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21. 发明申请

WO03075748A2 TRANSVENOUS STAPLES, ASSEMBLY AND METHOD FOR MITRAL VALVE REPAIR 审中-公开
标题翻译：多功能支架，组装和方法修复
公开(公告)号：WO03075748A2
公开(公告)日：2003-09-18
申请号：PCT/US0307022
申请日：2003-03-06
申请人： CARDIAC DIMENSIONS INC , ADAMS JOHN M , WOLF SCOTT J
发明人： ADAMS JOHN M , WOLF SCOTT J
IPC分类号： A61B20060101 , A61B17/00 , A61B17/068 , A61B17/08 , A61B17/10 , A61B17/22 , A61B
CPC分类号： A61B17/0684 , A61B17/00234 , A61B2017/00783 , A61B2017/00867 , A61B2017/22052 , A61F2/2451
摘要： A mitral valve staple device treats mitral regurgitation of a heart. The device includes first and second leg portions, each leg portion terminating in a tissue piercing end, and a connection portion extending between the first and second leg portions. The connection portion has an initial stressed and distorted configuration to separate the first and second leg portion by a first distance when the tissue piercing ends pierce the mitral valve annulus and a final unstressed and undistorted configuration after the tissue piercing ends pierce the mitral valve annulus to separate the first and second leg portions by a second distance which is shorter than the first distance. The device is deployed within the heart transvenously through a catheter positioned in the coronary sinus adjacent the mitral valve annulus. A tool forces the mitral valve staple device through the wall of the catheter for deployment in the heart.
摘要翻译：二尖瓣装置治疗心脏的二尖瓣反流。该装置包括第一和第二腿部，每个腿部终止于组织刺穿端，以及在第一和第二腿部之间延伸的连接部分。连接部分具有初始的应力和变形构造，当组织穿刺端部刺穿二尖瓣环时，将第一和第二腿部分开第一距离，并且在组织穿刺端部刺穿二尖瓣环至将第一和第二腿部分开比第一距离短的第二距离。该装置通过位于邻近二尖瓣环的冠状窦内的导管传递在心脏内。一个工具迫使二尖瓣装订装置穿过导管的壁部署在心脏中。

22. 发明申请

WO2009045777A3 A WEARABLE INFUSION DEVICE 审中-公开
标题翻译：一种可穿戴式输液装置
公开(公告)号：WO2009045777A3
公开(公告)日：2009-07-16
申请号：PCT/US2008077317
申请日：2008-09-23
申请人： CALIBRA MEDICAL INC , CROSS BRETT , CARTER BRETT J , ADAMS JOHN M , MCKENZIE JOHN , SAUL TOM A
发明人： CROSS BRETT , CARTER BRETT J , ADAMS JOHN M , MCKENZIE JOHN , SAUL TOM A
IPC分类号： A61M5/142 , A61M37/00
CPC分类号： A61M5/14248 , A61M2005/1405
摘要： A wearable infusion device comprises a component that causes a piston to move an incremental distance to cause the device to dispense a dose of medicament from a reservoir.
摘要翻译：可佩戴输注装置包括使活塞移动增量距离以使装置从储存器分配一剂药物的部件。

23. 发明申请

WO2009045779A3 DISPOSABLE INFUSION DEVICE WITH REUSE LOCK-OUT 审中-公开
标题翻译：具有重新锁定功能的可重复输注设备
公开(公告)号：WO2009045779A3
公开(公告)日：2009-06-04
申请号：PCT/US2008077319
申请日：2008-09-23
申请人： CALIBRA MEDICAL INC , CARTER BRETT J , ADAMS JOHN M , CROSS BRETT
发明人： CARTER BRETT J , ADAMS JOHN M , CROSS BRETT
IPC分类号： A61M5/142 , A61M37/00
CPC分类号： A61M5/1424 , A61M5/14248 , A61M5/1684 , A61M2039/009
摘要： A wearable infusion device comprises a reservoir that holds a liquid medicament, an outlet port that delivers the liquid medicament to a patient, a pump that displaces a volume of the liquid medicament to the outlet port when actuated, and a control that actuates the pump. A lock-out disables the device when a predefined amount of medicament has been delivered to the outlet.
摘要翻译：一种可佩戴的输注装置包括容纳液体药物的储存器，将液体药物递送到患者的出口端口;当被致动时将液体药物的体积移动到出口端口的泵以及致动泵的控制器。当预定量的药物已经被输送到出口时，锁定将禁用该装置。

24. 发明申请

WO03037171A9 FOCUSED COMPRESSION MITRAL VALVE DEVICE AND METHOD 审中-公开
标题翻译：聚焦压缩麻药装置及方法
公开(公告)号：WO03037171A9
公开(公告)日：2003-12-31
申请号：PCT/US0235196
申请日：2002-10-31
申请人： CARDIAC DIMENSIONS INC , ADAMS JOHN M , REUTER DAVID G , MATHIS MARK L , WOLF SCOTT J
发明人： ADAMS JOHN M , REUTER DAVID G , MATHIS MARK L , WOLF SCOTT J
IPC分类号： A61F2/24 , A61F2/958 , A61F2/06
CPC分类号： A61F2/2451 , A61M25/1006
摘要： A mitral valve therapy device and method treats dilated cardiomyopathy. The device is configured to be placed in the coronary sinus of a heart adjacent to the mitral valve annulus. The device includes a force distributor (32) that distributes an applied force along a pericardial wall of the coronary sinus, and a force applier (34) that applies the applied force to one or more discrete portions of a wall of the coronary sinus adjacent to the mitral valve annulus to reshape the mitral valve annulus in a localized manner.
摘要翻译：二尖瓣治疗装置及方法治疗扩张型心肌病。该装置被配置成放置在与二尖瓣环相邻的心脏的冠状窦中。该装置包括力分配器（32），其沿着冠状窦的心包壁分布施加的力，以及施力器（34），该施力器施加施加的力到邻近的冠状窦的壁的一个或多个离散部分二尖瓣环以局部方式重塑二尖瓣环。

25. 发明申请

WO03037171A2 FOCUSED COMPRESSION MITRAL VALVE DEVICE AND METHOD 审中-公开
标题翻译：聚焦压缩麻药装置及方法
公开(公告)号：WO03037171A2
公开(公告)日：2003-05-08
申请号：PCT/US0235196
申请日：2002-10-31
申请人： CARDIAC DIMENSIONS INC , ADAMS JOHN M , REUTER DAVID G , MATHIS MARK L , WOLF SCOTT J
发明人： ADAMS JOHN M , REUTER DAVID G , MATHIS MARK L , WOLF SCOTT J
IPC分类号： A61F2/24 , A61F2/958 , A61B
CPC分类号： A61F2/2451 , A61M25/1006
摘要： A mitral valve therapy device and method treats dilated cardiomyopathy. The device is configured to be placed in the coronary sinus of a heart adjacent to the mitral valve annulus. The device includes a force distributor that distributes an applied force along a pericardial wall of the coronary sinus, and a force applier that applies the applied force to one or more discrete portions of a wall of the coronary sinus adjacent to the mitral valve annulus to reshape the mitral valve annulus in a localized manner.
摘要翻译：二尖瓣治疗装置和方法治疗扩张型心肌病。该装置被配置成放置在与二尖瓣环相邻的心脏的冠状窦中。该装置包括力分配器，其沿着冠状窦的心包壁分布施加的力，以及施加力施加器，其将所施加的力施加到邻近二尖瓣环的冠状窦的壁的一个或多个离散部分，以重塑二尖瓣环以局部方式。

26. 发明申请

WO2009045785A3 DISPOSABLE INFUSION DEVICE WITH TACTILE DOSAGE VOLUME INDICATOR 审中-公开
标题翻译：具有消耗剂量指示剂的可移植输液装置
公开(公告)号：WO2009045785A3
公开(公告)日：2009-06-11
申请号：PCT/US2008077335
申请日：2008-09-23
申请人： CALIBRA MEDICAL INC , ADAMS JOHN M , CARTER BRETT J
发明人： ADAMS JOHN M , CARTER BRETT J
IPC分类号： A61M5/142 , A61M37/00
CPC分类号： A61M5/1424 , A61M5/14248 , A61M5/1684 , A61M2039/009
摘要： A wearable infusion device comprises a reservoir that holds a liquid medicament, an outlet port that delivers the liquid medicament to a patient, a pump that delivers a volume of the liquid medicament from the reservoir to the outlet when actuated, and a tactile indicator representing the volume of the liquid medicament delivered to the outlet with each actuation of the pump.
摘要翻译：一种可佩戴的输注装置包括容纳液体药物的储存器，将液体药物输送给患者的出口端口;当被致动时将液体药物从容器输送到出口的泵，以及表示在泵的每个致动下输送到出口的液体药物的体积。

27. 发明申请

WO2007059285A3 APPARATUS INCLUDING MULTIPLE INVAGINATORS FOR RESTORING A GASTROESOPHAGEAL FLAP VALVE AND METHOD 审中-公开
标题翻译：装置包括多个引导器用于恢复胃肠道瓣膜和方法
公开(公告)号：WO2007059285A3
公开(公告)日：2009-04-30
申请号：PCT/US2006044509
申请日：2006-11-15
申请人： ENDOGASTRIC SOLUTIONS INC , ADAMS JOHN M
发明人： ADAMS JOHN M
IPC分类号： A61B17/10 , A61B17/08
CPC分类号： A61F2/02 , A61B17/0487 , A61B2017/0464
摘要： A transoral gastroesophageal flap valve restoration assembly comprises a pair of tissue grippers. The device comprises an elongated member having a distal end arranged for being fed down an esophagus in communication with a stomach and a tissue shaper carried on the distal end of the longitudinal member. The tissue shaper comprises a first member adjacent the distal end of the elongated member and a second member. The first and second members are hingedly coupled to receive the stomach tissue to be shaped there between. The distal end of the elongated member has one of the tissue grippers that grips esophageal tissue oral of a Z line and the first member of the tissue shaper has the other tissue gripper that grips stomach tissue aboral of the Z line. A tissue fastener maintains the Shaped stomach tissue.
摘要翻译：经口胃食管瓣瓣修复组件包括一对组织夹持器。所述装置包括细长构件，所述细长构件具有远端，所述远端设置为向下馈送与胃相连的食道和沿所述纵向构件的远端承载的组织整形器。组织整形器包括邻近细长构件的远端的第一构件和第二构件。第一和第二构件被铰接地联接以接收待在其间形成的胃组织。细长构件的远端具有夹紧Z线的食管组织的组织夹具中的一个，并且组织整形器的第一构件具有夹住Z组织腹部胃部组织的另一个组织夹持器。组织紧固件保持形状的胃组织。

28. 发明申请

WO2009045776A2 DISPOSABLE INFUSION DEVICE WITH DUAL VALVE SYSTEM 审中-公开
标题翻译：具有双阀系统的一次性输液装置
公开(公告)号：WO2009045776A2
公开(公告)日：2009-04-09
申请号：PCT/US2008077314
申请日：2008-09-23
申请人： CALIBRA MEDICAL INC , CARTER BRETT J , ADAMS JOHN M
发明人： CARTER BRETT J , ADAMS JOHN M
IPC分类号： A61M5/142 , A61M37/00
CPC分类号： A61M5/14248 , A61M5/1424 , A61M5/145
摘要： A wearable infusion device comprises a first control movable between a first position and a second position that when in the first position, establishes a first fluid path between a reservoir and a pump and when in the second position, establishes a second fluid path between the pump and an outlet. A second control actuates the pump only when the second fluid path has been established by the first control.
摘要翻译：一种可佩戴输液装置包括可在第一位置和第二位置之间移动的第一控制装置，所述第一控制装置在第一位置时建立储存器与泵之间的第一流体路径，并且当处于第二位置时建立泵之间的第二流体路径和一个出口。只有当第一控制装置建立了第二流体路径时，第二控制装置才启动泵。

29. 发明申请

WO2006060549A2 FLEXIBLE TRANSORAL ENDOSCOPIC GASTROESOPHAGEAL FLAP VALVE RESTORATION DEVICE AND METHOD 审中-公开
标题翻译：灵活的内窥镜内窥镜气管瓣瓣修复装置及方法
公开(公告)号：WO2006060549A2
公开(公告)日：2006-06-08
申请号：PCT/US2005043436
申请日：2005-11-30
申请人： ENDOGASTRIC SOLUTIONS INC , CARTER BRETT J , ADAMS JOHN M , KRAEMER STEFAN J M , BAKER STEVE G , BAYNE JOHN C
发明人： CARTER BRETT J , ADAMS JOHN M , KRAEMER STEFAN J M , BAKER STEVE G , BAYNE JOHN C
IPC分类号： A61B17/08
CPC分类号： A61B17/29 , A61B17/00234 , A61B17/0643 , A61B17/068 , A61B17/10 , A61B2017/003 , A61B2017/00827 , A61B2017/2905
摘要： A transoral gastroesophageal flap valve restoration device has sufficient flexibility and dimension to be passed through the mouth, throat, and esophagus of a patient into the patient's stomach. The device includes a first member and a second member hingedly coupled to the first member The first and second members are configured to flex in a direction to follow the esophageal path into the stomach and to be substantially rigid when forming the restored gastroesophageal flap valve.
摘要翻译：经口胃食管瓣瓣修复装置具有足够的灵活性和尺寸，以通过患者的口腔，咽喉和食道进入患者的胃。该装置包括第一构件和第二构件，其铰接地联接到第一构件。第一构件和第二构件构造成在形成恢复的胃食管瓣阀时沿着食道进入胃的方向弯曲并且基本上是刚性的。

30. 发明申请

WO2011060364A3 WEARABLE INFUSION DEVICE AND SYSTEM 审中-公开
标题翻译：可口的输液装置和系统
公开(公告)号：WO2011060364A3
公开(公告)日：2011-10-13
申请号：PCT/US2010056715
申请日：2010-11-15
申请人： CALIBRA MEDICAL INC , CARTER BRETT J , MCKENZIE JOHN , ADAMS JOHN M , CROSS BRETT , MARSOT TRAVIS
发明人： CARTER BRETT J , MCKENZIE JOHN , ADAMS JOHN M , CROSS BRETT , MARSOT TRAVIS
IPC分类号： A61M5/14 , A61M5/162 , A61M37/00 , A61M39/06
CPC分类号： A61M5/158 , A61M5/14244 , A61M5/14248 , A61M5/162 , A61M5/1626 , A61M5/16831 , A61M39/26 , A61M2005/14252 , A61M2005/1585 , A61M2005/1588
摘要： Disclosed is a drug infusion system comprising a drug infusion device having a reservoir, a window for viewing the contents of the reservoir, a cannula arranged to be deployed beneath the skin of a patient, and an actuator configured to be manually actuated to drive a medicament from the reservoir to the cannula. The system also has a cannula cover and a needle handle that holds a needle for insertion into the patient. The cannula cover and needle handle are detachably attached to the drug infusion device, and each is attachable to the other. The device further comprises a septum and a septum pincher to seal the device. The device also comprises a pumping mechanism, part of which are a last-dose lock-out mechanism and an occlusion detection mechanism, both of which operate on the same actuator.
摘要翻译：公开了一种药物输注系统，其包括具有储存器的药物输注装置，用于观察储存器的内容物的窗口，布置成展开在患者皮肤下方的套管以及构造成手动致动以驱动药物的致动器从储存器到套管。该系统还具有套管盖和针柄，其保持用于插入患者体内的针头。套管盖和针柄可拆卸地附接到药物输注装置，并且每个可附接到另一个。该装置还包括隔膜和隔膜夹子以密封该装置。该装置还包括泵送机构，其一部分是最后剂量锁定机构和遮挡检测机构，两者都在相同的致动器上操作。

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