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    • 21. 发明申请
    • COMPOSITIONS COMPRISING BENZYL ALCOHOL DERIVATIVES AND FURTHER ANTIMICROBIAL ACTIVE COMPOUNDS
    • 包含苄基醇衍生物和进一步的抗微生物活性化合物的组合物
    • WO2008119841A2
    • 2008-10-09
    • PCT/EP2008/059037
    • 2008-07-10
    • SYMRISE GMBH & CO. KGSCHMAUS, GerhardPFEIFFER, Antje
    • SCHMAUS, GerhardPFEIFFER, Antje
    • A01N31/02A01N31/04A01P1/00
    • A61Q17/005A01N31/02A01N31/04A61K8/046A61K8/062A61K8/064A61K8/34A61K8/345A61K2800/524A61K2800/874A61Q5/02A61Q15/00A61Q17/04A61Q19/00A61Q19/004A61Q19/02A61Q19/04A01N35/02A01N37/06A01N37/10A01N37/40A01N39/00A01N43/50A01N43/80A01N47/12A01N47/28A01N47/36A01N2300/00
    • The present invention relates to a composition comprising or consisting of: (a) one, two or more compounds selected from the group consisting of benzyl alcohol derivatives of the formula (I), wherein each of the substituents R 1 , R 2 , and R 3 has a position at the aromatic ring, and wherein the substituents R 1 , R 2 , and R 3 independently of one another are selected from the group consisting of: H; OH; OCH 3 ; COOH; linear or branched, saturated aliphatic hydrocarbon radical having 1 to 8 carbon atoms; linear or branched, unsaturated aliphatic hydrocarbon radical having 2 to 8 carbon atoms; COOR 4 , wherein R 4 is a linear or branched alkyl radical having 1 to 8 carbon atoms; wherein the total number of carbon atoms in substituents R 1 , R 2 and R 3 is 1 to 12, and (b) one, two or more compounds selected from the group consisting of: (i) branched or unbranched 1,2-alkanediols having 3 to 14 carbon atoms, (ii) benzoic acid (INCI: Benzoic Acid) and its esters and salts, (iii) 4-hydroxybenzoic acid and its esters (INCI: Parabens) and salts, (iv) 2,4-hexadienoic acid (INCI: Sorbic Acid) and its salts, (v) 2-phenoxyethanol (INCI: Phenoxyethanol) (vi) 3-iodo-2-propinyl-butylcarbamate (INCI: Iodopropynyl Butylcarbamate), (vii) 3-(4-chlorphenoxy)-1,2-propane-1,2-diol (INCI: Chlorphenesin), (viii) urea (INCI: Urea) and derivatives thereof, in particular 1,1'-methylen-bis(3-(1- hydroxymethyl-2,4-dioximidazolidin-5-yl ))urea (INCI: Imidazolidinyl urea), N-hydroxymethyl-N-(1,3-di(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)-N'-hydroxy-methylurea (INCI: Diazolidinyl Urea) and N-(4-chlorophenyl)-N`-(3,4-dichlorophenyl)-urea (INCI: Triclocarban), (ix) 1,3-bis-(hydroxymethyl)-5,5-dimethyl-2,4-imidazolidindione (INCI: DMDM hydan- toin), (x) 1,2-propanediol, 3-(2-ethylhexyloxy) (INCI: Octoxyglycerin), (xi) isothiazolinones and mixtures thereof (e.g. a mixture of 5-chloro-2-methyl-3(2H)-isothiazolinone and 2-methyl-3(2H)-isothiazolinone with magnesium chloride and magnesium nitrate; INCI: Methylchloroisothiazolinone and Methylisothiazolinone).
    • 本发明涉及包含或由以下组成的组合物:(a)一种,两种或更多种选自式(I)的苯甲醇衍生物的化合物,其中每个取代基R 1 R 2,R 3和R 3在芳环上具有一个位置,并且其中取代基R 1,R 2, / SUP>和R 3彼此独立地选自:H; 哦; OCH 3 ; COOH; 具有1至8个碳原子的直链或支链饱和脂族烃基; 具有2-8个碳原子的直链或支链的不饱和脂族烃基; 其中R 4是具有1至8个碳原子的直链或支链烷基; 其中取代基R 1,R 2和R 3中的碳原子总数为1至12,和(b)一个,二个 或更多选自以下的化合物:(i)具有3至14个碳原子的支链或非支链的1,2-链烷二醇,(ii)苯甲酸(INCI:苯甲酸)及其酯和盐,(iii)4- 羟基苯甲酸及其酯(INCI:对羟基苯甲酸酯)和盐,(iv)2,4-己二烯酸(INCI:山梨酸)及其盐,(v)2-苯氧基乙醇(INCI:苯氧基乙醇)(vi) (Ⅳ)3-(4-氯苯氧基)-1,2-丙烷-1,2-二醇(INCI:Chlorphenesin),(ii)脲(INCI:尿素)和 其衍生物,特别是1,1'-亚甲基双(3-(1-羟甲基-2,4-二咪唑烷-5-基))脲(INCI:咪唑烷基脲),N-羟甲基-N-(1,3 (羟甲基)-2,5-二氧代咪唑烷-4-基)-N'-羟基 - 甲基脲(INCI:二唑烷基脲)和N-(4-氯苯基)-N'-(3,4-二氯苯基) - 脲 (INCI:Triclocarban) ,(ix)1,3-双 - (羟甲基)-5,5-二甲基-2,4-咪唑烷二酮(INCI:DMDM乙内酰脲),(x)1,2-丙二醇,3-(2-乙基己氧基) (INCI:Octoxyglycerin),(xi)异噻唑啉酮及其混合物(例如, 5-氯-2-甲基-3(2H) - 异噻唑啉酮和2-甲基-3(2H) - 异噻唑啉酮与氯化镁和硝酸镁的混合物; INCI:甲基氯异噻唑啉酮和甲基异噻唑啉酮)。