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21. 发明申请

WO2013022543A2 CATHETER SYSTEM FOR ACUTE NEUROMODULATION 审中-公开
标题翻译：用于急性神经调节的导管系统
公开(公告)号：WO2013022543A2
公开(公告)日：2013-02-14
申请号：PCT/US2012/046332
申请日：2012-07-11
申请人： SYNECOR LLC , RANSBURY, Terrance , SANDERS, William, E. , STACK, Richard, S. , MASSON, Stephen, C.
发明人： RANSBURY, Terrance , SANDERS, William, E. , STACK, Richard, S. , MASSON, Stephen, C.
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/056 , A61N1/36053 , A61N1/36135 , A61N1/36139
摘要： A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning with in a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts - so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is con figured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery. For treatment of heart failure, the first nerve fiber may be a vagus nerve and the second nerve fiber may be a sympathetic nerve fiber.
摘要翻译：神经调节系统包括适于定位在上腔静脉内的第一治疗元件和适于定位在肺动脉中的第二治疗元件。第一治疗元件承载在第一细长柔性轴上，并且第二治疗元件承载在第二细长柔性轴上。第一和第二轴中的一个可滑动地容纳在第一和第二轴中的另一个的内腔内，使得第二治疗元件可以相对于第一治疗元件在本体内前进。设置刺激器以激励第一血管内的第一治疗元件，以将治疗传递至布置在上腔静脉外部的第一神经纤维，并激励肺动脉内的第二治疗元件以将交感神经治疗递送至第二神经纤维布置在肺动脉的外部。为了治疗心力衰竭，第一神经纤维可以是迷走神经，第二神经纤维可以是交感神经纤维。

22. 发明申请

WO2011028737A2 BISPHOSPHONATE COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE 审中-公开
标题翻译：双膦酸盐组合物和治疗心力衰竭的方法
公开(公告)号：WO2011028737A2
公开(公告)日：2011-03-10
申请号：PCT/US2010/047417
申请日：2010-09-01
申请人： DUKE UNIVERSITY , LYLES, Kenneth, W. , COLON-EMERIC, Cathleen, S. , O'CONNOR, Christopher, M. , STACK, Richard, S. , STACK-D'NIAYE, Colleen
发明人： LYLES, Kenneth, W. , COLON-EMERIC, Cathleen, S. , O'CONNOR, Christopher, M. , STACK, Richard, S. , STACK-D'NIAYE, Colleen
IPC分类号： A61K31/66 , A61K31/675 , A61P9/04 , A61P9/00
CPC分类号： A61K31/663 , A61K31/66
摘要： The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, functional analogue or a pharmaceutically effective salt thereof.
摘要翻译：本发明提供了用于治疗和/或预防心脏功能障碍的方法和组合物，其通过向受试者施用治疗有效量的二膦酸盐，功能类似物或其药学上有效的盐来进行。

23. 发明申请

WO2007021707A3 LIQUID PERFLUOROPOLYMERS AND MEDICAL AND COSMETIC APPLICATIONS INCORPORATING SAME 审中-公开
标题翻译：液体全氟聚合物和包含其中的医药和化妆品应用
公开(公告)号：WO2007021707A3
公开(公告)日：2008-01-31
申请号：PCT/US2006030955
申请日：2006-08-04
申请人： LIQUIDIA TECHNOLOGIES INC , DESIMONE JOSEPH M , STACK RICHARD S
发明人： DESIMONE JOSEPH M , STACK RICHARD S
IPC分类号： A61L27/18 , A61F2/02 , A61F2/06 , A61F13/00 , A61L2/00 , A61L17/04 , A61L27/50 , A61N1/375 , B05D3/02 , B32B1/08 , B32B27/00 , C08J7/18 , G02C7/04
CPC分类号： A61L27/50 , A61L27/16 , A61L27/18 , A61L2400/06 , A61N1/375 , C08L71/00 , C08L101/04 , C08L71/02
摘要： Liquid curable perfluoropolyether (PFPE) materials are provided for use as coatings, sealants, flexible fillers, and structural parts for a wide variety of medical and cosmetic applications, particularly where silicone has been utilized conventionally. The PFPE material is oxygen permeable and bacterial impermeable and may contain one or more pharmacological agents elutably trapped therewithin for delivery within the body of a subject.
摘要翻译：提供液体可固化全氟聚醚（PFPE）材料用作各种医疗和化妆品应用的涂料，密封剂，柔性填料和结构部件，特别是在常规使用硅酮的情况下。 PFPE材料是透氧的和细菌不渗透的，并且可以含有一种或多种可被截留在其中以用于在受试者体内递送的药理学试剂。

24. 发明申请

WO2007038715A1 TRANSGASTRIC SURGICAL DEVICES AND PROCEDURES 审中-公开
标题翻译：转移性外科手术和手术
公开(公告)号：WO2007038715A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/037978
申请日：2006-09-27
申请人： SYNECOR, LLC , WILLIAMS, Michael, S. , STACK, Richard, S. , ORTH, Geoff , SMITH, Jeff , GLENN, Richard, A. , ATHAS, William, S. , PRYOR, Aurora
发明人： WILLIAMS, Michael, S. , STACK, Richard, S. , ORTH, Geoff , SMITH, Jeff , GLENN, Richard, A. , ATHAS, William, S. , PRYOR, Aurora
IPC分类号： A61B17/34
CPC分类号： A61B17/3421 , A61B17/0057 , A61B17/3417 , A61B17/3423 , A61B17/3478 , A61B17/3496 , A61B46/10 , A61B90/40 , A61B2017/00278 , A61B2017/00867 , A61B2017/00871 , A61B2017/3484 , A61B2017/3486 , A61B2017/3488 , A61B2017/349 , A61B2017/3492
摘要： Embodiments of surgical access cannulas and access systems for use in gaining access to a body cavity of a patient via a natural orifice are disclosed. A distal end of an access cannula is advanced through a natural orifice into a hollow organ. Instruments passed through the cannula are used to form an incision in the wall of the hollow organ. The access cannula is anchored in the incision with its distal opening giving access to a body cavity outside the hollow organ. Surgical instruments are passed through the access cannula and used to perform procedures in the body cavity.
摘要翻译：公开了用于通过自然孔口进入患者体腔的外科手术插管和进入系统的实施例。进入插管的远端通过自然孔进入中空器官。通过插管的仪器用于在中空器官的壁上形成切口。进入插管锚定在切口中，其远端开口进入中空器官外部的体腔。手术器械通过入口插管并用于在体腔中执行程序。

25. 发明申请

WO2005027734A3 METHOD AND APPARATUS FOR TREATING DISEASED OR FRACTURED BONE 审中-公开
标题翻译：用于治疗疾病或骨折的方法和设备
公开(公告)号：WO2005027734A3
公开(公告)日：2005-05-26
申请号：PCT/US2004030771
申请日：2004-09-17
申请人： SYNECOR LLC , WILLIAMS MICHAEL S , SMITH JEFFERY A , STACK RICHARD S , HOLBROOK KEVIN D , GLENN RICHARD A
发明人： WILLIAMS MICHAEL S , SMITH JEFFERY A , STACK RICHARD S , HOLBROOK KEVIN D , GLENN RICHARD A
IPC分类号： A61B20060101 , A61B17/00 , A61B17/70 , A61F2/00 , A61F2/44
CPC分类号： A61B17/8858 , A61B17/70 , A61B2017/00867
摘要： An apparatus according to the invention may comprise one or more expandable structural support pylons (140), means for deploying said one or more structural support pylons (138, 141), and one or more therapeutic substances. Structural support pylons (20) may comprise an elastomeric core (22), or may comprise one or more suitable metals, and may be deployed by shortening the length and increasing the height of the pylon. Alternatively, scaffold (200) may comprise a delivery configuration in which first unit (202) and second unit (204) he generally end to end, and a deployed configuration in which superior surfaces (216) and (218) exert an upward force and inferior surfaces (220) and (222) exert a downward force on superior and inferior vertebral surfaces respectively. A method according to the invention may comprise accessing an interior of a diseased or injured bone in a minimally invasive manner, creating a semi-circular path within said bone, deploying one or more structural support pylons within said interior, introducing structural reinforcement material, and if desired, repeating with one or more subsequent structural support pylons.
摘要翻译：根据本发明的装置可以包括一个或多个可膨胀结构支撑塔架（140），用于展开所述一个或多个结构支撑塔架（138,141）以及一种或多种治疗物质的装置。结构支撑塔架（20）可以包括弹性体芯（22），或者可以包括一种或多种适合的金属，并且可以通过缩短长度并增加塔架的高度来展开。或者，支架（200）可以包括输送构造，其中第一单元（202）和第二单元（204）通常首尾相接，以及展开构造，其中上表面（216）和（218）施加向上的力，并且下表面（220）和（222）分别向上和下椎骨表面施加向下的力。根据本发明的方法可以包括以微创方式进入患病或受损骨骼的内部，在所述骨内创建半圆形路径，在所述内部中布置一个或多个结构支撑柱，引入结构增强材料，以及如果需要，用一个或多个随后的结构支撑塔重复。

26. 发明申请

WO2005027734A2 METHOD AND APPARATUS FOR TREATING DISEASED OR FRACTURED BONE 审中-公开
标题翻译：用于治疗疾病或破骨的方法和装置
公开(公告)号：WO2005027734A2
公开(公告)日：2005-03-31
申请号：PCT/US2004/030771
申请日：2004-09-17
申请人： SYNECOR, LLC , WILLIAMS, Michael, S. , SMITH, Jeffery, A. , STACK, Richard, S. , HOLBROOK, Kevin, D. , GLENN, Richard, A.
发明人： WILLIAMS, Michael, S. , SMITH, Jeffery, A. , STACK, Richard, S. , HOLBROOK, Kevin, D. , GLENN, Richard, A.
IPC分类号： A61B
CPC分类号： A61B17/8858 , A61B17/70 , A61B2017/00867
摘要： An apparatus according to the invention may comprise one or more expandable structural support pylons (140), means for deploying said one or more structural support pylons (138, 141), and one or more therapeutic substances. Structural support pylons (20) may comprise an elastomeric core (22), or may comprise one or more suitable metals, and may be deployed by shortening the length and increasing the height of the pylon. Alternatively, scaffold (200) may comprise a delivery configuration in which first unit (202) and second unit (204) he generally end to end, and a deployed configuration in which superior surfaces (216) and (218) exert an upward force and inferior surfaces (220) and (222) exert a downward force on superior and inferior vertebral surfaces respectively. A method according to the invention may comprise accessing an interior of a diseased or injured bone in a minimally invasive manner, creating a semi-circular path within said bone, deploying one or more structural support pylons within said interior, introducing structural reinforcement material, and if desired, repeating with one or more subsequent structural support pylons.
摘要翻译：根据本发明的装置可以包括一个或多个可膨胀结构支撑塔（140），用于展开所述一个或多个结构支撑塔（138,141）的装置和一个或多个治疗物质。结构支撑塔（20）可以包括弹性体芯（22），或者可以包括一种或多种合适的金属，并且可以通过缩短长度和增加塔的高度来展开。或者，脚手架（200）可以包括其中大致端对端的第一单元（202）和第二单元（204）以及上表面（216）和（218）施加向上的力的展开构造的输送构型，以及下表面（220）和（222）分别在上下椎体表面上施加向下的力。根据本发明的方法可以包括以微创方式进入患病或受伤的骨骼的内部，在所述骨骼内产生半圆形路径，在所述内部内展开一个或多个结构支撑塔，引入结构增强材料，以及如果需要，用一个或多个随后的结构支撑塔重复。

27. 发明申请

WO2003017882A3 SATIATION DEVICES AND METHODS 审中-公开
公开(公告)号：WO2003017882A3
公开(公告)日：2003-03-06
申请号：PCT/US2002/027177
申请日：2002-08-26
申请人： SYNECOR, LLC , STACK, Richard, S. , GLENN, Richard, A. , MOODY, Trevor, J. , SILVERSTEIN, Fred, E. , EVERY, Nathan , EUBANKS, William, S., Jr.
发明人： STACK, Richard, S. , GLENN, Richard, A. , MOODY, Trevor, J. , SILVERSTEIN, Fred, E. , EVERY, Nathan , EUBANKS, William, S., Jr.
IPC分类号： A61F5/00
摘要： A device for inducing weight loss in a patient includes a tubular prosthesis self-expandable from a collapsed position in which the prosthesis has a first diameter to an expanded position in which the prosthesis has a second, larger, diameter. In a method for inducing weight loss, the prosthesis is placed in the collapsed position and inserted into a stomach of a patient. The prosthesis is allowed to self-expand from the collapsed position to the expanded position and into contact with the walls of the stomach, where it induces feelings of satiety and/or inhibits modulation of satiety-controlling factors such as Ghrelin.

28. 发明申请

WO1991017789A1 BIOABSORBABLE STENT 审中-公开
标题翻译：生物耐药性
公开(公告)号：WO1991017789A1
公开(公告)日：1991-11-28
申请号：PCT/US1991003454
申请日：1991-05-17
申请人： STACK, Richard, S. , CLARK, Howard, G., III , WALKER, William, F.
IPC分类号： A61M29/02
CPC分类号： A61F2/90 , A61F2/82 , A61F2/92 , A61F2/958 , A61F2210/0004 , A61F2250/0067 , A61L31/146 , A61L31/148 , A61L31/16
摘要： A bioabsorbable stent (10, 50, 80, 90) for placement at the locus of a stenotic portion of a body passage, such as a blood vessel, which is flexible and compliant for safe and effective delivery to the site of the stenotic portion of, for example, a blood vessel, so as to avoid the disadvantages of chronic implantation, such as arterial rupture or aneurism formation while exposed to the continuous stresses of a beating heart. The stent is formed from a bioabsorbable material and is porous or has apertures defined there through to facilitate tissue ingrowth and encapsulation of the stent. The stent is encapsulated and biodegrades or bioabsorbs within a period of days, weeks or months as desired following encapsulation to thereby minimize the likelihood of embolization or other risks of the dissolved material and to avoid the disavantages of chronic implantation.
摘要翻译：一种生物吸收性支架（10,50,80,90），用于放置在身体通道（例如血管）的狭窄部位的位置，该体动通道柔性且顺从地安全有效地输送到狭窄部位的位置，例如血管，以避免慢性植入的缺点，例如动脉破裂或动脉瘤形成，同时暴露于搏动心脏的持续压力。支架由生物可吸收材料形成并且是多孔的或具有限定在其中的孔，以便于组织向内生长和包封支架。在包囊后，根据需要在几天，几周或几个月的时间内将支架包封和生物降解或生物吸收，从而使栓塞的可能性或溶解的材料的其他风险最小化并避免慢性植入的缺点。

29. 发明申请

WO2013022543A3 CATHETER SYSTEM FOR ACUTE NEUROMODULATION 审中-公开
标题翻译：用于急性神经修复的导管系统
公开(公告)号：WO2013022543A3
公开(公告)日：2013-10-03
申请号：PCT/US2012046332
申请日：2012-07-11
申请人： SYNECOR LLC , RANSBURY TERRANCE , SANDERS WILLIAM E , STACK RICHARD S , MASSON STEPHEN C
发明人： RANSBURY TERRANCE , SANDERS WILLIAM E , STACK RICHARD S , MASSON STEPHEN C
IPC分类号： A61N1/36 , A61B18/14 , A61B18/18 , A61M25/04 , A61N1/362
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/056 , A61N1/36053 , A61N1/36135 , A61N1/36139
摘要： A neuromodulation system includes a first therapy element adapted for positioning within a superior vena cava, and a second therapy element adapted for positioning with in a pulmonary artery. The first therapy element is carried on a first elongate flexible shaft, and the second therapy element is carried on a second elongate flexible shaft. One of the first and second shafts is slidably received within a lumen of the other of the first and second shafts - so that the second therapy element may be advanced within the body relative to the first therapy element. A stimulator is con figured to energize the first therapy element within the first blood vessel to deliver therapy to a first nerve fiber disposed external to the superior vena cava and to energize the second therapy element within the pulmonary artery to deliver sympathetic therapy to a second nerve fiber disposed external to the pulmonary artery. For treatment of heart failure, the first nerve fiber may be a vagus nerve and the second nerve fiber may be a sympathetic nerve fiber.
摘要翻译：神经调节系统包括适于定位在上腔静脉内的第一治疗元件和适于定位在肺动脉中的第二治疗元件。第一治疗元件承载在第一细长柔性轴上，并且第二治疗元件承载在第二细长柔性轴上。第一和第二轴中的一个可滑动地容纳在第一和第二轴中的另一个的内腔中，使得第二治疗元件可相对于第一治疗元件在身体内前进。刺激器被配置为激活第一血管内的第一治疗元件，以将治疗递送至布置在上腔静脉外部的第一神经纤维，并激励肺动脉内的第二治疗元件以向第二神经递送交感神经治疗纤维布置在肺动脉外部。为了治疗心力衰竭，第一神经纤维可能是迷走神经，第二神经纤维可能是交感神经纤维。

30. 发明申请

WO2012149511A3 NEUROMODULATION SYSTEMS AND METHODS FOR TREATING ACUTE HEART FAILURE SYNDROMES 审中-公开
标题翻译：神经系统和治疗急性心力衰竭综合征的方法
公开(公告)号：WO2012149511A3
公开(公告)日：2013-02-28
申请号：PCT/US2012035712
申请日：2012-04-28
申请人： SYNECOR LLC , RANSBURY TERRANCE , SANDERS WILLIAM E , STACK RICHARD S , STACK COLLEEN
发明人： RANSBURY TERRANCE , SANDERS WILLIAM E , STACK RICHARD S , STACK COLLEEN
IPC分类号： A61N1/362 , A61B17/34 , A61B18/00 , A61M25/088 , A61N1/04
CPC分类号： A61N1/3621 , A61B5/01 , A61B5/0215 , A61B5/024 , A61M25/0074 , A61M25/0125 , A61M25/0147 , A61M25/04 , A61M2025/0175 , A61N1/056 , A61N1/057 , A61N1/36114 , A61N1/3627
摘要： A neuromodulation system for treating acute heart failure syndromes includes a first catheter having a parasympathetic therapy element adapted for positioning within a first blood vessel such as a superior vena cava, and a second catheter sympathetic therapy element adapted for positioning with a second, different, blood vessel such as the pulmonary artery. The catheters comprise a system in which one of catheters is slidably disposed over the other of the catheters. The system may further be slidably disposed over a third elongate element such as a Swan-Ganz catheter positionable within a pulmonary artery, such that the Swan- Ganz may be used for monitoring parameters such as blood pressure and cardiac output during neuromodulation therapy. The parasympathetic therapy element is energized to deliver neuromodulation therapy to a parasympathetic nerve fiber such as a vagus nerve, while the sympathetic therapy element is energized to deliver neuromodulation therapy to a sympathetic nerve fiber such as a sympathetic cardiac nerve fiber. For treatment of acute heart failure syndromes, the neuromodulation therapy may be used to lower heart rate and increase cardiac inotropy.
摘要翻译：用于治疗急性心力衰竭综合征的神经调节系统包括具有适于定位在诸如上腔静脉的第一血管内的副交感神经治疗元件的第一导管和适于与第二不同血液定位的第二导管交感神经治疗元件血管如肺动脉。导管包括其中一个导管可滑动地设置在另一个导管上的系统。系统还可以可滑动地设置在第三细长元件（例如可定位在肺动脉内的Swan-Ganz导管）之上，使得Swan-Ganz可用于监测神经调节治疗期间的血压和心输出量等参数。副交感神经治疗元件被激励以将神经调节治疗递送到副交感神经纤维例如迷走神经，而交感神经治疗元件通电以将神经调节治疗递送至交感神经纤维如交感神经纤维。对于急性心力衰竭综合征的治疗，神经调节治疗可用于降低心率并增加心脏内向性。

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