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31. 发明申请

WO2016004212A1 HYDROGELS FOR TREATING AND AMELIORATING WOUNDS AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：用于治疗和改善创伤的水晶及其制备和使用它们的方法
公开(公告)号：WO2016004212A1
公开(公告)日：2016-01-07
申请号：PCT/US2015/038848
申请日：2015-07-01
申请人： VICUS THERAPEUTICS, LLC
发明人： MAKI, John , BASCOMB, Newell , YOUNG, Fredric
IPC分类号： A61K35/12 , A61K35/36 , A61P17/02
CPC分类号： A61L27/60 , A61F2/105 , A61K31/07 , A61K31/16 , A61K31/195 , A61K31/197 , A61K31/355 , A61K31/375 , A61K31/455 , A61K31/56 , A61K31/7036 , A61K35/28 , A61K35/36 , A61K38/1816 , A61K38/1825 , A61K38/193 , A61L27/362 , A61L27/3641 , A61L27/3687 , A61L27/3691 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/406 , A61L2300/414 , A61L2300/418 , A61L2300/45 , A61L2430/34 , A61K2300/00
摘要： In alternative embodiments, provided are compositions, e.g., pharmaceutical compositions, formulations, kits and other products of manufacture, comprising a hydrogel and active ingredients, including mixed thickness skin micrografts, or full or split-thickness skin grafts, contained or mixed in or within the hydrogel; and methods for making and using them. In alternative embodiments, compositions and methods as provided herein are used for the treatment or amelioration of wounds and surgical sites, and include compositions and methods for micrografting, or for micrografting a wound, or for micrografting a wound for rapid re-epithelialization, or for micrografting a wound for rapid re-epithelialization of large non-healing wounds.
摘要翻译：在替代实施方案中，提供了组合物，例如药物组合物，制剂，试剂盒和其他制造产品，其包含水凝胶和活性成分，包括混合的厚度皮肤微移植物，或全部或分裂的皮肤移植物，其包含或混合在其中或内部水凝胶以及制作和使用它们的方法。在替代实施例中，本文提供的组合物和方法用于治疗或改善伤口和外科手术部位，并且包括用于微移植，或用于微创伤的组合物和方法，或用于微创伤以快速重新上皮化，或用于微创伤口用于快速重新上皮化大的非愈合伤口。

32. 发明申请

WO2015200868A1 METHODS FOR THE PRODUCTION OF HIGH ALPHA-CELLULOSE PULP 审中-公开
标题翻译：生产高脂细胞浆的方法
公开(公告)号：WO2015200868A1
公开(公告)日：2015-12-30
申请号：PCT/US2015/038138
申请日：2015-06-26
申请人： INVENTURE RENEWABLES, INC.
发明人： BERRY, William W. , SUTTERLIN, William Rusty , TEGEN, Mark G. , BLANCHARD, Cory
IPC分类号： D21C9/08
CPC分类号： D21C9/08 , C13K1/04 , D21C3/00
摘要： In alternative embodiments, provided herein are methods and industrial processes for generating high purity (high alpha cellulose) pulp from lignocellulosic feedstocks, comprising directly contacting a lignocellulosic feedstock with a system comprising a super critical or near-super critical fluid or mixture of fluids, whereby the partial pressure of the system provides for the alcoholysis, hydrolysis or a combination thereof of the feedstock at reduced temperatures and pressures, followed by an upgrading step wherein a low-purity cellulosic material generated in the super critical or near-super critical reaction step is treated with an alkaline solution. Also provided herein are systems and methods for producing a high purity cellulose material using reduced amounts of alkaline material.
摘要翻译：在替代实施方案中，本文提供了用于从木质纤维素原料产生高纯度（高α纤维素）纸浆的方法和工业方法，其包括将木质纤维素原料与包含超临界或近超临界流体或流体混合物的系统直接接触，由此系统的分压在降低的温度和压力下提供原料的醇解，水解或其组合，随后是升级步骤，其中在超临界或近超临界反应步骤中产生的低纯度纤维素材料是用碱性溶液处理。本文还提供了使用减少量的碱性材料来生产高纯度纤维素材料的系统和方法。

33. 发明申请

WO2015117094A1 COMPOSITIONS AND METHODS FOR SYNTHESIZING (2S,3S)-TRANS-EPOXYSUCCINYL-L-LEUCYL-AMIDO-3-METHYLBUTANE ETHYL ESTER 审中-公开
标题翻译：用于合成（2S，3S） - 顺式 - 环氧乙烷基-L-赖氨酸 - 氨基-3-甲基戊酸乙酯的组合物和方法
公开(公告)号：WO2015117094A1
公开(公告)日：2015-08-06
申请号：PCT/US2015/014131
申请日：2015-02-02
申请人： AMERICAN LIFE SCIENCE PHARMACEUTICALS, INC.
发明人： TERNANSKY, Robert J. , LIU, Hui , EISENREICH, Emerich , HAINES, Kenneth A. , LEVIN, Daniel , LIU, Xuejun
IPC分类号： A61P25/28 , A61K31/336
CPC分类号： C07D301/00 , C07B59/00 , C07B59/002 , C07B2200/05 , C07C209/26 , C07C231/12 , C07C237/06 , C07C269/06
摘要： In alternative embodiments the invention provides methods for synthesizing AB-007 (also called loxistatin, E64d, EST or ((2S,3S)-trans-epoxysuccinyl-L-leucyl-amido-3-methylbutane ethyl ester) and its acid form E64c (loxistatin acid), and various synthetic intermediates, and deuterated forms of these compounds, and stereoisomers thereof. In alternative embodiments the invention provides a tosylate salt of AB-007-4 or a tosylate salt of L-leucine isoamylamine, or equivalents thereof. A synthetic scheme of the invention provides kilogram quantities of AB-007 manufactured according to current good manufacturing practices (cGMP's), consistent with US FDA requirements for human use. In alternative embodiments the invention provides a tosylate salt of AB-007-4 or a tosylate salt of L-leucine isoamylamine, or equivalents thereof.
摘要翻译：在替代实施方案中，本发明提供了合成AB-007（也称为洛伐他汀，E64d，EST或（（2S，3S） - 反式 - 环氧琥珀酰基-L-亮氨酰氨基-3-甲基丁烷乙酯）和其酸形式E64c（在这些替代实施方案中，本发明提供了AB-007-4的甲苯磺酸盐或L-亮氨酸异戊胺的甲苯磺酸盐或其等同物。本发明的合成方案提供了符合美国FDA对人类使用要求的根据当前良好制造实践（cGMP）制造的千克量的AB-007。在替代实施方案中，本发明提供了AB-007-4或甲苯磺酸盐的甲苯磺酸盐 L-亮氨酸异戊胺盐或其等同物。

34. 发明申请

WO2015069752A9 ACETYLCHOLINE BINDING PROTEIN LIGANDS, COOPERATIVE NACHR MODULATORS AND METHODS FOR MAKING AND USING 审中-公开
公开(公告)号：WO2015069752A9
公开(公告)日：2015-05-14
申请号：PCT/US2014/064104
申请日：2014-11-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , FINN, W.G.
发明人： FINN, W.G. , TAYLOR, Palmer , KACZANOWSKA, Katarzyna
IPC分类号： A61K31/506 , A61P25/16 , A61P25/18
摘要： The invention provides compositions and methods a) for increasing or stimulating the release of other transmitters (excitatory amino acids, inhibitor amino acids and biogenic amines) in the central nervous system (CNS) or the brain, or modulating, decreasing or increasing the activity of an AChR in the CNS or brain, b) for treating, ameliorating, preventing or lessening the symptoms of an addiction or substance abuse involving modulating, decreasing or increasing levels or activity of dopamine in the CNS or brain, c) for treating, ameliorating, preventing or lessening the symptoms of an addiction or substance abuse involving e.g., drugs, narcotics or tobacco use, and d) for treating, ameliorating, preventing or lessening the symptoms of a disease or condition i.e., dementia, Parkinson's disease, pain or chronic pain, an allodynia, autism, psychosis or schizophrenia, responsive to the modulation of, or a decrease or an increase in the activity of nAChR.

35. 发明申请

WO2014151947A1 METHODS FOR ORGANIC NUCLEATING AGENTS 审中-公开
标题翻译：有机核试剂方法
公开(公告)号：WO2014151947A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/026712
申请日：2014-03-13
申请人： ENTROPY SOLUTIONS INC.
发明人： MAGILL, Monte, Christopher , EDGAR, Michael, Hugh , SUTTERLIN, William, Rusty
IPC分类号： C09K5/06 , C30B17/00 , C08L91/08
CPC分类号： C09K5/063 , C08L91/08 , C30B17/00 , C30B29/54
摘要： The invention provides phase change material comprising organic phase change materials comprising a miscible organic nucleating material, seed crystal or organic nucleating agent to minimize supercooling during the crystallization of the phase change material. The miscible organic material acting as an organic nucleating material, seed crystal or organic nucleating agent, is in sufficiently small enough ratios so as not to interfere with the latent heat properties of the phase change material, but amounts sufficient to inhibit the appearance of supercooling. The organic nucleating material, seed crystal or organic nucleating agent comprises a polyolefin or polyalkene, or a polyethylene or a polypropylene, or a nanoparticle or a microcapsule thereof. The invention provides an article of manufacture, a coating, a latent heat storage unit, a liquid, a gel, an antifreeze fluid, a fluid, an ink, an oil, a lubricant, a sealant, a paint, a textile, a cloth, or a bedding.
摘要翻译：本发明提供了相变材料，其包括有机相变材料，其包括可混溶的有机成核材料，晶种或有机成核剂，以使相变材料的结晶过程中的过冷化最小化。充当有机成核材料，晶种或有机成核剂的混溶性有机材料足够小的比例，以便不干扰相变材料的潜热性能，但足以抑制过冷却出现的量。有机成核材料，晶种或有机成核剂包括聚烯烃或聚烯烃，或聚乙烯或聚丙烯，或其纳米颗粒或微胶囊。本发明提供制品，涂层，潜热储存单元，液体，凝胶，防冻液，流体，油墨，油，润滑剂，密封剂，油漆，织物，布，或床上用品。

36. 发明申请

WO2013119772A1 PRODUCTS OF MANUFACTURE HAVING TANTALUM COATED NANOSTRUCTURES, AND METHODS OF MAKING AND USING THEM 审中-公开
标题翻译：具有TANTALUM涂层纳米结构的制造产品及其制造和使用方法
公开(公告)号：WO2013119772A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/025090
申请日：2013-02-07
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , JIN, Sungho , FRANDSEN, Christine
发明人： JIN, Sungho , FRANDSEN, Christine
IPC分类号： A61L27/30 , A61L27/38 , A61F2/28
CPC分类号： A61L27/306 , A61F2/30767 , A61F2002/3084 , A61L27/047 , A61L27/38 , A61L31/022 , A61L31/088 , A61L2400/12 , A61L2430/02 , A61L2430/24 , A61L2430/38 , B22F1/0025 , B22F1/025 , B82Y30/00 , C12M25/00 , Y10T428/12028 , Y10T428/24893 , Y10T428/24909 , Y10T428/25 , Y10T428/26 , Y10T428/31678
摘要： In alternative embodiments, the invention provides products (articles) of manufacture comprising nanostructures such as nanotubes having a surface comprising tantalum. In alternative embodiments, products of manufacture of the invention include nanostructures, e.g., nanotubes, nanowire, nanopore, and the like comprising a surface layer of tantalum. In alternative embodiments, products or articles of manufacture of the invention are bioimplants, and the tantalum-surface-coated nanostructures of the invention provide increased bioactivity and bone forming ability. In alternative embodiments, products or articles of manufacture of the invention, e.g., bioimplants, comprising the tantalum-surface-coated nanostructures of the invention are used for in vitro, ex vivo and in vivo testing, implants, biomedical devices and therapeutics.
摘要翻译：在替代实施例中，本发明提供包括纳米结构的制品（制品），例如具有包括钽的表面的纳米管。在替代实施方案中，本发明的制造产品包括纳米结构，例如包含钽表面层的纳米管，纳米线，纳米孔等。在替代实施方案中，本发明的产品或制品是生物植入物，并且本发明的钽表面包被的纳米结构提供增加的生物活性和骨形成能力。在替代实施方案中，本发明的产品或制品，例如包含本发明的钽表面包被的纳米结构的生物复合材料用于体外，离体和体内测试，植入物，生物医学装置和治疗剂。

37. 发明申请

WO2013010018A2 COMPOSITIONS AND METHODS FOR INHIBITING PROTEASES 审中-公开
标题翻译：用于抑制蛋白质的组合物和方法
公开(公告)号：WO2013010018A2
公开(公告)日：2013-01-17
申请号：PCT/US2012/046529
申请日：2012-07-12
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , GERWICH, William, H. , PEREIRA-BADILLA, Alban, R. , BYRUM, Tara , VALERIOTE, Frederick, A. , GILSON, Michael, Kenneth , FENLEY, Andrew , KALE, Andrew , DEBONSI, Hosana, M. , MOORE, Bradley , JOSEPHINE FORD CANCER CENTER
发明人： GERWICH, William, H. , PEREIRA-BADILLA, Alban, R. , BYRUM, Tara , VALERIOTE, Frederick, A. , GILSON, Michael, Kenneth , FENLEY, Andrew , KALE, Andrew , DEBONSI, Hosana, M. , MOORE, Bradley
IPC分类号： A61K31/175 , A61K31/16 , A61K31/155 , A61P35/00 , A61P31/12
CPC分类号： C07K5/0808 , A61K31/336 , C07K5/06052
摘要： In particular, in alternative embodiments, the invention provides pharmaceutical compounds and formulations comprising a family of epoxyketone compounds, which include racemic mixtures or racemates, isomers, stereoisomers, diastereoisomers, derivatives and analogs, and methods for making and using them. In alternative embodiments, pharmaceutical compositions and formulations of the invention are administered to an individual in need thereof in an amount sufficient to treat, prevent, reverse and/or ameliorate an infection, disease or condition that can be ameliorated, treated, prevented or reversed by partially or completely inhibiting a chymotrypsin-like protease or a proteasome activity, including e.g., a retroviral infection such as human immunodeficiency virus-1 (HIV-1) infection, an immune disorder, a neurodegenerative disease or condition, or a cancer such as a myeloma or multiple myeloma, an adenocarcinoma such as a lung adenocarcinoma, a pancreatic cancer, a B-cell related cancer, and lymphomas such as non-Hodgkin's lymphoma.
摘要翻译：特别地，在替代实施方案中，本发明提供包含一系列环氧酮化合物的药物化合物和制剂，其包括外消旋混合物或外消旋体，异构体，立体异构体，非对映异构体，衍生物和类似物，以及制备和使用它们的方法。在替代实施方案中，将本发明的药物组合物和制剂以足以治疗，预防，逆转和/或改善可被改善，治疗，预防或逆转的感染，疾病或病症的量施用于有需要的个体部分或完全抑制胰凝乳蛋白酶样蛋白酶或蛋白酶体活性，包括例如逆转录病毒感染如人免疫缺陷病毒-1（HIV-1）感染，免疫疾病，神经变性疾病或病症，或癌症如骨髓瘤或多发性骨髓瘤，腺癌如肺腺癌，胰腺癌，B细胞相关癌症，淋巴瘤如非霍奇金淋巴瘤。

38. 发明申请

WO2012099962A3 PHARMACEUTICAL COMPOSITIONS AND METHODS FOR MAKING AND USING THEM 审中-公开
公开(公告)号：WO2012099962A3
公开(公告)日：2012-07-26
申请号：PCT/US2012/021724
申请日：2012-01-18
申请人： VICUS THERAPEUTICS, LLC , MAKI, John , BASCOMB, Newell , TURNER, Timothy, J.
发明人： MAKI, John , BASCOMB, Newell , TURNER, Timothy, J.
IPC分类号： A61K31/455 , A61K31/20 , A61K31/133 , A61K9/06 , A61K9/70 , A61K9/12
摘要： In alternative embodiments the invention provides compositions, e.g., pharmaceutical compositions and preparations, formulations, kits and other products of manufacture, e.g., exemplary drug combinations packaged together or separately in blister packs, lidded blisters or blister cards, or wrapped in paper, plastic or cellophane wrappers (e.g., a shrink wrap), comprising combinations of beneficial ingredients that in alternative embodiments are serviceable as therapies or palliatives for treating, preventing or improving conditions, states and disease symptoms involving the use of targeted protein kinase inhibitors such as Multi-Kinase Inhibitors (MKIs) or Epidermal Growth Factor Receptor (EGFR) Inhibitors (EGFRIs), or the use of other oral oncolytics, such as capcitabine or erlotinib, known to be associated with drug-induced dermatological toxicity, e.g., in the amelioration or treatment of a cancer, a dermatitis, a rosacea, an eczema, an ichthyosis, or a related condition; and methods for making and using these compositions; and methods for making and using these compositions.

39. 发明申请

WO2011159924A3 COMPOSITIONS AND METHODS FOR IDENTIFYING AND MODIFYING CARBONACEOUS COMPOSITIONS 审中-公开
公开(公告)号：WO2011159924A3
公开(公告)日：2011-12-22
申请号：PCT/US2011/040742
申请日：2011-06-16
申请人： TAXON BIOSCIENCES, INC. , ASHBY, Matthew , WOOD, Ladonna , LIDSTRÖM, Ulrika , CLARKE, Christine , GOULD, Alison , STRAPOC, Dariusz , LAMBO, Adewale , HUIZINGA, Bradley, James
发明人： ASHBY, Matthew , WOOD, Ladonna , LIDSTRÖM, Ulrika , CLARKE, Christine , GOULD, Alison , STRAPOC, Dariusz , LAMBO, Adewale , HUIZINGA, Bradley, James
IPC分类号： C12Q1/68 , C12Q1/02 , C12N15/31 , C12N1/20 , C12P7/00
摘要： This invention generally relates to natural gas and methylotrophic energy generation, bio-generated fuels and microbiology. In alternative embodiments, the invention provides nutrient amendments and microbial compositions, e.g., consortia, that are both specifically optimized to stimulate methanogenesis, or for "methylotrophic" or other conversions. In alternative embodiments, the invention provides methods to develop nutrient amendments and microbial compositions that are both specifically optimized to stimulate methanogenesis in a given reservoir. The invention also provides methods for the evaluation of potentially damaging biomass formation and scale precipitation resulting from the addition of nutrient amendments. In other embodiments, the invention provides methods for simulating biogas in sub-surface conditions using a computational model.

40. 发明申请

WO2010135401A2 KINASE-MEDIATED CYTOPROTECTION AND ENHANCED CELLULAR ENGRAFTMENT AND PERSISTENCE 审中-公开
标题翻译：激酶介导的细胞保护和增强的细胞增殖和持续性
公开(公告)号：WO2010135401A2
公开(公告)日：2010-11-25
申请号：PCT/US2010/035362
申请日：2010-05-19
申请人： SAN DIEGO STATE UNIVERSITY FOUNDATION , SUSSMAN, Mark, A.
发明人： SUSSMAN, Mark, A.
IPC分类号： C12N9/12 , C12N15/54 , C12N15/63 , C12N5/10
CPC分类号： A61K35/39 , A61K48/00 , A61K2035/122 , C12N9/1205 , C12N2799/027
摘要： Disclosed are methods of protecting cells, especially non-vascular system, non-hematopoietic cells and tissues, from apoptosis and enhancing their engraftment, survival, and/or persistence by providing enhanced levels of PIM activity for the cell, including PIM-I activity. Also disclosed are cells that have been engineered to express enhanced levels of PIM kinase, and methods of administering those cells to vertebrates.
摘要翻译：公开了通过提供增强水平的PIM活性（包括PIM-1活性）来保护细胞，特别是非血管系统，非造血细胞和组织免受细胞凋亡和增强其移植，存活和/或持续性的方法。还公开了已被工程化以表达增强水平的PIM激酶的细胞，以及将这些细胞施用于脊椎动物的方法。

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