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    • 28. 发明申请
    • A PROCESS TO TREAT AVASCULAR NECROSIS (AVN) WITH OSTEOINDUCTIVE MATERIALS
    • 使用骨质疏松材料治疗AVASCARAR NECROSIS(AVN)的方法
    • WO2006033888A9
    • 2006-11-23
    • PCT/US2005032515
    • 2005-09-13
    • SDGI HOLDINGS INCNYCZ JEFFREY HSEROUSEK JON CMCKAY WILLIAM F
    • NYCZ JEFFREY HSEROUSEK JON CMCKAY WILLIAM F
    • A61K38/18A61B17/00A61P19/08
    • A61K38/1875A61B17/58A61F2/2814
    • A method of treating avascular necrosis ("AVN") comprising administering one or more osteoinductive formulations to the site of AVN disease progression. The method involves the combination of a core decompression technique, followed by the introduction of one or more osteoinductive formulations into the decompression core, and concluding with capping of the ateral aspect of the decompression core with a femoral core cap. The osteoinductive formulations of the invention comprise one or more osteoinductive agents and suitable carrier molecules. The femoral core cap retains the osteoinductive formulation within the decompression core, thereby preventing leakage of the osteoinductive formulation from the decompression core. The method of the invention optionally comprises introduction of autograft or allograft with the osteoinductive formulations of the invention. The method of the invention further optionally comprises incorporation of sustained release compositions to provide extended periods of osteogenesis.
    • 一种治疗无血管性坏死(“AVN”)的方法,包括向AVN疾病进展的部位施用一种或多种骨诱导性制剂。 该方法涉及核心减压技术的组合,随后将一种或多种骨诱导性制剂引入减压核心中,并且用股骨芯帽盖住减压核心的整体方面。 本发明的骨诱导性制剂包含一种或多种成骨诱导剂和合适的载体分子。 股骨芯帽将骨诱导制剂保留在减压芯内,从而防止骨诱导制剂从减压芯渗漏。 本发明的方法任选地包括用本发明的骨诱导制剂引入自体移植物或同种异体移植物。 本发明的方法还任选地包括并入缓释组合物以提供延长的成骨期。