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21. 发明申请

WO2006064274A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006064274A3
公开(公告)日：2007-05-31
申请号：PCT/GB2005004902
申请日：2005-12-16
申请人： MICROMASS LTD , GILES KEVIN
发明人： GILES KEVIN
IPC分类号： H01J49/04 , H01J49/42
CPC分类号： H01J49/062 , Y10T29/49165
摘要： A mass spectrometer is disclosed comprising an ion guide. The ion guide comprises a hollow tubular conductor (1) having a wall. One or more electrodes are provided in the wall of the tubular conductor (1). An exit aperture (3) is provided in the wall of the tubular conductor (1) downstream of the one or more electrodes (2). An AC or RF voltage is applied to the one or more electrodes (2) and a DC potential difference is maintained between the wall of the tubular conductor (1) and the one or more electrodes (2). The combination of a DC voltage gradient and applying an AC or RF voltage to the electrodes (2) is that ions are confined radially to a region which is preferably close to the one or more electrodes (2). Ions are preferably extracted from the ion guide via the exit aperture (3) by maintaining a pressure gradient between the inside of the tubular conductor (1) and the outside of the tubular conductor (1) and/or by maintaining a DC electric field which acts to extract ions through the exit aperture (3).
摘要翻译：公开了包括离子导向器的质谱仪。离子导向器包括具有壁的中空管状导体（1）。一个或多个电极设置在管状导体（1）的壁中。在一个或多个电极（2）的下游，在管状导体（1）的壁上设置出口孔（3）。对一个或多个电极（2）施加AC或RF电压，并且在管状导体（1）的壁和一个或多个电极（2）之间保持DC电位差。直流电压梯度和向电极（2）施加AC或RF电压的组合是离子被限制在优选地接近一个或多个电极（2）的区域。离子优选通过出口孔（3）从管状导体（1）的内部和管状导体（1）的外部之间保持压力梯度和/或通过维持DC电场而从离子导向器中提取出来，用于通过出口孔（3）提取离子。

22. 发明申请

WO2013005060A3 PHOTO-DISSOCIATION OF PROTEINS AND PEPTIDES IN A MASS SPECTROMETER 审中-公开
标题翻译：质谱仪中蛋白质和肽的光解离
公开(公告)号：WO2013005060A3
公开(公告)日：2013-07-04
申请号：PCT/GB2012051609
申请日：2012-07-06
申请人： MICROMASS LTD , KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH , GILES KEVIN , BROWN JEFFERY MARK
发明人： KENNY DANIEL JAMES , MURRAY PAUL , RICHARDSON KEITH , GILES KEVIN , BROWN JEFFERY MARK
IPC分类号： H01J49/00
CPC分类号： H01J49/0059 , G01N27/624 , H01J49/0027 , H01J49/0031 , H01J49/062 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/422 , H01J49/4245
摘要： A method of mass spectrometry is disclosed comprising automatically and repeatedly performing multiple cycles of operation, wherein a cycle of operation comprises the steps of: (i) mass analysing first ions; (ii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions and mass analysing the second ions; and (iii) exposing the first ions to a first photo-dissociation device to form a plurality of second ions, fragmenting the second ions to form a plurality of third ions and mass analysing the third ions.
摘要翻译：公开了质谱法，包括自动重复执行多个操作循环，其中操作循环包括以下步骤：（i）质量分析第一离子; （ii）将所述第一离子暴露于第一光离解装置以形成多个第二离子并对所述第二离子进行质量分析; 和（iii）将第一离子暴露于第一光离解装置以形成多个第二离子，将第二离子碎裂以形成多个第三离子并且质量分析第三离子。

23. 发明申请

WO2006085110A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006085110A3
公开(公告)日：2007-07-26
申请号：PCT/GB2006000504
申请日：2006-02-14
申请人： MICROMASS LTD , GILES KEVIN
发明人： GILES KEVIN
IPC分类号： H01J49/42 , H01J49/00 , H01J49/04
CPC分类号： H01J49/065 , G01N27/624
摘要： A device (6) for separating ions according to differences in their ion mobility as a function of electric field strength is disclosed. The device (6) comprises an upper electrode (7a), a lower electrode (7b) and a plurality of intermediate electrodes (8). An asymmetric voltage waveform is applied to the upper electrode (7a) and a DC compensating voltage is applied to the lower electrode (7b).
摘要翻译：公开了一种用于根据离子迁移率的差异分离离子作为电场强度的函数的装置（6）。装置（6）包括上电极（7a），下电极（7b）和多个中间电极（8）。对上部电极（7a）施加非对称电压波形，向下部电极（7b）施加直流补偿电压。

24. 发明申请

WO2014140546A3 TOROIDAL TRAPPING GEOMETRY PULSED ION SOURCE 审中-公开
公开(公告)号：WO2014140546A3
公开(公告)日：2016-06-09
申请号：PCT/GB2014050704
申请日：2014-03-10
申请人： MICROMASS LTD
发明人： GILES KEVIN , GREEN MARTIN RAYMOND , WILDGOOSE JASON LEE
IPC分类号： H01J49/42
CPC分类号： H01J49/423 , H01J49/40 , H01J49/427 , H01J49/4295
摘要： An ion trap is disclosed comprising: a plurality of electrodes (4) which define a toroidal or annular ion confining volume that extends around a central axis; a first device arranged and adapted to apply one or more DC voltages to said plurality of electrodes (4) in order to generate a DC potential well which acts to confine ions in a radial direction within said toroidal or annular ion confining volume, wherein said radial direction is substantially perpendicular to said central axis; and a control system arranged and adapted to non-mass selectively eject ions from said toroidal or annular ion confining volume. The ion trap enables a large number of ions to be trapped and ejected simultaneously.
摘要翻译：公开了一种离子阱，其包括：多个电极（4），其限定围绕中心轴线延伸的环形或环形离子约束体积; 布置并适于将一个或多个DC电压施加到所述多个电极（4）的第一装置，以便产生用于在所述环形或环形离子约束体积内沿径向限制离子的DC势阱，其中所述径向方向基本上垂直于所述中心轴线; 以及布置和适于非质量地选择性地从所述环形或环形离子限制体积排出离子的控制系统。离子阱能使大量离子同时被捕获和排出。

25. 发明申请

WO2015071648A3 ION TRAP MASS SPECTROMETERS 审中-公开
标题翻译：离子阱质谱仪
公开(公告)号：WO2015071648A3
公开(公告)日：2015-11-26
申请号：PCT/GB2014053334
申请日：2014-11-11
申请人： MICROMASS LTD
发明人： GILES KEVIN , GREEN MARTIN RAYMOND , RICHARDSON KEITH , WILDGOOSE JASON LEE
IPC分类号： H01J49/00 , G01N27/62
CPC分类号： H01J49/06 , G01N27/622 , H01J49/004 , H01J49/38
摘要： A method of mass spectrometry or ion mobility spectrometry is disclosed comprising: providing ions towards an ion storage region(10); selecting a target maximum charge desired to be stored within the ion storage region (10) at any given time;and reducing the ion current passing to the ion storage region (10) such that the ions entering the ion storage region (10) do not cause the total charge within the storage region (10) to rise above said target maximum charge. The step of reducing the ion current passing to the ion storage region (10) comprises: temporally separating the ions according to their ion mobility in an ion mobility separator (4); and mass filtering the ions according to mass to charge ratio with a mass filter (6). Said steps of separating and mass filtering the ions result in substantially only target ions having selected combinations of ion mobility and mass to charge ratio being transmitted towards the ion storage region (10). The method further comprises accumulating the target ions within the ion storage region (10) during an ion accumulation period.
摘要翻译：公开了一种质谱法或离子迁移谱法的方法，包括：向离子存储区（10）提供离子; 在任何给定时间选择期望存储在离子存储区域（10）内的目标最大电荷;以及减少传递到离子存储区域（10）的离子电流，使得进入离子存储区域（10）的离子不会导致存储区域（10）内的总电荷上升到所述目标最大电荷以上。减少通向离子存储区域（10）的离子电流的步骤包括：在离子迁移率分离器（4）中根据离子迁移率暂时分离离子; 并且用质量过滤器（6）根据质荷比过滤离子。所述对离子进行分离和质量过滤的步骤基本上仅导致目标离子具有向离子存储区域（10）传输的离子迁移率和质荷比的选定组合。该方法进一步包括在离子累积时段期间在离子存储区域（10）内累积目标离子。

26. 发明申请

WO2013140132A3 MULTI-DIMENSIONAL SURVEY SCANS FOR IMPROVED DATA DEPENDENT ACQUISITIONS 审中-公开
标题翻译：用于改进数据依赖性收购的多维度调查扫描
公开(公告)号：WO2013140132A3
公开(公告)日：2014-04-10
申请号：PCT/GB2013050595
申请日：2013-03-11
申请人： MICROMASS LTD
发明人： GILES KEVIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , G01N27/624 , G01N30/72 , H01J49/004 , H01J49/40
摘要： A method of analysing ions is disclosed comprising performing an initial multi- dimensional survey scan comprising separating parent ions according to a first physico- chemical property (e.g. ion mobility) and then separating the parent ions according to a second physico-chemical property (e.g. mass to charge ratio). A plurality of parent ions of interest are then determined from the initial multi-dimensional survey scan. Once parent ions of interest have been determined, the plurality of parent ions of interest are sequentially selected based upon the first and second physico-chemical properties during a single cycle of separation. The parent ions of interest may then be fragmented and corresponding fragment ions may then be mass analysed.
摘要翻译：公开了分析离子的方法，其包括进行初始多维测量扫描，其包括根据第一物理化学性质（例如离子迁移率）分离亲本离子，然后根据第二物理化学性质（例如质量充电比）。然后从初始多维测量扫描确定多个感兴趣的母体离子。一旦已经确定感兴趣的亲本离子，则在分离的单个循环期间，基于第一和第二物理化学性质依次选择多个感兴趣的母体离子。然后可以将感兴趣的母体离子片段化，然后对相应的碎片离子进行质量分析。

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