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1. 发明申请

WO2015006897A1 一种乌发中药制剂的配方及制备方法审中-公开
公开(公告)号：WO2015006897A1
公开(公告)日：2015-01-22
申请号：PCT/CN2013/079361
申请日：2013-07-15
申请人：田艺儿
发明人：田艺儿
IPC分类号： A61K36/9068 , A61K35/64 , A61K35/58 , A61K35/413 , A61P17/00
CPC分类号： A61K8/97 , A61K8/922 , A61K8/981 , A61K35/413 , A61K35/583 , A61K35/63 , A61K36/00 , A61K2800/5922 , A61Q5/065 , A61K2300/00
摘要：本发明公开了一种乌发中药制剂的配方及制备方法，本发明制剂是由茶籽油、生姜汁、黑猪胆汁、茵陈、黄芪、黑蚂蚁、黑芝麻、骨碎补、橘子核、蜈蚣、榧子、桑叶、木贼草、蛇蜕、杜仲、山茱萸、鸡血藤、郁金经过混合、粉粹、煎煮、搅拌等工序制备成的组合物膏状制剂，本发明可以适用于各种特点的毛发和头皮，用其清洗头发后无过敏反应，无毒副作用，使药物能迅速渗入使皮肤吸收，达到乌发的目的，而且见效快，乌发养发效果好，成本低廉、制取工艺简便易行。

2. 发明申请

WO2013049595A1 METHODS AND COMPOSITIONS OF BILE ACIDS 审中-公开
标题翻译：双酸的方法和组合
公开(公告)号：WO2013049595A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/057958
申请日：2012-09-28
申请人： ETHICON ENDO-SURGERY, INC. , THE GENERAL HOSPITAL CORPORATION D/B/A
发明人： KAPLAN, Lee M. , AHMAD, Nadia N. , HARRIS, Jason L. , FELDER, Kevin D. , PASTORELLI, Alessandro
IPC分类号： A61K35/413 , A61P1/00 , G01N33/48
CPC分类号： A61K31/56 , A61K35/413
摘要： Methods and compositions are provided for treating metabolic disorders by modulating bile acid levels. Generally, the methods and compositions can modulate bile acid levels, such as serum bile acid levels, to treat a metabolic disorder. In one embodiment, a method of modulating a bile acid level includes measuring a bile acid level and delivering a composition effective to modulate the bile acid level. A method for modulating a bile acid profile includes comparing a bile acid profile to a target profile and delivering a bile acid cocktail to increase bile acid levels. In another embodiment, a pharmaceutical composition for increasing bile acid levels includes a bile acid cocktail effective to increase bile acid levels. The composition is further useful as part of an implantable system.
摘要翻译：提供了通过调节胆汁酸水平来治疗代谢紊乱的方法和组合物。通常，方法和组合物可以调节胆汁酸水平，例如血清胆汁酸水平，以治疗代谢紊乱。在一个实施方案中，调节胆汁酸水平的方法包括测量胆汁酸水平并递送有效调节胆汁酸水平的组合物。用于调节胆汁酸分布的方法包括将胆汁酸分布与目标分布进行比较，并递送胆汁酸混合物以增加胆汁酸水平。在另一个实施方案中，用于增加胆汁酸水平的药物组合物包括有效提高胆汁酸水平的胆汁酸混合物。组合物作为可植入系统的一部分是更有用的。

3. 发明申请

WO03101389A2 RELIEF OF AIDS SYMPTOMS 审中-公开
标题翻译：艾滋病症状的救济
公开(公告)号：WO03101389A2
公开(公告)日：2003-12-11
申请号：PCT/US0317131
申请日：2003-05-29
申请人： BIO DEFENSE NUTRITIONALS , HALSTEAD TERRI , WANG ZHENGUO
发明人： HALSTEAD TERRI , WANG ZHENGUO
IPC分类号： A61K31/19 , A61K31/195 , A61K31/198 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K31/708 , A61K35/413 , A61K36/068 , A61K36/07 , A61K36/074 , A61K36/232 , A61K36/258 , A61K36/28 , A61K36/284 , A61K36/315 , A61K36/428 , A61K36/481 , A61K36/484 , A61K36/489 , A61K36/53 , A61K36/638 , A61K36/716 , A61K36/73 , A61K36/748 , A61K36/804 , A61K36/81 , A61K45/06 , A61K
CPC分类号： A61K31/7076 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K35/413 , A61K36/068 , A61K36/07 , A61K36/074 , A61K36/232 , A61K36/258 , A61K36/28 , A61K36/284 , A61K36/315 , A61K36/428 , A61K36/481 , A61K36/484 , A61K36/489 , A61K36/53 , A61K36/638 , A61K36/716 , A61K36/73 , A61K36/748 , A61K36/804 , A61K36/81 , A61K45/06 , A61K2300/00
摘要： Compositions and methods of improving the quality of life of an AIDS patient comprise combinations of herbal compositions and at least one of a bile product and a chelator. Additional subject matter includes methods of marketing compositions and methods.
摘要翻译：提高艾滋病患者生活质量的组合物和方法包括草药组合物和胆汁产品和螯合剂中的至少一种的组合。附加主题包括营销组合和方法的方法。

4. 发明申请

WO0101995A3 METHOD FOR TREATMENT OF ASTHMA SYNDROME 审中-公开
标题翻译：治疗哮喘综合症的方法
公开(公告)号：WO0101995A3
公开(公告)日：2001-11-15
申请号：PCT/US0018508
申请日：2000-07-06
申请人： NUTRICOLOGY INC
发明人： HOANG BA X , LEVINE STEPHEN A
IPC分类号： A61K31/122 , A61K31/575 , A61K35/37 , A61K35/413 , A61K35/50 , A61K35/55 , A61P11/06 , A61K35/12
CPC分类号： A61K35/12 , A61K31/122 , A61K31/575 , A61K35/413 , A61K35/50
摘要： A method of treating asthma in a patient is disclosed. The method includes administering to the patient, a therapeutically effective amount of (i) Moschus moschiferus or its active ingredient muscone, (ii) Calculus Bovis or its major active ingredients cholic acid and urodesoxychloic acid, or (iii) Placental extract or powder from humans or mammals. The compound is preferably administered orally, twice or three time a day.
摘要翻译：公开了一种治疗患者哮喘的方法。该方法包括向患者施用治疗有效量的（i）Moschus moschiferus或其活性成分麝香酮，（ii）牛黄牙或其主要活性成分胆酸和尿脱氧尿酸，或（iii）来自人的胎盘提取物或粉末或哺乳动物。该化合物优选口服给药，一天两次或三次。

5. 发明申请

WO01076613A1 EXTRACT FOR ABSTAINING FROM NARCOTICS AND ITS PREPARATION 审中-公开
公开(公告)号：WO01076613A1
公开(公告)日：2001-10-18
申请号：PCT/CN2000/000086
申请日：2000-04-11
IPC分类号： A61K35/413 , A61K35/50 , A61K35/58 , A61K36/00 , A61K35/78
CPC分类号： A61K35/58 , A61K35/413 , A61K35/50 , A61K36/00 , A61K2300/00
摘要： An extract is disclosed, the extract can be extracted from the following components: component A is Hominis Placenta . Flower of Datura metel L , toxin of Fugu ocellatus and/or toxin of Naja naja : component B is Root of Panax ginseng , Ginseng Radix Ferum , Ginseng Radix Coreensis and/or Panacis Quinquefolii Radix ; component C is Root of Aconitum carmicharli Debx. and/or Skin of Cinnamomum cassia Presl; component D is Herb of Chelidonium majus L; component E is Stem of Corydalis turtschaninovii Bess. f. yuanhusuo Y.H. Chou et c.c. Hsu(yuan hu); component F is Gallstones of Bos taurus domesticus Gmelin and/or Trunk of Dryobalanops aromatica Gaertn. f. ; component G is Fruit of Cannabis sativa L. and/or Fruit of Biota orientalis (L) Endl.; component H is Stem of Aipinia officinarum Hance and/or Stem of Zingiber officinale Rosc.; component I is Root of Salvia miltiorrhiza >Bge.; component J is Ziziphus jujuba Mill. and/or Fruit of Ziziphus jujuba Mill. var.inermis (Bge.) Rehd.; component K is Root of Glycyrrhiza uralensis Fish. and/or Honey-Fried Root of Glycyrrhiza uralensis Fish.. The inventive extract has effects including helping narcotic addicts to abstain physiological dependency and psychological dependency, and possesses very low retaking rate, moreover, it can be used to keep calm and ease pain. The invention also provides the preparation of the extract.

6. 发明申请

WO98052585A1 IMMUNOMODULATING, BILE-DERIVABLE COMPOSITIONS FOR THE TREATMENT OF VIRAL DISORDERS 审中-公开
标题翻译：免疫调节剂，用于治疗病毒性疾病的BILE-DERIVABLE组合物
公开(公告)号：WO98052585A1
公开(公告)日：1998-11-26
申请号：PCT/CA1998/000494
申请日：1998-05-22
IPC分类号： A61K35/413 , A61K31/00 , A61K31/52 , A61K31/56 , A61K31/66 , A61K31/70 , A61K38/19 , A61K38/21 , A61K45/06
CPC分类号： A61K45/06 , A61K31/00 , A61K31/52 , A61K31/56 , A61K31/66 , A61K31/70 , A61K35/413 , A61K38/21 , A61K31/13 , A61K2300/00
摘要： The present invention relates to the use of a composition exhibiting antiviral properties, comprising small molecular weight components of less than 3000 daltons, and having the following properties: a) is extractable from bile of animals; b) is capable of stimulating monocytes and macrophages in vitro and in vivo; c) is capable of modulating tumor necrosis factor production; d) contains no measurable IL-1 alpha , IL-1 beta , TNF, IL-6, IL-8, IL-4, GM-CSF or IFN- gamma ; e) shows no cytotoxicity to human peripheral blood mononuclear cells or lymphocytes; and f) is not an endotoxin. The invention also relates to the use of the antiviral composition when used in conjunction with other drugs such as antiviral compounds or immunomodulators such as interferon.
摘要翻译：本发明涉及显示抗病毒性质的组合物的用途，其包含小于3000道尔顿的小分子量组分，并且具有以下性质：a）可从胆汁中提取; b）能够在体外和体内刺激单核细胞和巨噬细胞; c）能调节肿瘤坏死因子的产生; d）不含可测量的IL-1α，IL-1β，TNF，IL-6，IL-8，IL-4，GM-CSF或IFN-γ; e）对人外周血单核细胞或淋巴细胞无细胞毒性; 和f）不是内毒素。本发明还涉及当与其它药物如抗病毒化合物或免疫调节剂如干扰素联合使用时的抗病毒组合物的用途。

7. 发明申请

WO2018048274A1 간손상 예방, 개선 또는 치료용 조성물 审中-公开
标题翻译：用于预防，改善或治疗肝损伤的组合物
公开(公告)号：WO2018048274A1
公开(公告)日：2018-03-15
申请号：PCT/KR2017/009953
申请日：2017-09-11
申请人： 경상대학교 산학협력단 , 대한민국 (낙동강유역환경청장)
发明人： 연성찬 , 이후장 , 홍일화 , 이성규 , 홍성진 , 주기회
IPC分类号： A61K35/413 , A23L33/10
CPC分类号： A23L33/10 , A61K35/413
摘要： 본 발명은 뉴트리아 유래 담즙을 유효성분으로 포함하는 간질환 예방 또는 치료용 약학 조성물, 간질환의 예방 또는 치료 방법 및 뉴트리아 유래 담즙을 유효성분으로 포함하는 간 보호 또는 간 질환의 예방 또는 개선용 식품 조성물에 관한 것이다. 본 발명에 따르면 뉴트리아 담즙을 유효성분으로 포함하여 웅담 대용품으로 활용하여 부작용 없이 간기능 개선, 간손상 억제, 간질환 예방 및 치료를 위해 사용될 수 있다.
摘要翻译：
本发明是交叉保护性的或交叉，包括预防或治疗肝病的胆汁衍生为含有肝海狸鼠衍生胆汁作为活性成分作为有效成分的用于预防或治疗方法和海狸鼠的药物组合物用于预防或改善疾病的食物组合物。根据本发明，包括海狸鼠胆汁作为有效成分，改善无副作用通过使用替代功能熊胆，肝脏损害抑制肝脏的，可用于肝脏疾病的预防和治疗。

8. 发明申请

WO2018018391A1 一种治疗小儿口腔溃疡的中药组合物审中-公开
公开(公告)号：WO2018018391A1
公开(公告)日：2018-02-01
申请号：PCT/CN2016/091648
申请日：2016-07-25
申请人：顾湘
发明人：顾湘
IPC分类号： A61K36/8964 , A61P1/00 , A61K33/06 , A61K35/413
CPC分类号： A61K33/06 , A61K35/413 , A61K36/8964 , A61P1/00
摘要：一种治疗小儿口腔溃疡的中药组合物，包括如下重量份的原料：寒水石20～30份，青黛10～20份，贯众10～20份，知母20~30份，牡丹皮10～20份，金银花4～8份,连翘20~30份，蒲公英6～12份，牛黄4～6份，茯苓2～4份，夏枯草4～8份，黄连6～12份，鱼腥草10~20份,槐花20～30份，赤芍5～15份，黄连2～10份。一种治疗小儿口腔溃疡的中药组合物，使用效果好，有效治疗口腔溃疡，作用温和，无毒副作用，并且该药物的生产工艺简单、易于服用、疗效显著，是一种理想的提高人体免疫、抗疲劳的药物。

9. 发明申请

WO2017185593A1 具有活血化痰功能的添味块填充物及制备方法审中-公开
公开(公告)号：WO2017185593A1
公开(公告)日：2017-11-02
申请号：PCT/CN2016/099559
申请日：2016-09-21
申请人：郑志炫 , 郑俊祥
发明人：郑志炫 , 郑俊祥
IPC分类号： A24F47/00 , A61K36/8888 , A61P9/10 , A61P11/10 , A61K35/413 , A61K31/045
CPC分类号： A24F47/00 , A61K31/045 , A61K35/413 , A61K36/8888
摘要：一种具有活血化痰功能的添味块填充物，所述的添味块填充物可应用于电子烟的通气孔中，所述的添味块填充物为透气性较好材料制成，添味块上设有植物添加物；经过1)浸泡、2)烘干、3)均匀混合增味、4)包裹的具有化痰功能的添味块填充物制备方法得到；将该添味块填充物放置在电子烟的通气孔内得到具有化痰功能的电子烟。所述的添味块填充物可应用于电子烟行业中分体式烟嘴(吸嘴)、一体式烟嘴(吸嘴)等多种结构的通气孔中，具有口感更加接近传统烟，更容易被用户接近和更有利于生产销售的优点，适合在电子烟领域广泛的推广。

10. 发明申请

WO2011053690A1 MULTIPOTENT STEM CELLS FROM THE EXTRAHEPATIC BILLARY TREE AND METHODS OF ISOLATING SAME 审中-公开
标题翻译：多余的干细胞来自非常优秀的树苗及其分离方法
公开(公告)号：WO2011053690A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/054450
申请日：2010-10-28
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , REID, Lola, M. , WANG, Yunfang , CARDINALE, Vincenzo , GAUDIO, Eugenio , CARPINO, Guido , ALVARO, Domenico , CUI, Cai-Bin
发明人： REID, Lola, M. , WANG, Yunfang , CARDINALE, Vincenzo , GAUDIO, Eugenio , CARPINO, Guido , ALVARO, Domenico , CUI, Cai-Bin
IPC分类号： C12N5/071
CPC分类号： C12N5/0672 , A61K35/413 , C12N5/0678 , C12N2500/20 , C12N2500/22 , C12N2500/25 , C12N2500/34 , C12N2500/36 , C12N2500/38 , C12N2501/115 , C12N2501/39 , C12N2533/54 , C12N2533/80 , C12N2537/10
摘要： The present invention relates to a multipotent stem cell, multipotent cell populations, and an enriched multipotent cell population, each found in fetal, neonatal, pediatric, and adult biliary tree tissue and up to 72 hours post mortem (although preferentially, within 10 hours post mortem) and capable of maturing into multiple endodermal tissues that include liver, biliary and pancreatic tissues. The multipotent stem/progenitor cell and cell populations are found in peribiliary glands, and progenitors descending from them are present throughout the biliary tree including in the gallbladder. High numbers of the peribiliary glands are found in the branching locations of the biliary tree such as hilum, common hepatic duct, cystic duct, common duct, common hepato-pancreatic duct and gallbladder. Related multipotent cells, multipotent cell populations and their descendent progenitors are found throughout the biliary tree including in the gall bladder, which does not have peribiliary glands. Compositions comprising same, methods of identifying and isolating same, maintaining same in culture, expanding same in culture and differentiating or lineage restricting the same in vitro or in vivo to hepatic, biliary or pancreatic fates (e.g., as hepatocytes, cholangiocytes, and/or pancreatic islet cells) are also provided. Methods of using the multipotent cells and/or multipotent cell populations are also provided.
摘要翻译：本发明涉及多潜能干细胞，多潜能细胞群和富含多能细胞群，每种细胞在胎儿，新生儿，儿科和成人胆汁树组织中发现，并且在死后72小时内（尽管优选在10小时后死亡），并且能够成熟为包括肝，胆汁和胰腺组织的多个内胚层组织。多能干/祖细胞和细胞种群存在于周围，并且从它们下降的祖细胞存在于胆囊中，包括胆囊内。胆囊内分泌位置较多，例如门，普通肝管，囊性管，普通管，普通肝胰胆管和胆囊。相关的多能细胞，多能细胞群及其后代祖细胞遍及胆囊树，包括胆囊内，不具有近端腺体。包含其的组合物，鉴定和分离相同的方法，在培养中保持相同的方式，在培养中扩展相同的，在体外或体内限制其在肝，胆或胰的命运（例如肝细胞，胆管细胞和/或胰岛细胞）。还提供了使用多潜能细胞和/或多潜能细胞群体的方法。

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