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    • 30. 发明申请
    • BILE PREPARATIONS FOR COLORECTAL DISORDERS
    • 颜色障碍的BILE准备
    • WO2008033142A1
    • 2008-03-20
    • PCT/US2006/036325
    • 2006-09-15
    • YOO, Seo Hong
    • YOO, Seo Hong
    • A61K35/413A61P1/00A61P35/00
    • A61K9/08A61K31/575A61K31/718A61K35/413A61K45/06A61K2300/00
    • The present disclosure relates to methods and compositions to ameliorate or treat at least one symptom of colorectal cancer and/or adenomatous polyposis coli (APC). For example, some embodiments of the methods and compositions may reduce recurrence of colorectal adenomas and/or extend the life of a subject having colorectal cancer and/or APC. Some embodiments of the disclosure include maintaining a the total body weight in a subject having colorectal cancer and/or APC. According to some embodiments, a method of the disclosure may include administering a bile acid composition to a subject. A bile acid composition may include, in some embodiments, an aqueous solution that is free or substantially free of precipitates or particles. A aqueous solution may include (1) a bile acid, an aqueous soluble derivative of a bile acid, a bile acid salt, and/or 7-ketolithocholic acid, (2) a carbohydrate, and (3) water. An aqueous composition may further include an alkali.
    • 本公开涉及改善或治疗结肠直肠癌和/或腺瘤性息肉病大肠杆菌(APC)的至少一种症状的方法和组合物。 例如,方法和组合物的一些实施方案可以减少结肠直肠腺瘤的复发和/或延长具有结肠直肠癌和/或APC的受试者的寿命。 本公开的一些实施方案包括在具有结肠直肠癌和/或APC的受试者中维持总体重。 根据一些实施方案,本公开的方法可以包括向受试者施用胆汁酸组合物。 在一些实施方案中,胆汁酸组合物可包括游离或基本上不含沉淀物或颗粒的水溶液。 水溶液可以包括(1)胆汁酸,胆汁酸的水溶性衍生物,胆汁酸盐和/或7-酮皮磷酸,(2)碳水化合物和(3)水。 水性组合物还可以包含碱。