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31. 发明申请

WO2005026375A2 RECOMBINANT CARRIER MOLECULE FOR EXPRESSION, DELIVERY AND PURIFICATION OF TARGET POLYPEPTIDES 审中-公开
标题翻译：用于表达，递送和纯化目标多肽的重组载体分子
公开(公告)号：WO2005026375A2
公开(公告)日：2005-03-24
申请号：PCT/US2004/016452
申请日：2004-05-24
申请人： FRAUNHOFER USA, INC. , YUSIBOV, Vidadi , METT, Vadim , MUSIYCHUK, Konstantin , PIRUZIAN, Eleonora , GOLDENKOVA, Irina
发明人： YUSIBOV, Vidadi , METT, Vadim , MUSIYCHUK, Konstantin , PIRUZIAN, Eleonora , GOLDENKOVA, Irina
IPC分类号： C12Q
CPC分类号： C12N9/2448 , A61K2039/6031 , C07K16/1027 , C07K16/1278 , C07K2319/35 , C12N15/62 , C12Y302/01073
摘要： Recombinant carrier molecules having amino acid sequences from thermostable enzymes and methods of use for expression, recovery and delivery of foreign sequences (peptides and polypeptides) produced in different systems (bacteria, yeast, DNA, cell cultures such as mammalian, plant, insect cell cultures, protoplast and whole plants in vitro or in vivo are provided. The recombinant carrier molecule using sequences from lichenase B (Lic B) were also made and used it as part of carrier protein to express, recover and deliver a variety of target polypeptides of interest.
摘要翻译：具有来自耐热性酶的氨基酸序列的重组载体分子和用于表达，回收和递送在不同系统（细菌，酵母，DNA，细胞培养物如哺乳动物，植物，昆虫细胞培养物）中产生的外来序列（肽和多肽）的方法，体外或体内的原生质体和全植株，还制备使用来自地衣多克B（Lic B）的序列的重组载体分子，并将其用作载体蛋白的一部分，以表达，回收和递送多种感兴趣的靶多肽。

32. 发明申请

WO2004029540A3 DETERMINATION OF THE ANGULAR POSITION OF A LASER BEAM 审中-公开
公开(公告)号：WO2004029540A3
公开(公告)日：2004-04-08
申请号：PCT/US2003/030428
申请日：2003-09-26
申请人： METRON SYSTEMS, INC.
发明人： JOHNSTON, Kyle, S. , FRANKLIN, Joseph, A. , NELSON, Spencer, G. , BASS, Charles, M.
IPC分类号： G01B11/26
摘要： A system for measuring the external surface profile of a component using a non-contact optical technique which scans the field of view with a spot of light through a range of angles by utilizing a rotating mirror system and which precisely determines the angular position of the spot of light during scanning.

33. 发明申请

WO2003084538A1 METHODS FOR TREATING ROSACEA WITH PYRIDONES 审中-公开
标题翻译：用吡啶处理罗非鱼的方法
公开(公告)号：WO2003084538A1
公开(公告)日：2003-10-16
申请号：PCT/US2003/010316
申请日：2003-04-04
申请人： MEDICIS PHARMACEUTICAL CORPORATION
发明人： GANS, Eugene, H.
IPC分类号： A61K31/44
CPC分类号： A61K45/06 , A61K31/44 , A61K2300/00
摘要： The present invention is a method of treating rosacea and a method of preventing recurrences of rosacea manifestations by applying a composition comprising one or more 1-hydroxy-2-pyridones in a dermatologically acceptable carrier.
摘要翻译：本发明是一种治疗红斑痤疮的方法和通过将包含一种或多种1-羟基-2-吡啶酮的组合物施用于皮肤病学可接受的载体中来预防红斑痤疮表现复发的方法。

34. 发明申请

WO2002101456A1 ULTRATHIN MESH OPTICAL PANEL AND A METHOD OF MAKING AN ULTRATHIN MESH OPTICAL PANEL 审中-公开
标题翻译：超光栅光学面板和制造超细网格光学面板的方法
公开(公告)号：WO2002101456A1
公开(公告)日：2002-12-19
申请号：PCT/US2002/018382
申请日：2002-06-11
申请人： SCRAM TECHNOLOGIES, INC.
发明人： DESANTO, Leonard , BREWSTER, Calvin
IPC分类号： G03B21/00
CPC分类号： G02B6/08 , G03B21/56 , Y10S385/901
摘要： An ultrathin mesh optical panel and a method of use and making are disclosed. One embodiment of the optical panel includes a plurality of optical waveguides, wherein each optical waveguide is formed of a mesh material surrounding an optically clear core. The optical panel further includes a light generator. Each optical waveguide internally reflects the light incoming at the inlet of the waveguide to the outlet of the waveguide. The optical panel may optionally include a light redirecting coupling layer and/or a diffuser. An alternate embodiment of the ultrathin optical panel includes a plurality of optical waveguides, wherein the mesh material serves as the light transmissive material. A method of making and using is applicable to both major embodiments. A modification of either embodiment is disclosed wherein the optical waveguide is aligned to be non-perpendicular to the panel face.
摘要翻译：公开了一种超薄网眼光学面板及其制造方法。光学面板的一个实施例包括多个光波导，其中每个光波导由围绕光学透明芯的网状材料形成。光学面板还包括光发生器。每个光波导内部将在波导入口处的光反射到波导的出口。光学面板可以可选地包括光重定向耦合层和/或漫射器。超薄光学面板的替代实施例包括多个光波导，其中网状材料用作透光材料。制造和使用的方法适用于两个主要实施例。公开了任一实施例的修改，其中光波导被对准为不垂直于面板面。

35. 发明申请

WO2002094251A1 COMPOSITIONS FOR THE TREATMENT OF PIGMENTATION DISORDERS AND METHODS FOR THEIR MANUFACTURE 审中-公开
标题翻译：用于治疗染色体病症的组合物及其制造方法
公开(公告)号：WO2002094251A1
公开(公告)日：2002-11-28
申请号：PCT/US2002/015548
申请日：2002-05-16
申请人： MEDICIS PHARMACEUTICAL CORP.
发明人： WORTZMAN, Mitchell, S. , GORDON, Philip, J. , GANS, Eugene, H. , PATEL, Bhiku, G.
IPC分类号： A61K31/02
CPC分类号： A61Q19/02 , A61K8/23 , A61K8/347 , A61K8/676 , A61K31/02 , A61K31/20 , A61K31/34 , A61K31/375 , A61K45/06 , Y10S514/844 , Y10S514/846 , A61K2300/00
摘要： The present invention addresses the problem of excessive discoloration in hydroquinone compositions of a neutral pH. Antioxidants in the hydroquinone phase and inorganic or amino acyl cationic salts of acidic ascorbyl esters, preferably sodium metabisulfite and magnesium ascorbyl phosphate respectively, are effective in stabilizing such hydroquinone compositions, which are used in treatment of pigmentation disorders. Protected retinoid may be added to these compositions for additional skin benefit effects.
摘要翻译：本发明解决了中性pH的氢醌组合物过度变色的问题。氢醌相中的抗氧化剂和酸性抗坏血酸酯，优选偏亚硫酸氢钠和抗坏血酸磷酸镁的无机或氨基酰基阳离子盐分别有效稳定了这些用于治疗色素沉着病症的氢醌组合物。可以将保护的类视色素添加到这些组合物中以获得额外的皮肤益处效果。

36. 发明申请

WO2002062950A2 METHOD FOR QUANTIFICATION OF RECOMBINANT VIRUSES 审中-公开
标题翻译：重组病毒的定量方法
公开(公告)号：WO2002062950A2
公开(公告)日：2002-08-15
申请号：PCT/US2002/000247
申请日：2002-01-07
申请人： SBARRO INSTITUTE FOR CANCER RESEARCH AND MOLECULAR MEDICINE , CLAUDIO, Pier, Paolo
发明人： CLAUDIO, Pier, Paolo
IPC分类号： C12N
CPC分类号： G01N33/582 , C12N2799/022 , C12N2799/027 , C12Q1/70 , G01N33/57407 , C12Q2545/114
摘要： Titration is an important and critical step in dosing recombinant virus for gene therapy. A relatively fast, convenient and sensitive method that allows for precise quantification of recombinant retrovirus is presented. The method is based on PCR amplification of a foreign gene by the PRINS (primer in situ DNA synthesis) technique. The PRINS technique is based on the sequence-specific annealing of unlabeled oligonucleotide DNA in situ. This oligonucleotide operates as a primer for in situ chain elongation catalyzed by the Taq I polymerase. Using -labeled nucleotides as a substrate for chain elongation, the neo-synthetic DNA is labeled by an FITC-conjugated anti- antibody. To avoid the possibility of false positives, the puromycin resistance gene, which is associated with the transgene in the same viral vector and is not normally present in mammalian cells was amplified. The retroviral titer was evaluated by counting FITC-positive cells after PRINS labeling, while knowing the number of cells that were transduced with different amounts of viral supernatant. A comparable viral concentration of 1 X 10 7 infectious units/mL was found among the retroviruses.
摘要翻译：滴定是给予重组病毒进行基因治疗的重要和关键步骤。提出了一种相对快速，方便和灵敏的方法，可以对重组逆转录病毒进行精确定量。该方法基于PRINS（引物原位DNA合成）技术对外源基因的PCR扩增。 PRINS技术是基于原位未标记的寡核苷酸DNA的序列特异性退火。该寡核苷酸作为由Taq I聚合酶催化的原位链延长引物。使用标记的核苷酸作为链延长的底物，新合成的DNA用FITC缀合的抗体标记。为了避免假阳性的可能性，扩增了与同一病毒载体中的转基因相关并且通常不存在于哺乳动物细胞中的嘌呤霉素抗性基因。通过在PRINS标记后计数FITC阳性细胞来评估逆转录病毒滴度，同时知道用不同量的病毒上清转导的细胞数。在逆转录病毒中发现1×10 7感染单位/ mL的相当的病毒浓度。

37. 发明申请

WO2009035627A3 SYSTEM AND METHOD FOR TISSUE CHANGE MONITORING DURING HIFU TREATMENT 审中-公开
公开(公告)号：WO2009035627A3
公开(公告)日：2009-03-19
申请号：PCT/US2008/010605
申请日：2008-09-11
申请人： FOCUS SURGERY, INC. , CHEN, Wo-Hsing , CARLSON, Roy , WEIS, Clint, S. , SEIP, Ralf , SANGHVI, Narendra, T.
发明人： CHEN, Wo-Hsing , CARLSON, Roy , WEIS, Clint, S. , SEIP, Ralf , SANGHVI, Narendra, T.
IPC分类号： A61N7/02 , A61B8/08
摘要： A method and apparatus is disclosed for determining the presence of tissue change due to exposure to HIFU Therapy.

38. 发明申请

WO2006055960A2 DEVICE FOR EMISSION OF HIGH FREQUENCY SIGNALS 审中-公开
标题翻译：用于排放高频信号的装置
公开(公告)号：WO2006055960A2
公开(公告)日：2006-05-26
申请号：PCT/US2005/042392
申请日：2005-11-21
申请人： SALSMAN, Kenneth, E.
发明人： SALSMAN, Kenneth, E.
IPC分类号： H01Q1/26
CPC分类号： H03H9/2426 , H01Q1/26 , H03H9/2452
摘要： A device for emission of high frequency signals is provided. The emission device is capable of emission of signals in the Gigahertz (GHz) and Terahertz (THz) range. The device may utilize, for example, a cantilever comprising a material that is capable of altering its electrical properties when flexed.
摘要翻译：提供了用于发射高频信号的装置。发射装置能够发射千兆兹（GHz）和太赫兹（THz）范围内的信号。该装置可以利用例如悬臂，其包括当弯曲时能够改变其电性能的材料。

39. 发明申请

WO2006014236A1 DELIVERY SYSTEM FOR TOPICAL MEDICATIONS 审中-公开
标题翻译：局部药物输送系统
公开(公告)号：WO2006014236A1
公开(公告)日：2006-02-09
申请号：PCT/US2005/022162
申请日：2005-06-23
申请人： MEDICIS PHARMACEUTICAL COPORATION
IPC分类号： A61K31/74 , A61K9/00 , A61K6/00 , A01N59/02 , A01N41/06
CPC分类号： A61K9/7023 , A61K9/0014 , A61K31/327 , A61K31/74 , A61M35/006
摘要： The present invention is a delivery system comprising a pad and a liquid composition, comprising an insoluble dermatologically active ingredient with a viscosity that permits substantially uniform absorption of the composition onto the pad, and the pad is in then packaged in a sealed container.
摘要翻译：本发明是包括垫和液体组合物的递送系统，其包含不溶性皮肤病学活性成分，其粘度使组合物基本均匀地吸收到垫上，然后将垫包装在密封容器中。

40. 发明申请

WO2005038760A2 INTERACTIVE DISPLAY SYSTEM HAVING A MATRIX OPTICAL DETECTOR 审中-公开
标题翻译：具有矩阵光学检测器的交互式显示系统
公开(公告)号：WO2005038760A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/027029
申请日：2004-08-20
申请人： BROOKHAVEN SCIENCE ASSOCIATES , VELIGDAN, James, T. , DESANTO, Leonard
发明人： VELIGDAN, James, T. , DESANTO, Leonard
IPC分类号： G09G
CPC分类号： G06F3/0423 , G02B6/08 , G02B6/3512 , G02B6/3588 , G06F3/0386 , G06F3/0412 , G06F3/042 , G09G3/002 , H04N5/7458 , Y10S385/901
摘要： A display system includes a waveguide optical panel having an inlet face and an opposite outlet face. An image beam is projected across the inlet face laterally and transversely for display on the outlet face. An optical detector including a matrix of detector elements is optically aligned with the inlet face for detecting a corresponding lateral and transverse position of an inbound light spot on the outlet face.
摘要翻译：显示系统包括具有入口面和相对出口面的波导光学面板。图像光束横跨入口面横向和横向投射，以便在出口面上显示。包括检测器元件的矩阵的光学检测器与入口面光学对准，用于检测出口面上的入射光斑的相应的横向和横向位置。

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