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21. 发明申请

WO2003055413A2 A SUPPORT FRAME FOR AN EMBOLIC PROTECTION DEVICE 审中-公开
标题翻译：用于防爆装置的支撑框架
公开(公告)号：WO2003055413A2
公开(公告)日：2003-07-10
申请号：PCT/IE2002/000175
申请日：2002-12-23
申请人： SALVIAC LIMITED , BRADY, Eamon , VALE, David , KELLY, Ronald , NEILAN, John , HORAN, Steven , RABITTE, Gerard , MCCAFFREY, Gerry
发明人： BRADY, Eamon , VALE, David , KELLY, Ronald , NEILAN, John , HORAN, Steven , RABITTE, Gerard , MCCAFFREY, Gerry
IPC分类号： A61F2/06
CPC分类号： A61F2/013 , A61B2017/2212 , A61B2017/2215 , A61F2002/016 , A61F2002/018 , A61F2230/0067 , A61F2230/0093
摘要： A support (103) for an embolic protection device comprises round wires (116) which may form one or more support hoops for a filter body. The circumferential hoop formed by the wires (116) ensures that in the expanded position, the filter body (102) will be supported by the support frame (103) in circumferential apposition with the interior wall of the vasculature. The wires (116) may have a strain distributing linkage element in the form of a loop (120) in. The loop (120) acts as a diameter or circumference adjuster allowing an embolic protection device to adapt to different vessel contours and sizes whilst maintaining apposition with the vessel wall. The strain relieving geometry of the loops enhances the compliance of the bend points without creating a weakened hinge point, thus ensuring that there is no discontinuity in the circumferential seal against the vessel wall.
摘要翻译：用于栓塞保护装置的支撑件（103）包括圆形线（116），其可以形成用于过滤器主体的一个或多个支撑环。由电线（116）形成的圆周环保证了在扩张位置，过滤器本体（102）将与支撑框架（103）一起与脉管系统的内壁周向配合地支撑。电线（116）可以具有环形（120）形式的应变分布联动元件。环（120）用作直径或圆周调节器，允许栓塞保护装置适应不同的血管轮廓和尺寸，同时保持与血管壁相连。环的应变消除几何增加弯曲点的顺应性，而不产生削弱的铰链点，从而确保在围绕血管壁的周向密封中不存在中断。

22. 发明申请

WO2018046408A3 A CLOT RETRIEVAL DEVICE FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血管中去除闭塞血栓的血液回收装置
公开(公告)号：WO2018046408A3
公开(公告)日：2018-03-15
申请号：PCT/EP2017/072030
申请日：2017-09-01
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , FAHY, Brian , BRADY, Eamon , HOLIAN, Maeve , KING, Daniel , GILVARRY, Michael , O'GORMAN, Jacqueline
IPC分类号： A61B17/221 , A61B17/3207 , A61B17/22 , A61B90/00
摘要： A clot retrieval device (1) has a clot engaging portion configured at the distal end of an elongate shaft (6) having an outer expandable member (2) comprising multiple expandable segments (26), and an inner expandable member (3) to facilitate restoration of blood flow through clot immediately after the clot retrieval device (1) is deployed at an obstructive site. The outer member (2) and inner expandable (member (3) comprises a collapsed configuration for delivery and an expanded configuration for clot retrieval, flow restoration and fragmentation protection. Proximal radiopaque markers (82) are positioned at the distal end of struts (20) of the outer member (2) just proximal to two proximal crowns (81). This position is advantageous because it denotes the start of the fully expanded diameter of the device, which is the portion of the device that is most desirable to deploy under the clot for optimal grip of the clot.
摘要翻译：（1）具有配置在具有包括多个可膨胀节段（26）的外部可膨胀元件（2）的细长轴（6）的远端处的凝块接合部分，以及内部可膨胀元件（3），以便在凝块取出装置（1）部署在阻塞部位之后立即恢复通过凝块的血流。外部构件2和内部可膨胀构件3包括用于输送的收缩构造和用于凝块收回，流动恢复和碎裂保护的扩张构造。最近的不透射线标记（82）位于支柱（20）的远端）紧邻两个近端冠（81），这个位置是有利的，因为它表示装置的完全扩张直径的开始，该装置是最想要展开的装置的部分凝块的最佳抓地力。

23. 发明申请

WO2017097616A1 DEVICES AND METHODS FOR REMOVAL OF ACUTE BLOCKAGES FROM BLOOD VESSELS 审中-公开
标题翻译：用于从血管中去除急性阻塞的装置和方法
公开(公告)号：WO2017097616A1
公开(公告)日：2017-06-15
申请号：PCT/EP2016/078973
申请日：2016-11-28
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , GILVARRY, Michael , MCARDLE, Kevin , HOLIAN, Maeve , HARDIMAN, David , KEANE, Alan , KING, Daniel , O'GORMAN, Jacqueline , BRADY, Eamon
IPC分类号： A61B17/22 , A61M1/00
CPC分类号： A61B17/22031 , A61B17/22 , A61B17/29 , A61B17/3421 , A61B2017/22034 , A61B2017/22067 , A61B2017/22079 , A61B2017/2212 , A61B2017/2215 , A61B2217/005 , A61M1/008
摘要： A catheter has an expansile tip 901 that can be delivered in a constricted form. The increased tip diameter facilitates the aspiration and removal of large clot volumes by increasing the area of the catheter tip that applies aspiration to the clot. The tip 901 comprises a support frame which can be cut from a metal or polymer tube, covered with a thin polymer sleeve 909 containing highly elastic properties. This construction provides good pushability and high compressive resistance. The cut pattern can contain axial connections of the support frame 908 and ring members 906, which will provide a large level of axial support, lateral flexibility and hoop strength to withstand aspiration. The tip of the device can contain a section 907 proximal of the highly flexible area 905 that can expand to except clot. This potential to increase body diameter facilitates the retrieval of large volume clots while the construction of the catheter provides good column stiffness to avoid axial collapse and still maintain good flexibility.
摘要翻译：导管具有可以收缩形式递送的可膨胀尖端901。增加的尖端直径通过增加导管尖端的适用于凝块的抽吸区域来促进大量凝块体积的抽吸和去除。尖端901包括支撑框架，该支撑框架可以由金属或聚合物管切割，覆盖有包含高度弹性特性的薄聚合物套筒909。这种结构提供了良好的可推送性和高抗压性。切割图案可以包含支撑框架908和环形构件906的轴向连接，这将提供大水平的轴向支撑，侧向柔性和箍强度以抵抗抽吸。装置的尖端可以包含高度柔性区域905的近端部分907，其可以膨胀至除凝块外。这种增加身体直径的可能性有助于取回大体积凝块，而导管的构造提供良好的柱刚度以避免轴向坍塌并仍保持良好的柔韧性。

24. 发明申请

WO2020039082A1 APPARATUS FOR MANAGING ACUTE ISCHEMIC EVENTS 审中-公开
公开(公告)号：WO2020039082A1
公开(公告)日：2020-02-27
申请号：PCT/EP2019/072613
申请日：2019-08-23
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , MIRZA, Mahmood , MCCARTHY, Ray
IPC分类号： A61B17/22 , A61B17/221 , A61M25/01
摘要： A method for managing one or more acute ischemic events. The method can include determining criteria of a clot; classifying the clot based on the criteria and generating a classification; determining an individualized treatment protocol for the clot based on the classification, the individualized treatment protocol comprising one or more techniques selected from using aspiration, restoring perfusion using a first reperfusion device, and/or restoring perfusion using a second reperfusion device; and treating the clot based on the individualized treatment protocol.

25. 发明申请

WO2018033401A1 A CLOT RETRIEVAL SYSTEM FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血管中清除堵塞物的CLOT RETRIEVAL系统
公开(公告)号：WO2018033401A1
公开(公告)日：2018-02-22
申请号：PCT/EP2017/069668
申请日：2017-08-03
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , FAHY, Brian , MCARDLE, Kevin , BRADY, Eamon , AMSTUTZ, Jill , HOLIAN, Maeve , KING, Daniel , GILVARRY, Michael
IPC分类号： A61B17/22 , A61B17/221 , A61M25/10
摘要： A clot capture catheter comprises an elongate tubular shaft having a proximal end, a distal end and an inflatable expansile member at the distal end. The expansile member is inflatable from a collapsed delivery configuration to an expanded configuration. In the expanded configuration, the expansile member extends to define a funnel shape having an enlarged distal clot entry mouth at the distal-most end of the catheter. In the expanded configuration, the expansile member may extend distally beyond the distalmost tip of the shaft. The expansile member may be integral with the distal tip of the catheter shaft.
摘要翻译：凝块捕获导管包括具有近端，远端和位于远端处的可膨胀的可膨胀构件的细长管状轴。膨胀构件可从收缩的输送构造膨胀成膨胀构造。在膨胀构型中，可膨胀构件延伸以限定漏斗形状，所述漏斗形状在导管的最远端具有扩大的远端凝块进入口。在扩张构型中，可扩张构件可以向远侧延伸超过轴的最远侧尖端。扩张件可以与导管轴的远端尖端成一体。

26. 发明申请

WO2014140090A1 A CLOT REMOVAL DEVICE 审中-公开
标题翻译： CLOT移除装置
公开(公告)号：WO2014140090A1
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054826
申请日：2014-03-12
申请人： NEURAVI LIMITED
发明人： BRADY, Eamon , CASEY, Brendan , GILVARRY, Michael , VALE, David
IPC分类号： A61B17/221 , A61B17/00
CPC分类号： A61B17/22031 , A61B17/221 , A61B2017/00309 , A61B2017/00336 , A61B2017/00853 , A61B2017/00858 , A61B2017/22001 , A61B2017/2215 , A61B2090/08021
摘要： A clot retrieval system comprises a clot retrieval device, a catheter 51, and a tubular shield element 61. The clot retrieval device comprises an elongate member 53 having a proximal end and a distal end, and a clot engaging element 54 at the distal end of the elongate member 53 the clot engaging element 54 having a collapsed delivery configuration and an expanded deployed configuration. The catheter is adapted for placement at a location at which a distal end of the catheter is proximal of the clot engaging element and the tubular shield element 61 extends over the elongate member 53 and is adapted for location between the distal end of the catheter and the proximal end of the clot engaging element 54. The tubular shield element 61 is movable relative to the elongate member 54 when the clot engaging element is in the expanded configuration in that the force that is applied on retraction of the elongate member is spread over the outer surface of the tubular shield element. The force that would usually be exerted on vessels on retrieval of the clot engaging element is spread by the shield element thus reducing the effects of abrasion.
摘要翻译：凝块回收系统包括凝块取回装置，导管51和管状屏蔽元件61.凝块回收装置包括具有近端和远端的细长构件53和在远端处的血块接合元件54 细长构件53具有折叠输送构型的凝块接合元件54和扩展的展开构型。导管适于放置在导管远端处于凝块接合元件的近侧的位置处，并且管状屏蔽元件61延伸在细长构件53上并且适于位于导管的远端和凝块接合元件54的近端。当凝块接合元件处于膨胀构型时，管状屏蔽元件61可相对于细长构件54移动，因为在细长构件缩回时施加的力分布在外部管状屏蔽元件的表面。通常在血管接合元件回收时对血管施加的力由屏蔽元件扩散，从而减少磨损的影响。

27. 发明申请

WO2016083472A1 A CLOT RETRIEVAL DEVICE FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血液瓶中移除堵塞物的衣服检索装置
公开(公告)号：WO2016083472A1
公开(公告)日：2016-06-02
申请号：PCT/EP2015/077692
申请日：2015-11-25
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , GILVARRY, Michael , O'GORMAN, Jacqueline , MCARDLE, Kevin
IPC分类号： A61B17/221 , A61F2/01 , A61B17/3207
CPC分类号： A61B17/221 , A61B17/320725 , A61B2017/00327 , A61B2017/22034 , A61B2017/2215 , A61F2/013 , A61F2002/016 , A61F2230/008 , A61F2230/0091
摘要： A clot retrieval device for removal of occlusive clot from a blood vessel comprises a clot engaging element (700) having a constrained delivery configuration and an expanded deployed configuration. In the expanded configuration peripheral portions are laterally spaced-apart and the clot engaging section (700) extends between the peripheral portions. The device (700) may have two superimposed wave patterns provided by a large amplitude curve (723) and shorter pitch sinusoidal patterns (721, 722). A wave shape varies the contact pressure between a clot and the device along the length of the device, reducing the compression of the clot by the device at some locations. The device can elongate when placed under tension which aids elongation of the clot during dislodgement.
摘要翻译：用于从血管去除闭塞凝块的凝块取回装置包括具有约束输送构型和扩张部署构型的凝块接合元件（700）。在扩展构造中，外围部分横向间隔开，并且凝块接合部分（700）在周边部分之间延伸。装置（700）可以具有由大振幅曲线（723）和较短音调正弦曲线（721,722）提供的两个叠加波形图案。波形沿着装置的长度改变凝块和装置之间的接触压力，从而减少在某些位置处装置对凝块的压缩。该装置在放置在张力下时可以伸长，这有助于在移动期间凝块的伸长。

28. 发明申请

WO2015189354A1 DEVICES FOR REMOVAL OF ACUTE BLOCKAGES FROM BLOOD VESSELS 审中-公开
标题翻译：从血液管中移除急性阻塞的装置
公开(公告)号：WO2015189354A1
公开(公告)日：2015-12-17
申请号：PCT/EP2015/063104
申请日：2015-06-11
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , GILVARRY, Michael , MCARDLE, Kevin , HOLIAN, Maeve , HARDIMAN, David , KEANE, Alan , KING, Daniel
IPC分类号： A61B17/22
CPC分类号： A61B17/22032 , A61B17/22 , A61B17/221 , A61B2017/00778 , A61B2017/22051 , A61B2017/22067 , A61B2017/22079 , A61B2017/2215 , A61B2017/3435 , A61M1/0031 , A61M1/008 , A61M25/0082 , A61M2210/12
摘要： A catheter 101 provides a proximal seal 102 against a guide catheter inner lumen 103 so that aspiration may be applied through a guide catheter 108 and thus take advantage of the large proximal lumen. The catheter 101 is a rapid exchange (RX) catheter with an exit port 105 that defines a transfer port for aspiration and provides a deliverability advantage of minimal frictional engagement with the guide catheter 108 proximal of the exit port 105. Aspiration can be applied to the lumen of the guide catheter 108 and is directed to and effective at the tip of the Rx aspiration catheter 101 due to the presence of flow a restrictor or seal 102 between the outer surface of the Rx aspiration catheter 101 and the inner guide catheter 108. This seals the lumen between the outside of the Rx aspiration catheter 101 and the inner surface of the guide catheter 03 and prevents backflow of blood into the tip of guide catheter 108 reducing the effectiveness of the aspiration. An expansile tip 112 of the Rx catheter 101 facilitates aspiration and retrieval of the clot 110 by expanding under load. The expansile tip 112 can also partially or fully occlude the vessel providing flow arrest and thereby improving aspiration effectiveness.
摘要翻译：导管101提供靠近引导导管内腔103的近端密封件102，使得可以通过引导导管108施加抽吸，从而利用大的近端内腔。导管101是具有限定用于抽吸的传送端口的出口105的快速交换（RX）导管，并提供与出口端口105附近的引导导管108的最小摩擦接合的可传送性优点。吸入可应用于由于在Rx吸液导管101的外表面和内引导导管108之间存在限流器或密封件102，所以引导导管108的内腔被引导并且有效地在Rx抽吸导管101的尖端处。密封Rx吸液导管101的外侧和引导导管03的内表面之间的内腔，并防止血液回流到引导导管108的顶端，从而降低吸气的效果。 Rx导管101的扩张尖端112有助于通过在负载下扩张来抽吸和取出凝块110。膨胀尖端112还可以部分地或完全地封闭提供流动停止的血管，从而改善吸气效果。

29. 发明申请

WO2017089424A1 A CLOT RETRIEVAL DEVICE FOR REMOVING OCCLUSIVE CLOT FROM A BLOOD VESSEL 审中-公开
标题翻译：一种用于从血管中去除闭塞血栓的血液回收装置
公开(公告)号：WO2017089424A1
公开(公告)日：2017-06-01
申请号：PCT/EP2016/078595
申请日：2016-11-23
申请人： NEURAVI LIMITED
发明人： VALE, David , CASEY, Brendan , GILVARRY, Michael , O'GORMAN, Jacqueline , KING, Daniel , MCARDLE, Kevin , FAHY, Brian
IPC分类号： A61B17/221
CPC分类号： A61B17/221 , A61B17/3207 , A61B2017/22034
摘要： A clot removal device (2000) for removing clot from a body vessel comprises an expandable structure and an elongate member. The expandable structure has a constrained delivery configuration, an expanded clot engaging deployed configuration, and an at least partially constrained clot pinching configuration. At least a portion of the expandable structure is configured to engage clot in the expanded deployed configuration and to pinch clot on movement from the deployed configuration to the clot capture configuration. The expandable structure may comprise a main body portion (2002) and a clot pinching structure (2001) and wherein a diameter of the clot pinching structure (2001) is less than a diameter of the main body portion (2002). The clot pinching structure in some cases is substantially tubular and may be of spiral form.
摘要翻译：用于从体内血管去除凝块的凝块去除装置（2000）包括可膨胀结构和细长构件。可膨胀结构具有受限输送构型，膨胀的凝块接合展开构型和至少部分受限的凝块捏挟构型。可扩张结构的至少一部分被配置为在扩张的展开构型中接合凝块并且在从展开构型移动到凝块捕获构型时夹住凝块。可扩张结构可以包括主体部分（2002）和凝块夹紧结构（2001），并且其中凝块夹紧结构（2001）的直径小于主体部分（2002）的直径。在某些情况下，凝块夹紧结构基本上是管状的，并且可以是螺旋形式。

30. 发明申请

WO2014140092A2 DEVICES AND METHODS FOR REMOVAL OF ACUTE BLOCKAGES FROM BLOOD VESSELS 审中-公开
标题翻译：从血管中移除急性阻塞的装置和方法
公开(公告)号：WO2014140092A2
公开(公告)日：2014-09-18
申请号：PCT/EP2014/054828
申请日：2014-03-12
申请人： NEURAVI LIMITED
发明人： BRADY, Eamon , CASEY, Brendan , GILVARRY, Michael , HARDIMAN, David , VALE, David
IPC分类号： A61B17/221
CPC分类号： A61B17/221 , A61B2017/00526 , A61B2017/00867 , A61B2017/00942 , A61B2017/00951 , A61B2017/22034 , A61B2017/2212 , A61B2017/2217 , A61B2090/3966 , A61L31/022 , B05D1/322 , B05D3/12
摘要： A clot retrieval device comprises an elongate shaft (104) and an expandable clot retrieval element (2101) on the shaft, the clot retrieval element comprising a framework formed from a substrate material such as Nitinol and having a plurality of struts (2105) and crowns (2102), at least some of the struts (2105) comprises at least one widened portion (2104) of the substrate material to provide enhanced radiopacity. The framework is coated with a radiopaque material such as gold. The device is rendered radiopaque with reduced damping effects.
摘要翻译：凝块取出装置包括在轴上的细长轴（104）和可膨胀的凝块回缩元件（2101），所述凝块回收元件包括由诸如镍钛诺的基底材料形成的骨架，并且具有多个支柱（2105）和冠（2102）中，所述支柱（2105）中的至少一些包括所述基底材料的至少一个加宽部分（2104），以提供增强的不透射线性。该框架涂有不透射线的材料，例如金。该设备被渲染为不透射线，减少了阻尼效应。

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