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31. 发明申请

WO2008057132A2 OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION 审中-公开
标题翻译： LID生物传感器共振检测的优化方法
公开(公告)号：WO2008057132A2
公开(公告)日：2008-05-15
申请号：PCT/US2007/004626
申请日：2007-02-20
申请人： CORNING INCORPORATED , GOLLIER, Jacques , PIECH, Garrett, A. , WEBB, Michael, Brian , WU, Qi
发明人： GOLLIER, Jacques , PIECH, Garrett, A. , WEBB, Michael, Brian , WU, Qi
IPC分类号： G01J3/28 , G01N21/27
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
摘要翻译：这里描述了一种光学询问系统，其可以询问独立于标签的检测（LID）生物传感器并监测生物传感器顶部的生物事件，而不会遭受有问题的寄生反射和/或有问题的像素化效应。在一个实施例中，光学询问系统能够询问生物传感器并且使用低通滤波算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在生物传感器。在另一实施例中，光学询问系统能够询问生物传感器并且使用过采样/平滑算法来减少由成问题的像素效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件发生在生物传感器上。

32. 发明申请

WO2007106306A2 REFERENCE MICROPLATES AND METHODS FOR MAKING AND USING THE REFERENCE MICROPLATES 审中-公开
标题翻译：参考微量元素和制备和使用参考微量的方法
公开(公告)号：WO2007106306A2
公开(公告)日：2007-09-20
申请号：PCT/US2007004537
申请日：2007-02-20
申请人： CORNING INC , PASTEL DAVID A , PIECH GARRETT A , SHEDD GORDON M , SHELTON BRETT C , ZAINUL MOHAMED A
发明人： PASTEL DAVID A , PIECH GARRETT A , SHEDD GORDON M , SHELTON BRETT C , ZAINUL MOHAMED A
IPC分类号： G01N21/25 , B01L3/00 , G01N21/27
CPC分类号： G01N21/0332 , B01L3/5085 , B01L3/50851 , B01L2200/148 , B01L2300/0636 , B01L2300/0654 , B01L2300/0829 , B01L2300/168 , B01L2300/1827 , G01N21/253 , G01N21/274 , G01N21/278 , G01N21/31 , G01N35/00594 , G01N35/028 , G01N2001/2893 , G01N2021/0325
摘要： A reference microplate is described herein which can be used to help calibrate and troubleshoot an optical interrogation system. In one embodiment, the reference microplate has a frame with an array of wells each of which contains an optical biosensor and each optical biosensor is at least partially coated with a substance (e.g., elastomer, optical epoxy). In another embodiment, the reference microplate in addition to having its optical biosensors at least partially covered with a substance (e.g., elastomer, optical epoxy) also has a controllable heating device attached thereto which is used to heat the optical biosensors.
摘要翻译：本文描述了参考微孔板，其可用于帮助校准和诊断光学询问系统。在一个实施方案中，参考微量培养板具有一个具有孔阵列的框架，每个孔包含光学生物传感器，并且每个光学生物传感器至少部分涂覆有物质（例如弹性体，光学环氧树脂）。在另一个实施方案中，参考微板除了使其光学生物传感器至少部分被物质（例如弹性体，光学环氧树脂）覆盖之外，还具有连接到其上的可控加热装置，其用于加热光学生物传感器。

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