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21. 发明申请

WO2008040015A2 3D MICRO-SCALE ENGINEERED TISSUE MODEL SYSTEMS 审中-公开
标题翻译： 3D微型工程组织模型系统
公开(公告)号：WO2008040015A2
公开(公告)日：2008-04-03
申请号：PCT/US2007079979
申请日：2007-09-28
申请人： UNIV WASHINGTON , LI WEI , WANG HAI
发明人： LI WEI , WANG HAI
IPC分类号： B01L3/00
CPC分类号： B01L3/502753 , B01L3/5025 , B01L3/5027 , B01L2200/12 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , C12M23/16 , C12M25/14 , C12M35/08
摘要： A polymeric chip having at least one three-dimensional porous scaffold, a microfluidic channel inlet to the porous scaffold, and a microfluidic channel outlet from the porous scaffold. In one embodiment, the polymeric chip has two three-dimensional porous scaffolds: one scaffold comprises liver cells and the other scaffold comprises cancer cells. The chip can be used as a multi-organ tissue model system.
摘要翻译：具有至少一个三维多孔支架，多孔支架的微流体通道入口和多孔支架的微流体通道出口的聚合物芯片。在一个实施方案中，聚合物芯片具有两个三维多孔支架：一个支架包含肝细胞，另一个支架包含癌细胞。该芯片可以用作多器官组织模型系统。

22. 发明申请

WO2006094445A8 CATALYST FOR OLEFIN POLYMERIZATION AND PREPARATION THEREOF AND POLYMERIZATION PROCESS 审中-公开
标题翻译：烯烃聚合催化剂及其制备方法及聚合方法
公开(公告)号：WO2006094445A8
公开(公告)日：2007-01-04
申请号：PCT/CN2006000274
申请日：2006-02-24
申请人： YINGKOU XIANGYANG CATALYST CO , UNIV DALIAN TECH , WANG LICAI , LI WEI , ZHENG GUOTONG , DONG QINGXIN , WANG JINGZHUANG , CAI SHIMIAN , GAO ZHANXIAN , LIU RIPING , WANG XIAOHUAN , ZHANG NAN
发明人： WANG LICAI , LI WEI , ZHENG GUOTONG , DONG QINGXIN , WANG JINGZHUANG , CAI SHIMIAN , GAO ZHANXIAN , LIU RIPING , WANG XIAOHUAN , ZHANG NAN
IPC分类号： C08F4/65 , B01J21/00 , B01J31/00 , B01J37/00 , C08F2/34 , C08F4/646 , C08F10/00 , C08F210/00
CPC分类号： C08F10/00 , B01J21/063 , B01J35/023 , B01J35/1019 , C08F110/06 , C08F4/6543 , C08F4/651 , C08F4/6545 , C08F2500/15 , C08F2500/18
摘要： The catalyst for olefin polymerization contains three components A, B and C. The component A is a solid catalyst containing titanium, magnesium, chlorine element and an internal electron donor, the internal electron donor consists of 1,4 aromatic diether [2,2'-dialkoxy-1,1'-biphenyl, 2,2'-dialkoxy-1,1'-binaphthalene, 10,10'-dialkoxy-9,9'-biphenanthrene] and organic acid ester or 1,3-diether[9,9-bis (methoxymethyl) fluorene, 2,2-dialkyl-1,3-dimethoxypropane]; the component B is an organoaluminum compound; the component C is external electron donor-organic silicon compound or the 1,4 aromatic diether. The catalyst has high catalytic activity, and can be adjusted in the range from 40,000 to 150,000 gPP/gCat when used in propylene polymerization. The polymer made therefrom has isotacticity of 80 to 99 percent and the molecular weight distribution can be adjusted in a wide range. The invention provides a novel method for preparing the 1,4 aromatic diether.
摘要翻译：用于烯烃聚合的催化剂包含三种组分A，B和C.组分A是含有钛，镁，氯元素和内电子给体的固体催化剂，内部电子给体由1,4芳族二醚[2,2' 二烷氧基-1,1'-联苯，2,2'-二烷氧基-1,1'-联萘，10,10'-二烷氧基-9,9'-联菲]和有机酸酯或1,3-二醚[9 ，9-双（甲氧基甲基）芴，2,2-二烷基-1,3-二甲氧基丙烷]; 组分B是有机铝化合物; 组分C是外电子给体 - 有机硅化合物或1,4-芳族二醚。该催化剂具有高催化活性，当用于丙烯聚合时可以将其调节至40,000至150,000gPP / gCat。由其制备的聚合物具有80-99％的全同立构规整度，并且可以在宽范围内调节分子量分布。本发明提供了一种制备1,4芳族二醚的新方法。

23. 发明申请

WO2013033625A2 SYSTEMS AND METHODS FOR SWITCHING A RELAY AT ZERO CROSS 审中-公开
标题翻译：用于在零交叉点切换继电器的系统和方法
公开(公告)号：WO2013033625A2
公开(公告)日：2013-03-07
申请号：PCT/US2012053509
申请日：2012-08-31
申请人： OSRAM SYLVANIA INC , LI WEI , BLISS CANYON
发明人： LI WEI , BLISS CANYON
CPC分类号： H01H9/56 , H01H47/325 , H01H2009/566
摘要： Circuitry, systems and methods that address the need to coordinate relay switching with another event, such as a zero crossing of an alternating current (AC) voltage waveform are described. In some embodiments, the systems and methods continuously or periodically calibrate the timing of control signals to a relay, such that the switching of the relay in response to some (e.g., second or subsequent) control signals occurs closer in time to a zero crossing of an AC line voltage than the switching of the relay in response to other (e.g., initial or first) control signals.
摘要翻译：描述了解决需要协调继电器切换与另一事件（例如交流（AC）电压波形的过零）的电路，系统和方法。在一些实施例中，系统和方法连续或周期性地对中继器的控制信号的定时校准，使得响应于一些（例如，第二或后续）控制信号的继电器的切换在时间上更接近于零交叉响应于其它（例如，初始或第一）控制信号的继电器的切换而言的AC线电压。

24. 发明申请

WO2011159739A3 REGISTER MAPPING TECHNIQUES FOR EFFICIENT DYNAMIC BINARY TRANSLATION 审中-公开
标题翻译：用于有效动态二进制翻译的注册映射技术
公开(公告)号：WO2011159739A3
公开(公告)日：2012-04-05
申请号：PCT/US2011040406
申请日：2011-06-14
申请人： INTEL CORP , OTTONI GUILHERME D , WANG HONG , LI WEI
发明人： OTTONI GUILHERME D , WANG HONG , LI WEI
IPC分类号： G06F9/45 , G06F9/24 , G06F9/30
CPC分类号： G06F8/441 , G06F9/45525
摘要： Generally, the present disclosure provides a system and method for mapping registers from a system with more registers to a system with fewer registers. Regions may be formed that include one or more blocks of code with relatively frequent register accesses. The most frequently accessed source registers may be mapped to target registers. Each block in the region may be bounded by a prologue and at least one epilogue. The prologue may be configured to implement register mapping and the epilogue(s) may be configured to manage program flow from a block in the region to another block in the region or to a block not in the region.
摘要翻译：通常，本公开提供了一种用于将具有更多寄存器的系统的寄存器映射到具有较少寄存器的系统的系统和方法。可以形成包括具有相对频繁的寄存器访问的一个或多个代码块的区域。最常访问的源寄存器可能被映射到目标寄存器。该区域中的每个块可以由前序和至少一个结尾界定。序言可以被配置为实现寄存器映射，并且结尾可以被配置为管理从该区域中的块到该区域中的另一块或者不在该区域中的块的程序流。

25. 发明申请

WO2010074776A3 COMPOUNDS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症的化合物
公开(公告)号：WO2010074776A3
公开(公告)日：2010-08-19
申请号：PCT/US2009047572
申请日：2009-06-16
申请人： UNIV TENNESSEE RES FOUNDATION , UNIV OHIO STATE RES FOUND , MILLER DUANE D , LI WEI , WANG ZHAO , LU YAN , CHEN JIANJUN , DALTON JAMES T , LI CHIEN-MING
发明人： MILLER DUANE D , LI WEI , WANG ZHAO , LU YAN , CHEN JIANJUN , DALTON JAMES T , LI CHIEN-MING
IPC分类号： A01N43/64 , A61K31/41
CPC分类号： C07D403/04 , A61K31/421 , A61K31/426
摘要： Compounds according to formula (I) are disclosed, (I), where Q is S, N, or O; X is optional, and can be O=, S=, =N-NH2, =N-OH, or -OH; Y is optional and can be -N(H)-, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
摘要翻译：公开了根据式（I）的化合物，（I），其中Q是S，N或O; X是可选的，并且可以是O =，S =，= N-NH 2，= N-OH或-OH; Y是任选的并且可以是-N（H） - ，O或C1至C20烃; 并且R 1和R 2各自独立地为取代或未取代的单环，稠环或多环芳基或（杂）环系。还公开了制备这些化合物的方法，含有该化合物的药物组合物及其用途，特别是用于治疗或预防癌症的用途。

26. 发明申请

WO2008137816A8 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶抑制剂的三聚体化合物
公开(公告)号：WO2008137816A8
公开(公告)日：2010-01-28
申请号：PCT/US2008062593
申请日：2008-05-05
申请人： WYETH CORP , LI WEI , LI JIANCHANG , WU YUCHUAN , WU JUNJUN , HOTCHANDANI RAJEEV , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFADYEN IAIN
发明人： LI WEI , LI JIANCHANG , WU YUCHUAN , WU JUNJUN , HOTCHANDANI RAJEEV , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFADYEN IAIN
IPC分类号： C07D307/91 , A61K31/343 , A61K31/381 , A61P19/00 , A61P35/00 , C07D333/76 , C07D405/04 , C07D405/06 , C07D407/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
CPC分类号： C07D307/91 , C07D333/76 , C07D405/04 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present teachings relate to compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, R4, X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I and methods of inhibiting matrix metalloproteinases, in particular, MMP-12, that may be involved in pathological disorders found in mammals, including a human.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1，R 2，R 3，R 4，X和Y如本文所定义。本教导还提供制备式I化合物的方法和抑制基质金属蛋白酶特别是MMP-12的方法，所述方法可能涉及哺乳动物（包括人）中发现的病理学障碍。

27. 发明申请

WO2009129361A2 MACROCYCLIC COMPOUNDS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：大环化合物及其制备和使用方法
公开(公告)号：WO2009129361A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040747
申请日：2009-04-16
申请人： UNIV UTAH RES FOUND , KECK GARY E , KRAFT MATTHEW B , TRUONG ANH P , SANCHEZ CARINA C , LI WEI , COVEL JONATHAN A , WELCH DENNIE , POUDEL YAM
发明人： KECK GARY E , KRAFT MATTHEW B , TRUONG ANH P , SANCHEZ CARINA C , LI WEI , COVEL JONATHAN A , WELCH DENNIE , POUDEL YAM
IPC分类号： C07D493/22 , A61K31/365 , A61P25/28 , A61P35/00 , C07F7/08
CPC分类号： C07D259/00 , A61K31/351 , A61K31/695 , C07D309/22 , C07D323/00 , C07D471/04 , C07D493/18 , C07D493/22 , C07F7/08 , C07F7/1876 , C07F7/1892
摘要： Described herein are tricyclic macrolactones. The macrolactones have a high binding affinity for PKC. The compounds described herein can be used in a number of therapeutic applications including cancer and Alzheimer's prevention and treatment. The compounds described herein can also treat memory loss. Also described herein are methods for producing macrolactones. The methods permit the high-yield synthesis of macrolactones in fewer steps and with a higher degree of substitution and specificity.
摘要翻译：本文描述的是三环大环内酯。该大环内酯对PKC具有高的结合亲和力。本文所述的化合物可用于许多治疗应用，包括癌症和阿尔茨海默病的预防和治疗。本文所述的化合物还可以治疗记忆丧失。本文还描述了生产羟基己内酯的方法。该方法允许以较少的步骤和更高的取代度和特异性高产率地合成大分子内酯。

28. 发明申请

WO2009072095A3 PAGE INDEXER 审中-公开
公开(公告)号：WO2009072095A3
公开(公告)日：2009-10-15
申请号：PCT/IB2008055666
申请日：2008-12-03
申请人： FRANCE TELECOM , BAJAJ RASHMI , LI WEI
发明人： BAJAJ RASHMI , LI WEI
IPC分类号： G06F17/30
CPC分类号： G06F17/30864 , G06F17/30867
摘要： The invention relates to a method to enhance the relevance of search results provided by a search engine server accessible through an operator network, said method comp rising the acts of: - collecting data related to a subscriber to said operator network, - aggregating said data to built a network profile for said subscriber, - receiving a search query from said subscriber addressed to the search engine server, - transmitting the search query to said search engine server through the network, said query being associated to at least part of the subscriber network profile, - receiving search results from the search engine server, said search results being ranked according to said at least part of the subscriber network profile.
摘要翻译：本发明涉及一种增强搜索引擎服务器提供的搜索结果的相关性的方法，所述搜索引擎服务器通过运营商网络可访问，所述方法提升以下行为： - 将与用户有关的数据收集到所述运营商网络; - 将所述数据聚合到为所述订户建立网络简档， - 从所述订户接收到寻址到搜索引擎服务器的搜索查询， - 通过网络将搜索查询发送到所述搜索引擎服务器，所述查询与至少部分订户网络简档 - 从搜索引擎服务器接收搜索结果，所述搜索结果根据所述至少部分订户网络简档进行排序。

29. 发明申请

WO2009004600A3 BPSK PPM CDMA SYSTEM 审中-公开
标题翻译： BPSK PPM CDMA系统
公开(公告)号：WO2009004600A3
公开(公告)日：2009-03-19
申请号：PCT/IB2008053509
申请日：2008-06-26
申请人： FRANCE TELECOM , LI WEI , BENKO JOHN
发明人： LI WEI , BENKO JOHN
IPC分类号： H04L25/49 , H04B1/707
CPC分类号： H04L25/4902 , H04B1/707 , H04B14/026
摘要： A method and system for modulating a signal includes providing a carrier including periodic waves, peaks of the periodic waves defining a carrier shape of the carrier; changing a plurality of the periodic waves so that peaks of the changed waves form a shaped signal having a signal shape which is different from the carrier shape; and detecting the shaped signal. The system is identical to a BPSK PPM CDMA system.
摘要翻译：用于调制信号的方法和系统包括提供包括周期波的载波，定义载波的载波形状的周期波的峰值; 改变多个周期波，使得改变的波的峰值形成具有不同于载体形状的信号形状的成形信号; 并检测成形信号。该系统与BPSK PPM CDMA系统相同。

30. 发明申请

WO2008057254A2 TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：作为基质金属蛋白酶抑制剂的三聚体化合物
公开(公告)号：WO2008057254A2
公开(公告)日：2008-05-15
申请号：PCT/US2007022651
申请日：2007-10-26
申请人： WYETH CORP , LI WEI , LI JIANCHANG , WU YUCHUAN , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFAYDEN IAIN , HOTCHANDANI RAJEEV , WU JUNJUN
发明人： LI WEI , LI JIANCHANG , WU YUCHUAN , TAM STEVE , MANSOUR TAREK , SYPEK JOSEPH P , MCFAYDEN IAIN , HOTCHANDANI RAJEEV , WU JUNJUN
IPC分类号： C07D307/91 , A61K31/343 , A61K31/381 , A61K31/4155 , A61K31/4192 , A61K31/443 , A61K31/496 , A61K31/5377 , C07D333/76 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04
CPC分类号： C07D307/91 , C07D333/76 , C07D405/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The present invention relates to compositions of the formula (I): and pharmaceutically acceptable salts, hydrates, or esters thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 , X, and Y are as defined herein. The present teachings also provide methods of making the compounds of formula I, and methods of treating pathologic conditions or disorders mediated wholly or in part by matrix metalloproteinases, such as asthma and chronic obstructive pulmonary disease, comprising administering a therapeutically effective amount of a compound of formula (I) to a mammal (e.g., a human) in need thereof.
摘要翻译：本发明涉及式（I）的组合物及其药学上可接受的盐，水合物或酯，其中R 1，R 2，R 3， R 4，R 5，R 5，X和Y如本文所定义。本教导还提供了制备式I化合物的方法，以及治疗由基质金属蛋白酶如哮喘和慢性阻塞性肺疾病全部或部分介导的病理状况或病症的方法，包括给予治疗有效量的式（I）给予有需要的哺乳动物（例如，人）。

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