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21. 发明申请

WO2019056334A1 AQUEOUS POLYMER COMPOSITION 审中-公开
公开(公告)号：WO2019056334A1
公开(公告)日：2019-03-28
申请号：PCT/CN2017/103087
申请日：2017-09-25
申请人： DOW GLOBAL TECHNOLOGIES LLC , ROHM AND HAAS COMPANY , CHEN, Chen , ZHENG, Baoqing , XU, Yawei , YANG, Xiaohong , FENG, Shaoguang , WANG, Yujiang , RICHEY, Brough , SHI, Fengzhe
发明人： CHEN, Chen , ZHENG, Baoqing , XU, Yawei , YANG, Xiaohong , FENG, Shaoguang , WANG, Yujiang , RICHEY, Brough , SHI, Fengzhe
IPC分类号： C08K5/25 , C09D5/00
摘要： An aqueous polymer composition comprising a multiethylenically unsaturated carboxylic acid monohydrazide and a keto-functionalized polymer, and an aqueous coating composition comprising such aqueous polymer composition and providing coatings with improved water resistance and alcohol resistance without compromising early block resistance.

22. 发明申请

WO2018038820A1 SYSTEMS AND METHODS FOR FACILITATING INTERAURAL LEVEL DIFFERENCE PERCEPTION BY ENHANCING THE INTERAURAL LEVEL DIFFERENCE 审中-公开
标题翻译：通过增强国际水平差异来促进国际水平差异感知的系统和方法
公开(公告)号：WO2018038820A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/042273
申请日：2017-07-14
申请人： ADVANCED BIONICS AG , CHEN, Chen , SWAN, Dean , LITVAK, Leonid M.
发明人： CHEN, Chen , SWAN, Dean , LITVAK, Leonid M.
IPC分类号： H04R25/00
摘要： A binaural hearing system ("system") enhances and/or preserves interaural level differences between first and second signals. The system includes first and second audio detectors associated with first and second ears of a user, respectively. The audio detectors detect an audio signal presented to the user and generate the first and second signals to represent the audio signal as detected at the first and second ears, respectively. The system also includes a first sound processor that receives the first signal from the first audio detector and the second signal from a second sound processor via a communication link with the second sound processor. The first sound processor generates a directional signal representative of a spatial filtering of the audio signal detected at the first ear according to an end-fire directional polar pattern and presents an output signal representative of the directional signal to the user at the first ear.
摘要翻译：双耳听力系统（“系统”）增强和/或保持第一和第二信号之间的耳间水平差异。该系统包括分别与用户的第一和第二耳朵相关联的第一和第二音频检测器。音频检测器检测呈现给用户的音频信号并且生成第一和第二信号以分别表示在第一和第二耳朵处检测到的音频信号。该系统还包括第一声音处理器，其经由与第二声音处理器的通信链路从第一音频检测器接收第一信号，并且从第二声音处理器接收第二信号。第一声音处理器根据端射定向极性图案产生表示在第一耳朵处检测到的音频信号的空间滤波的定向信号，并且在第一耳朵处向用户呈现表示定向信号的输出信号。 / p>

23. 发明申请

WO2009046064A2 TRACK SWITCHING FOR A MAGNETICALLY LEVITATED TRANSPORTATION SYSTEM AND METHOD 审中-公开
标题翻译：用于磁悬浮运输系统的轨道切换和方法
公开(公告)号：WO2009046064A2
公开(公告)日：2009-04-09
申请号：PCT/US2008/078392
申请日：2008-10-01
申请人： LAUNCHPOINT TECHNOLOGIES, INC. , FISKE, Orlo, James , CHEN, Chen , RICCI, Michael , PADEN, Bradley Evan
发明人： FISKE, Orlo, James , CHEN, Chen , RICCI, Michael , PADEN, Bradley Evan
IPC分类号： B60L13/04
CPC分类号： B60L13/003 , B60L13/06 , B60L2200/26
摘要： A magnetically levitated transportation system employs permanent magnet rails along a guideway that interact with permanent magnets on a vehicle. The rails are optimized to reduce magnetic mass and cost of materials, while maximizing lift force. The vehicle is stabilized in the lateral and yaw directions with feedback controlled lateral control coils that interact with the permanent magnet rails on the guideway. A track switching structure employs permanent magnet rails that gradually widen along a segment of track and separate into two identical diverging rails. Feedback controlled lateral control coils in a moving vehicle stabilize that vehicle over one or the other pairs of diverging rails, as directed by a control computer, thereby causing the vehicle to continue along one path or the other, with no moving or active elements required in the track
摘要翻译：磁悬浮运输系统采用沿着导轨的永磁轨道，其与车辆上的永磁体相互作用。导轨经过优化以减少材料的磁性质量和成本，同时最大限度地提升升力。通过反馈控制的侧向控制线圈，车辆在侧向和偏航方向上稳定，侧向控制线圈与导轨上的永磁轨道相互作用。轨道切换结构采用永磁轨道，所述永磁轨道沿着一段轨道逐渐变宽并分成两个相同的分叉轨道。在移动车辆中的反馈控制的横向控制线圈稳定该车辆在一对或另一对分叉轨道上，如控制计算机所指示的，由此使车辆沿着一条路径或另一条路径继续，而不需要移动或活动元件轨道

24. 发明申请

WO2005100364A1 PROCESSES FOR THE PREPARATION OF CLOPIDOGREL HYDROGEN SULFATE POLYMORPHIC FORM I 审中-公开
标题翻译：制备氯膦酸硫酸酯多晶型I的方法
公开(公告)号：WO2005100364A1
公开(公告)日：2005-10-27
申请号：PCT/EP2005/004160
申请日：2005-04-19
申请人： KRKA, TOVARNA ZDRAVIL, D.D. NOVO MESTO , MAO, Haifang , QIAN, Hongguang , CHEN, Chen
发明人： MAO, Haifang , QIAN, Hongguang , CHEN, Chen
IPC分类号： C07D495/04
CPC分类号： C07D487/04
摘要： Processes for the preparation of clopidogrel hydrogen sulfate of polymorphic form I are described which include use of specific solvents and process measures to avoid formation of undesired by-products.
摘要翻译：描述了制备多晶型I的氯吡格雷硫酸氢盐的方法，其包括使用特定溶剂和方法措施以避免形成不期望的副产物。

25. 发明申请

WO2005040109A1 LIGANDS OF MELANOCORTIN RECEPTORS AND COMPOSITIONS AND METHODS RELATED THERETO 审中-公开
标题翻译： MELANOCORTIN受体的配体及其组合物及其相关方法
公开(公告)号：WO2005040109A1
公开(公告)日：2005-05-06
申请号：PCT/US2004/035343
申请日：2004-10-22
申请人： NEUROCRINE BIOSCIENCES, INC. , CHEN, Chen , TRAN, Joe, Ahn , TUCCI, Fabio, C. , CHEN, Wei-Chuan, C., , JIANG, Wanlong , MARINKOVIC, Dragan , ARELLANO, Melissa , WHITE, Nicole
发明人： CHEN, Chen , TRAN, Joe, Ahn , TUCCI, Fabio, C. , CHEN, Wei-Chuan, C., , JIANG, Wanlong , MARINKOVIC, Dragan , ARELLANO, Melissa , WHITE, Nicole
IPC分类号： C07D207/16
CPC分类号： C04B35/632 , C07D207/16 , C07D207/277 , C07D263/24 , C07D295/185 , C07D307/24 , C07D307/33 , C07D317/32 , C07D333/38 , C07D333/48 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D417/12
摘要： Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds have the following structure (I): (R 4 ) s (R 2 ) n N~ X 1 -X 2 (CR 1a CR lb ) q 1~ N R 1 -lm 1 O R 3 (I) including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein m, n, q, s, R 1 , R 1a , R 1b , R 2 , R 3 , R 4 , X 1 X 2 and X 3 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
摘要翻译：作为黑皮质素受体配体起作用并可用于治疗基于黑皮质素受体的疾病的化合物。该化合物具有以下结构（I）：（R4）s（R 2）n N〜X1-X2（CR1aCRlb）q 1〜N R1-lm 1 O R3（I），包括其立体异构体，前药和药学上可接受的盐其中m，n，q，s，R1，R1a，R1b，R2，R3，R4，X1 X2和X3如本文所定义。还公开了含有结构（I）化合物的药物组合物以及与其用途有关的方法。

26. 发明申请

WO2003094918A1 SUBSTITUTED PIPERAZINE AS MELANOCORTIN RECEPTORS LIGANDS 审中-公开
标题翻译：替代哌嗪作为MELANOCORTIN受体配体
公开(公告)号：WO2003094918A1
公开(公告)日：2003-11-20
申请号：PCT/US2003/014628
申请日：2003-05-09
申请人： NEUROCRINE BIOSCIENCES, INC. , PONTILLO, Joseph , MARINKOVIC, Dragan , LANIER, Marion, C. , TRAN, Joe, Ahn , ARELLANO, Melissa , PARKER, Jessica , NELSON, Jodie , CHEN, Chen , CHEN, Caroline , JIANG, Wanglong , WHITE, Nicole , TUCCI, Fabio, C.
发明人： PONTILLO, Joseph , MARINKOVIC, Dragan , LANIER, Marion, C. , TRAN, Joe, Ahn , ARELLANO, Melissa , PARKER, Jessica , NELSON, Jodie , CHEN, Chen , CHEN, Caroline , JIANG, Wanglong , WHITE, Nicole , TUCCI, Fabio, C.
IPC分类号： A61K31/496
CPC分类号： C07D207/27 , C07D207/14 , C07D207/16 , C07D207/273 , C07D207/335 , C07D211/14 , C07D211/26 , C07D211/28 , C07D211/58 , C07D211/60 , C07D211/62 , C07D213/38 , C07D213/74 , C07D217/26 , C07D223/04 , C07D233/36 , C07D241/08 , C07D265/30 , C07D277/28 , C07D295/185 , C07D295/215 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/22 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14
摘要： Compounds which function as melanocortin receptor ligands and having utility in the treatment of melanocortin receptor-based disorders. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein Ar, R 1 , R 2 , R 3a , R 3b , R 4a , R 4b , R 5 , R 7a , R 7b , q , r , X, Y 1 , Y 2 , Y 3 and Y 4 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.
摘要翻译：作为黑皮质素受体配体起作用并可用于治疗基于黑皮质素受体的疾病的化合物。其中Ar，R 1，R 2，R 3a，R 3b，R 4a，R 4b，R 5，R 7a，R 7b，q，r，X，Y 1， Y2，Y3和Y4如本文所定义。还公开了含有结构（I）化合物的药物组合物以及与其用途有关的方法。

27. 发明申请

WO2003013528A1 SUBSTITUTED PYRIDIN-4-ONES AND THEIR USE AS GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS. 审中-公开
标题翻译：取代的吡啶-4-酮及其作为促性腺激素释放激素受体拮抗剂的用途。
公开(公告)号：WO2003013528A1
公开(公告)日：2003-02-20
申请号：PCT/US2002/024643
申请日：2002-08-02
申请人： NEUROCRINE BIOSCIENCES, INC. , TUCCI, Fabio, C. , CONNORS, Patrick, J. , ZHU, Yun-Fei , CHEN, Chen
发明人： TUCCI, Fabio, C. , CONNORS, Patrick, J. , ZHU, Yun-Fei , CHEN, Chen
IPC分类号： A61K31/45
CPC分类号： C07D213/69 , C07D211/86 , C07D213/68 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/04 , C07D409/14 , C07D453/02 , C07D453/06 , C07D473/24
摘要： GnRH receptor antagonists of formula (I) are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof, including stereosomers, prodrugs and pharmaceutically acceptable salts thereof, wherein: A is O or a bond; n is 1, 2, 3 or 4; R 1 and R 2 are the same or different and independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, susbstituted heterocyclealkyl, -C(R 8 )(=NR 9 ) or -C(NR 10 R 11 )(=NR 9 ); or R 1 and R 2 taken together with the nitrogen atom to which they are attached form a heterocycle or a substituted heterocycle; R 3a and R 3b are the same or different and, at each occurrence, independently hydrogen, alkyl, substituted alkyl, alkoxy, alkylthio, alkylamino, aryl, substituted aryl, arylakyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl, substituted heterocyclealkyl, -COOR 12 or -CONR 10 R 11 ; or R 3ab and R 3b taken together with the carbon atom to which they are attached form a homocycle, substituted homocycle, heterocycle or substituted heterocycle; or R 3a and the carbon to which it is attached taken together with R 1 and the nitrogen to which it is attached form a heterocycle or substituted heterocycle; R 4 is hydrogen, alkyl or substituted alkyl; R 5 is arylalkyl, substituted arylalkyl, heteroarylalkyl or substituted heteroalalkyl; R 6 is aryl, substituted aryl, heteroaryl or substituted heteroaryl; R 7 is hydrogen, alkyl or substituted alkyl; R 8 , R 9 , R 10 and R 11 are the same or different and, at each occurrence, independently hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, arylalkyl, substituted arylalkyl, heterocycle, substituted heterocycle, heterocyclealkyl or substituted heterocyclealkyl, and R 12 is hydrogen, alkyl or substituted alkyl.
摘要翻译：公开了式（I）的GnRH受体拮抗剂，其可用于治疗男性和女性中各种性激素相关病症。还公开了含有本发明化合物与药学上可接受的载体的组合物，以及涉及其在有需要的受试者中拮抗促性腺激素释放激素的用途的方法，包括立体异构体，前药和药学上可接受的盐，其中：A为O或键; n为1,2,3或4; R 1和R 2相同或不同，并且独立地是氢，烷基，取代的烷基，芳基，取代的芳基，芳基烷基，取代的芳基烷基，杂环，取代的杂环，杂环烷基，取代的杂环烷基，-C（R 8）（= NR 9） NR 10 R 11）（= NR 9）; 或者R 1和R 2与它们所连接的氮原子一起形成杂环或取代的杂环; R3a和R3b相同或不同，并且在每次出现时独立地为氢，烷基，取代的烷基，烷氧基，烷硫基，烷基氨基，芳基，取代的芳基，芳基烷基，取代的芳基烷基，杂环，取代的杂环，杂环烷基，取代的杂环烷基，-COOR12 或-CONR10R11; 或者R3ab和R3b与它们所连接的碳原子一起形成同质环，取代的杂环，杂环或取代的杂环; 或R 3a，并且其连接的碳与R 1一起并且与其连接的氮形成杂环或取代的杂环; R4是氢，烷基或取代的烷基; R5是芳基烷基，取代的芳基烷基，杂芳基烷基或取代的杂芳烷基; R6是芳基，取代的芳基，杂芳基或取代的杂芳基; R7是氢，烷基或取代的烷基; R8，R9，R10和R11相同或不同，并且在每次出现时独立地为氢，烷基，取代的烷基，芳基，取代的芳基，芳基烷基，取代的芳基烷基，杂环，取代的杂环，杂环烷基或取代的杂环烷基，R12为氢，烷基或取代的烷基。

28. 发明申请

WO2018038821A1 SYSTEMS AND METHODS FOR FACILITATING INTERAURAL LEVEL DIFFERENCE PERCEPTION BY PRESERVING THE INTERAURAL LEVEL DIFFERENCE 审中-公开
标题翻译：用于通过保持国际水平差异来促进国际水平差异感知的系统和方法
公开(公告)号：WO2018038821A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/042274
申请日：2017-07-14
申请人： ADVANCED BIONICS AG , CHEN, Chen , SWAN, Dean , LITVAK, Leonid M.
发明人： CHEN, Chen , SWAN, Dean , LITVAK, Leonid M.
IPC分类号： H04R25/00
摘要： A binaural hearing system (system) enhances and/or preserves interaural level differences between first and second signals. The system includes first and second audio detectors associated with first and second ears of a user, respectively. The audio detectors detect an audio signal presented to the user and generate the first and second signals to represent the audio signal as detected at the first and second ears, respectively. The system also includes a first sound processor that receives the first signal from the first audio detector and the second signal from a second sound processor via a communication link. The first sound processor compares the first and second signals to generate a gain processing parameter, and performs a gain processing operation on a signal based on the gain processing parameter prior to presenting a gain-processed output signal representative of the first signal to the user at the first ear of the user.
摘要翻译：双耳听力系统（系统）增强和/或保持第一和第二信号之间的耳间水平差异。该系统包括分别与用户的第一和第二耳朵相关联的第一和第二音频检测器。音频检测器检测呈现给用户的音频信号并且生成第一和第二信号以分别表示在第一和第二耳朵处检测到的音频信号。该系统还包括第一声音处理器，其经由通信链路接收来自第一音频检测器的第一信号和来自第二声音处理器的第二信号。第一声音处理器比较第一和第二信号以产生增益处理参数，并且在将表示第一信号的经增益处理的输出信号呈现给用户之前，基于增益处理参数对信号执行增益处理操作用户的第一只耳朵。

29. 发明申请

WO2017100706A1 METHOD, APPARATUS, AND SYSTEMS FOR WIRELESS EVENT DETECTION AND MONITORING 审中-公开
标题翻译：用于无线事件检测和监测的方法，装置和系统
公开(公告)号：WO2017100706A1
公开(公告)日：2017-06-15
申请号：PCT/US2016/066015
申请日：2016-12-09
申请人： ORIGIN WIRELESS, INC. , XU, Qinyi , ZHANG, Feng , CHEN, Chen , WANG, Beibei , SAFAR, Zoltan , HAN, Yi , LAI, Hung-Quoc Duc , LIU, K. J. Ray
发明人： XU, Qinyi , ZHANG, Feng , CHEN, Chen , WANG, Beibei , SAFAR, Zoltan , HAN, Yi , LAI, Hung-Quoc Duc , LIU, K. J. Ray
IPC分类号： H04W4/02 , H04W88/02 , H04W76/02
CPC分类号： G08B29/185 , G01S13/04 , G08B13/08 , G08B13/187 , H04W4/80
摘要： An apparatus for detecting events includes a processor and a storage device storing instructions that when executed by the processor cause the processor to train a classifier for classifying channel state information (CSI) and detecting an event based on the classification of the CSI obtained during a monitoring phase. The training of the classifier includes: for each of the known events to be detected, during a time period in which the known event occurs in a venue, obtain training CSI of a wireless multipath channel between a wireless transmitter and a wireless receiver in the venue, in which the training CSI is derived from one or more probing signals sent from the transmitter through the wireless multipath channel to the receiver, and train the classifier based on the known events and the training CSI associated with each of the events.
摘要翻译：用于检测事件的设备包括存储指令的处理器和存储设备，所述指令在由处理器执行时使处理器训练用于分类信道状态信息（CSI）和基于在监测阶段获得的CSI的分类。分类器的训练包括：对于每一个待检测的已知事件，在会场发生已知事件的时间段内，获取会场中无线发射器与无线接收器之间的无线多径信道的训练CSI ，其中训练CSI是从通过无线多路径信道从发射机发送到接收机的一个或多个探测信号导出的，并且基于已知事件和与每个事件相关联的训练CSI来训练分类器。 >

30. 发明申请

WO2017011196A1 SYSTEMS AND METHODS FOR FACILITATING INTERAURAL TIME DIFFERENCE PERCEPTION BY A BINAURAL COCHLEAR IMPLANT PATIENT 审中-公开
标题翻译：用于促进双侧植入物患者的间歇时间差异的系统和方法
公开(公告)号：WO2017011196A1
公开(公告)日：2017-01-19
申请号：PCT/US2016/040332
申请日：2016-06-30
申请人： ADVANCED BIONICS AG , CHEN, Chen , LITVAK, Leonid M.
发明人： CHEN, Chen , LITVAK, Leonid M.
IPC分类号： A61N1/36 , H04R25/00
CPC分类号： A61N1/36038 , A61N1/36036 , H04R25/407 , H04R25/552 , H04R25/554 , H04R2225/43 , H04R2225/67
摘要： A binaural cochlear implant system (system) includes first and second microphones associated with first and second ears of a patient, respectively. The microphones detect an audio signal presented to the patient and output first and second signals representative of the audio signal as detected at the first and second ears, respectively. The system also includes a first sound processor that receives the first signal from the first microphone and the second signal from a second sound processor by way of a communication link with the second sound processors. The first sound processor generates first and second fine structure signals representative of fine structure information of the first and second signals, respectively, and generates a timing pulse signal based on the first and second fine structure signals. The first sound processor uses the timing pulse signal to represent to the patient an interaural time difference between the first and second signals.
摘要翻译：双耳耳蜗植入系统（系统）分别包括与患者的第一耳和第二耳相关联的第一和第二麦克风。麦克风检测呈现给患者的音频信号，并分别输出表示在第一耳朵和第二耳朵处检测到的音频信号的第一和第二信号。该系统还包括第一声音处理器，其通过与第二声音处理器的通信链路接收来自第一麦克风的第一信号和来自第二声音处理器的第二信号。第一声音处理器分别产生表示第一和第二信号的精细结构信息的第一和第二精细结构信号，并且基于第一和第二精细结构信号产生定时脉冲信号。第一声音处理器使用定时脉冲信号向患者表示第一和第二信号之间的耳间时间差。

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