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21. 发明申请

WO2006029107A2 HEAT-RADIATING DEVICE WITH A GUIDE STRUCTURE 审中-公开
标题翻译：具有导向结构的热辐射装置
公开(公告)号：WO2006029107A2
公开(公告)日：2006-03-16
申请号：PCT/US2005031602
申请日：2005-09-06
申请人： MOLEX INC , ZHANG JIE
发明人： ZHANG JIE
CPC分类号： G06F1/20 , F28F3/02 , F28F13/06 , H01L23/3672 , H01L2924/0002 , H01L2924/00
摘要： A heat-radiating device with a guide includes a radiator and a fan. The radiator includes a base and a plurality of radiating fins protruding upward from the top surface of the base. The fan is mounted to one side of the radiator, the air flow from the fan passes through the air gap between two adjacent radiating fins so as to flow out from the side opposite the fan. These radiating fins is protruded bently toward its one side to form a guide structure which inclines from the further side of the base to the closer side of the base in the air flow direction so that the air flow flows downward to the heated electronic elements to radiate heat for them. The guide structure of the present invention is formed integrally with the radiating fins, thus advantages of low cost and easy manufacture are obtained.
摘要翻译：具有导轨的散热装置包括散热器和风扇。散热器包括基座以及从基座的上表面向上突出的多个散热片。风扇安装在散热器的一侧，来自风扇的气流经过两个相邻散热片之间的气隙，从而从风扇对面的一侧流出。这些散热片向其一侧倾斜地突出以形成引导结构，该引导结构从空气流动方向上的基座的另一侧向基座的较近侧倾斜，使得气流向下流动到加热的电子元件以辐射为他们加热。本实用新型的导向结构与散热片一体成型，具有低成本，易于制造的优点。

22. 发明申请

WO2005053609A3 METHODS OF NAD+-DEPENDENT DEACETYLASE INHIBITORS 审中-公开
标题翻译： NAD +依赖性脱乙酰酶抑制剂的方法
公开(公告)号：WO2005053609A3
公开(公告)日：2005-09-01
申请号：PCT/US2004039220
申请日：2004-11-23
申请人： GUILFORD PHARM INC , ZHANG JIE , XU WEIZHENG
发明人： ZHANG JIE , XU WEIZHENG
IPC分类号： A61K20060101 , A61K31/12 , A61K31/38 , A61K31/54
CPC分类号： A61K31/54 , A61K31/12 , A61K31/38
摘要： The present invention relates to methods of treating cancer, cardiovascular disorders, and neurological disorders using NAD+-dependent deacetylase inhibitors.
摘要翻译：本发明涉及使用NAD +依赖性脱乙酰酶抑制剂治疗癌症，心血管病症和神经病症的方法。

23. 发明申请

WO2005056020A3 NF-KB OLIGONUCLEOTIDE DECOY MOLECULES 审中-公开
标题翻译： NF-κB寡核苷酸decoy分子
公开(公告)号：WO2005056020A3
公开(公告)日：2005-08-04
申请号：PCT/US2004040673
申请日：2004-12-02
申请人： CORGENTECH INC , MCEVOY LESLIE M , PARHAM CHRISTI , ZHANG JIE
发明人： MCEVOY LESLIE M , PARHAM CHRISTI , ZHANG JIE
IPC分类号： A61K48/00 , C07H21/04 , C12N15/113 , C12N15/115 , A61K31/70
CPC分类号： C12N15/115 , C12N15/113 , C12N2310/13 , C12N2310/315 , C12N2310/345 , C12N2310/53
摘要： The present invention concerns double-stranded NF-KB decoy oligodeoxynucleotide (NF-KB dsODN) molecules that contain a core sequence capable of specific binding to an NF-KB transcription factor. In a particular aspect, the invention concerns NF-KB decoy molecules that preferentially bind p50/p65 and/or cRel/p50 heterodimers over p50/p50 homodimers. In another aspect, the invention concerns NF-KB decoy molecules with improved binding affinity to p65.
摘要翻译：本发明涉及含有能够与NF-κB转录因子特异性结合的核心序列的双链NF-κB诱饵寡脱氧核苷酸（NF-KB dsODN）分子。在一个特定的方面，本发明涉及相对于p50 / p50同型二聚体优先结合p50 / p65和/或cRel / p50异二聚体的NF-κB诱饵分子。另一方面，本发明涉及对p65具有改善的结合亲和力的NF-κB诱饵分子。

24. 发明申请

WO0153454A9 METHODS AND MATERIALS RELATING TO G PROTEIN-COUPLED RECEPTOR-LIKE POLYPEPTIDES AND POLYNUCLEOTIDES 审中-公开
标题翻译：与G蛋白偶联受体多聚体和多核苷酸相关的方法和材料
公开(公告)号：WO0153454A9
公开(公告)日：2002-12-05
申请号：PCT/US0034983
申请日：2000-12-22
申请人： HYSEQ INC , YAMAZAKI VICTORIA , TANG Y TOM , LIU CHENGHUA , ZHOU PING , WANG DUNRUI , ZHANG JIE , REN FEIYAN , ASUNDI VINOD , DRMANAC RADOJE T
发明人： YAMAZAKI VICTORIA , TANG Y TOM , LIU CHENGHUA , ZHOU PING , WANG DUNRUI , ZHANG JIE , REN FEIYAN , ASUNDI VINOD , DRMANAC RADOJE T
IPC分类号： C07K14/47 , C07K14/705 , C07K14/775 , C07H21/02 , C07H21/04 , C12N5/10 , C12N15/09
CPC分类号： C07K14/47 , A61K2039/505 , C07K14/705 , C07K14/775
摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted GPCR-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA libraries from human leukocyte mRNA (GIBCO Laboratories) (SEQ ID NO: 1), from human adult liver mRNA (GIBCO) (SEQ ID NO: 10); from human adult kidney mRNA (GIBCO) (SEQ ID NO: 17); from human adult brain mRNA (GIBCO) (SEQ ID NO: 26) and from human adult kidney mRNA (Invitrogen) (SEQ ID NO: 33). Other aspects of the invention include vectors containing processes for producing novel human secreted GPCR-like polypeptides, and antibodies specific for such polypeptides.
摘要翻译：本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，以及与新型人分泌的GPCR样多肽相对应的突变体或其变体。这些多核苷酸包含从人成年肝mRNA（GIBCO）（SEQ ID NO：10）中分离自人白细胞mRNA（GIBCO Laboratories）（SEQ ID NO：1）的cDNA文库的核酸序列; 来自人成年肾mRNA（GIBCO）（SEQ ID NO：17）; 来自人成年大脑mRNA（GIBCO）（SEQ ID NO：26）和人成年肾mRNA（Invitrogen）（SEQ ID NO：33）。本发明的其它方面包括含有产生新型人类分泌的GPCR样多肽的方法的载体和对这些多肽具有特异性的抗体。

25. 发明申请

WO0191796A8 METHODS, COMPOUNDS AND COMPOSITIONS FOR TREATING GOUT 审中-公开
标题翻译：方法，用于处理GOUT的化合物和组合物
公开(公告)号：WO0191796A8
公开(公告)日：2002-05-23
申请号：PCT/US0117686
申请日：2001-06-01
申请人： GUILFORD PHARM INC , ZHANG JIE , LI JIA HE
发明人： ZHANG JIE , LI JIA-HE
IPC分类号： A61K31/00 , A61K31/47
CPC分类号： A61K31/47 , A61K31/00
摘要： L'invention concerne des méthodes de prévention, de traitement ou de réduction de la gravité de la goutte par administration d'inhibiteurs PARP.

26. 发明申请

WO0218424A2 NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
公开(公告)号：WO0218424A2
公开(公告)日：2002-03-07
申请号：PCT/US0127093
申请日：2001-08-31
申请人： HYSEQ INC , TANG Y TOM , ASUNDI VINOD , ZHOU PING , XUE AIDONG J , REN FEIYAN , ZHANG JIE , WANG JIAN RUI , ZHAO QING A , WANG DUNRUI , LIU CHENGHUA , DRMANAC RADOJE T , WEHRMAN TOM
发明人： TANG Y TOM , ASUNDI VINOD , ZHOU PING , XUE AIDONG J , REN FEIYAN , ZHANG JIE , WANG JIAN-RUI , ZHAO QING A , WANG DUNRUI , LIU CHENGHUA , DRMANAC RADOJE T , WEHRMAN TOM
IPC分类号： A61K38/00 , C07K14/47 , C12N15/12 , C07K14/00
CPC分类号： C07K14/47 , A61K38/00
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.

27. 发明申请

WO0039104A9 PHENAZINE COMPOUNDS, METHODS AND PHARMACEUTICAL COMPOSITIONS FOR INHIBITING PARP 审中-公开
标题翻译： PHENAZINE化合物，用于抑制PARP的方法和药物组合物
公开(公告)号：WO0039104A9
公开(公告)日：2001-08-16
申请号：PCT/US9930979
申请日：1999-12-28
申请人： GUILFORD PHARM INC , ZHANG JIE , TAYS KEVIN LEONARD , LI JIA HE
发明人： ZHANG JIE , TAYS KEVIN LEONARD , LI JIA-HE
IPC分类号： A61P39/00 , C07D241/46 , C07D405/12 , C07D417/12 , A61K31/498
CPC分类号： C07D405/12 , C07D241/46 , C07D417/12
摘要： This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of formula (I) wherein R1-R9 and Z are independently hydrogen, hydroxy, halo, haloalkyl, thiocarbonyl, cyano, nitro, amino, imino, alkylamino, aminoalkyl, sulfhydryl, thioalkyl, alkylthio, sulfonyl, alkylsulfonyl, C1-C9 straight or branched chain alkyl, C2-C9 straight or branched chain alkenyl, C2-C9 straight or branched chain alkynyl, C1-C6 straight or branched chain alkoxy, C2-C6 straight or branched chain alkenoxy, C2-C6 straight or branched chain alkynoxy, aryl, carbocycle, heterocycle, aralkyl, alkylaryl, alkylaryloxy, aryloxy, aralkyloxy, aralkylsulfonyl, aralkylamino, arylamino, arylazo, arylthio, or aralkylthio; or Z is formula (II) wherein U is C or N, and R7 and R8 are defined above; and X and Y are independently aryl, carbocycle, or heterocycle.
摘要翻译：本发明涉及使用式（I）化合物的化合物，药物组合物和方法，其中R 1 -R 9和Z独立地是氢，羟基，卤素，卤代烷基，硫代羰基，氰基，硝基，氨基，亚氨基，烷基氨基，氨基烷基，巯基烷硫基，磺酰基，烷基磺酰基，C1-C9直链或支链烷基，C2-C9直链或支链烯基，C2-C9直链或支链炔基，C1-C6直链或支链烷氧基，C2-C6直链或支链烯氧基，C 2 -C 6直链或支链炔氧基，芳基，碳环，杂环，芳烷基，烷基芳基，烷芳基氧基，芳氧基，芳烷氧基，芳烷基磺酰基，芳烷基氨基，芳基氨基，芳基偶氮，芳硫基或芳烷硫基。或Z是式（II）其中U是C或N，并且R7和R8如上定义; X和Y独立地是芳基，碳环或杂环。

28. 发明申请

WO2007070695A3 FLUX-ENABLING COMPOSITIONS AND METHODS FOR DERMAL DELIVERY OF DRUGS 审中-公开
标题翻译：助燃剂组合物和用于药物递送的方法
公开(公告)号：WO2007070695A3
公开(公告)日：2008-08-21
申请号：PCT/US2006048061
申请日：2006-12-14
申请人： ZARS INC , ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
发明人： ZHANG JIE , WARNER KEVIN S , SHARMA SANJAY
IPC分类号： A61K8/02 , A61F13/00
CPC分类号： A61K9/7015 , A61K9/0014 , A61K9/0017
摘要： The present invention is drawn to adhesive solidifying formulations, methods of drug delivery, and solidified layers for dermal delivery of a drug. The formulation can include a drug, a solvent vehicle, and a solidifying agent. The solvent vehicle can include a volatile solvent system comprising at least one volatile solvent, and a non-volatile solvent system comprising at least one non-volatile solvent, wherein at least one non-volatile solvent is a flux-enabling non-volatile solvent(s) capable of facilitating the delivery of the drug at therapeutically effective rates over a sustained period of time. The formulation can have a viscosity suitable for application to a skin surface prior to evaporation of the volatile solvents system. When applied to the skin, the formulation can form a solidified layer after at least a portion of the volatile solvent system is evaporated.
摘要翻译：本发明涉及粘合剂凝固制剂，药物递送方法和用于药物真皮递送的固化层。制剂可以包括药物，溶剂载体和固化剂。溶剂载体可以包括包含至少一种挥发性溶剂的挥发性溶剂体系和包含至少一种非挥发性溶剂的非挥发性溶剂体系，其中至少一种非挥发性溶剂是助熔剂非挥发性溶剂（ s），其能够在持续的时间段内以治疗有效率促进药物的递送。在挥发性溶剂体系蒸发之前，配方可以具有适用于皮肤表面的粘度。当施用于皮肤时，在挥发性溶剂体系的至少一部分蒸发后，制剂可以形成固化层。

29. 发明申请

WO2004009834A3 NOVEL NUCLEIC ACIDS AND SECRETED POLYPEPTIDES 审中-公开
标题翻译：新型核酸和分泌多糖
公开(公告)号：WO2004009834A3
公开(公告)日：2007-09-20
申请号：PCT/US0222858
申请日：2002-07-19
申请人： NUVELO INC , TANG Y TOM , YANG YONGHONG , WENG GEZHI , ZHANG JIE , REN FEIYAN , XUE AIDONG , WANG JIAN-RUI , WEHRMAN TOM , GHOSH MALABIKA J , WANG DUNRUI , ZHAO QING A , WANG ZHIWEI
发明人： TANG Y TOM , YANG YONGHONG , WENG GEZHI , ZHANG JIE , REN FEIYAN , XUE AIDONG , WANG JIAN-RUI , WEHRMAN TOM , GHOSH MALABIKA J , WANG DUNRUI , ZHAO QING A , WANG ZHIWEI
IPC分类号： C07K5/00 , A61K38/00 , C07H21/00 , C07H21/04 , C07K14/47 , C07K14/705 , C07K14/715 , C07K14/81 , C07K16/00 , C12N9/16 , C12N9/64 , C12Q1/68
CPC分类号： C07K14/70503 , A61K38/00 , A61K2039/505 , C07K14/47 , C07K14/715 , C07K14/8107 , C07K16/00 , C12N9/16 , C12N9/6432 , C12Q1/6886 , C12Y304/21006
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译：本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。

30. 发明申请

WO0187917A8 NOVEL NUCLEIC ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：新型核酸和多糖
公开(公告)号：WO0187917A8
公开(公告)日：2007-07-19
申请号：PCT/US0114826
申请日：2001-05-16
申请人： HYSEQ INC , TANG Y TOM , ASUNDI VINOD , ZHOU PING , XUE AIDONG J , REN FEIYAN , ZHANG JIE , WANG JIAN-RUI , YANG YONGHONG , ZHAO QING A , GOODRICH RYLE W , LIU CHENGHUA , DRMANAC RADOJE T , WEHRMAN TOM , CHEN RUI-HONG
发明人： TANG Y TOM , ASUNDI VINOD , ZHOU PING , XUE AIDONG J , REN FEIYAN , ZHANG JIE , WANG JIAN-RUI , YANG YONGHONG , ZHAO QING A , GOODRICH RYLE W , LIU CHENGHUA , DRMANAC RADOJE T , WEHRMAN TOM , CHEN RUI-HONG
IPC分类号： A61K38/00 , C07K14/47
CPC分类号： C07K14/47 , A61K38/00 , A61K2039/505
摘要： The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
摘要翻译：本发明提供了新的核酸，由这些核酸编码的新的多肽序列及其用途。

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