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21. 发明申请

WO2008024180A1 INTEGRATED CARDIAC RHYTHM MANAGEMENT SYSTEM WITH HEART VALVE 审中-公开
标题翻译：整体心脏循环管理系统与心脏瓣膜
公开(公告)号：WO2008024180A1
公开(公告)日：2008-02-28
申请号：PCT/US2007/017119
申请日：2007-07-31
申请人： CARDIAC PACEMAKERS, INC. , SHUROS, Allan C. , KANE, Michael J.
发明人： SHUROS, Allan C. , KANE, Michael J.
IPC分类号： A61N1/365
CPC分类号： A61N1/3621 , A61F2/2403 , A61N1/36514 , A61N1/3962
摘要： Systems and methods using a heart valve and an implantable medical device, such as for event detection and optimization of cardiac output. The cardiac management system includes a heart valve, having a physiological sensor. The physiological sensor is adapted to measure at least one of an intrinsic electrical cardiac parameter, a hemodynamic parameter or the like. The system further includes an implantable electronics unit, such as a cardiac rhythm management unit, coupled to the physiological sensor of the heart valve to receive physiological information. The electronics unit is adapted to use the received physiological information to control delivery of an electrical output to the subject.
摘要翻译：使用心脏瓣膜和可植入医疗装置的系统和方法，例如用于事件检测和心输出量的优化。心脏管理系统包括具有生理传感器的心脏瓣膜。生理传感器适于测量本征电心脏参数，血液动力学参数等中的至少一个。该系统还包括可植入电子单元，例如心律管理单元，其耦合到心脏瓣膜的生理传感器以接收生理信息。电子单元适于使用所接收的生理信息来控制向对象的电输出的传递。

22. 发明申请

WO2012005989A2 CARDIAC FUNCTION MONITOR USING INFORMATION INDICATIVE OF LEAD MOTION 审中-公开
标题翻译：使用指示铅动作信息的心脏功能监测
公开(公告)号：WO2012005989A2
公开(公告)日：2012-01-12
申请号：PCT/US2011/041860
申请日：2011-06-24
申请人： SWEENEY, Robert J. , SHUROS, Allan C. , SIEJKO, Krzysztof Z. , OLSON, David C. , INGLE, Frank
发明人： SWEENEY, Robert J. , SHUROS, Allan C. , SIEJKO, Krzysztof Z. , OLSON, David C. , INGLE, Frank
IPC分类号： A61N1/37
CPC分类号： A61N1/36514 , A61B5/02133 , A61B5/026 , A61N1/08 , A61N1/36142 , A61N1/36578
摘要： Systems and methods to monitor cardiac function using information indicative of lead motion are described. In an example, a system including an implantable medical device can include a receiver circuit configured to be electrically coupled to conductor comprising a portion of an implantable lead and be configured to obtain information indicative of a movement of the implantable lead due at least in part to a motion of a heart. The system can include a sensing circuit configured to obtain information indicative of cardiac electrical activity. The system can include a processor circuit configured to construct a template representative of a contraction of the heart, where the template can be constructed using the information indicative of the movement of the implantable lead due at least in part to the motion of the heart during the contraction, and using the information indicative of the cardiac electrical activity sensed during the contraction.
摘要翻译：描述了使用指示导程运动的信息来监测心脏功能的系统和方法。在一个示例中，包括可植入医疗设备的系统可以包括接收器电路，该接收器电路被配置为电耦合到包括可植入引线的一部分的导体并且被配置为获得指示可植入引线的移动的信息，这至少部分地由于心脏的运动。该系统可以包括配置成获得指示心脏电活动的信息的感测电路。该系统可以包括处理器电路，该处理器电路被配置为构建表示心脏收缩的模板，其中可以使用指示可植入引线的移动的信息来构建模板，该信息至少部分地由于心脏在收缩，并使用指示在收缩过程中感测到的心脏电活动的信息。

23. 发明申请

WO2014099625A1 STIMULATION PATCH WITH ACTIVE ADHESION 审中-公开
标题翻译：具有活性粘合的刺激贴
公开(公告)号：WO2014099625A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/074758
申请日：2013-12-12
申请人： CARDIAC PACEMAKERS, INC.
发明人： SHUROS, Allan C. , GULER, Ismail , GUNDERSON, Richard Charles , GROVER, Joel P. , MOKELKE, Eric A. , GROVENDER, Adam
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/36117 , A61N1/0558
摘要： System and methods for adhering a patch of stimulation electrode(s) to blood vessels to stimulate a target site on the blood vessel are described. In one embodiment, the system includes an adhesion patch and at least one electrode. The adhesion patch includes an active adhesion mechanism that may produce an adhesive force sufficiently strong to adhere the adhesion patch to the exterior of the blood vessel and to operationally position the at least one electrode for use in electrically stimulating a target site of the blood vessel. The adhesion patch may also include a release mechanism that is configured for a user to disengage the patch from the exterior of the blood vessel without significant trauma to the blood vessel. After being released, the adhesion patch may be re-adhered to a different target site of the blood vessel and stimulate the different target site.
摘要翻译：描述了将一束刺激电极粘附到血管上以刺激血管上的靶位点的系统和方法。在一个实施例中，系统包括粘附贴片和至少一个电极。粘合贴片包括主动粘合机构，其可以产生足够强的粘附力，以将粘附贴片粘附到血管外部，并且可操作地定位用于电刺激血管的靶位点的至少一个电极。粘合贴片还可以包括释放机构，该释放机构构造成使用者能够将血块从血管的外部脱离，而不会对血管造成显着损伤。释放后，粘附贴片可以再粘附到血管的不同靶位点并刺激不同的靶位点。

24. 发明申请

WO2019089539A1 SYSTEMS FOR HIS-BUNDLE PACING 审中-公开
公开(公告)号：WO2019089539A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058140
申请日：2018-10-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： SHUROS, Allan C. , CASAVANT, David Arthur
IPC分类号： A61N1/05 , A61N1/36 , A61N1/362 , A61N1/368
CPC分类号： A61N1/368 , A61B5/0452 , A61N1/056 , A61N1/362 , A61N1/36507 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/3684 , A61N1/3702 , A61N1/371 , A61N1/3712
摘要： Systems and methods for pacing cardiac conductive tissue are described. A medical system includes an electrostimulation circuit to generate His-bundle pacing (HBP) pulses for delivery at or near a His bundle of the heart. A control circuit may time the delivery of the HBP pulses within a tissue refractory period subsequent to an intrinsic His-bundle activation of a first His-bundle portion. Based on an evoked His-bundle activation of a second His-bundle portion, the system may determine whether correction of intra-Hisian block has occurred. The system additionally includes a threshold test circuit to determine an individualized pacing threshold representing minimal energy to excite the His bundle and to correct the cardiac conduction abnormality.

25. 发明申请

WO2015095024A3 SYSTEM FOR MEASURING AN ELECTRICAL CHARACTERISTIC OF TISSUE TO IDENTIFY A NEURAL TARGET FOR A THERAPY 审中-公开
公开(公告)号：WO2015095024A3
公开(公告)日：2015-06-25
申请号：PCT/US2014/070299
申请日：2014-12-15
申请人： CARDIAC PACEMAKERS, INC.
发明人： MOKELKE, Eric A. , TERNES, David J. , SHUROS, Allan C. , CAO, Hong
IPC分类号： A61B5/00 , A61B5/053 , A61B18/14 , A61N1/05 , A61N1/36
摘要： A system (515) comprises a patch (516) of electrodes for placement on tissue containing neural tissue and a tissue tester (517) configured to measure an electrical characteristic of tissue. The tissue tester includes a test controller (518) and switches (521). The test controller and the switches are configured to connect electrodes to create subsets of two or more electrodes. The test controller is configured to measure an electrical characteristic of tissue using the subsets within the set of electrodes placed on the tissue, to compare measurements of the electrical characteristic and to identify a neural target for a therapy based on the comparison of the measurements of the electrical characteristic for tissue at the neural target relative to adjacent non-neural tissue.

26. 发明申请

WO2019089528A1 SYSTEM FOR RECOGNITION OF HIS-BUNDLE PACING CAPTURE 审中-公开
公开(公告)号：WO2019089528A1
公开(公告)日：2019-05-09
申请号：PCT/US2018/058125
申请日：2018-10-30
申请人： CARDIAC PACEMAKERS, INC.
发明人： SHUROS, Allan C. , CASAVANT, David Arthur , WARIAR, Ramesh
IPC分类号： A61N1/362 , A61N1/368 , A61N1/37
CPC分类号： A61N1/368 , A61B5/0452 , A61N1/056 , A61N1/362 , A61N1/36507 , A61N1/36521 , A61N1/36564 , A61N1/36578 , A61N1/3684 , A61N1/3702 , A61N1/371 , A61N1/3712
摘要： Systems for pacing cardiac conductive tissue are described. A medical system includes an electrostimulation circuit that may generate His- bundle pacing (HBP) pulses for delivery at or near the His bundle. In response to the delivery of the HBP pulse, the system senses a near-field cardiac activity representative of excitation of a para-Hisian myocardial tissue, and a far-field cardiac activity representative of excitation of the His bundle and a ventricle. The system classifies a tissue response to HBP into one of a plurality of capture types based on the sensed near-field and far-field cardiac activities. The system includes a control circuit to adjust one or more stimulation parameters based on the classified capture type. The electrostimulation circuit generates and delivers the HBP pulses according to the adjusted stimulation parameters to excite the His bundle.

27. 发明申请

WO2016141046A1 SYSTEMS AND METHODS FOR TREATING CARDIAC ARRHYTHMIAS 审中-公开
标题翻译：用于治疗心脏病的系统和方法
公开(公告)号：WO2016141046A1
公开(公告)日：2016-09-09
申请号：PCT/US2016/020432
申请日：2016-03-02
申请人： CARDIAC PACEMAKERS, INC.
发明人： SHUROS, Allan C. , SALO, Rodney W. , KANE, Michael J. , HOPPER, Donald L.
IPC分类号： A61N1/375 , A61N1/365 , A61N1/372 , A61N1/05 , A61B5/08 , A61B5/091 , A61B5/113 , A61B5/00
CPC分类号： A61N1/36585 , A61B5/0538 , A61B5/0816 , A61B5/091 , A61B5/113 , A61B5/4836 , A61B5/686 , A61B5/6869 , A61B2562/0219 , A61B2562/0247 , A61N1/0587 , A61N1/36514 , A61N1/36542 , A61N1/36578 , A61N1/37205 , A61N1/3756
摘要： Systems and methods for rate-adaptive pacing are disclosed. In one illustrative embodiment, a medical device for delivering electrical stimulation to a heart may include a housing configured to be implanted on the heart or within a chamber of the heart, one or more electrodes connected to the housing, and a controller disposed within the housing. The controller may be configured to sense a first signal and determine a respiration rate based at least in part on the sensed first signal. In at least some embodiments, the controller may be further configured to adjust a rate of delivery of electrical stimulation by the medical device based at least in part on the determined respiration rate.
摘要翻译：公开了用于速率自适应起搏的系统和方法。在一个说明性实施例中，用于向心脏递送电刺激的医疗装置可以包括被配置为植入心脏或心脏室内的壳体，连接到壳体的一个或多个电极以及设置在壳体内的控制器。控制器可以被配置为至少部分地基于所感测的第一信号来感测第一信号并确定呼吸速率。在至少一些实施例中，控制器可以被进一步配置成至少部分地基于确定的呼吸速率来调整医疗设备的电刺激的传送速率。

28. 发明申请

WO2014099595A3 APPARATUS FOR RIGHT VENTRICULAR RESYNCHRONIZATION 审中-公开
公开(公告)号：WO2014099595A3
公开(公告)日：2014-06-26
申请号：PCT/US2013/074618
申请日：2013-12-12
申请人： CARDIAC PACEMAKERS, INC.
发明人： SHUROS, Allan C. , DING, Jiang , MASKARA, Barun , YU, Yinghong
IPC分类号： A61N1/365 , A61N1/368
摘要： An apparatus comprises a cardiac signal sensing circuit and a first implantable electrode pair. At least one electrode of the first implantable electrode pair is configured for placement at a location in a right branch of a His bundle of the subject. The apparatus can include a therapy circuit and a control circuit. The control circuit can include an AH delay calculation circuit configured to calculate an optimal paced AH delay interval. The pacing stimulation location is distal to a location of RV conduction block in a right branch of the His bundle. The control circuit initiates delivery of an electrical stimulation pulse to the stimulation location in the His bundle according to the calculated paced AH delay interval and in response to an intrinsic depolarization event sensed in an atrium of the subject.

29. 发明申请

WO2013096199A1 ECTOPIC-TRIGGERED PARA-HIS STIMULATION 审中-公开
公开(公告)号：WO2013096199A1
公开(公告)日：2013-06-27
申请号：PCT/US2012/070094
申请日：2012-12-17
申请人： CARDIAC PACEMAKERS, INC.
发明人： DING, Jiang , SHUROS, Allan C. , LI, Dan , YU, Yinghong , HAHN, Stephen J.
IPC分类号： A61N1/365 , A61N1/37 , A61B5/0468
CPC分类号： A61N1/36592 , A61B5/02152 , A61B5/0464 , A61B5/0468 , A61N1/365 , A61N1/37 , A61N1/371
摘要： Ectopic cardiac activity can be detected, such as in the absence of a diagnosed tachyarrhythmia episode. In response to the detected ectopic activity, electrostimulation can be provided to a para-Hisian region, such as to activate natural cardiac contraction mechanisms or to interrupt re-entrant cardiac activity. Subsequent ectopic cardiac activity can be detected, and subsequent electrostimulation can be provided to the para-Hisian region, such as according to one or more adjustable electrostimulation parameters.
摘要翻译：可以检测异位心脏活动，例如在没有诊断的快速性心律失常发作时。响应于检测到的异位活动，可以向对等神经区域提供电刺激，例如激活自然心脏收缩机制或中断再入心脏活动。可以检测随后的异位心脏活动，并且可以根据一个或多个可调节的电刺激参数来向对 - Hisian区域提供随后的电刺激。

30. 发明申请

WO2018064070A1 MAPPING AND/OR ABLATION CATHETER WITH A CLOSED DISTAL LOOP 审中-公开
标题翻译：制动和/或消融导管的闭环远端循环
公开(公告)号：WO2018064070A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/053533
申请日：2017-09-26
申请人： CARDIAC PACEMAKERS, INC.
发明人： SHUROS, Allan C. , KAUPHUSMAN, James
IPC分类号： A61B5/00 , A61B18/14
摘要： An apparatus (200, 202, 206) is disclosed for performing at least one of mapping and ablation functions. The apparatus includes a catheter (200) sized and shaped for vascular access and having a tip section (224) forming a closed loop and one or more electrode structures (226) arranged with the closed loop.
摘要翻译：公开了一种用于执行映射和消融功能中的至少一个的装置（200,202,206）。该设备包括导管（200），导管（200）的大小和形状适合血管通路并具有形成闭合回路的尖端部分（224）以及与闭合回路一起布置的一个或多个电极结构（226）。

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