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31. 发明申请

WO2014058804A2 MICRONIZED COMPOSITIONS COMPOSED OF BONE GRAFTS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：骨组合物的微组合物及其制备方法和使用方法
公开(公告)号：WO2014058804A2
公开(公告)日：2014-04-17
申请号：PCT/US2013/063736
申请日：2013-10-07
申请人： MIMEDX GROUP, INC. , DANIEL, John , SPENCER, Randall , TOFE, Robert
发明人： DANIEL, John , SPENCER, Randall , TOFE, Robert
IPC分类号： A61L27/36
CPC分类号： A61L27/3604 , A61L27/3608 , A61L2400/06 , A61L2430/02 , A61L2430/24
摘要： Described herein are compositions composed of micronized particles derived from one or more components present in placental tissue in combination with one or more bone grafts. The compositions have numerous medical applications. Methods for making and using the micronized compositions are also described herein.
摘要翻译：本文描述的是由一个或多个组分组成的微粉化颗粒组成的组合物，其中一种或多种组分与一种或多种骨移植组合。该组合物具有许多医学应用。本文还描述了制备和使用微粉化组合物的方法。

32. 发明申请

WO2014028327A1 MICRONIZED PLACENTAL TISSUE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：微孔组织织物组合物及其制备方法及使用方法
公开(公告)号：WO2014028327A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/054322
申请日：2013-08-09
申请人： MIMEDX GROUP INC.
发明人： DANIEL, John , SPENCER, Randall , SITH, Somaly
IPC分类号： A01N63/00 , A61K35/66
CPC分类号： A61K35/50 , A01N1/0284 , A61F2/02 , A61K9/0019 , A61K9/14 , A61K45/06 , A61K47/02 , A61L26/0057 , A61L27/36 , A61L29/005 , A61L31/005 , F26B21/004 , A61K2300/00
摘要： Described herein are compositions composed of micronized placental components, extracts of micronized placental components, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions and the extracts thereof are also described herein.
摘要翻译：本文描述的是由微粉化的胎盘组分，微粉化的胎盘组分的提取物及其药物组合物组成的组合物。该组合物具有许多医学应用。本文还描述了制备和使用微粉化组合物及其提取物的方法。

33. 发明申请

WO2021257799A1 MESHED UMBILICAL CORD TISSUE GRAFTS 审中-公开
公开(公告)号：WO2021257799A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037780
申请日：2021-06-17
申请人： MIMEDX GROUP, INC.
发明人： MCQUEEN, Adam , LEVAUGHN, Rick , KOOB, Thomas J. , MASSEE, Michelle
IPC分类号： A61K35/50 , A61K35/51 , A61L27/00 , A61L27/36 , A61L27/50 , A61L2400/06 , A61L2430/34 , A61L27/3604 , A61L27/3695
摘要： A meshed, dehydrated, umbilical tissue allograft that can be used in the treatment of wounds. Specifically, the meshed allograft has the property of being able to be expanded to cover an irregularly shaped wound, therefore reducing the need to apply multiple, uniform sized grafts to a single wound site. The meshed, dehydrated umbilical tissue allograft is sourced from a human donor, and is then processed to remove any potential contaminants or microbes prior to applying a specific mesh pattern to the tissue. The meshed, dehydrated, umbilical tissue graft is reconstituted prior to applying to the subject, and can then be configured to optimally cover the shape of the wound site.

34. 发明申请

WO2019220421A1 PLACENTAL TISSUE COMPONENT COMPOSITIONS FOR TREATMENT OF SKIN DEFECTS AND METHODS USING SAME 审中-公开
公开(公告)号：WO2019220421A1
公开(公告)日：2019-11-21
申请号：PCT/IB2019/054157
申请日：2019-05-20
申请人： MIMEDX GROUP, INC.
发明人： LEVAUGHN, Rick , ARJUNON, Sivakkumar , TAYLOR, Olivia
IPC分类号： A61K35/50
摘要： The present disclosure provides methods of treating defects such as wrinkles or scars via a subdermal injection of placental tissue components. It also provides placental tissue compositions maintained within the barrel of a syringe, which may be for use in treating such defects.

35. 发明申请

WO2016128916A1 COLLAGEN AND MICRONIZED PLACENTAL TISSUE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：胶原和微孔化的组织组织及其制备和使用方法
公开(公告)号：WO2016128916A1
公开(公告)日：2016-08-18
申请号：PCT/IB2016/050713
申请日：2016-02-11
申请人： MIMEDX GROUP, INC.
发明人： KOOB, Thomas J. , MASSEE, Michelle
IPC分类号： A61L26/00
CPC分类号： A61L27/3604 , A61K9/14 , A61K9/7007 , A61K35/50 , A61K38/39 , A61L26/0033 , A61L26/0057 , A61L26/0061 , A61L26/0095 , A61L27/24 , A61L27/54 , A61L2430/10 , A61L2430/34
摘要： Described herein are compositions of collagen and micronized placental tissue components, methods for producing the same and methods for using the same for wound healing, repairing damaged tendons, cosmetic applications and covering biocompatible materials and/or devices.
摘要翻译：本文描述了胶原蛋白和微粉化胎盘组织成分的组合物，其制备方法及其使用方法用于伤口愈合，修复损伤的腱，化妆品应用和覆盖生物相容性材料和/或装置。

36. 发明申请

WO2016007554A1 MICRONIZED WHARTON'S JELLY 审中-公开
公开(公告)号：WO2016007554A1
公开(公告)日：2016-01-14
申请号：PCT/US2015/039444
申请日：2015-07-07
申请人： MIMEDX GROUP, INC.
发明人： SPENCER, Randall , SITH, Somaly , KOOB, Thomas
IPC分类号： C12N5/073 , A61K35/50 , A61L27/38
CPC分类号： A61K35/51 , A61K9/0019 , A61K9/14 , A61K9/16 , C12N5/065 , C12N2509/10
摘要： Provided are compositions and formulations of micronized Wharton's jelly having a controlled viscosity such that when delivered to the injured region of a subject, it remains substantially localized with little or no migration out of the injured region for the repair and/or regeneration thereof. Micronized Wharton's Jelly can be suspended in a pharmaceutically acceptable aqueous carrier, such as saline, sterile water, or any suitable buffer, to form a suspension or a gelatinous gel composition, or it can be in the form of a paste and administered topically or injected into the body through the use of a needle and syringe. Accordingly, micronized Wharton's Jelly, compositions, or formulations thereof, can be delivered in a manner that is more convenient than Wharton's jelly that has not been micronized.
摘要翻译：提供了具有受控粘度的微粉化沃顿的果冻的组合物和制剂，使得当被递送到受试者的受损区域时，其保持基本上定位，很少或没有移出受损区域以进行修复和/或再生。微粉心的沃顿的果冻可以悬浮在药学上可接受的水性载体中，例如盐水，无菌水或任何合适的缓冲液，以形成悬浮液或凝胶状凝胶组合物，或者它可以是糊剂形式，局部施用或注射通过使用针头和注射器进入身体。因此，可以以比尚未微粉碎的沃顿的果冻更方便的方式递送微波沃顿沃顿的果冻，组合物或其制剂。

37. 发明申请

WO2014168956A1 NDGA POLYMERS AND METAL COMPLEXES THEREOF 审中-公开
标题翻译： NDGA聚合物及其金属复合物
公开(公告)号：WO2014168956A1
公开(公告)日：2014-10-16
申请号：PCT/US2014/033346
申请日：2014-04-08
申请人： MIMEDX GROUP, INC.
发明人： KOOB, Thomas J.
IPC分类号： A61K31/047 , A61K31/045 , A61K31/05 , A61P35/00
CPC分类号： A61K33/34 , A01N59/16 , A01N59/20 , A61K33/24 , A61K33/26 , A61K47/58 , A61L27/54 , A61L31/16 , A61L2300/104 , C08G65/38 , C08G65/44 , C08K3/015 , A01N25/10
摘要： Provided herein are NDGA polymers and metal complexes of such polymers, preferably those metal complexes of the polymers that are insoluble or substantially insoluble in an aqueous solvent, and processes for making the same.
摘要翻译：本文提供了这样的聚合物的NDGA聚合物和金属络合物，优选那些不溶于或基本上不溶于水性溶剂的聚合物的金属络合物及其制备方法。

38. 发明申请

WO2014113733A1 METHODS FOR TREATING CARDIAC CONDITIONS 审中-公开
标题翻译：治疗心脏病症的方法
公开(公告)号：WO2014113733A1
公开(公告)日：2014-07-24
申请号：PCT/US2014/012141
申请日：2014-01-17
申请人： MIMEDX GROUP, INC.
发明人： KOOB, Thomas J. , BURROWS, H. Frank
IPC分类号： A61K35/50 , C12N5/073 , A61P9/00
CPC分类号： A61K35/50 , A61K38/1709 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/2026 , A61K38/2066 , A61K38/45 , A61K38/57 , C12N5/0605 , C12Y207/08001
摘要： Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
摘要翻译：本文描述了使用修饰的胎盘组织或胎盘组织提取物治疗心脏病症的组合物和方法，其能够在体内和体外募集干细胞或促进愈合。

39. 发明申请

WO2014028326A1 TISSUE GRAFTS COMPOSED OF MICRONIZED PLACENTAL TISSUE AND METHODS OF MAKING AND USING THE SAME 审中-公开
标题翻译：组织的组织培养物组成的组织培养物及其制备和使用方法
公开(公告)号：WO2014028326A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/054320
申请日：2013-08-09
申请人： MIMEDX GROUP INC.
发明人： KOOB, Tom , DANIEL, John , SPENCER, Randall
IPC分类号： A61L27/38 , A61L27/56 , C12N5/07 , A61F2/04 , A61F2/02
CPC分类号： A61K35/50
摘要： Described herein are tissue grafts composed of at least one membrane, where at least one side of the membrane has micronized placental tissue applied it. Also described herein are methods for making and using the tissue grafts.
摘要翻译：这里描述的是由至少一个膜组成的组织移植物，其中膜的至少一侧具有微粉化的胎盘组织。本文还描述了用于制造和使用组织移植物的方法。

40. 发明申请

WO2013067294A1 IMPLANTABLE COLLAGEN DEVICES AND RELATED METHODS AND SYSTEMS OF MAKING SAME 审中-公开
标题翻译：可植入胶原蛋白装置及其相关方法和制备方法
公开(公告)号：WO2013067294A1
公开(公告)日：2013-05-10
申请号：PCT/US2012/063229
申请日：2012-11-02
申请人： MIMEDX GROUP, INC.
发明人： KOOB, Thomas J.
IPC分类号： A61L27/24 , A61F2/08 , A61F2/02
CPC分类号： C12N5/066 , A61F2/0095 , A61F2/02 , A61F2/08 , A61L27/24 , A61L27/3804 , A61L27/386 , A61L2430/10 , C12N2506/1307 , C12N2506/1346 , C12N2527/00 , C12N2533/54
摘要： The invention relates to implantable collagen devices made by seeding at least one elongate collagen construct, e.g., comprising at least one elongate synthetic collagen fiber with a plurality of cells and applying a strain and/or stress to the at least one elongate collagen fiber to induce the cells to differentiate into target phenotypes, e.g., tendon or ligament phenotype cells (and/or fibroblasts), typically with an extracellular matrix of collagen to organize into a tissue on the at least one collagen fiber.
摘要翻译：本发明涉及通过将至少一个细长的胶原构建体接种而制备的可植入胶原蛋白装置，例如，包含至少一个细长的合成胶原纤维与多个细胞，并向至少一个细长的胶原纤维施加应变和/或应激以诱导细胞分化成目标表型，例如，肌腱或韧带表型细胞（和/或成纤维细胞），通常具有胶原的细胞外基质以组织到至少一种胶原纤维上的组织中。

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