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31. 发明申请

WO2015051135A3 ORGANIC COMPOSITIONS TO TREAT HEPCIDIN-RELATED DISEASES 审中-公开
标题翻译：治疗肝素相关疾病的有机组合物
公开(公告)号：WO2015051135A3
公开(公告)日：2015-09-03
申请号：PCT/US2014058851
申请日：2014-10-02
申请人： NOVARTIS AG , BARYZA JEREMY LEE , BLOMMERS MARCEL , BORLAND TODD , FERNANDEZ CESAR , GEBUHR TOM , GENO ERIN , GOSSERT ALVAR , GREENIDGE PAULETTE , HUESKEN DIETER , HUNZIKER JUERG , NATT FRANCOIS JEAN-CHARLES , PATNAIK ANUP , PATTERSON ANDREW , RONDEAU JEAN-MICHEL RENE , SOLOMON JONATHAN , WEILER JAN , ZHU MEICHENG
发明人： BARYZA JEREMY LEE , BLOMMERS MARCEL , BORLAND TODD , FERNANDEZ CESAR , GEBUHR TOM , GENO ERIN , GOSSERT ALVAR , GREENIDGE PAULETTE , HUESKEN DIETER , HUNZIKER JUERG , NATT FRANCOIS JEAN-CHARLES , PATNAIK ANUP , PATTERSON ANDREW , RONDEAU JEAN-MICHEL RENE , SOLOMON JONATHAN , WEILER JAN , ZHU MEICHENG
IPC分类号： C12N15/113 , A61K31/713 , A61P7/06
CPC分类号： C12N15/113 , C12N15/1136 , C12N2310/14 , C12N2310/321 , C12N2310/344 , C12N2310/351 , C12N2320/51
摘要： The present disclosure relates to methods of treating Hepcidin-related diseases such as anemia, iron-deficient erythropoiesis, hypoferremia, impaired dietary iron uptake, iron sequestration, anemia of inflammation (AI) (sometimes designated anemia of chronic disease or ACD), atherosclerosis, diabetes, and multiple neurodegenerative disorders such as Alzheimers disease, Parkinsons disease and Friedrichs ataxia, heart failure, chronic kidney disease, cardiorenal-anemia syndrome, infection, blood loss, hemolysis, vitamin B12 or folate deficiency, hyperparathyroidism, hemoglobinopathies and malignancies, cancer, AIDS, surgery, runted growth, and hair loss, using a therapeutically effective amount of a RNAi agent to Hepcidin.
摘要翻译：本发明涉及治疗铁调素相关疾病例如贫血，铁缺乏性红细胞生成，低铁血症，饮食铁摄取受损，铁螯合，炎症贫血（AI）（有时称为慢性疾病或ACD贫血），动脉粥样硬化，糖尿病和多种神经退行性疾病如阿尔茨海默病，帕金森病和弗里德里希共济失调，心力衰竭，慢性肾病，心肾综合征，感染，失血，溶血，维生素B12或叶酸缺乏症，甲状旁腺功能亢进症，血红蛋白病和恶性肿瘤，艾滋病，手术，运行的生长和脱发，使用治疗有效量的RNAi剂对Hepcidin。

32. 发明申请

WO2015051366A2 NOVEL FORMATS FOR ORGANIC COMPOUNDS FOR USE IN RNA INTERFERENCE 审中-公开
标题翻译：用于RNA干扰的有机化合物的新形式
公开(公告)号：WO2015051366A2
公开(公告)日：2015-04-09
申请号：PCT/US2014/059301
申请日：2014-10-06
申请人： NOVARTIS AG , BARYZA, Jeremy Lee , BLOMMERS, Marcel , CHUTKOW, William , FERNANDEZ, Cesar , GENO, Erin , GOSSERT, Alvar , GREENIDGE, Paulette , HUESKEN, Dieter , HUNZIKER, Juerg , NATT, Francois Jean-Charles , PATNAIK, Anup , PATTERSON, Andrew , RONDEAU, Jean-Michel Rene , WEILER, Jan , ZHU, Meicheng
发明人： BARYZA, Jeremy Lee , BLOMMERS, Marcel , CHUTKOW, William , FERNANDEZ, Cesar , GENO, Erin , GOSSERT, Alvar , GREENIDGE, Paulette , HUESKEN, Dieter , HUNZIKER, Juerg , NATT, Francois Jean-Charles , PATNAIK, Anup , PATTERSON, Andrew , RONDEAU, Jean-Michel Rene , WEILER, Jan , ZHU, Meicheng
IPC分类号： A61K48/00 , C07H21/02 , C07F9/6512
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/332 , C12N2310/341 , C12N2310/351 , C12N2310/3515 , C12N2310/3521 , C12N2310/3525 , C12N2310/3533
摘要： The disclosure relates to compositions comprising a RNAi agent having a novel format including a spacer subunit. The disclosure relates to compositions comprising a RNAi agent having a novel format: an 18-mer format with at least one internal spacer. These RNAi agents comprise a first and a second 18-mer strand, wherein the first strand is 18 ribonucleotides or 18 total ribonucleotides and spacer subunit(s), and the second strand is 18 total ribonucleotides and spacer subunit(s), wherein: each spacer subunit consists of: (a) a phosphate or modified internucleoside linker and (b) a spacer; a spacer subunit can be at any position in the strand; the two strands form a duplex with at least one blunt end; and the 3 end of one or both strands terminates in a phosphate or modified internucleoside linker and further comprises, in 5 to 3 order: a second spacer; a second phosphate or modified internucleoside linker, and a 3 end cap. In various embodiments, the RNAi agents comprise a first and a second strand, wherein each strand is a 30-mer or shorter, the first strand comprises ribonucleotides, and the second strand comprises ribonucleotides and one or more spacer subunit(s), wherein: each spacer subunit consists of: (a) a phosphate or modified internucleoside linker and (b) a spacer; a spacer subunit can be at any position in the strand. In some embodiments, the 3 end of both strands further comprise, in 5 to 3 order: a second spacer; a second phosphate or modified internucleoside linker; and a 3 end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3 end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker. Optionally, the first two base-pairing nucleotides on the 3 end of the one or both strand are 2-MOE. Optionally, the RNAi agent can be modified on one or both 5 end. Optionally, the first or second strand is the sense strand, and the sense strand can comprise a 5 end cap which reduces the amount of the RNA interference mediated by this strand. Optionally, the RNAi agent is attached to a ligand. This format can be used to devise RNAi agents to a variety of different targets and sequences. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.
摘要翻译：本公开涉及包含具有包括间隔子亚基的新型形式的RNAi剂的组合物。本公开涉及包含具有新形式的RNAi剂的组合物：具有至少一个内部间隔区的18聚体形式。这些RNAi剂包含第一条和第二条18-mer链，其中第一条链是18个核糖核苷酸或总共18个核糖核苷酸和间隔亚基，第二条链是18个总核糖核苷酸和间隔亚基，其中：各个间隔子单元由以下组成：（a）磷酸盐或修饰的核苷间连接体和（b）间隔物; 间隔子亚基可以位于链中的任何位置; 两条链与至少一个钝端形成双链体; 并且一条或两条链的3末端以磷酸盐或修饰的核苷间连接体终止，并进一步包含5至3次：第二间隔物; 第二磷酸盐或修饰的核苷间接头，和3个端帽。在各种实施方案中，RNAi剂包含第一链和第二链，其中每条链是30聚体或更短，第一链包含核糖核苷酸，并且第二链包含核糖核苷酸和一个或多个间隔子亚基，其中：每个间隔子亚基由以下组成：（a）磷酸盐或修饰的核苷间连接物和（b）间隔物; 间隔子亚基可以位于链中的任何位置。在一些实施方案中，两条链的3端进一步包含5至3个顺序：第二间隔区; 第二磷酸盐或修饰的核苷间连接体; 和3个端盖。两条链可以具有相同或不同的间隔区，磷酸盐或修饰的核苷间接头，和/或3个端帽。链可以是核糖核苷酸，或者任选地，一个或多个核苷酸可以被修饰或取代。任选地，至少一个核苷酸包含修饰的核苷间连接体。任选地，一条或两条链的3末端上的前两个碱基配对核苷酸是2-MOE。任选地，可以在5个末端的一个或两个上修饰RNAi剂。任选地，第一链或第二链是有义链，并且有义链可以包含减少由该链介导的RNA干扰量的5端帽。任选地，RNAi剂附着于配体。该格式可用于将RNAi试剂设计为多种不同的靶标和序列。本公开还涉及制备这种组合物的方法，以及这些组合物的方法和用途，例如介导RNA干扰。

33. 发明申请

WO2015050871A3 ORGANIC COMPOUNDS TO TREAT HEPATITIS B VIRUS 审中-公开
公开(公告)号：WO2015050871A3
公开(公告)日：2015-04-09
申请号：PCT/US2014/058314
申请日：2014-09-30
申请人： NOVARTIS AG , BARYZA, Jeremy, Lee , BLOMMERS, Marcel , FERNANDEZ, Cesar , GENO, Erin , GOSSERT, Alvar , GREENIDGE, Paulette , HUESKEN, Dieter , HUNZIKER, Juerg , NATT, Francois, Jean-Charles , PATNAIK, Anup , PATTERSON, Andrew , RONDEAU, Jean-Michel, Rene , WEILER, Jan , ZHU, Meicheng , HOLDORF, Meghan
发明人： BARYZA, Jeremy, Lee , BLOMMERS, Marcel , FERNANDEZ, Cesar , GENO, Erin , GOSSERT, Alvar , GREENIDGE, Paulette , HUESKEN, Dieter , HUNZIKER, Juerg , NATT, Francois, Jean-Charles , PATNAIK, Anup , PATTERSON, Andrew , RONDEAU, Jean-Michel, Rene , WEILER, Jan , ZHU, Meicheng , HOLDORF, Meghan
IPC分类号： A61K31/713 , C12N15/113
摘要： The disclosure relates to compositions comprising a HBV RNAi agent. In some embodiments, the HBV RNAi agent comprises a sense and an anti-sense strand, each strand being an 18-mer and the strands together forming a blunt-ended duplex, wherein the 3' end of at least one strand terminates in a phosphate or modified internucleoside linker and further comprises, in 5' to 3' order: a spacer; a second phosphate or modified internucleoside linker; and a 3' end cap. In some embodiments, the 3' end of both the sense and anti-sense strand further comprise, in 5' to 3' order: a spacer; a second phosphate or modified internucleoside linker; and a 3' end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3' end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker. Optionally, the RNAi agent can be modified on one or both 5' end. Optionally, the sense strand can comprise a 5' end cap which reduces the amount of the RNA interference mediated by this strand. Optionally, the RNAi agent is attached to a ligand. This format can be used to devise RNAi agents to a variety of different targets and sequences. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference. The disclosure also pertains to methods of treating, ameliorating and preventing HBV in a patient involving the step of administering to the patient a therapeutic amount of a HBV RNAi agent.

34. 发明申请

WO2010144231A3 COMPOSITIONS AND METHODS FOR TREATING AIDS OR CANCER BY INHIBITING THE SECRETION OF MICROPARTICLES 审中-公开
标题翻译：通过抑制微生物分泌来治疗艾滋病或癌症的组合物和方法
公开(公告)号：WO2010144231A3
公开(公告)日：2011-04-21
申请号：PCT/US2010035698
申请日：2010-05-21
申请人： MOREHOUSE SCHOOL OF MEDICINE , BOND VINCENT CRAIG , POWELL MICHAEL , HUANG MING BO , ALI SYED , RAYMOND ANDREA D , SHELTON MARTIN NEVILLE , VILLINGER FRANCOIS JEAN
发明人： BOND VINCENT CRAIG , POWELL MICHAEL , HUANG MING BO , ALI SYED , RAYMOND ANDREA D , SHELTON MARTIN NEVILLE , VILLINGER FRANCOIS JEAN
IPC分类号： C07K7/08 , A61K38/17 , A61P31/18 , C07K14/435 , C12N15/63
CPC分类号： C07K7/08 , A61K38/00 , C07K7/06 , C07K14/005 , C12N2740/16033 , C12N2740/16322
摘要： Novel peptides that inhibit the release of microparticles from cells are disclosed. The peptide contains at least one VGFPV motif at the N-terminal and has a length of 10-100 amino acids. Also disclosed is polynucleotide encoding the peptide, expression vectors carrying the polynucleotide, and methods for treating AIDS and tumors using the novel peptides.
摘要翻译：公开了抑制细胞释放微粒的新型肽。肽在N-末端含有至少一个VGFPV基序，长度为10-100个氨基酸。还公开了编码肽的多核苷酸，携带多核苷酸的表达载体，以及使用新肽治疗AIDS和肿瘤的方法。

35. 发明申请

WO2009101327A3 METHOD AND DEVICE FOR CONTACT SIMULATION USING LAYERED DEPTH IMAGES 审中-公开
标题翻译：使用层状深度图像进行接触模拟的方法和装置
公开(公告)号：WO2009101327A3
公开(公告)日：2009-10-15
申请号：PCT/FR2009050170
申请日：2009-02-04
申请人： UNIV JOSEPH FOURIER , FAURE FRANCOIS JEAN ROGER
发明人： FAURE FRANCOIS JEAN ROGER
IPC分类号： G06T17/40 , G06F17/10
CPC分类号： G06T19/00 , G06T15/205 , G06T2210/12 , G06T2210/21
摘要： The invention relates to a method for the interactive simulation of an intersection between at least two volumetric objects modelled using geometric primitives. The method first comprises applying a Layered Depth Image (LDI) algorithm along a first display axis in order to determine a set of contact pixels. According to the invention, the method comprises: - calculating an intersection volume (V) from the contact pixels; - at each summit of the geometric primitives, calculating a partial derivative of the size of the intersection volume (V) relative to the coordinate of the summit along the projection axis; repeating the preceding steps for the two other orthogonal display axes in order to determine a vector containing the partial derivatives of the size of the volume relative to the coordinates of each of the summits; and - at each summit, associating a force f calculated from said partial derivatives.
摘要翻译：本发明涉及一种用于使用几何图元建模的至少两个体积对象之间的交集的交互模拟的方法。该方法首先包括沿着第一显示轴应用分层深度图像（LDI）算法，以便确定一组接触像素。根据本发明，该方法包括： - 从接触像素计算交集体积（V）; - 在几何图元的每个顶点处，计算相对于沿着投影轴的顶点的坐标的交集体积（V）的大小的偏导数; 重复前述两个正交显示轴的步骤，以便确定包含相对于每个峰顶的坐标的体积大小的偏导数的矢量; 以及 - 在每个峰会处，将从所述偏导数计算的力f相关联。

36. 发明申请

WO2007090980A3 METHOD FOR ESTIMATING A NOISE GENERATED IN AN ELECTRONIC SYSTEM AND RELATED METHOD FOR TESTING NOISE IMMUNITY 审中-公开
标题翻译：用于估计电子系统中产生的噪声的方法和用于测试噪声免疫的相关方法
公开(公告)号：WO2007090980A3
公开(公告)日：2008-03-27
申请号：PCT/FR2007050740
申请日：2007-02-02
申请人： COUPLING WAVE SOLUTIONS CWS , FABIN BENOIT EMMANUEL , CLEMENT FRANCOIS JEAN RAYMOND , DHIA AMINE
发明人： FABIN BENOIT EMMANUEL , CLEMENT FRANCOIS JEAN RAYMOND , DHIA AMINE
IPC分类号： G06F17/50
CPC分类号： G06F17/5036
摘要： The invention concerns a method for testing immunity to noise derived from interferences between components in a mixed analogic and digital electronic system. Said method consists in: determining by simulating the highest-level noise observed in the system, or the worst noise generated by interferences. If a test for noise sensitivity is successful with this injected worst noise, then the system is accepted. In the case where the worst noise test fails, the method consists in calculating by simulating the lowest-level noise observed in said system, or the injected best noise. And if a test for noise sensitivity fails with this injected best signal, then the system is rejected. The invention also concerns extraction of macromodel current sources of the cells for injecting said worst and said best noises. Said extraction is performed based on a detailed model of each cell, by comparing the frequency spectra obtained for different switching patterns applied in input of the circuit cells.
摘要翻译：本发明涉及一种用于测试来自混合模拟和数字电子系统中的组件之间的干扰的噪声的抗扰度的方法。所述方法包括：通过模拟系统中观察到的最高级噪声或由干扰产生的最差噪声来确定。如果使用这种注入的最差噪声对噪声敏感度进行了测试，那么系统就被接受。在最差噪声测试失败的情况下，该方法包括通过模拟在所述系统中观察到的最低级噪声或注入的最佳噪声来计算。如果用这种注入的最佳信号对噪声敏感度进行测试失败，则系统被拒绝。本发明还涉及提取用于注入所述最差和所述最佳噪声的细胞的宏模型电流源。通过比较在电路单元的输入中应用的不同切换模式获得的频谱，基于每个单元的详细模型来执行所述提取。

37. 发明申请

WO2007071310A1 HEAVY-DUTY ROUNDSLING 审中-公开
标题翻译：重型ROUNDSLING
公开(公告)号：WO2007071310A1
公开(公告)日：2007-06-28
申请号：PCT/EP2006/011406
申请日：2006-11-28
申请人： DSM IP ASSETS B.V. , GOOSSENS, Francois, Jean, Venlentine , GROOTENHORST, Rdwin, Jacco
发明人： GOOSSENS, Francois, Jean, Venlentine , GROOTENHORST, Rdwin, Jacco
IPC分类号： B66C1/18 , D07B1/02 , B66C1/12
CPC分类号： B66C1/12 , D07B2201/1016 , D07B2201/209 , D07B2201/20903 , D07B2201/20907 , D07B2205/2014 , Y10T442/30 , D07B2801/10 , D07B2801/22
摘要： The invention relates to a heavy-duty roundsling, which comprises an endless load-bearing core containing multiple turns of a strand material comprising high-performance fibres, and a protective cover made from interlaced strands comprising high-performance fibres, and wherein the mass ratio of high-performance fibres in the core to high-performance fibres in the cover is from 0.15 to 2.0. Said roundsling shows an advantageous combination of properties, like high strength, low weight, and high durability; enabling a higher number of lifting operations than known metal or synthetic slings, especially of heavy goods with e.g. sharp edges.
摘要翻译：本发明涉及一种重型圆锯，其包括包含多匝包含高性能纤维的股线材的无端承载芯，以及由包含高性能纤维的交织股线制成的保护罩，其中质量比高性能纤维在芯中的高性能纤维的覆盖率为0.15〜2.0。所述的圆形显示出优异的性能组合，如高强度，低重量和高耐久性; 使得能够比已知的金属或合成吊索更高数量的提升操作，特别是具有例如重型货物的重型货物。锋利的边缘。

38. 发明申请

WO2003082255A2 USE OF MOB-5 IN PAIN 审中-公开
标题翻译：使用MOB-5在疼痛中
公开(公告)号：WO2003082255A2
公开(公告)日：2003-10-09
申请号：PCT/EP2003/003469
申请日：2003-04-02
申请人： NOVARTIS AG , NOVARTIS PHARMA GMBH , BARCLAY, Jane , BUXTON, Francis, Paul , GANJU, Pamposh , NATT, Francois, Jean-Charles , SONG, Chuanzheng , WEILER, Jan , WISHART, William
发明人： BARCLAY, Jane , BUXTON, Francis, Paul , GANJU, Pamposh , NATT, Francois, Jean-Charles , SONG, Chuanzheng , WEILER, Jan , WISHART, William
IPC分类号： A61K31/00
CPC分类号： A61K31/00 , A01K2267/0356 , C12N15/1136 , C12N15/115 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/15 , C12N2310/16 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , G01N2500/04 , G01N2500/10 , G01N2800/2842 , C12N2310/3525
摘要： The invention discloses Mob-5 as a suitable target for the development of new therapeutics to treat or ameliorate chronic pain. The invention relates to methods to treat and/or ameliorate chronic pain and pharmaceutical compositions therefor comprising modulators with inhibitory or stimulatory effect on Mob-5 activity and/or Mob-5 gene expression. The invention also relates to a method to identify compounds with therapeutic usefulness to treat chronic pain, comprising identifying compounds that can inhibit or stimulate Mob-5 activity and/or gene expression which can also reverse the pathological effects of chronic pain in vivo.
摘要翻译：本发明公开了Mob-5作为治疗或改善慢性疼痛的新疗法的开发的合适靶标。本发明涉及治疗和/或改善慢性疼痛的方法及其药物组合物，其包含对Mob-5活性和/或Mob-5基因表达具有抑制或刺激作用的调节剂。本发明还涉及鉴定具有治疗慢性疼痛的治疗有用性的化合物的方法，其包括鉴定能够抑制或刺激Mob-5活性和/或基因表达的化合物，其还可逆转慢性疼痛在体内的病理作用。

39. 发明申请

WO0031199A9 A PRESSURE-SENSITIVE ADHESIVE LAMINATE, A METHOD AND A DEVICE FOR MODIFYING AN INITIAL RELEASE FORCE IN SUCH A LAMINATE 审中-公开
标题翻译：压敏粘合层压板，用于修改这种层压板的初始释放力的方法和装置
公开(公告)号：WO0031199A9
公开(公告)日：2001-04-05
申请号：PCT/BE9900151
申请日：1999-11-23
申请人： FRANCOIS JEAN MARC
发明人： FRANCOIS JEAN-MARC
IPC分类号： B05D3/06 , B65C9/00 , C09J7/02 , C09J9/00 , C09J11/00 , C09J201/00
CPC分类号： C09J7/40 , C09J7/10 , C09J2205/31 , C09J2475/005 , C09J2483/005
摘要： The present invention relates to a pressure-sensitive adhesive laminate having at least one release layer and one adhesive layer contacting each other. At least one of those layers comprises a compound that is reactive on application of an ionising and/or actinic radiation. The presence of that compound enables to modify the initial release force of the laminate by application of an ionising and/or actinic radiation.
摘要翻译：本发明涉及具有至少一个释放层和一个彼此接触的粘合剂层的压敏粘合剂层压体。这些层中的至少一层包括在施加电离和/或光化辐射时具有反应性的化合物。该化合物的存在使得能够通过施加电离和/或光化辐射来改变层压体的初始释放力。

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