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21. 发明申请

WO1997033609A1 VASOACTIVE EFFECTS AND FREE RADICAL GENERATION BY 'beta'-AMYLOID PEPTIDES 审中-公开
标题翻译：通过β亚型胶原蛋白的血管生成和免费放射生成
公开(公告)号：WO1997033609A1
公开(公告)日：1997-09-18
申请号：PCT/US1997003781
申请日：1997-03-10
申请人： UNIVERSITY OF SOUTH FLORIDA , THOMAS, Thomas, N. , MULLAN, Michael
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A61K38/44
CPC分类号： A61K45/06 , A61K31/00 , A61K31/277 , A61K38/1709 , A61K38/446 , A61K33/00 , A61K2300/00
摘要： A method is disclosed for treating and preventing diseases, wherein at least one of the causes of the disease is beta -amyloid peptide induced change in free radical production resulting in vascular endothelial dysfunction and vasoactivity, by antagonizing vascular free radicals in excess of functional equilibrium.
摘要翻译：公开了用于治疗和预防疾病的方法，其中所述疾病的至少一个原因是β-淀粉样蛋白肽通过拮抗超过功能平衡的血管自由基而引起自由基产生的变化导致血管内皮功能障碍和血管活性。

22. 发明申请

WO1997017091A1 GUINEA PIG MODEL FOR LEIOMYOMAS AND ATHEROSCLEROSIS 审中-公开
标题翻译： GUINEA PIG模型用于眼底和皮质囊肿
公开(公告)号：WO1997017091A1
公开(公告)日：1997-05-15
申请号：PCT/US1996017969
申请日：1996-11-08
申请人： UNIVERSITY OF SOUTH FLORIDA , TSIBRIS, John, C., M. , PORTER, Kathy, B.
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A61K49/00
CPC分类号： A01K67/027 , A01K2227/105 , A01K2267/03 , A01K2267/0331 , A61K49/0008
摘要： A method of making a model test system in guinea pigs for leiomyomas and early stage atherosclerosis by ovariectomizing young female guinea pigs, and co-implanting continuous slow release device for releasing an estrogenic compound or analogues thereof and a retinoid compound or analogues thereof.
摘要翻译：一种通过卵巢切除年轻雌性豚鼠制备用于平滑肌瘤和早期动脉粥样硬化的豚鼠模型试验系统的方法，以及共同植入用于释放雌激素化合物或其类似物的连续缓释装置和类视黄醇化合物或其类似物。

23. 发明申请

WO1996038172A1 CONNECTIVE TISSUE GROWTH FACTOR 审中-公开
标题翻译：连接组织生长因子
公开(公告)号：WO1996038172A1
公开(公告)日：1996-12-05
申请号：PCT/US1996008140
申请日：1996-05-31
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , GROTENDORST, Gary, R. , BRADHAM, Douglass, M., Jr.
IPC分类号： A61K39/395
CPC分类号： C07K14/475 , A61K38/00 , A61K38/1841 , A61K38/39 , C12N5/0655 , A61K2300/00
摘要： The present invention provides a novel polypeptide, Connective Tissue Growth Factor (CTGF), polynucleotides CTGF, and including 5'and 3' untranslated nucleotides, antibodies reactive with CTGF and means for producing CTGF. Also provided are diagnostic and therapeutic methods for using CTGF, as well as an assay for identifying compositions which affect the expression of CTGF polynucleotide. The invention provides a novel TGF- beta responsive element upstream of the polynucleotide encoding CTGF structural gene.
摘要翻译：本发明提供新型多肽，结缔组织生长因子（CTGF），多核苷酸CTGF，包括5'和3'非翻译核苷酸，与CTGF反应的抗体和用于产生CTGF的方法。还提供了使用CTGF的诊断和治疗方法，以及用于鉴定影响CTGF多核苷酸表达的组合物的测定法。本发明提供了编码CTGF结构基因的多核苷酸上游的新型TGF-β应答元件。

24. 发明申请

WO1996012587A1 A DUAL-LASER PROCESS FOR FILM DEPOSITION 审中-公开
标题翻译：一种用于膜沉积的双激光工艺
公开(公告)号：WO1996012587A1
公开(公告)日：1996-05-02
申请号：PCT/US1995013111
申请日：1995-10-20
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , WITANACHCHI, Sarath , MUKHERJEE, Pritish
IPC分类号： B23K26/00
CPC分类号： C23C14/28
摘要： A dual-laser process for thin film deposition includes spatially overlapping a first pulsed infrared laser (10) and a second pulsed ultraviolet laser (20) on a target (30) to form a thin film by laser ablation deposition.
摘要翻译：用于薄膜沉积的双激光工艺包括在靶（30）上空间重叠第一脉冲红外激光器（10）和第二脉冲紫外激光器（20），以通过激光烧蚀沉积形成薄膜。

25. 发明申请

WO1995007315A1 METALLOSPHERES AND SUPERCLUSTERS 审中-公开
标题翻译：金属和超级电容器
公开(公告)号：WO1995007315A1
公开(公告)日：1995-03-16
申请号：PCT/US1994009114
申请日：1994-08-10
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , NEWKOME, George, R. , MOOREFIELD, Charles, N.
IPC分类号： C08J09/00
CPC分类号： B82Y5/00 , A61K47/6907 , A61K47/6949 , C08G79/08 , C08G83/003 , C08G85/00 , C08J9/00
摘要： Unimolecular micelles, generally referred to as cascade polymers, are constructed via the addition of successive layers, or tiers, of designed monomers, or building blocks, that possess a predetermined, branched superstructure consisting of connected physical matter inherently defining an internal void volume or void area within the molecular framework. Each of the branches define a flexible arm from a central core atom and terminate with a hydrodynamic reactive group. A method is described for manipulating such cascade polymers.
摘要翻译：一般称为级联聚合物的单分子胶束是通过添加连续的层或层的设计的单体或结构单元来构建的，所述单体或结构单元具有预定的分支的上层结构，其由连接的物理物质固有地限定内部空隙体积或空隙分子框架内的区域。每个分支从中心核心原子定义柔性臂，并以流体动力学反应基团终止。描述了用于操纵这种级联聚合物的方法。

26. 发明申请

WO1993021144A1 T-BUTYL CASCADE POLYMERS 审中-公开
标题翻译： T-BUTYL CASCADE聚合物
公开(公告)号：WO1993021144A1
公开(公告)日：1993-10-28
申请号：PCT/US1993003616
申请日：1993-04-16
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , NEWKOME, George, R. , MOOREFIELD, Charles, N. , BEHERA, Rajani, Kanta
IPC分类号： C07C61/12
CPC分类号： C08G83/003 , C07C201/12 , C07C205/51 , C07C227/04 , C07C229/24 , C07C231/02 , C07C233/63 , C07C237/22 , C07C2603/74
摘要： A method for forming cascade polymers specifically utilizing the amine monomer of formula (I). The monomer is made by initially reacting nitromethane and CH2=CHCO2-TBu by nucleophilic addition to form the triester nitrotrialkanoate of formula (II), and then reducing the nitrosubstituent to afford the said amine monomer.
摘要翻译：特别利用式（I）的胺单体形成级联聚合物的方法。单体通过首先通过亲核加成使硝基甲烷和CH 2 = CHCO 2 -TBu反应形成式（II）的三酯三异丙酸酯，然后还原亚硝基取代基得到所述胺单体。

27. 发明申请

WO1990007954A1 APPARATUS AND METHODS FOR PERFORMING ELECTROFUSION 审中-公开
标题翻译：用于执行电气的装置和方法
公开(公告)号：WO1990007954A1
公开(公告)日：1990-07-26
申请号：PCT/US1989001773
申请日：1989-04-27
申请人： UNIVERSITY OF SOUTH FLORIDA
发明人： UNIVERSITY OF SOUTH FLORIDA , GRASSO, Robert, J.
IPC分类号： A61N01/32
CPC分类号： A61F9/013 , A61F9/007 , C12M35/02
摘要： Electrofusion of biological particles to specific areas of tissue is accomplished in vivo through the use of electrode members (12, 14) that conform to the configuration and dimension of the tissue (11) at the electrofusion site. The electrode members are positioned in close physical proximity to one another so that when an electrical potential difference is established between them, current flow is limited to the area of tissue between the electrodes so that tissue remote from the selected electrofusion site is substantially unaffected by such current flow. A general apparatus and method is supplemented with two illustrative apparatus and methods for accomplishing in vivo electrofusion on corneas and in cervical areas.
摘要翻译：通过使用符合电熔融部位处的组织（11）的构型和尺寸的电极构件（12,14），在体内实现生物颗粒到组织的特定区域的电融合。电极构件彼此紧密地物理接近，使得当它们之间建立电位差时，电流被限制在电极之间的组织区域，使得远离所选择的电融合部位的组织基本上不受这样的影响当前流。一般的装置和方法补充有用于在角膜和宫颈区域中实现体内电融合的两个说明性装置和方法。

28. 发明申请

WO1998008491A1 LOCK AND KEY MICELLES 审中-公开
标题翻译：锁和钥匙
公开(公告)号：WO1998008491A1
公开(公告)日：1998-03-05
申请号：PCT/US1997014985
申请日：1997-08-26
申请人： UNIVERSITY OF SOUTH FLORIDA , NEWKOME, George, R. , MOOREFIELD, Charles, N.
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： A61K09/50
CPC分类号： C07D213/75 , B82Y5/00 , C07C233/47 , C07D213/68 , C07D239/62 , C07D239/64 , C08G73/028 , C08G73/0627 , Y10S424/16 , Y10S525/936 , Y10S530/816 , Y10T428/2985 , Y10T428/2987
摘要： A lock unimolecular micelle includes at least one engineered acceptor specifically binding a ligand (or specifically a "key" unimolecular micelle) thereto. A key unimolecular micelle comprises a core molecule and a plurality of branches extending therefrom, at least one of the branches including a shank portion extending therefrom having a terminal moiety at an end thereof for binding to a complimentary acceptor of a lock unimolecular micelle. Together, the lock and key micelles form a unit, either irreversibly or reversibly bound wherein the lock micelle is a soluble receptor engineered to specifically bind to the specifically engineered key micelle.
摘要翻译：锁定单分子胶束包括至少一个工程化的受体，其特异性结合配体（或特别是“键”单分子胶束）。关键的单分子胶束包括芯分子和从其延伸的多个分支，至少一个分支包括从其延伸的柄部分，其末端具有末端部分，用于结合锁定单分子胶束的互补受体。一起，锁和键胶束形成单位，不可逆或可逆地结合，其中锁定胶束是被设计成特异性结合特异性工程化键键合物的可溶性受体。

29. 发明申请

WO1997018481A1 METHOD AND APPARATUS FOR USE IN IDDQ INTEGRATED CIRCUIT TESTING 审中-公开
标题翻译：用于IDDQ集成电路测试的方法和装置
公开(公告)号：WO1997018481A1
公开(公告)日：1997-05-22
申请号：PCT/US1996018426
申请日：1996-11-15
申请人： UNIVERSITY OF SOUTH FLORIDA , ATHAN, Stephan, P.
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： G01R31/28
CPC分类号： G01R31/3008 , G01R31/3004 , G01R31/3012
摘要： A built-in current sensor circuit (BICS) for use in integrated circuit testing utilizing the quiescent power supply testing technique includes a detecting transistor (m10), an s-RAM (m5-m8, m3 and m9) cell and a buffer cell (m11-m14) electrically coupled in a cascaded configuration to perform a comparator function, a reference source (34) comprised of a current generating transistor (m1) and a voltage level setting transistor (m2), and an active output load (38) comprised of a single P-MOSFET (m12) sized to draw a unique amount of current when a respective circuit under test (CUT) is determined to be defective. Whereby the additional current drawn by the active output load (38) is readily observable on the bias line by an external standard off the shelf current monitor. The built-in current sensor circuit (BICS) thereby alleviating the excessive use of area overhead in deep submicron integrated circuits and the need for separately propagating a defect signal to an output pin.
摘要翻译：使用静态电源测试技术的集成电路测试中使用的内置电流传感器电路（BICS）包括检测晶体管（m10），s-RAM（m5-m8，m3和m9）单元和缓冲单元电流耦合在级联配置中以执行比较器功能，包括电流产生晶体管（m1）和电压电平设置晶体管（m2）的参考源（34）和有源输出负载（38），其包括的单个P-MOSFET（m12），其尺寸被设计成当相应的被测电路（CUT）被确定为有缺陷时绘制唯一量的电流。由此，有源输出负载（38）所引起的附加电流可以通过外部标准在电流监视器上在偏置线上容易地观察到。内置的电流传感器电路（BICS）从而减轻了深亚微米集成电路中过度使用区域开销，以及需要将缺陷信号单独传播到输出引脚。

30. 发明申请

WO1997003086A1 EARLY ONSET ALZHEIMER'S DISEASE GENE AND GENE PRODUCTS 审中-公开
标题翻译：早期的阿尔茨海默病基因和基因产物
公开(公告)号：WO1997003086A1
公开(公告)日：1997-01-30
申请号：PCT/US1996011064
申请日：1996-06-26
申请人： UNIVERSITY OF SOUTH FLORIDA , HARDY, John, A.
发明人： UNIVERSITY OF SOUTH FLORIDA
IPC分类号： C07H21/04
CPC分类号： C07K14/4711 , A61K38/00 , C12Q1/6883 , C12Q2600/112 , C12Q2600/158
摘要： This invention relates to polynucleotide and polypeptide sequences of the Early Onset Alzheimer's Disease gene (herein "EOAD gene"). More particularly, this invention relates to fragments and mutants EOAD gene useful as probes and amplification primers for the identification of a predisposition or diagnosis of Alzheimer's Disease.
摘要翻译：本发明涉及早发性阿尔茨海默氏病基因的多核苷酸和多肽序列（本文中为“EOAD基因”）。更具体地，本发明涉及可用作鉴定阿尔茨海默氏病倾向或诊断的探针和扩增引物的片段和突变体EOAD基因。

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