至相变材料。传感器电路被配置为获取指示相变材料的相组成状态的数据。管理器电路被配置为确定相变材料的相组成状态与目标相组成状态之间的差异。控制器电路被配置成以估计的量将热量传递至相变材料，以将相变材料的相组成状态改变为目标相组成状态。

36. 发明申请

WO2016200771A1 MULTI-MONODOSE CONTAINERS 审中-公开
标题翻译：多单体容器
公开(公告)号：WO2016200771A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/036151
申请日：2016-06-07
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , ECKHOFF, Philip, A. , FOWLER, Lawrence, Morgan , LIU, Shieng , NATARAJAN, Krishnan , PETERSON, Nels, R. , WOOD, Lowell, L., Jr.
IPC分类号： A61J1/06 , B65D77/22 , B65D1/09 , A61J1/14 , A61J3/00
CPC分类号： A61J1/16 , A61J1/1406 , A61J1/1412 , A61J1/18 , A61J2200/70 , A61J2200/72 , A61J2205/30
摘要： Multi-monodose containers are described including a row of at least two vials, a first vial connected to an adjacent second vial through an articulating joint, the articulating joint sufficiently flexible to reversibly mate a planar outer surface of the first vial with a planar outer surface of the adjacent second vial; wherein the row of the at least two vials is configured to form a first rectangular packing cross-sectional area in an expanded configuration and configured to form a second rectangular packing cross-sectional area in a folded configuration, the second rectangular packing cross-sectional area smaller than the first rectangular packing cross-sectional area.
摘要翻译：描述了包含一行至少两个小瓶的多单容器容器，通过铰接接头连接到相邻的第二小瓶的第一小瓶，所述铰接接头足够柔软以使第一小瓶的平面外表面与平面外表面的相邻第二小瓶; 其中所述至少两个小瓶的所述行被配置为形成膨胀构型中的第一矩形填充横截面积并且构造成在折叠构型中形成第二矩形填充横截面积，所述第二矩形填充横截面积小于第一矩形填料横截面积。

37. 发明申请

WO2016191462A1 IMAGE ANALYSIS SYSTEMS AND RELATED METHODS 审中-公开
标题翻译：图像分析系统及相关方法
公开(公告)号：WO2016191462A1
公开(公告)日：2016-12-01
申请号：PCT/US2016/034050
申请日：2016-05-25
申请人： TOKITAE LLC
发明人： CHAMPLIN, Cary Richard , DELAHUNT, Charles , HORNING, Matthew P. , HU, Liming , MCGUIRE, Shawn Keith , MEHANIAN, Courosh , THOMPSON, Clay Matthew , WILSON, Benjamin K.
IPC分类号： G01N21/64 , G02B21/36
CPC分类号： G06T7/0012 , G06K9/00147 , G06K9/4652 , G06T2207/10024 , G06T2207/10056 , G06T2207/10148 , G06T2207/20084 , G06T2207/30004 , G06T2207/30024
摘要： Embodiments disclosed herein are directed to systems and methods for determining a presence and an amount of an analyte in a biological sample. The systems and methods for determining the presence of an analyte utilize a plurality of images of a sample slide including multiple fields-of-view having multiple focal planes therein. The systems and methods utilize algorithms configured to color and grayscale intensity balance the plurality of images and based thereon determine if the plurality of images contain the analyte therein.
摘要翻译：本文公开的实施例涉及用于确定生物样品中分析物的存在和量的系统和方法。用于确定分析物存在的系统和方法利用包括具有多焦点平面的多个视场的样本载片的多个图像。系统和方法利用被配置为对多个图像进行着色和灰度强度平衡的算法，并且基于此确定多个图像是否包含其中的分析物。

38. 发明申请

WO2016022681A1 TEMPERATURE-CONTROLLED MEDICINAL STORAGE DEVICES 审中-公开
标题翻译：温度控制药物储存装置
公开(公告)号：WO2016022681A1
公开(公告)日：2016-02-11
申请号：PCT/US2015/043808
申请日：2015-08-05
申请人： TOKITAE LLC
发明人： CHOU, Fong-Li , ECKHOFF, Philip A. , FOWLER, Lawrence Morgan , LARUSSON, Fridrik , LIU, Shieng , PETERSON, Nels R. , TEGREENE, Clarence T. , WOOD, Lowell L., Jr.
IPC分类号： A61J1/14 , A61J1/00
CPC分类号： F25D16/00 , A61J1/00 , F25B25/02 , F25D2400/02
摘要： In some embodiments, a medicinal storage container includes: a desiccant unit including external walls forming a gas-impermeable barrier around an interior desiccant region and including an aperture; a heating element; a controller operably attached to the heating element; a cooling unit; a compressor system including at least one evaporator coil unit, the compressor operably connected to the controller; a vapor conduit, the vapor conduit attached to a the desiccant unit at a first end, the vapor conduit attached to the evaporative cooling unit at a second end, the vapor conduit forming an internal, gas-impermeable passageway between the desiccant unit and the cooling unit; a vapor control unit attached to the vapor conduit and operably attached to the controller; and a medicinal storage unit including external walls encircling a medicinal storage region including a temperature sensor operably connected to the controller.
摘要翻译：在一些实施方案中，药物储存容器包括：干燥剂单元，其包括在内部干燥剂区域周围形成气体不可渗透屏障并包括孔的外壁; 加热元件; 可操作地连接到加热元件的控制器; 冷却单元; 压缩机系统，包括至少一个蒸发器盘管单元，所述压缩机可操作地连接到所述控制器; 蒸汽导管，在第一端处附接到干燥剂单元的蒸汽导管，在第二端处附接到蒸发冷却单元的蒸汽导管，蒸汽导管在干燥剂单元和冷却剂之间形成内部不透气通道单元; 蒸汽控制单元，其连接到蒸汽管道并可操作地附接到控制器; 以及医疗储存单元，其包括围绕包括可操作地连接到所述控制器的温度传感器的医疗储存区域的外壁。

39. 发明申请

WO2015195736A1 AFFIXED GROUPS OF PHARMACEUTICAL VIALS INCLUDING FRANGIBLE CONNECTORS 审中-公开
标题翻译：包括可变连接器在内的药物组合
公开(公告)号：WO2015195736A1
公开(公告)日：2015-12-23
申请号：PCT/US2015/036129
申请日：2015-06-17
申请人： TOKITAE LLC
发明人： BOOMGARD, John , CHOU, Fong-Li , ECKHOFF, Philip A. , LARUSSON, Fridrik , SHIENG, Liu , NATARAJAN, Krishnan , PETERSON, Nels R. , WOOD, Lowell L., Jr.
IPC分类号： A61J1/00
CPC分类号： A61J1/16 , A61J1/065 , A61J1/1406 , A61J1/1412 , A61J2205/10 , A61J2205/30 , A61J2205/60 , B65D1/095 , B65D21/0201
摘要： In some embodiments, an affixed group of pharmaceutical vials with frangible connectors includes: a plurality of pharmaceutical vials arranged as a group of pharmaceutical vials, each of the plurality of pharmaceutical vials shaped and positioned to minimize a total volume of the group of pharmaceutical vials, each of the pharmaceutical vials including at least one external side with a surface configured to reversibly mate with a corresponding external side and a surface of an adjacent pharmaceutical vial; and a plurality of frangible connectors, wherein at least one frangible connector is affixed to the surface of at least two of the plurality of pharmaceutical vials within the group of pharmaceutical vials, and at least one frangible connector is affixed to each of the plurality of pharmaceutical vials.
摘要翻译：在一些实施方案中，具有易碎连接器的固定的药物小瓶组包括：多个药物小瓶，其布置成一组药物小瓶，所述多个药物小瓶中的每一个成形并定位成使得该组药瓶的总体积最小化，每个药瓶包括至少一个外表面，其表面被配置为可逆地与相应的药物瓶的相应外侧和表面配合; 以及多个易碎连接器，其中至少一个易碎连接器固定到药物小瓶组内的多个药物小瓶中的至少两个的表面上，并且至少一个易碎连接器固定到多个药物小瓶。

40. 发明申请

WO2015009800A1 MULTI-COMPARTMENT PHARMACEUTICAL VIALS 审中-公开
标题翻译：多层药水
公开(公告)号：WO2015009800A1
公开(公告)日：2015-01-22
申请号：PCT/US2014/046813
申请日：2014-07-16
申请人： TOKITAE LLC
发明人： ECKHOFF, Philip, A. , ISHIKAWA, Muriel, Y. , LEVINE, Orin , PETERSON, Nels, R. , WOOD, Lowell, L., Jr. , WOOD, Victoria Y., H.
IPC分类号： A61J1/06 , B65D1/09 , B65D25/06
CPC分类号： A61J1/1425 , A61J1/05 , A61J1/1406
摘要： Multi-compartment pharmaceutical vials are described. In some embodiments, a multi-compartment pharmaceutical vial includes: a multi-compartment pharmaceutical storage region including a bottom wall, at least one outer wall and at least one interior wall, the bottom wall, the at least one outer wall and the at least one interior wall forming a plurality of pharmaceutical storage compartments, each pharmaceutical storage compartment including an aperture positioned opposite to the bottom wall of the pharmaceutical storage region; and an access region attached to the pharmaceutical storage region, the access region including a plurality of conduits, each with a first end and a second end, wherein the first end of each conduit is connected to one aperture in a pharmaceutical storage compartment, and the second end of each conduit circumscribes an aperture positioned opposite to the bottom wall.
摘要翻译：描述了多室药物小瓶。在一些实施方案中，多隔室药物瓶包括：多室药物储存区域，包括底壁，至少一个外壁和至少一个内壁，底壁，至少一个外壁和至少一个内壁形成多个药物储存室，每个药物储存室包括与药物储存区域的底壁相对定位的孔口; 以及附接到所述药物储存区域的进入区域，所述进入区域包括多个导管，每个导管具有第一端和第二端，其中每个导管的第一端连接到药物储存室中的一个孔，并且每个导管的第二端围绕与底壁相对定位的孔。

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