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31. 发明申请

WO2004069795A2 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND TREATMENT OF CHRONIC TISSUE DAMAGE 审中-公开
标题翻译：用于诊断和治疗慢性组织损伤的方法和组合物
公开(公告)号：WO2004069795A2
公开(公告)日：2004-08-19
申请号：PCT/US2004/002881
申请日：2004-02-02
申请人： PFIZER PRODUCTS INC. , OXFORD GLYCOSCIENCES (UK) LTD. , BUTT, Richard , RUMPEL, Klaus , WILLIAMS-JONES, Bryn, I. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , ROHLFF, Christian , BRUCE, James, A. , PATEL, Thakorbhai, P.
发明人： BUTT, Richard , RUMPEL, Klaus , WILLIAMS-JONES, Bryn, I. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , ROHLFF, Christian , BRUCE, James, A. , PATEL, Thakorbhai, P.
IPC分类号： C07D
CPC分类号： G01N33/6881 , A61K38/2006 , G01N2500/00 , G01N2800/20
摘要： This invention relates to use of proteins associated with chronic tissue damage, e.g., chronic dermal ulcers. The proteins identified are useful for clinical screening, diagnosis, prognosis, therapy, and prophylaxis, as well as for drug screening and drug development.
摘要翻译：本发明涉及与慢性组织损伤相关的蛋白质的使用，例如慢性皮肤溃疡。鉴定的蛋白质可用于临床筛选，诊断，预后，治疗和预防以及药物筛选和药物开发。

32. 发明申请

WO2003028543A3 NUCLEIC ACID MOLECULES, POLYPEPTIDES AND USES THEREFOR, INCLUDING DIAGNOSIS AND TREATMENT OF ALZHEIMER'S DISEASE 审中-公开
公开(公告)号：WO2003028543A3
公开(公告)日：2003-04-10
申请号：PCT/US2002/031642
申请日：2002-10-03
申请人： PFIZER PRODUCTS INC. , OXFORD GLYCOSCIENCES (UK) LTD. , DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
发明人： DURHAM, L., Kathryn , FRIEDMAN, David, L. , HERATH, Herath, Mudiyanselage, Athula, Chandrasiri , KIMMEL, Lida, H. , PAREKH, Rajesh, Bhikhu , POTTER, David, M. , ROHLFF, Christian , SILBER, B., Michael , SNYDER, Peter, Jeffrey , SOARES, Holly, Daria , STIGER, Thomas, R. , SUNDERLAND, P., Trey , TOWNSEND, Robert, Reid , WHITE, W., Frost , WILLIAMS, Stephen, A.
IPC分类号： C07K5/00
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of Alzheimer's disease, for monitoring the effectiveness of Alzheimer's disease treatment, and for drug development. Alzheimer's Disease-Associated features (AFs), detectable by two-dimensional electrophoresis of cerebrospinal fluid, serum or plasma are described. The invention further provides Alzheimer's Disease-Associated Protein Isoforms (APIs) detectable in cerebrospinal fluid, serum or plasma, preparations comprising isolated APIs antibodies immunospecific for APIs, pharmaceutical compositions, diagnostic and therapeutic methods, and kits comprising or based on the same.

33. 发明申请

WO2013001369A4 THERAPEUTIC AND DIAGNOSTIC TARGET 审中-公开
公开(公告)号：WO2013001369A4
公开(公告)日：2013-01-03
申请号：PCT/IB2012/001680
申请日：2012-06-28
申请人： OXFORD BIOTHERAPEUTICS LTD. , ROHLFF, Christian , STAMPS, Alasdair
发明人： ROHLFF, Christian , STAMPS, Alasdair
IPC分类号： A61K39/00 , C07K16/28 , C07K16/30 , C12Q1/68 , G01N33/574
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer, for monitoring the effectiveness of acute myeloid leukemia (AML), B-cell chronic lymphocytic leukemia, breast cancer, colorectal cancer, kidney cancer, head and neck cancer, lung cancer, ovarian cancer or pancreatic cancer treatment, and for drug development. The present invention also provides methods and compositions for depletion of immune cells to treat inflammatory diseases.

34. 发明申请

WO2009044208A1 PROTEIN 审中-公开
标题翻译：蛋白
公开(公告)号：WO2009044208A1
公开(公告)日：2009-04-09
申请号：PCT/GB2008/050902
申请日：2008-10-03
申请人： OXFORD GENOME SCIENCES (UK) LIMITED , ROHLFF, Christian
发明人： ROHLFF, Christian
IPC分类号： A61K39/00 , C12N15/11
CPC分类号： G01N33/57438 , A61K39/00 , C12N15/1138 , C12N2310/11 , C12N2310/12 , G01N33/5011 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57446 , G01N2333/70546 , G01N2500/04 , Y10T436/143333
摘要： The present invention provides methods and compositions for treatment, screening, diagnosis and prognosis of breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer and pancreatic cancer, for monitoring the effectiveness of breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer and pancreatic cancer treatment, and for drug development.
摘要翻译：本发明提供乳腺癌，结肠直肠癌，胃癌，肝细胞癌，肺癌和胰腺癌的治疗，筛选，诊断和预后的方法和组合物，用于监测乳腺癌，结肠直肠癌，胃癌，肝细胞癌的有效性，肺癌和胰腺癌治疗以及药物开发。

35. 发明申请

WO2008104803A3 PROTEINS 审中-公开
标题翻译：蛋白质
公开(公告)号：WO2008104803A3
公开(公告)日：2009-01-15
申请号：PCT/GB2008050124
申请日：2008-02-25
申请人： OXFORD GENOME SCIENCES UK LTD , STAMPS ALASDAIR , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： G01N33/574 , C07K14/705 , G01N33/68
CPC分类号： A61K39/39558 , C07K14/705 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K2317/734 , C12Q1/6886 , G01N33/57407 , G01N33/57419 , G01N33/57423 , G01N33/57426 , G01N33/57438 , G01N33/57449 , Y10T436/143333
摘要： The present invention provides methods and compositions for treatment, prevention, diagnosis and monitoring of colorectal cancer, kidney cancer, lung cancer and/orpancreatic cancer in particular relating to a polypeptide OGTA066.
摘要翻译：本发明提供了用于治疗，预防，诊断和监测结直肠癌，肾癌，肺癌和/或胰腺癌的方法和组合物，特别是涉及多肽OGTA066。

36. 发明申请

WO2008104805A3 PROTEINS 审中-公开
标题翻译：蛋白质
公开(公告)号：WO2008104805A3
公开(公告)日：2008-11-20
申请号：PCT/GB2008050126
申请日：2008-02-25
申请人： OXFORD GENOME SCIENCES UK LTD , ROHLFF CHRISTIAN , STAMPS ALASDAIR
发明人： ROHLFF CHRISTIAN , STAMPS ALASDAIR
IPC分类号： C07K14/435 , C07K16/18
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides new polypeptides. Said polypeptides are of use in the screening, diagnosis and prognosis of B-cell non-Hodgkin's lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer, in monitoring the effectiveness of B-cell non-Hodgkin s lymphoma, breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, lung cancer, lymphoid leukaemia (particularly acute T-cell leukaemia), melanoma, osteosarcoma, ovarian cancer, pancreatic cancer, prostate cancer and renal cell cancer treatment, and in drug development. Also provided are antibodies (and other affinity reagents such as Affibodies) which interact with or modulate the expression or activity of the polypeptides.
摘要翻译：本发明提供了新的多肽。所述多肽可用于B细胞非霍奇金淋巴瘤，乳腺癌，结肠直肠癌，胃癌，肝细胞癌，肺癌，淋巴白血病（特别是急性T细胞白血病），黑素瘤，骨肉瘤的筛选，诊断和预后，卵巢癌，胰腺癌，前列腺癌和肾细胞癌，用于监测B细胞非霍奇金淋巴瘤，乳腺癌，结肠直肠癌，胃癌，肝细胞癌，肺癌，淋巴样白血病（特别是急性T- 细胞白血病），黑素瘤，骨肉瘤，卵巢癌，胰腺癌，前列腺癌和肾细胞癌治疗，以及药物开发。还提供了与多肽的表达或活性相互作用或调节多肽的抗体（和其它亲和试剂如亲体）。

37. 发明申请

WO2008026010A1 IDENTIFICATION OF PROTEIN ASSOCIATED WITH HEPATOCELLULAR CARCINOMA, GLIOBLASTOMA AND LUNG CANCER 审中-公开
标题翻译：鉴定与肝细胞癌，玻璃体和肺癌相关的蛋白
公开(公告)号：WO2008026010A1
公开(公告)日：2008-03-06
申请号：PCT/GB2007/050515
申请日：2007-08-29
申请人： OXFORD GENOME SCIENCES (UK) LTD , ROHLFF, Christian
发明人： ROHLFF, Christian
IPC分类号： G01N33/574
CPC分类号： G01N33/57492 , A61K39/39558 , A61K2039/505 , C07K16/2803 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N2333/70503
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of HCC, glioblastoma and lung cancer, for monitoring the effectiveness of HCC, glioblastoma and lung cancer treatment, and for drug development using protein 0GTA025.
摘要翻译：本发明提供用于监测HCC，成胶质细胞瘤和肺癌的筛选，诊断和预后的方法和组合物，用于监测HCC，成胶质细胞瘤和肺癌治疗的有效性，以及使用蛋白质0GTA025的药物开发。

38. 发明申请

WO2008026009A1 PROTEIN 审中-公开
标题翻译：蛋白
公开(公告)号：WO2008026009A1
公开(公告)日：2008-03-06
申请号：PCT/GB2007/050514
申请日：2007-08-29
申请人： OXFORD GENOME SCIENCES (UK) LTD , ROHLFF, Christian
发明人： ROHLFF, Christian
IPC分类号： G01N33/574 , G01N33/50
CPC分类号： G01N33/57419 , G01N33/57423 , G01N33/57492 , G01N2500/00
摘要： The present invention provides methods and compositions for screening, diagnosis and prognosis of colorectal cancer or lung cancer, for monitoring the effectiveness of colorectal cancer or lung cancer treatment, and for drug development.
摘要翻译：本发明提供了用于筛选，诊断和预后结直肠癌或肺癌的方法和组合物，用于监测结肠直肠癌或肺癌治疗的有效性以及用于药物开发。

39. 发明申请

WO2008012362A3 NEW PROTEIN ISOFORMS AND USES THEREOF 审中-公开
标题翻译：新蛋白质的身份及其用途
公开(公告)号：WO2008012362A3
公开(公告)日：2008-03-06
申请号：PCT/EP2007057766
申请日：2007-07-27
申请人： OXFORD GENOME SCIENCES UK LTD , ROHLFF CHRISTIAN
发明人： ROHLFF CHRISTIAN
IPC分类号： C07K14/705 , G01N33/68
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47 , G01N2800/2814
摘要： There is provided, inter alia, a method of diagnosing MCI in a subject, differentiating MCI from AD in a subject, guiding therapy in a subject suffering from MCI, or assigning a prognostic risk of one or more future clinical outcomes to a subject suffering from MCI, the method comprising: (a) performing assays configured to detect a polypeptide derived from a protein selected from the list consisting of proteins defined by SEQ ID Nos 1-18 as a marker in one or more samples obtained from said subject; and (b) correlating the results of said assay(s) to the presence or absence of MCI and AD in the subject, to a therapeutic regimen to be used in the subject, or to the prognostic risk of one or more clinical outcomes for the subject suffering from MCI.
摘要翻译：特别地，提供了诊断受试者中MCI的方法，区分受试者中的MCI与AD，指导患有MCI的受试者的治疗，或将一种或多种未来临床结果的预后风险指定给患有 MCI，所述方法包括：（a）进行配置以检测来源于选自SEQ ID No.1-18所定义的蛋白质的蛋白质的多肽的测定作为从所述受试者获得的一个或多个样品中的标记物; 和（b）将所述测定的结果与受试者中MCI和AD的存在或不存在相关，以用于受试者中使用的治疗方案，或将所述测定的一个或多个临床结果的预后风险与受试者患有MCI。

40. 发明申请

WO2008012362A2 NEW PROTEIN ISOFORMS AND USES THEREOF 审中-公开
标题翻译：新的蛋白质异形体及其用途
公开(公告)号：WO2008012362A2
公开(公告)日：2008-01-31
申请号：PCT/EP2007/057766
申请日：2007-07-27
申请人： Oxford Genome Sciences (UK) Ltd , ROHLFF, Christian
发明人： ROHLFF, Christian
IPC分类号： C07K14/705 , G01N33/68
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/47 , G01N2800/2814
摘要： There is provided, inter alia, a method of diagnosing MCI in a subject, differentiating MCI from AD in a subject, guiding therapy in a subject suffering from MCI, or assigning a prognostic risk of one or more future clinical outcomes to a subject suffering from MCI, the method comprising: (a) performing assays configured to detect a polypeptide derived from a protein selected from the list consisting of proteins defined by SEQ ID Nos 1-18 as a marker in one or more samples obtained from said subject; and (b) correlating the results of said assay(s) to the presence or absence of MCI and AD in the subject, to a therapeutic regimen to be used in the subject, or to the prognostic risk of one or more clinical outcomes for the subject suffering from MCI.
摘要翻译：尤其提供了一种诊断受试者中的MCI，在受试者中分化MCI与AD的方法，指导患有MCI的受试者中的治疗或指定一种或多种患者的预后风险的方法（a）进行测定，所述测定被配置为检测源自选自由SEQ ID No.1-18定义的蛋白质组成的列表的蛋白质中的多肽作为一种或多种从所述受试者获得的样品; 和（b）将所述测定的结果与受试者中MCI和AD的存在或不存在，受试者中使用的治疗方案或受试者的一种或多种临床结果的预后风险相关联患有MCI的受试者。

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