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21. 发明申请

WO2012154312A1 NEUTRALIZING ANTIBODIES TO HIV-1 AND THEIR USE 审中-公开
标题翻译：将抗体中和到HIV-1及其使用
公开(公告)号：WO2012154312A1
公开(公告)日：2012-11-15
申请号：PCT/US2012/030465
申请日：2012-03-23
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES , MASCOLA, John, R. , NABEL, Gary, J. , KWONG, Peter, D. , SHAPIRO, Lawrence, S. , ZHU, Jiang , WU, Xueling , ZHANG, Zhenhai , ZHOU, Tongqing
发明人： MASCOLA, John, R. , NABEL, Gary, J. , KWONG, Peter, D. , SHAPIRO, Lawrence, S. , ZHU, Jiang , WU, Xueling , ZHANG, Zhenhai , ZHOU, Tongqing
IPC分类号： C07K16/10 , G01N33/569 , C12N15/13 , G06F19/14
CPC分类号： C07K16/1063 , C07K2317/21 , C07K2317/35 , C07K2317/52 , C07K2317/56 , C07K2317/76 , G01N33/56988 , G06F19/18
摘要： Monoclonal neutralizing antibodies are disclosed that specifically bind to the CD4 binding site of HIV-1 gpl20. The identification of these antibodies, and the use of these antibodies are also disclosed. Methods are also provided for enhancing the binding and neutralizing activity of any antibody using epitope scaffold probes.
摘要翻译：公开了特异性结合HIV-1 gp120的CD4结合位点的单克隆中和抗体。还公开了这些抗体的鉴定，以及这些抗体的用途。还提供了用于增强使用表位支架探针的任何抗体的结合和中和活性的方法。

22. 发明申请

WO2012006180A1 HIV IMMUNOGENS 审中-公开
标题翻译：艾滋病毒免疫球蛋白
公开(公告)号：WO2012006180A1
公开(公告)日：2012-01-12
申请号：PCT/US2011/042434
申请日：2011-06-29
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , PURDUE RESEARCH FOUNDATION , NABEL, Gary, J. , YANG, Zhi-yong , AKAHATA, Wataru , KANEKIYO, Masaru , XU, Ling , KWONG, Peter, D. , ZHOU, Tongqing , BOYINGTON, Jeffrey, C. , GEORGIEV, Ivelin, S. , ZHU, Jiang , ROSSMANN, Michael
发明人： NABEL, Gary, J. , YANG, Zhi-yong , AKAHATA, Wataru , KANEKIYO, Masaru , XU, Ling , KWONG, Peter, D. , ZHOU, Tongqing , BOYINGTON, Jeffrey, C. , GEORGIEV, Ivelin, S. , ZHU, Jiang , ROSSMANN, Michael
IPC分类号： C12N15/49 , A61K39/21 , A61P31/18
CPC分类号： A61K39/21 , A61K39/12 , A61K2039/5258 , A61K2039/545 , A61K2039/57 , C07K14/005 , C12N2740/16034 , C12N2740/16122 , C12N2740/16134 , Y02A50/383
摘要： Disclosed are HIV immunogens. Also disclosed are nucleic acids encoding these immunogens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-1) infection in a subject.
摘要翻译：披露的是艾滋病毒免疫原。还公开了编码这些免疫原的核酸和产生这些抗原的方法。还公开了在受试者中产生免疫应答的方法。在一些实施方案中，该方法是用于治疗或预防受试者中的人类免疫缺陷1型（HIV-1）感染的方法。

23. 发明申请

WO2008145563A2 PROCESS FOR PREPARING TRIAZOLONES 审中-公开
标题翻译：制备三唑的方法
公开(公告)号：WO2008145563A2
公开(公告)日：2008-12-04
申请号：PCT/EP2008/056166
申请日：2008-05-20
申请人： F. HOFFMANN-LA ROCHE AG , ARZENO, Humberto, Bartolome , LEE, Gary, M. , MARTIN, Michael , SARMA, Keshab , ZHU, Jiang
发明人： ARZENO, Humberto, Bartolome , LEE, Gary, M. , MARTIN, Michael , SARMA, Keshab , ZHU, Jiang
IPC分类号： C07D249/10
CPC分类号： C07D249/12 , C07C17/18 , C07C45/004 , C07C253/14 , C07C253/30 , C07C25/18 , C07C47/55 , C07C255/54 , C07C255/56
摘要： The present process provides a improved method for the preparation of alkylsulfanyl substituted triazoles 2 which are useful intermediates in a new process for the preparation of triazolones
摘要翻译：本发明方法提供了制备烷基硫烷基取代的三唑2的改进方法，它们是制备三唑酮的新方法中有用的中间体

24. 发明申请

WO2007095069A2 NF-YA ACTIVATES MULTIPLE HEMATOPOIETIC STEM CELL (HSC) REGULATORY GENES AND PROMOTES HSC SELF-RENEWAL 审中-公开
标题翻译： NF-YA激活多重HEMATOPOIETIC干细胞（HSC）调节基因和促进HSC自我更新
公开(公告)号：WO2007095069A2
公开(公告)日：2007-08-23
申请号：PCT/US2007/003434
申请日：2007-02-08
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , EMERSON, Stephen, G. , ZHU, Jiang , DOMASHENKO, Alevtina
发明人： EMERSON, Stephen, G. , ZHU, Jiang , DOMASHENKO, Alevtina
IPC分类号： A61K39/12
CPC分类号： C07K14/4702 , C12N5/0647
摘要： Provide are methods for enhancing hematopoietic stem cell (HSC) self-renewal and/or proliferation resulting from increasing the intracellular concentration of NF-Ya in the cell, as well as, the resulting enhanced HSC resulting from the use of the provided methods, therapeutic use of such enhanced HSC and kits relating thereto.
摘要翻译：提供的是增加造血干细胞（HSC）自我更新和/或增殖的方法，其是由于增加细胞中NF-Ya的细胞内浓度，以及由使用所提供的方法得到的增强的HSC，治疗使用与之相关的增强型HSC和套件。

25. 发明申请

WO2015142476A1 ELECTRONIC DEVICE WITH SLOT ANTENNA AND PROXIMITY SENSOR 审中-公开
标题翻译：带天线和接近传感器的电子设备
公开(公告)号：WO2015142476A1
公开(公告)日：2015-09-24
申请号：PCT/US2015/016909
申请日：2015-02-20
申请人： APPLE INC.
发明人： ZHU, Jiang , GOMEZ ANGULO, Rodney, A. , LI, Qingxiang
IPC分类号： H01Q1/22 , H01Q13/10 , G06F1/16
CPC分类号： H01Q13/10 , G01V3/00 , G06F1/1613 , H01Q1/2266 , H01Q1/243
摘要： An electronic device may be provided with slot antennas. A slot antenna may be formed from metal structures that have a dielectric gap defining an antenna slot. The metal structures may include multiple metal layers that overlap a plastic antenna window and that serve as capacitive electrodes in a capacitive proximity sensor. The metal structures may also include a metal electronic device housing. The metal electronic device housing and the metal layers may be formed on opposing sides of the antenna slot. The metal layers may have a notch that locally widens the antenna slot at an open end of the antenna slot. One of the metal layers may be shorted to the metal electronic device housing at an opposing closed end of the antenna slot. The antenna slot may be indirectly fed using a near-field-coupled antenna feed structure such as a metal patch that overlaps the antenna slot.
摘要翻译：电子设备可以设置有缝隙天线。缝隙天线可以由具有限定天线槽的电介质间隙的金属结构形成。金属结构可以包括与塑料天线窗重叠并且用作电容式接近传感器中的电容电极的多个金属层。金属结构还可以包括金属电子器件壳体。金属电子器件壳体和金属层可以形成在天线槽的相对侧上。金属层可以具有在天线槽的开放端局部加宽天线槽的陷波。金属层之一可能在天线槽的相对的封闭端与金属电子器件外壳短路。可以使用与天线槽重叠的诸如金属贴片的近场耦合天线馈送结构间接馈送天线槽。

26. 发明申请

WO2014051927A1 DISTRIBUTED LOOP SPEAKER ENCLOSURE ANTENNA 审中-公开
标题翻译：分布式环路扬声器外壳天线
公开(公告)号：WO2014051927A1
公开(公告)日：2014-04-03
申请号：PCT/US2013/057360
申请日：2013-08-29
申请人： APPLE INC.
发明人： ZHU, Jiang , LI, Qingxiang , SCHLUB, Robert, W. , CABALLERO, Ruben
IPC分类号： H01Q1/24 , H01Q1/44 , H01Q7/00
CPC分类号： H01Q1/243 , H01Q1/44 , H01Q7/00
摘要： An electronic device may be provided with antenna structures. The antenna structures may be formed using a dielectric carrier structure such as a speaker enclosure, so that interior space within the electronic device that is occupied by a speaker can be used in forming an antenna. A speaker driver may be mounted in the speaker enclosure. Openings in the speaker enclosure may allow sound from the speaker driver to be emitted from the speaker enclosure. The antenna structures may have first and second loop antenna resonating elements. The first loop antenna resonating element may indirectly feed the second loop antenna resonating element. The second loop antenna resonating element may be a distributed loop element formed from a strip of metal with a width that loops around the speaker enclosure. Openings in the second loop antenna resonating element may be aligned with the speaker enclosure openings.
摘要翻译：电子设备可以设置有天线结构。天线结构可以使用诸如扬声器外壳的电介质载体结构来形成，使得由扬声器占据的电子设备内的内部空间可以用于形成天线。扬声器驱动器可以安装在扬声器外壳中。扬声器外壳中的开口可能允许来自扬声器驱动器的声音从扬声器外壳发射。天线结构可以具有第一和第二环形天线谐振元件。第一环形天线谐振元件可以间接馈送第二环形天线谐振元件。第二环形天线谐振元件可以是由具有环绕扬声器外壳的宽度的金属条形成的分布式环形元件。第二环形天线谐振元件中的开口可与扬声器外壳开口对准。

27. 发明申请

WO2013165809A1 ANTENNA STRUCTURES HAVING SLOT-BASED PARASITIC ELEMENTS 审中-公开
标题翻译：天线结构具有基于槽的PARASITIC元素
公开(公告)号：WO2013165809A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/038232
申请日：2013-04-25
申请人： APPLE INC.
发明人： ZHU, Jiang , GUTERMAN, Jerzy , PASCOLINI, Mattia , HU, Hongfei
IPC分类号： H01Q9/42 , H01Q1/24 , H01Q1/52 , H01Q21/28 , H01Q13/10
CPC分类号： H01Q1/243 , H01Q1/521 , H01Q9/42 , H01Q13/10 , H01Q21/28
摘要： Electronic devices may include radio-frequency transceiver circuitry and antenna structures. The antenna structures may include antenna resonating elements and antenna ground plane structures. An electronic device may have antennas formed from the antenna resonating elements and an antenna ground plane. The antenna ground plane may have slot structures. The slot structures may be configured to form a slot-based parasitic antenna element to minimize coupling between the antennas in a device. The slot-based parasitic antenna element may be located between the antennas in a device. The slots structures from which a parasitic antenna element is formed may include open slots and closed slots. Slots may have one or more arms and one or more bends. Slots may be formed in internal housing members, traces on dielectric carriers, and other conductive structures.
摘要翻译：电子设备可以包括射频收发器电路和天线结构。天线结构可以包括天线谐振元件和天线接地平面结构。电子设备可以具有由天线谐振元件和天线接地层形成的天线。天线接地平面可以具有槽结构。槽结构可以被配置为形成基于槽的寄生天线元件，以最小化设备中的天线之间的耦合。基于时隙的寄生天线元件可以位于设备中的天线之间。形成寄生天线元件的槽结构可以包括开放槽和闭合槽。插槽可以具有一个或多个臂和一个或多个弯曲。插槽可以形成在内部壳体构件中，电介质载体上的迹线以及其它导电结构。

28. 发明申请

WO2013165700A1 CORNER BRACKET SLOT ANTENNAS 审中-公开
标题翻译：角撑架天线
公开(公告)号：WO2013165700A1
公开(公告)日：2013-11-07
申请号：PCT/US2013/037198
申请日：2013-04-18
申请人： APPLE INC.
发明人： ZHU, Jiang , LI, Qingxiang , SCHLUB, Robert, W. , SAMARDZIJA, Miroslav , COUTTS, Gordon , GOMEZ ANGULO, Rodney, A. , JIANG, Yi , SHIU, Boon, W. , YARGA, Salih , MCMILIN, Emily, B.
IPC分类号： H01Q1/24 , H01Q1/44 , H01Q13/10
CPC分类号： H01Q1/243 , H01Q1/44 , H01Q13/10
摘要： A display cover layer may be mounted in an electronic device housing using housing structures such as corner brackets. A slot antenna may be formed from a corner bracket opening, metal traces on a hollow plastic support structure, or other conductive structures. The slot antenna may have a main portion with opposing ends. An antenna feed may be located at one of the ends. The slot antenna may have a slot with one or more bends. The bends may provide the slot antenna with a C-shaped outline. A side branch slot may extend from the main portion of the slot at a location between the two bends. The presence of the side branch slot may enhance antenna bandwidth. A hollow enclosure may serve as an antenna support structure and as a speaker box enclosing a speaker driver. The antenna feed may be positioned so as to overlap the speaker driver.
摘要翻译：显示器盖层可以使用诸如角落托架的外壳结构安装在电子设备外壳中。狭缝天线可以由角架支架开口，中空塑料支撑结构上的金属轨迹或其它导电结构形成。缝隙天线可以具有相对端部的主要部分。天线馈电可以位于其中一端。缝隙天线可以具有带有一个或多个弯曲部的槽。弯曲可以为狭缝天线提供C形轮廓。侧分支槽可以在两个弯曲之间的位置处从槽的主要部分延伸。侧分支插槽的存在可以增强天线带宽。中空的外壳可以用作天线支撑结构和用作包围扬声器驱动器的扬声器盒。天线馈电可以被定位成与扬声器驱动器重叠。

29. 发明申请

WO2014028118A1 ANTENNAS INTEGRATED WITH SPEAKERS AND METHODS FOR SUPPRESSING CAVITY MODES 审中-公开
标题翻译：天线与扬声器集成在一起，并用于抑制空气质量模式
公开(公告)号：WO2014028118A1
公开(公告)日：2014-02-20
申请号：PCT/US2013/046115
申请日：2013-06-17
申请人： APPLE INC.
发明人： ZHU, Jiang , LI, Quingxiang , GOMEZ ANGULO, Rodney, A. , SAMARDZIJA, Miroslav , COUTTS, Gordon , SCHLUB, Robert, W.
IPC分类号： H01Q1/24 , H01Q9/42 , H01Q1/22
CPC分类号： H01Q1/2266 , H01Q1/243 , H01Q9/42
摘要： An electronic device may be provided with a speaker box (54) antenna (40) for transmitting and receiving radio- frequency signals. A speaker box antenna may be formed from a hollow dielectric speaker box containing a speaker driver. An opening in the speaker box adjacent to the speaker driver may be aligned with a speaker port opening in a conductive electronic device housing structure. The speaker box may be surrounded by conductive structures that form a cavity for the antenna. The conductive structures may include parts of the conductive electronic device housing structure. The speaker box may have opposing upper and lower surfaces. Metal plates may form parts of the upper and lower surfaces and may be shorted together using a conductive layer such as a strip of metal tape. Frequencies of operation may be selected for the antenna that suppress undesired cavity modes and enhance antenna performance.
摘要翻译：电子设备可以设置有用于发射和接收射频信号的扬声器箱（54）天线（40）。扬声器箱形天线可以由包含扬声器驱动器的中空介电扬声器盒形成。与扬声器驱动器相邻的扬声器盒中的开口可以与导电电子器件壳体结构中的扬声器端口对准。扬声器盒可以被形成用于天线的空腔的导电结构包围。导电结构可以包括导电电子器件壳体结构的部分。扬声器盒可以具有相对的上表面和下表面。金属板可以形成上表面和下表面的部分，并且可以使用导电层例如金属带条将其短路在一起。可以为天线选择抑制不需要的腔模的操作频率并提高天线性能。

30. 发明申请

WO2013184331A1 METHODS FOR FORMING ELONGATED ANTENNAS WITH PLASTIC SUPPORT STRUCTURES FOR ELECTRONIC DEVICES 审中-公开
标题翻译：用于形成用于电子设备的塑料支撑结构的延长天线的方法
公开(公告)号：WO2013184331A1
公开(公告)日：2013-12-12
申请号：PCT/US2013/041692
申请日：2013-05-17
申请人： APPLE INC.
发明人： GUTERMAN, Jerzy , HAYLOCK, Jonathan, M. , SHIU, Boon, W. , JEZIOREK, Peter, N. , IRCI, Erdinc , ZHU, Jiang , PASCOLINI, Mattia
IPC分类号： H01Q1/12 , B29C45/00 , H01Q1/22 , H01Q1/38 , H01Q7/00 , B29C45/36 , B29C33/76 , B29L31/34
CPC分类号： B29C45/0055 , B29C33/76 , B29C45/14639 , B29C45/16 , B29C2045/0058 , H01Q1/12 , H01Q1/2266 , H01Q1/38 , H01Q7/00
摘要： Electronic devices (10) may be provided with antenna structures (28). The antenna structures may include an antenna support structure (46) covered with patterned antenna traces (32,34). An antenna support structure (46) may be mounted in an electronic device (10) so that a surface (58) of the antenna support structure that is covered with patterned antenna traces lies flush with a planar surface (59) of the electronic device housing (12). A display cover layer (50) or other planar structure may be attached to the surface (58) of the antenna support structure (46) and the planar surface of the housing using adhesive (54). Injection molding and extrusion techniques may be used in forming a support structure (46) with elongated parallel cavities (62,64).
摘要翻译：电子设备（10）可以设置有天线结构（28）。天线结构可以包括覆盖有图案化天线迹线（32,34）的天线支撑结构（46）。天线支撑结构（46）可以安装在电子设备（10）中，使得被图案化天线迹线覆盖的天线支撑结构的表面（58）与电子设备壳体的平面（59）齐平（12）。可以使用粘合剂（54）将显示器覆盖层（50）或其他平面结构附接到天线支撑结构（46）的表面（58）和壳体的平面表面。注塑和挤出技术可用于形成具有细长平行腔（62,64）的支撑结构（46）。

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