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    • 24. 发明申请
    • METHOD AND SYSTEM FOR CHARACTERIZING A PIGMENTED BIOLOGICAL TISSUE.
    • 用于表征色素生物组织的方法和系统。
    • WO2008152292A4
    • 2009-02-19
    • PCT/FR2008050911
    • 2008-05-27
    • FORCE ACENTRE NAT RECH SCIENTUNIV PARIS SUDCEROVIC ZORANMOISE NICOLAELATOUCHE GWENDALGOULAS YVES
    • CEROVIC ZORANMOISE NICOLAELATOUCHE GWENDALGOULAS YVES
    • G01N21/64G01N21/27
    • G01N21/64G01N21/274G01N21/645G01N2021/6419G01N2021/6421G01N2021/6491G01N2201/0221G01N2201/062G01N2201/0627
    • Method for determining the content of a chromophoric and nonfluorescent compound, referred to as first compound, of a biological tissue (30) of a biological entity, wherein said biological tissue (30) also comprises a chromophoric and fluorescent compound, referred to as second compound, and wherein said method comprises at least one iteration of the following operations: emission, in the direction of said tissue (30), of a first, "reference", optical radiation and of a second, "measuring", optical radiation, each chosen so as to induce a fluorescence radiation from said second compound, wherein each of said first and second radiations is partially absorbed by said first compound, measurement of said fluorescence radiations induced by said first and second radiations, and determination, from said measurement, of the content of said first compound in said tissue; characterized in that said method also comprises at least one compensation for saturation of the measurement due to too great an absorption of the measuring radiation by said first compound, wherein said compensation comprises a choice, for said measuring radiation, of a wavelength corresponding to a weaker absorption in the absorption spectrum of the first compound.
    • 用于确定生物实体的生物组织(30)的称为第一化合物的发色和非荧光化合物的含量的方法,其中所述生物组织(30)还包含发色和荧光化合物,称为第二化合物 ,并且其中所述方法包括以下操作的至少一次迭代:在所述组织(30)的方向上,发射第一“参考”光辐射和第二“测量”光辐射,其中每个 以便诱导来自所述第二化合物的荧光辐射,其中所述第一和第二辐射中的每一个被所述第一化合物部分吸收,测量由所述第一和第二辐射引起的所述荧光辐射,并且根据所述测量确定 所述第一化合物在所述组织中的含量; 其特征在于,所述方法还包括由于所述第一化合物对测量辐射的吸收太大而对测量饱和的至少一个补偿,其中所述补偿包括对于所述测量辐射选择对应于较弱的波长 吸收第一化合物的吸收光谱。
    • 26. 发明申请
    • OPTICAL BLOOD ANALYTE MONITOR
    • 光学分析仪
    • WO2008031756A1
    • 2008-03-20
    • PCT/EP2007/059341
    • 2007-09-06
    • FOSS ANALYTICAL ABWIHLBORG, Nils
    • WIHLBORG, Nils
    • A61B5/00G01N21/35
    • G01N21/359A61B5/14532A61B5/1455A61B5/1495G01N2021/3133G01N2021/3177G01N2201/0627G01N2201/129
    • An optical blood analyte monitor (2) comprises a near infra-red light source and a complementary detection (6) means; a component analyser (12) having access to a chemometric model linking optical spectral features to a level of blood analyte of interest and configured to apply the model to signals received from the detection (6) means and a tilting filter arrangement (8) having a plurality of optical interference filters (20a..e;56a..d), each filter being tiltable to vary a wavelength of incident light from the source transmitted there through. The light source comprises a plurality of light emitters (4a..e) each being arranged to emit light along a different associated light-path (16a..e) in which is located an associated different one of the plurality of the interference filters (20a..e) and towards a same analysing region (18) at which a tissue volume (finger for example) containing a blood sample to be analysed is located in use.
    • 光学血液分析物监测器(2)包括近红外光源和互补检测(6)装置; 组件分析器(12),其访问化学计量模型,其将光谱特征与感兴趣的血液分析物的水平相关联并且被配置为将模型应用于从检测装置(6)装置接收的信号和倾斜滤波器装置(8) 多个光学干涉滤光器(20a..e; 56a..d),每个滤光器可倾斜以改变从其透射的源的入射光的波长。 光源包括多个发光体(4a..e),每个发光体被设置成沿着不同的相关光路(16a..e)发射光,其中位于多个干涉滤光器之间的相关不同的一个 并且朝向相同的分析区域(18),在该分析区域(18)处,使用含有待分析的血样的组织体积(例如手指)。