专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO1995009620A1 SULFOXIMINE AND SULFODIIMINE MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译： SULFOXIMINE和SULFODIIMINE MATRIX金属蛋白酶抑制剂
公开(公告)号：WO1995009620A1
公开(公告)日：1995-04-13
申请号：PCT/US1994011164
申请日：1994-10-03
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , SCHWARTZ, Martin, A. , WART, Hal, Van
IPC分类号： A61K31/16
CPC分类号： C07D233/64 , A61K38/00 , C07C381/10 , C07D209/18 , C07D263/26 , C07D403/12 , C07K5/06 , C07K5/06078 , Y10S514/824 , Y10S514/825 , Y10S514/843 , Y10S514/912
摘要： Novel sulfoximine and sulfodiimine matrix metalloproteinase inhibitors of formula (I), wherein: R is selected from the group consisting of lower-alkyl, hydroxy lower-alkyl, amino lower-alkyl, carbamoyl lower-alkyl, lower-alkyl carbonyl, lower-alkyoxyalkyl, aralkyl and heteroaralkyl; X is NH or O; R is selected from the group consisting of hydrogen, lower-alkyl and aralkyl; R is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, aralkyl and heteroaralkyl; and R is selected from the group consisting of lower alkyl, aralkyl and -CH(R )-C(O)NH2, wherein R is selected from the group consisting of hydrogen, lower-alkyl, amino lower-alkyl, guanyl lower-alkyl, imidazoylalkyl, hydroxymethyl, 1-hydroxyethyl, mercapto lower-alkyl and methylthio lower-alkyl; useful for modulating physiological functions or treating diseases and disease conditions associated with matrix metalloproteinase modulation.
摘要翻译：式（I）的新型磺酰亚胺和亚磺酰亚胺基质金属蛋白酶抑制剂，其中：R 1选自低级烷基，羟基低级烷基，氨基低级烷基，氨基甲酰基低级烷基，低级烷基羰基，低级烷氧基烷基，芳烷基和杂芳烷基; X是NH或O; R 2选自氢，低级烷基和芳烷基; R 3选自氢，低级烷基，氨基低级烷基，鸟烷基低级烷基，芳烷基和杂芳烷基; 和R 4选自低级烷基，芳烷基和-CH（R 5）-C（O）NH 2，其中R 5选自氢，低级烷基，氨基低级烷基，鸟嘌呤低级烷基，咪唑基烷基，羟甲基，1-羟乙基，巯基低级烷基和甲硫基低级烷基; 可用于调节生理功能或治疗与基质金属蛋白酶调节相关的疾病和疾病状况。

22. 发明申请

WO1994021252A1 TAXANES HAVING A PYRIDYL SUBSTITUTED SIDE-CHAIN 审中-公开
标题翻译：具有吡啶取代的侧链的TAXANES
公开(公告)号：WO1994021252A1
公开(公告)日：1994-09-29
申请号：PCT/US1994003094
申请日：1994-03-21
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , HOLTON, Robert, A. , RENGAN, Kasthuri
IPC分类号： A61K31/335
CPC分类号： C07D405/12 , C07D205/08 , C07D305/14 , C07D407/12 , C07F7/1804 , Y02P20/55
摘要： Taxane derivatives having a pyridyl substituted C13 side-chain.
摘要翻译：具有吡啶基取代的C13侧链的紫杉烷衍生物。

23. 发明申请

WO1994021251A1 TAXANES HAVING AN AMINO SUBSTITUTED SIDE-CHAIN 审中-公开
标题翻译：具有氨基取代的侧链的TAXANES
公开(公告)号：WO1994021251A1
公开(公告)日：1994-09-29
申请号：PCT/US1994003093
申请日：1994-03-21
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , HOLTON, Robert, A. , NADIZADEH, Hossain , RENGAN, Kasthuri , TAO, Chunlin
IPC分类号： A61K31/335
CPC分类号： C07D407/12 , C07C227/22 , C07C231/12 , C07C233/87 , C07C2601/14 , C07C2601/16 , C07C2603/62 , C07D205/08 , C07D305/14 , C07D409/12 , C07F7/1804
摘要： Taxanes having side-chain substituted by a group CONX8X10 wherein X8 is hydrogen, alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterosubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl, and X10 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterosubstituted alkyl, alkenyl, alkynyl, aryl, heteroaryl. The taxanes are useful anti-cancer and anti-leukemia agents.
摘要翻译：具有由CONX8X10基团取代的侧链的紫杉烷，其中X 8是氢，烷基，烯基，炔基，芳基，杂芳基或杂取代的烷基，烯基，炔基，芳基，杂芳基和X 10是烷基，烯基，炔基，芳基，杂芳基，或杂取代的烷基，烯基，炔基，芳基，杂芳基。紫杉烷是有用的抗癌和抗白血病药物。

24. 发明申请

WO1994011362A1 FURYL OR THIENYL CARBONYL SUBSTITUTED TAXANES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
标题翻译：呋喃或三羰基取代的TAXANES和含有它们的药物组合物
公开(公告)号：WO1994011362A1
公开(公告)日：1994-05-26
申请号：PCT/US1993010473
申请日：1993-11-01
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , HOLTON, Robert, A. , RENGAN, Kasthuri , NADIZADEH, Hossain
IPC分类号： C07D333/10
CPC分类号： C07D407/12 , C07C227/22 , C07C231/12 , C07C233/87 , C07C2601/14 , C07C2601/16 , C07C2603/62 , C07D305/14 , C07D409/12 , C07F7/1804 , Y02P20/55
摘要： Taxane derivatives of formula (3) wherein R1 is phenyl or p-nitrophenyl, R3 is furyl or thienyl, T1 is hydrogen, hydroxyl protecting group, or -COT2, T2 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl or monocyclic aryl, Ac is acetyl, and E1 and E2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
摘要翻译：式（3）的紫杉烷衍生物其中R1是苯基或对硝基苯基，R3是呋喃基或噻吩基，T1是氢，羟基保护基或-COT2，T2是H，C1-C6烷基，C2-C6烯基，C2- C6炔基或单环芳基，Ac是乙酰基，E1和E2独立地选自氢，并且增加紫杉烷衍生物的水溶性的官能团可用作抗肿瘤剂。

25. 发明申请

WO1993022306A1 LOW SELF-ABSORBING, INTRINSICALLY SCINTILLATING POLYMERS 审中-公开
标题翻译：低自吸收率，本征性聚合物
公开(公告)号：WO1993022306A1
公开(公告)日：1993-11-11
申请号：PCT/US1993003718
申请日：1993-04-20
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , SCHLENOFF, Joseph, B. , DHARIA, Jayesh , JOHNSON, Kurtis, F.
IPC分类号： C07D311/04
CPC分类号： C08L25/18 , C07D311/30 , C08F12/32
摘要： Polymers containing covalently-bonded, low self-absorbing, scintillating chromophores, polymerizable chromophores of formula (1), wherein R1 is vinyl, α-methyl vinyl, vinyl phenyl, or vinyl benzyl, and R2 and R3 are independently hydrogen, alkyl, aryl, cyano, nitro, halo, or ether, and a process for the preparation of polymers containing low self-absorbing, scintillating chromophores.

26. 发明申请

WO1998014190A1 PHARMACEUTICAL COMPOUNDS COMPRISING POLYAMINES SUBSTITUTED WITH ELECTRON-AFFINIC GROUPS 审中-公开
标题翻译：包含用电子组织取代的聚氨酯的药物化合物
公开(公告)号：WO1998014190A1
公开(公告)日：1998-04-09
申请号：PCT/US1997017408
申请日：1997-09-29
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , YANG, Li-xi , HOFER, Kurt, G.
IPC分类号： A61K31/415
CPC分类号： C07D233/95 , C07C211/22 , C07F15/0093
摘要： A compound or a salt thereof comprising a polyamine containing at least 2 electron-affinic groups is provided. In a preferred embodiment, the polyamine compound has structure (1), wherein, A is a spacer; R , R , R3, and R4 are independently hydrogen, hydrocarbon, heterosubstituted hydrocarbon, heteroaryl, heterosubstituted heteroaryl, or an electron-affinic group containing substituent; and the compound contains at least one tertiary amine functionality having three substituents each of which independently contain at least one electron-affinic group or hydrophilic group.
摘要翻译：提供了包含含有至少2个电子亲和基团的多胺的化合物或其盐。在优选的实施方案中，多胺化合物具有结构（1），其中A是间隔基; R 1，R 2，R 3和R 4独立地为氢，烃，杂取代的烃，杂芳基，杂取代的杂芳基或含有取代基的电子亲和基团。并且该化合物含有至少一个具有三个取代基的叔胺官能团，每个取代基独立地含有至少一个电子亲和基团或亲水基团。

27. 发明申请

WO1997042181A1 1-DEOXY BACCATIN III, 1-DEOXY TAXOL AND 1-DEOXY TAXOL ANALOGS AND METHOD FOR THE PREPARATION THEREOF 审中-公开
标题翻译： 1-DEOXY BACCATIN III，1-DEOXY TAXOL和1-DEOXY TAXOL类似物及其制备方法
公开(公告)号：WO1997042181A1
公开(公告)日：1997-11-13
申请号：PCT/US1997007569
申请日：1997-05-05
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , HOLTON, Robert, A. , TANG, Suhan , LIANG, Feng , SOMOZA, Carmen
IPC分类号： C07D305/14
CPC分类号： C07C49/733 , C07C49/737 , C07D305/14 , C07D317/70 , C07F7/1804
摘要： 1-Deoxybaccatin III, 1-deoxytaxol and 1-deoxy taxol analogs and method for the preparation thereof.
摘要翻译： 1-脱氧浆果赤霉素III，1-脱氧紫杉醇和1-脱氧紫杉醇类似物及其制备方法。

28. 发明申请

WO1996032175A2 ACCELERATED METHODS OF OXIDIZING ORGANIC CONTAMINANTS IN AQUEOUS MEDIUMS USING CORONA INDUCED REACTIONS AND PARTICLES THEREWITH 审中-公开
标题翻译：使用CORONA诱导反应和颗粒的氨基酸氧化有机污染物的加速方法
公开(公告)号：WO1996032175A2
公开(公告)日：1996-10-17
申请号：PCT/US1996004797
申请日：1996-04-04
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , LOCKE, Bruce, R. , FINNEY, Wright, C. , GRYMONPRE, David, R.
IPC分类号： B01D00/00
CPC分类号： C02F1/4608 , B01J19/088 , B01J2219/0849 , C01B15/027 , C02F1/30 , C02F1/725 , C02F2305/10
摘要： Novel accelerated methods involving corona discharge, and preferably pulsed streamer high voltage corona discharge, in combination with an effective amount of suitable particles to break down organic contaminants, such as phenol and phenol red, in aqueous mediums are disclosed. More particularly, it has been discovered that the addition of an effective amount of suitable particles to the aqueous phase of a corona reactor greatly affects the properties of the corona discharge, i.e., streamer length, intensity, number of streamers and sparkover voltage, thereby significantly increasing the breakdown voltage (i.e., the maximum voltage prior to sparkover), so that the removal of organic contaminants may be accelerated, since the production of hydroxyl radicals, aqueous electrons and hydrogen peroxide increases with increases in the applied discharge voltage. As a result, it has been discovered that the addition of such particles to the fluid in the corona reactor leads to a decrease in exposure time and increase in efficiency. The methods may be practiced in a corona reactor containing a grounded plane electrode suspended above a hollow needle point electrode connected to a high voltage rotating spark gap pulsed power supply.
摘要翻译：公开了涉及电晕放电的新型加速方法，优选脉冲拖缆高压电晕放电，与有效量的合适颗粒结合在水介质中分解有机污染物如苯酚和酚红。更具体地，已经发现，向电晕反应器的水相中加入有效量的合适的颗粒极大地影响电晕放电的性质，即拖缆长度，强度，拖缆数和火花放电电压，从而显着地增加击穿电压（即，火花放电之前的最大电压），从而可以加速有机污染物的去除，因为羟基自由基，含水电子和过氧化氢的产生随着施加的放电电压的增加而增加。结果发现，这种颗粒在电晕反应器中的流体中的添加导致曝光时间的减少和效率的提高。该方法可以在电晕反应器中实施，所述电晕反应器包含悬挂在连接到高压旋转火花隙脉冲电源的空心针尖电极上的接地平面电极。

29. 发明申请

WO1996030365A1 RADIOSENSITIZING DIAMINES AND THEIR PHARMACEUTICAL PREPARATIONS 审中-公开
标题翻译：放射性核素及其药物制剂
公开(公告)号：WO1996030365A1
公开(公告)日：1996-10-03
申请号：PCT/US1996000222
申请日：1996-01-03
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , HOFER, Kurt, G. , YANG, Li-Xi
IPC分类号： C07D403/12
CPC分类号： C07C211/22 , C07D233/95 , C07F15/0093
摘要： A compound comprising a diamine containing from 2-4 electron-affinic radiosensitizing functional groups or a salt thereof is provided. In a preferred embodiment the compound has formula (1), wherein A comprises a carbon chain having from about 2-10 carbons in the chain, R , R , R , and R are H, or T, T is formula (2), wherein A' comprises a carbon chain having from about 1-8 carbons in the chain, R is H, lower alkyl, or halo, and R is H, lower alkyl, halo or nitro, provided that at least one of R and R , and at least one of R and R is T. Intermediates for, pharmaceutical compositions containing, methods for making and methods for using such compounds to radiosensitize and kill hypoxic tumor cells are also provided.
摘要翻译：提供包含含有2-4个电子亲和性放射增敏官能团的二胺或其盐的化合物。在优选的实施方案中，化合物具有式（1），其中A包含链中具有约2-10个碳的碳链，R 1，R 2，R 3和R 4是 H或T，T为式（2），其中A'包含链中具有约1-8个碳原子的碳链，R 5为H，低级烷基或卤素，R 6为H ，低级烷基，卤素或硝基，条件是R 1和R 2中的至少一个以及R 3和R 4中的至少一个是T.用于药物组合物的中间体，其含有还提供了使用这些化合物放射增敏和杀死缺氧肿瘤细胞的方法和方法。

30. 发明申请

WO1995023347A1 SOLID SCINTILLATORS FOR DETECTING RADIOACTIVE IONS IN SOLUTION 审中-公开
标题翻译：用于检测解决方案中的放射性离子的固体扫描仪
公开(公告)号：WO1995023347A1
公开(公告)日：1995-08-31
申请号：PCT/US1995002237
申请日：1995-02-22
申请人： FLORIDA STATE UNIVERSITY
发明人： FLORIDA STATE UNIVERSITY , SCHLENOFF, Joseph, B.
IPC分类号： G01T01/20
CPC分类号： G01T1/203 , G01T7/02
摘要： A scintillator for absorbing and concentrating radioactive ions within a solution, the scintillator including a solid scintillator (12) and an ionic layer on a surface (20) of and in contact with the solid scintillator. When radioactive ions are absorbed by the ionic layer, the scintillator acts as a light source.
摘要翻译：一种用于吸收和浓缩溶液中的放射性离子的闪烁体，所述闪烁体包括固体闪烁体（12）和在固体闪烁体的表面（20）上的离子层。当放射性离子被离子层吸收时，闪烁体充当光源。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式