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    • 33. 发明申请
    • PHARMACEUTICAL FORMULATION FOR TREATING CARDIOVASCULAR DISEASE
    • 用于治疗心血管疾病的药物制剂
    • WO2009127974A3
    • 2010-03-25
    • PCT/IB2009006277
    • 2009-02-23
    • HANALL PHARMACEUTICAL CO LTDKIM SUNG WUKJUN SUNG SOOKOO JA SEONGKIM JIN WOOKPARK SUN WOOJANG SEOK YOUNGLEE SANG JUJO YOUNG GWANLEE JUN YOUNG
    • KIM SUNG WUKJUN SUNG SOOKOO JA SEONGKIM JIN WOOKPARK SUN WOOJANG SEOK YOUNGLEE SANG JUJO YOUNG GWANLEE JUN YOUNG
    • A61K9/52A61K9/22A61K9/28A61K31/40A61K31/44A61K47/38A61P9/00A61P13/12
    • A61K31/44A61K9/209
    • The present invention provides a pharmaceutical formulation comprising: an early release portion comprising as a pharmaceutical active ingredient a statin-based hypolipidic agent, an isomer thereof, or a pharmaceutically acceptable salt thereof; and a slow release portion comprising as a pharmaceutical active ingredient a dihydropyridine-based calcium channel blocking agent, an isomer thereof, or a pharmaceutically acceptable salt thereof. When compared with a single formulation of each of the drugs or a simple combination formulation of the drugs, the pharmaceutical formulation according to the present invention comprising an early release portion comprising a statin-based hypolipidic agent and a slow release portion comprising a dihydropyridine-based calcium channel blocking agent is pharmaceutically, scientifically, and economically very useful in preventing or treating cardiovascular disease, pulmonary heart disease, pulmonary disease, or kidney disease of patients who have a metabolic syndrome, insulin resistance, diabetes, or prediabetes. The formulation of the present invention is effective in preventing antagonistic and side effects between the drugs by making the dissolution rate of the statin-based hypolipidic agent different from that of the dihydropyridine-based calcium channel blocking agent, and in facilitating patient compliance in taking the drugs by administering the two different drugs simultaneously.
    • 本发明提供一种药物制剂,其包含:早期释放部分,其包含作为药物活性成分的基于他汀类的降血糖剂,​​其异构体或其药学上可接受的盐; 以及缓释部分,其包含基于二氢吡啶的钙通道阻断剂,其异构体或其药学上可接受的盐作为药物活性成分。 当与药物的单一制剂或药物的简单组合制剂相比时,根据本发明的药物制剂包含早期释放部分,其包含基于他汀类的降血脂药和包含基于二氢吡啶的缓释部分 钙通道阻断剂在预防或治疗具有代谢综合征,胰岛素抵抗,糖尿病或糖尿病前期的患者的心血管疾病,肺心病,肺部疾病或肾脏疾病方面在药学,科学和经济上非常有用。 本发明的制剂通过使基于他汀类的降血糖剂与二氢吡啶类钙通道阻断剂的溶解速率不同而使药物的拮抗作用和副作用有效,并且为了便于患者服用 药物同时服用两种不同药物。