专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO1993020188A1 PROCESS AND CULTURE MEDIUM FOR THE PRODUCTION OF CELLS INFECTED BY A MULTIPLE SCLEROSIS ASSOCIATED VIRUS 审中-公开
标题翻译：用于生产多发性相关感染病毒感染的细胞的过程和培养基
公开(公告)号：WO1993020188A1
公开(公告)日：1993-10-14
申请号：PCT/FR1993000336
申请日：1993-04-02
申请人： BIO MERIEUX , PERRON, Hervé , SEIGNEURIN, Jean-Marie
发明人： BIO MERIEUX
IPC分类号： C12N07/00
CPC分类号： G01N33/56983 , C07K14/005 , C07K16/10 , C12N7/00 , C12N15/85 , C12N2710/16622 , C12N2740/10022 , C12N2740/10051 , G01N2469/20
摘要： Process for in vitro production of a culture or cell line infected by a viral strain associated with multiple sclerosis. According to the process, a sample is taken from a person with multiple sclerosis, the sample is cultivated in a medium promoting the growth of infected cells to obtain a culture of primary infected cells. A sample of the primary cell culture or a sub-culture of the latter is then cultivated in series, i.e. by means of successive cultures, in said culture medium to obtain the culture or cell line infected by a multiple sclerosis associated virus. The invention is characterized in that the culture medium further contains a beta anti-interferon antibody or antibody which is directed against an antigenically close molecule. Said antibody plays an inhibiting role in viral expression, has long-lasting expression and propagates the viral strain in the culture or cell line.

22. 发明申请

WO1998029194A1 PROCESS AND DEVICE FOR COVERING THE SURFACE OF A SUBSTRATE WITH A LAYER OF FLUID MATERIAL 审中-公开
标题翻译：用于覆盖基材表面与流体材料层的工艺和装置
公开(公告)号：WO1998029194A1
公开(公告)日：1998-07-09
申请号：PCT/IB1997001608
申请日：1997-12-30
申请人： BIO MERIEUX , COLIN, Bruno
发明人： BIO MERIEUX
IPC分类号： B05B15/04
CPC分类号： B05B7/2483 , B05B14/30 , Y02P70/36
摘要： Disclosed is a process for covering a surface (1a) of a substrate (1) with a layer (2) of fluid material, said process being characterized by the following: (a) a containing wall (3) forming an enclosure and disposed at a distance and above the surface to be covered (1a), the lower edge (3a) of this wall forming a peripheral void (4) with the surface, said wall being used to define a processing chamber (5) which outlines an area (6) to be treated on said surface to be covered; (b) controlled negative pressure is established within the processing chamber (5), by means of the admission of an incoming gas stream (7) via the peripheral void (4), and of the extraction from the processing chamber of an outgoing gas stream (8), in order to obtain an internal pressure within said chamber which is lower than the external pressure; (c) a controlled fluid flow (10) is introduced into the processing chamber (5) under pressure, said flow comprising the fluid covering material which, together with the incoming gas stream (7), forms a turbulent flow in the peripheral void. Upon contact with the processed surface (1b), the turbulent flow is aspirated into the area (6) to be treated, depositing the fluid material in this area; the fluid flow is then evacuated with the outgoing gas stream (8).
摘要翻译：公开了一种用流体材料层（2）覆盖基板（1）的表面（1a）的方法，所述方法的特征在于：（a）形成外壳的容纳壁（3），并设置在一个距离和待覆盖的表面（1a）上方，该壁的下边缘（3a）形成具有表面的周边空隙（4），所述壁用于限定一个处理室（5），该处理室（5） 6）待被覆盖的所述表面处理; （b）通过经由周边空隙（4）的进入气流（7）的入口和从处理室中排出的气流（5）提取而在处理室（5）内建立受控的负压（8），以便获得所述室内的内压低于外部压力; （c）受控流体流（10）在压力下引入处理室（5）中，所述流动包括流体覆盖材料，其与进入的气流（7）一起在周边空隙中形成湍流。与经处理的表面（1b）接触时，将湍流吸入待处理的区域（6）中，将流体材料沉积在该区域中; 然后用输出气流（8）抽空流体流。

23. 发明申请

WO1998005766A1 TARGET NUCLEIC ACID SEQUENCE AMPLIFICATION METHOD 审中-公开
标题翻译：目标核酸序列放大方法
公开(公告)号：WO1998005766A1
公开(公告)日：1998-02-12
申请号：PCT/FR1997001445
申请日：1997-08-01
申请人： BIO MERIEUX , GUILLOU-BONNICI, Françoise , DEFRANC, Eric , HOANG, Antoine , LAAYOUN, Ali , LHOMME, Jean , TREVISIOL, Emmanuelle
发明人： BIO MERIEUX
IPC分类号： C12N15/10
CPC分类号： C12P19/34 , C07H19/06 , C07H21/00 , C12N15/10 , C12P19/30 , C12Q1/686 , C12Q2527/125 , C12Q2525/101
摘要： A target nucleic acid sequence amplification method wherein at least the target nucleic acid sequence, at least one oligonucleotide primer specific for the target sequence, one or more enzymatic activities and nucleotides are provided, and the target sequence is amplified under conditions suitable in particular for said enzymatic or activity or activities, is disclosed. According to the method, at least one of the nucleotides is a prefunctionalised nucleotide that differs from the other nucleotides at least in that it includes at least one unprotected reactive covalence function in at least one predetermined site of the base of said nucleotide, in order to give a prefunctionalised amplification product including at least one such prefunctionalised nucleotide. Nucleotides for carrying out the method are also disclosed.
摘要翻译：一种目标核酸序列扩增方法，其中至少提供了靶核酸序列，至少一种针对靶序列特异性的寡核苷酸引物，一种或多种酶活性和核苷酸，并且靶序列在适合于所述酶或活性或活性。根据该方法，至少一个核苷酸是与其它核苷酸不同的预功能化核苷酸，至少其中包括至少一个在所述核苷酸碱基的至少一个预定位点的未保护的反应性共价功能，以便给出包含至少一种这样的预功能化核苷酸的前功能化扩增产物。还公开了用于实施该方法的核苷酸。

24. 发明申请

WO1998004735A1 METHOD FOR DEMONSTRATING AN ENZYMATIC ACTIVITY OF MICRO-ORGANISMS 审中-公开
标题翻译：用于演示微生物酶活性的方法
公开(公告)号：WO1998004735A1
公开(公告)日：1998-02-05
申请号：PCT/FR1997001415
申请日：1997-07-29
申请人： BIO MERIEUX , ORENGA, Sylvain
发明人： BIO MERIEUX
IPC分类号： C12Q01/04
CPC分类号： C12Q1/37 , C12Q1/04 , C12Q2337/50
摘要： The method consists in the use of one compound of formula: X-NH-R in which X represents one 5-bromoindole-3-yle group and R represents the acyl radical of one amino acid selected between leucine and alanine, as tracer for demonstrating, by the formation of a coloured product, a peptidase activity in a culture of micro-organisms.
摘要翻译：该方法包括使用一种式：X-NH-R的化合物，其中X代表一个5-溴吲哚-3-基，R代表在亮氨酸和丙氨酸之间选择的一个氨基酸的酰基作为示踪剂，通过形成有色产物，在微生物培养物中的肽酶活性。

25. 发明申请

WO1997046700A1 NUCLEOTIDE PROBES AND METHOD FOR DETERMINING HLA DQB1 TYPING 审中-公开
标题翻译：核糖核酸探针和确定HLA DQB1型的方法
公开(公告)号：WO1997046700A1
公开(公告)日：1997-12-11
申请号：PCT/FR1997000980
申请日：1997-06-03
申请人： BIO MERIEUX , MOUGIN, Bruno
发明人： BIO MERIEUX
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6881 , C12Q2600/156
摘要： Nucleotide probe selected in particular among the following: TG CGT TAT GTG ACC AGA , GT G CGT CTT GTG ACC AGA , GT CTT GTA ACC AGA CAC AT, CG T CTT GTA ACC AGA TAC AT, CG T CTT GTG AGC AGA AGC AT, CG ACC GAG CTC GTG CGG CG T G, G T AC CGG GCA GTG AC G C, G A CG CCG CTG GGI CCG CCT G , G A CG CCG CTG GGG CCG CCT G , G G AG GGI ACC CIG GCI GA G T, G G AG GGG ACC CGG GCG GA G T, TC G GTG GAC ACC GTA TGC AG A C, GG ACG GAG CGC GTG CG, C ATC TAT AAC CGA GA , and their complementary sequences, being understood that the said probes have at least the underlined sequence, and can further contain one or two bases selected, respecting the sequence continuity, among the non-underlined bases. These probes are useful for determining a person's HLA DQ beta genotype. They have in particular the advantage of being useable at a single hybridization temperature, in particular 37 DEG C.
摘要翻译：选择以下特定的核苷酸探针：TG CGT TAT GTG ACC AGA，GTG CGT CTT GTG ACC AGA，GTCTT GTA ACC AGA CAC AT，CGT CTT GTA ACC AGA TAC AT，CGT CTT GTG AGC AGA AGC AT，CG ACC GAG CTC GTG CGG CG TG ，GT ACGG GCA GTG AC GC，GA CG CCG CTG GGI CCG CCT G，GA CG CCG CTG GGG CCG CCT G，GG < AG AG GGI ACC CIG GCI GA GT，GGGGGG ACC CGG GCG GA GT，TCG GTG GAC ACC GTA TGC AG AC，GG ACG GAG CGC GTG CG，C ATC TAT AAC CGA GA及其互补序列，应理解为所述探针至少具有下划线序列，并且还可含有一个或两个在不带下划线的基础之间选择了基于序列连续性的基因。这些探针可用于确定一个人的HLA DQβ基因型。它们特别具有在单一杂交温度，特别是37℃下可用的优点。

26. 发明申请

WO1997046318A1 SINGLE-USE ANALYSIS CARD COMPRISING A LIQUID FLOW CHANNEL 审中-公开
标题翻译：包含液体流通道的单次使用分析卡
公开(公告)号：WO1997046318A1
公开(公告)日：1997-12-11
申请号：PCT/FR1997001020
申请日：1997-06-09
申请人： BIO MERIEUX , COLIN, Bruno , JARAVEL, Cécile , CLEUZIAT, Philippe
发明人： BIO MERIEUX
IPC分类号： B01L03/00
CPC分类号： B01L3/502
摘要： The invention features an analysing device (1) comprising a body (2) in which are arranged or provided: an intake aperture (3) for a starting liquid sample, a liquid flow circuit (5) comprising at least one operating cell (6) for a processed liquid sample, obtained from all or part of the original sample, communicating with the said intake aperture (3), the said flow circuit defining, in at least two dimensions of the card, one determined geometric line, such that any alteration in the card orientation in a three-dimensional reference frame, causes the liquid to flow under gravity only, from one part of the said circuit to another,for instance from one side or another of the operating cell, (6) characterised in that, the flow circuit (5) is continuous, and looped on itself between the said aperture (3) and the said operating cell (6).
摘要翻译：本发明的特征在于一种分析装置（1），包括其中布置或提供的主体（2）：用于起始液体样品的进气孔（3），包括至少一个操作室（6）的液体流动回路（5）对于从全部或部分原始样品获得的经处理的液体样品，与所述进气孔（3）连通，所述流动回路在卡的至少两个维度上限定一个确定的几何线，使得任何改变在三维参考框架中的卡片取向中，使得液体仅在重力下从所述电路的一部分流向另一部分，例如从操作单元的一侧或另一侧流出，其特征在于，流动回路（5）是连续的，并且环绕在所述孔（3）和所述操作室（6）之间。

27. 发明申请

WO1997033466A1 NON-GENETICALLY MODIFIED MAMMAL AS A MODEL FOR MULTIPLE SCLEROSIS 审中-公开
标题翻译：非基因修饰的MAMMAL作为多发性硬化症的模型
公开(公告)号：WO1997033466A1
公开(公告)日：1997-09-18
申请号：PCT/FR1997000469
申请日：1997-03-14
申请人： BIO MERIEUX , RIEGER, François , PERRON, Hervé , BENJELLOUN, Nabila
发明人： BIO MERIEUX
IPC分类号： A01K67/027
CPC分类号： C07K14/4713 , A01K67/027
摘要： A non-human mammal genetically modified without affecting its genome and having any two of the following pathological signs: (a) a blood-brain barrier that is open or permeable to water-soluble blood molecules non-specific for the cerebral parenchyma, (b) an astrocyte disorder revealed particularly by physical network disorganisation, the disappearance of perivascular feet around the capillaries, and gliosis, (c) microglial cell activation, (d) demyelinisation plates, particularly in the brain stem and/or the cerebral white matter, and (e) central nervous system glial and endothelial cell lesions, as well as the uses of said animal, are disclosed.
摘要翻译：遗传修饰的非人类哺乳动物不影响其基因组并具有以下两种以下病理征象：（a）对脑实质非特异性的水溶性血液分子是开放的或可渗透的血脑屏障，（b ）特别是通过物理网络混乱，毛细血管周围血管周围的脚消失，胶质增生，（c）小胶质细胞活化，（d）脱髓鞘平板，特别是脑干和/或脑白质的星形胶质细胞异常，以及（e）中枢神经系统胶质细胞和内皮细胞病变以及所述动物的用途。

28. 发明申请

WO1996029601A1 METHOD AND DEVICE FOR MAGNETICALLY DETERMINING AN ANALYTE, PARTICULARLY A BACTERIUM 审中-公开
标题翻译：用于磁性测定分析物，特别是细菌的方法和装置
公开(公告)号：WO1996029601A1
公开(公告)日：1996-09-26
申请号：PCT/IB1996000245
申请日：1996-03-20
申请人： BIO MERIEUX , COLIN, Bruno , THERETZ, Alain
发明人： BIO MERIEUX
IPC分类号： G01N33/543
CPC分类号： G01N33/54333 , G01N35/00029 , G01N35/0098 , G01N2446/20 , G01N2446/30 , Y10S436/806
摘要： A method for determining an analyte, comprising (i) providing a liquid-phase sample; (ii) providing at least one reagent which includes a liquid-phase suspension of magnetic or magnetisable reactive metal particles each comprising a metal core to which an anti-ligand is directly or indirectly attached; (iii) contacting the sample with the reagent to give a liquid-phase intermediate mixture of metal complexes of the reactive particles that have reacted with the analyte; (iv) separating the metal complexes using a magnetic field; and (v) detecting the separated metal complexes to give a detection signal representing the metal mass of said complexes; wherein (a) in step (v), the separated metal complexes are detected by passing them in front of an electromagnetic sensor; and (b) in step (iv), the separated metal complexes are confined to give a measurement aggregate detectable by said electromagnetic sensor, in front thereof.
摘要翻译：一种用于测定分析物的方法，包括（i）提供液相样品; （ii）提供至少一种试剂，其包括磁性或可磁化的反应性金属颗粒的液相悬浮液，每个包含直接或间接附着抗配体的金属核; （iii）使样品与试剂接触，得到与分析物反应的反应性颗粒的金属络合物的液相中间体混合物; （iv）使用磁场分离金属络合物; 和（v）检测分离的金属络合物以产生表示所述络合物的金属质量的检测信号; 其中（a）在步骤（v）中，通过将其分离在电磁传感器前面来检测分离的金属络合物; 和（b）在步骤（iv）中，将分离的金属配合物限制在前面由所述电磁传感器得到的测量集合体。

29. 发明申请

WO1995029199A1 ELECTRICALLY CONDUCTIVE ELECTROACTIVE FUNCTIONALISED CONJUGATED POLYMERS, AND USES THEREOF 审中-公开
标题翻译：电导电性功能性结合聚合物及其用途
公开(公告)号：WO1995029199A1
公开(公告)日：1995-11-02
申请号：PCT/FR1995000536
申请日：1995-04-24
申请人： BIO MERIEUX , GARNIER, Francis
发明人： BIO MERIEUX
IPC分类号： C08G61/12
CPC分类号： G01N33/5438 , C08G61/124 , C12Q1/002 , C12Q1/6825 , H01B1/127 , Y10S530/81 , Y10S530/812 , Y10S530/815 , Y10S530/816 , Y10S530/817
摘要： Electrically conductive electroactive conjugated polymers, and uses thereof, said polymers including at least one functional group covalently bonded to a first biological molecule or anti-ligand of formula (II), wherein n is an integer other than zero and i is an integer from 2 to n-1, and each of R , R' and R' , which are the same or different, is H or a functional group covalently bonded or bondable to a first biological molecule or anti-ligand.
摘要翻译：导电电活性共轭聚合物及其用途，所述聚合物包括共价键合到式（II）的第一生物分子或抗配体的至少一个官能团，其中n是不为零的整数，i是2的整数至n-1，并且相同或不同的R 1，R'和R'n n各自为H或与第一生物分子共价结合或可键合的官能团，配体。

30. 发明申请

WO1995021859A1 CYTOTOXIC FACTOR ASSOCIATED WITH DISSEMINATED SCLEROSIS, ITS DETECTION AND QUANTIFICATION 审中-公开
标题翻译：与感染性SCLEROSIS相关的细胞因子，其检测和定量
公开(公告)号：WO1995021859A1
公开(公告)日：1995-08-17
申请号：PCT/FR1995000178
申请日：1995-02-15
申请人： BIO MERIEUX , PERRON, Hervé , DOBRANSKY, Tomas , RIEGER, François , MANDRAND, Bernard
发明人： BIO MERIEUX
IPC分类号： C07K14/47
CPC分类号： C07K14/4713 , A61K38/00 , G01N33/5091 , Y10S424/16 , Y10S435/964 , Y10S436/827 , Y10S436/828
摘要： Gliotoxic factor, in isolated or purified condition, characterized in that it has a toxic activity on animal or human astrocytic cells resulting in a cytomorphological disorganization of their network of intermediary filaments and/or a degradation of the proteins of said intermediary filaments and/or cell death particularly, by apoptosis.
摘要翻译：在分离或纯化条件下的胶质毒性因子，其特征在于其对动物或人星形细胞细胞具有毒性活性，导致其中间丝的网络的细胞形态学紊乱和/或所述中间丝和/或细胞的蛋白质的降解死亡特别是凋亡。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式