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21. 发明申请

WO2006015057A2 C-TERMINALLY TRUNCATED INTERFERON 审中-公开
标题翻译： C-端子截断干扰器
公开(公告)号：WO2006015057A2
公开(公告)日：2006-02-09
申请号：PCT/US2005026674
申请日：2005-07-27
申请人： LARGE SCALE BIOLOGY CORP , REINL STEPHEN J , POGUE GREGORY P
发明人： REINL STEPHEN J , POGUE GREGORY P
IPC分类号： C07H21/04 , A61K38/21 , C07K14/56 , C12P21/04
CPC分类号： C12N15/8221 , A61K38/00 , C07K14/56 , C12N15/8257
摘要： The invention described herein provides a C-terminally truncated interferon having enhanced biological activity and the polynucleotides encoding such interferon. Also provided are methods for producing and using such truncated interferon.
摘要翻译：本文描述的本发明提供了具有增强的生物活性的C-末端截短的干扰素和编码这种干扰素的多核苷酸。还提供了用于生产和使用这种截短的干扰素的方法。

22. 发明申请

WO2005108564A2 PRODUCTION OF PEPTIDES IN PLANTS AS VIRAL COAT PROTEIN FUSION 审中-公开
标题翻译：作为病毒蛋白质融合的植物生产肽
公开(公告)号：WO2005108564A2
公开(公告)日：2005-11-17
申请号：PCT/US2005010192
申请日：2005-03-25
申请人： LARGE SCALE BIOLOGY CORP , PALMER KENNETH E , TOTH RACHEL L , JONES MIKE , CHAPMAN SEAN , SMOLENSKA LISA , MCCORMICK ALISON A , POGUE GREGORY P , NGUYEN LONG V
发明人： PALMER KENNETH E , TOTH RACHEL L , JONES MIKE , CHAPMAN SEAN , SMOLENSKA LISA , MCCORMICK ALISON A , POGUE GREGORY P , NGUYEN LONG V
IPC分类号： C12N9/10 , C12N15/82
CPC分类号： C12N15/8257 , A61K2039/5256 , A61K2039/6075 , C12N15/8258 , C12N2710/20022 , C12N2740/15022 , C12N2740/16022 , C12N2750/14322 , C12N2760/12222 , C12N2760/14122
摘要： Vaccines and diagnostic composition are made and used for preventing, treating and detecting antigens from a papilloma virus, ebola virus, HIV virus, Rift Valley Fever virus or a parvovirus. The epitopes of these viruses are produced as genetically engineered fusion peptides in plants by infection with a recombinant tobamovirus vectors to express fusion proteins containing the epitope peptides.
摘要翻译：疫苗和诊断组合物被制备并用于预防，治疗和检测来自乳头瘤病毒，埃博拉病毒，HIV病毒，裂谷热病毒或细小病毒的抗原。这些病毒的表位通过用重组烟草花叶病毒载体感染来表达含有表位肽的融合蛋白，作为遗传工程改造的融合肽在植物中产生。

23. 发明申请

WO2004031362A3 MULTIMERIC PROTEIN ENGINEERING 审中-公开
公开(公告)号：WO2004031362A3
公开(公告)日：2004-12-02
申请号：PCT/US0331420
申请日：2003-10-03
申请人： LARGE SCALE BIOLOGY CORP , REINL STEPHEN J , EDWARDS PATRICIA
发明人： REINL STEPHEN J , EDWARDS PATRICIA
IPC分类号： C07H21/04 , C07K16/00 , C07K16/32 , C07K16/46 , A01H5/00 , C12N15/00
CPC分类号： C07K16/32 , C07H21/04 , C07K16/00 , C07K16/46 , C07K2317/13 , C07K2317/31 , C07K2317/55
摘要： The invention described herein encompasses (1) artificial preproteins and the polynucleotides encoding them, (2) methods for producing these biomolecules, and (3) methods for their use. The artificial preproproteins of this invention comprise a protein assembly capable of producing a multimeric protein from a single protein. Figure 4 illustrates generally the process by which a polynucleotide encoding the artificial preproprotein is introduced into a cell and a biomolecule of interest is produced.

24. 发明申请

WO03103605A2 FLEXIBLE VACCINE ASSEMBLY AND VACCINE DELIVERY PLATFORM 审中-公开
标题翻译：灵活的疫苗组装和疫苗输送平台
公开(公告)号：WO03103605A2
公开(公告)日：2003-12-18
申请号：PCT/US0318247
申请日：2003-06-06
申请人： LARGE SCALE BIOLOGY CORP
发明人： MCCORMICK ALISON A , SMITH MARK L , PALMER KENNETH E , LINDBO JOHN A , NGUYEN LONG V , POGUE GREGORY P
IPC分类号： A61K20060101 , A61K39/12 , A61K39/385 , A61K48/00 , C07K14/025 , C07K14/08 , C07K14/11 , C07K14/115 , C07K14/12 , C07K14/47 , C07K19/00 , C12N7/00 , C12N7/01 , C12N7/04 , C12N15/86 , A61K
CPC分类号： C07K14/005 , A61K39/0011 , A61K39/12 , A61K39/385 , A61K2039/5258 , A61K2039/55516 , A61K2039/6075 , A61K2039/627 , A61K2039/64 , C07K14/4748 , C07K2319/00 , C12N7/00 , C12N2710/20022 , C12N2710/20034 , C12N2760/16122 , C12N2760/18022 , C12N2770/00022 , C12N2770/00023
摘要： Herein described are various methods for making a vaccine that are made of re-assembled virus like particles (VLP). First, the VLPs are disassembled into encapsidation intermediate populations. Each encapsidation intermediate population undergoes, for instance, chemical conjugation of unique peptide or nucleic moieties to form separate populations. Thereafter, a predetermined amount of each of the several (one or more) different encapsidation intermediates from the different populations is mixed and joined, forming intact VLPs, surrounding a nucleic acid core, that are composed of different encapsidation intermediate such that the reassembled VLP displays more than one peptide or nucleic acid. The nucleic acid can function either as a scaffold alone or can be engineered for the expression of an immunomodulatory protein in a eukaryotic cell.
摘要翻译：本文描述了制备由重新组装的病毒样颗粒（VLP）制成的疫苗的各种方法。首先，将VLP分解成壳化中间种群。每个壳化中间体经历例如独特的肽或核酸部分的化学共轭以形成分开的群体。此后，将来自不同群体的几种（一种或多种）不同的壳化中间体中的每一种的预定量混合并连接，形成围绕核酸核心的完整的VLP，其由不同的包封中间体组成，使得重新组装的VLP显示多于一种肽或核酸。核酸可以作为单独的支架起作用，或者可以被工程化以在真核细胞中表达免疫调节蛋白。

25. 发明申请

WO02059336A3 CYTOPLASMIC INHIBITION OF GENE EXPRESSION AND EXPRESSION OF A FOREIGN PROTEIN IN A MONOCOT PLANT BY A PLANT VIRAL VECTOR 审中-公开
标题翻译：基因表达抑制和植物病毒载体在单株植物中表达外源蛋白的表达
公开(公告)号：WO02059336A3
公开(公告)日：2003-09-04
申请号：PCT/US0203916
申请日：2002-01-23
申请人： LARGE SCALE BIOLOGY CORP , HOLZBERG STEVEN P , POGUE GREGORY P
发明人： HOLZBERG STEVEN P , POGUE GREGORY P
IPC分类号： C07K14/08 , C12N15/82
CPC分类号： C07K14/005 , C12N15/8216 , C12N15/8218 , C12N2770/00022
摘要： The present invention relates to recombinant viral vectors encoding a transcriptional unit, that encodes a fusion protein, or a foreign protein or a gene of interest to be silenced, which can be expressed in a host. The present invention also relates to the use of these recombinant viral vectors to express a fusion protein, a foreign protein, to silence a gene of interest in a host. The present invention also relates to the use of these recombinant viral vectors to screen a cDNA or genomic library in order to correlate a nucleotide sequence with a phenotypic or biochemical change.
摘要翻译：本发明涉及编码融合蛋白的转录单位的重组病毒载体，或可以在宿主中表达的待沉默的外源蛋白或感兴趣的基因。本发明还涉及这些重组病毒载体在宿主中表达融合蛋白，一种外来蛋白质以使感兴趣的基因沉默的用途。本发明还涉及这些重组病毒载体筛选cDNA或基因组文库以使核苷酸序列与表型或生物化学变化相关联的用途。

26. 发明申请

WO0208411A3 METHODS OF CREATING DWARF PHENOTYPES IN PLANTS 审中-公开
标题翻译：在植物中形成DWARF PHENOTYPES的方法
公开(公告)号：WO0208411A3
公开(公告)日：2003-03-27
申请号：PCT/US0123315
申请日：2001-07-20
申请人： LARGE SCALE BIOLOGY CORP , POGUE GREGORY P , DELLA-CIOPPA GUY R , WOLFE GERSHON M , ZHENG WENJIN
发明人： POGUE GREGORY P , DELLA-CIOPPA GUY R , WOLFE GERSHON M , ZHENG WENJIN
IPC分类号： C07K14/415 , C12N15/29 , C12N15/82 , A01H5/00
CPC分类号： C12N15/8216 , C07K14/415 , C12N15/8203 , C12N15/8243 , C12N15/8247 , C12N15/8261 , Y02A40/146
摘要： The invention is directed to the application of gene sequences which cause a dwarf phenotype in plants to the fields of forestry plants, ornamental horticultural plants, medicinal plants, and Nicotiana plants which are used for purposes other than for traditional tobacco products. The invention provides cDNAs identified by the polynucleotide sequences SEQ ID NO: 1-122 that may be used to create transfected or transgenic plants exhibiting a dwarf phenotype. The invention also provides methods of creating a transfected or transgenic plant exhibiting a dwarf phenotype by expressing in the plant DNA or mRNA identified by the sequences SEQ ID NO:1-122.
摘要翻译：本发明涉及在植物中引起矮化表型的基因序列在用于除传统烟草制品之外的目的的林业植物，观赏园艺植物，药用植物和烟草植物的领域中的应用。本发明提供通过多核苷酸序列SEQ ID NO：1-122鉴定的cDNA，其可用于产生表现出矮化表型的转染或转基因植物。本发明还提供了通过在由SEQ ID NO：1-122序列识别的植物DNA或mRNA中表达来产生表现出矮化表型的转染或转基因植物的方法。

27. 发明申请

WO0177350A3 COMPOSITIONS AND METHODS FOR INHIBITING GENE EXPRESSION 审中-公开
标题翻译：用于抑制基因表达的组合物和方法
公开(公告)号：WO0177350A3
公开(公告)日：2002-08-08
申请号：PCT/US0111436
申请日：2001-04-04
申请人： LARGE SCALE BIOLOGY CORP , PALMER KENNETH E , POGUE GREGORY P
发明人： PALMER KENNETH E , POGUE GREGORY P
IPC分类号： C12N15/79
CPC分类号： C12N15/79
摘要： The present invention provides an eukaryotic recombinant vector suited for bi-directional transcription of a transgene to yield both sense and antisense RNA transcripts of the transgene in an eukaryotic cell. The invention vectors are particularly suited for mediating gene silencing in a variety of biological systems. The present invention also provides host cells and transgenic plants comprising the invention vectors. Further provided by the invention are methods of inhibiting expression of an endogenous gene present in an eukaryotic cell. Also included is a method of identifying a biological function(s) of an endogenous gene of interest in an eukaryotic cell by selectively inhibiting the expression of the endogenous gene.
摘要翻译：本发明提供了适用于转基因双向转录的真核重组载体，以产生真核细胞中转基因的有义和反义RNA转录物。本发明载体特别适用于介导各种生物系统中的基因沉默。本发明还提供宿主细胞和包含本发明载体的转基因植物。本发明进一步提供的是抑制存在于真核细胞中的内源基因表达的方法。还包括通过选择性抑制内源基因的表达来鉴定真核细胞中感兴趣的内源基因的生物学功能的方法。

28. 发明申请

WO0166778A2 PRODUCTION OF FOREIGN POLYPEPTIDES IN PLANTS AS VIRAL COAT PROTEIN FUSIONS 审中-公开
标题翻译：在植物中生产外源性多糖作为病毒蛋白融合蛋白
公开(公告)号：WO0166778A2
公开(公告)日：2001-09-13
申请号：PCT/US0107355
申请日：2001-03-08
申请人： LARGE SCALE BIOLOGY CORP , POGUE GREGORY P , LINDBO JOHN A , MCCULLOCH MICHAEL J , LAWRENCE JONATHAN E , GROSS CYNTHIA S , GARGER STEPHEN J
发明人： POGUE GREGORY P , LINDBO JOHN A , MCCULLOCH MICHAEL J , LAWRENCE JONATHAN E , GROSS CYNTHIA S , GARGER STEPHEN J
IPC分类号： A01H5/00 , A61K39/00 , C07K14/08 , C07K14/445 , C12N5/10 , C12N7/00 , C12N7/01 , C12N7/02 , C12N15/09 , C12N15/40 , C12N15/82 , C12P21/02 , C12P21/04 , C12N5/14 , C12N15/62
CPC分类号： C07K14/005 , A61K39/00 , C07K14/445 , C07K2319/00 , C12N15/8203 , C12N15/8257 , C12N15/8258 , C12N2770/00022
摘要： The present invention relates to foreign peptide sequences fused to the amino-terminal of plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The foreign peptide sequences can be cleaved from the fusion proteins by proteolytic enzymes or chemical reagents. The foreign peptide sequences of the invention have many uses. Such uses include use as antigens for inducing the production of antibodies having desired binding properties, e.g., protective antibodies, for use as vaccine antigens for the induction of protective immunity, including immunity against parasitic infections, for use as a protein involved in hormonal activity, or for use as a protein involved in immunoregulatory activity.
摘要翻译：本发明涉及与植物病毒结构蛋白的氨基末端融合的外来肽序列及其制备方法。融合蛋白在生物学含有的烟草花叶病毒的高水平植物中经济合成。外源肽序列可以通过蛋白水解酶或化学试剂从融合蛋白中切割出来。本发明的外源肽序列具有许多用途。这样的用途包括用作诱导产生具有所需结合特性的抗体的抗原，例如保护性抗体，用作诱导保护性免疫的疫苗抗原，包括针对寄生虫感染的免疫，用作参与激素活性的蛋白质，或用作参与免疫调节活性的蛋白质。

29. 发明申请

WO0108094A2 TRAINABLE ADAPTIVE FOCUSED REPLICATOR NETWORK FOR ANALYSING DATA 审中-公开
标题翻译：用于分析数据的可控自适应聚焦复制器网络
公开(公告)号：WO0108094A2
公开(公告)日：2001-02-01
申请号：PCT/US0020479
申请日：2000-07-25
申请人： LARGE SCALE BIOLOGY CORP , MALYJ WASYL
发明人： MALYJ WASYL
IPC分类号： G06N3/00 , G06F19/22 , G06K9/66 , G06T9/00 , H04N7/30 , G06N
CPC分类号： G06K9/6232 , G06F19/22 , G06T9/008 , Y10S707/99933
摘要： Electronic data is classified using adaptive focused replicator network (AFRNs). AFRNs are sets of array elements, each array element being trainable in order to replicate a predetermined sub-group of data. Unknown data is inputted into each and every array element in an AFRN array and then replicated by each element array. A comparison is made for each array element to determine the accuracy of each replication. If only one array element successfully replicates the unknown data, then the unknown data is classified in accordance with the corresponding predetermined sub-group of data.
摘要翻译：电子数据使用自适应聚焦复制器网络（AFRN）进行分类。 AFRN是数组元素的集合，每个数组元素可训练以便复制预定的子组数据。未知数据输入到AFRN数组中的每个数组元素，然后由每个元素数组复制。对每个数组元素进行比较以确定每个复制的准确性。如果只有一个数组元素成功地复制未知数据，则根据相应的预定数据子组对未知数据进行分类。

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