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21. 发明申请

WO2002059618A2 GROWTH FACTOR POLYPEPTIDES AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：生长因子多肽和核酸编码相同
公开(公告)号：WO2002059618A2
公开(公告)日：2002-08-01
申请号：PCT/US2001/048901
申请日：2001-11-16
申请人： CURAGEN CORPORATION , SHIMKETS, Richard, A. , LICHENSTEIN, Henri , HERRMANN, John, L. , BOLDOG, Ferenc, L. , MINSKOFF, Stacey , JEFFERS, Michael , ANDREWS, David , LAROCHELLE, Wiliam
发明人： SHIMKETS, Richard, A. , LICHENSTEIN, Henri , HERRMANN, John, L. , BOLDOG, Ferenc, L. , MINSKOFF, Stacey , JEFFERS, Michael , ANDREWS, David , LAROCHELLE, Wiliam
IPC分类号： G01N33/68
CPC分类号： G01N33/57488 , G01N33/74
摘要： Disclosed are novel nucleic acids encoding proteins and polypeptides related to bone morphogenetic protein-1 (BMF1) and to vascular endothelial growth factor E (VEGF-E) and platelet derived growth factor (PDGF). Also disclosed are vectors, host cells, antibodies, and recombinant methods for producing these nucleic acids and polypeptides. Methods of use include detecting and staging of cancers.
摘要翻译：公开了编码与骨形态发生蛋白-1（BMF1）和血管内皮生长因子E（VEGF-E）和血小板衍生生长因子（PDGF）相关的蛋白质和多肽的新型核酸。还公开了用于产生这些核酸和多肽的载体，宿主细胞，抗体和重组方法。使用方法包括检测和分期癌症。

22. 发明申请

WO0125437A3 GROWTH FACTOR POLYPEPTIDES AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：生长因子多肽和核酸编码相同
公开(公告)号：WO0125437A3
公开(公告)日：2002-04-18
申请号：PCT/US0027671
申请日：2000-10-06
申请人： CURAGEN CORP , SHIMKETS RICHARD A , LICHENSTEIN HENRI , HERRMANN JOHN L , BOLDOG FERENC L , MI STACEY , JEFFERS MICHAEL
发明人： SHIMKETS RICHARD A , LICHENSTEIN HENRI , HERRMANN JOHN L , BOLDOG FERENC L , MINSKOFF STACEY , JEFFERS MICHAEL
IPC分类号： G01N33/50 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/02 , A61P7/04 , A61P7/06 , A61P9/10 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/04 , A61P37/06 , A61P43/00 , C07K14/47 , C07K14/485 , C07K14/49 , C07K14/51 , C07K14/52 , C07K16/18 , C07K16/22 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/06 , C12N5/10 , C12N15/09 , C12N15/18 , C12N15/19 , C12P21/02 , C12P21/08 , C12Q1/02 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , A61K38/17 , C07K16/24 , G01N33/68
CPC分类号： C07K14/52 , A61K38/00 , C07K14/47 , C07K14/49 , C07K14/51
摘要： Disclosed are novel nucleic acids encoding proteins and polypeptides related to bone morphogenetic protein-1 (BMF1) and to vascular endothelial growth factor E (VEGF-E) and platelet derived growth factor (PDGF).
摘要翻译：公开了编码与骨形态发生蛋白-1（BMF1）和血管内皮生长因子E（VEGF-E）和血小板衍生生长因子（PDGF）相关的蛋白质和多肽的新型核酸。

23. 发明申请

WO9943311A2 CONJUGATED SURAMIN OR DERIVATIVES THEREOF WITH PEG, POLYASPARTATE OR POLYGLUTAMATE FOR CANCER TREATMENT 审中-公开
标题翻译：用PEG，聚天冬氨酸或聚谷氨酸盐共轭的SURAMIN或其衍生物用于癌症治疗
公开(公告)号：WO9943311A2
公开(公告)日：1999-09-02
申请号：PCT/US9904336
申请日：1999-02-26
申请人： US HEALTH , WEBB CRAIG P , JEFFERS MICHAEL E , CZERWINSKI GREGORZ , MICHEJDA CHRISTOPHER J , VANDE WOUDE GEORGE F
发明人： WEBB CRAIG P , JEFFERS MICHAEL E , CZERWINSKI GREGORZ , MICHEJDA CHRISTOPHER J , VANDE WOUDE GEORGE F
IPC分类号： A61K47/48 , C09B69/10 , C12Q1/37 , A61K31/185
CPC分类号： C12Q1/37 , A61K47/60 , A61K47/645 , C09B69/106 , G01N2333/9723
摘要： The present invention provides an assay that identifies compounds which inhibit cleavage of HGF/SF by serum proteases such as uPA, and methods in which such compounds are provided to reaction solutions, to cultured cells in vitro, or to a mammal in vivo, to inhibit cleavage of HGF/SF and to inhibit chemical and biological effects resulting from the activation of c-Met receptor by HGF/SF. The invention also provides methods for modifying suramin and suramin-related polysulfonated compounds that inhibit HGF/SF cleavage, by attaching PEG or polyanions such as polyglutamate or polyaspartate to the compounds to reduce cellular uptake of the compounds, thereby reducing their cytotoxicity. Also provided are a pharmaceutical composition containing at least one polysulfonated HGF/SF cleavage-inhibiting compound other than suramin, and a pharmaceutical composition containing at least one HGF/SF cleavage-inhibiting form of suramin or a suramin-related polysulfonated compound that is modified by conjugation to a chemical moiety that reduces uptake of the compound into cells. The present invention further includes methods wherein such pharmaceutical compositions are administered to a mammal with a tumor that is stimulated to grow by HGF/SF, to inhibit the growth or metastasis of the tumor in the mammal.
摘要翻译：本发明提供了鉴定通过血清蛋白酶如uPA来抑制HGF / SF裂解的化合物的测定法，以及将这些化合物提供给反应溶液，体外培养细胞或体内哺乳动物以提供抑制切割HGF / SF并抑制由HGF / SF激活c-Met受体引起的化学和生物效应。本发明还提供了通过将PEG或聚阴离子如聚谷氨酸盐或聚天冬氨酸连接到化合物以减少化合物的细胞摄取从而减少它们的细胞毒性来修饰抑制HGF / SF切割的苏拉明和苏拉明相关多磺化化合物的方法。还提供了一种药物组合物，其含有至少一种除苏拉明以外的多磺化HGF / SF裂解抑制化合物，以及一种药物组合物，该药物组合物含有至少一种被修饰的苏拉明或苏拉明相关多磺化化合物的HGF / SF切割抑制形式缀合至减少化合物向细胞摄取的化学部分。本发明进一步包括这样的方法，其中将这种药物组合物给予患有被HGF / SF刺激生长的肿瘤的哺乳动物，以抑制哺乳动物中肿瘤的生长或转移。

24. 发明申请

WO2005112979A3 METHODS OF PREVENTING AND TREATING ALIMENTARY MUCOSITIS 审中-公开
公开(公告)号：WO2005112979A3
公开(公告)日：2005-12-01
申请号：PCT/US2005/010545
申请日：2005-03-29
申请人： CURAGEN CORPORATION , ALVAREZ, Enrique , LICHENSTEIN, Henri , PRADYUMNA, Namdev, K. , VALAX, Pascal , YIM, Zachary , CHILLAKURU, Rajeev, A. , HAHNE, William , JEFFERS, Michael, E. , LAROCHELLE, William, J.
发明人： ALVAREZ, Enrique , LICHENSTEIN, Henri , PRADYUMNA, Namdev, K. , VALAX, Pascal , YIM, Zachary , CHILLAKURU, Rajeev, A. , HAHNE, William , JEFFERS, Michael, E. , LAROCHELLE, William, J.
IPC分类号： A61K38/00 , A61K38/18
摘要： The present invention relates to compositions and methods for preventing and treating alimentary mucositis. More particularly, the present invention provides methods for presenting and/or treating alimentary mucositis by using compositions comprising FGF-20, a fragment, a derivative, a variant, a homolog, or an analog thereof.

25. 发明申请

WO2003050245A3 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
公开(公告)号：WO2003050245A3
公开(公告)日：2003-06-19
申请号：PCT/US2002/038594
申请日：2002-12-03
申请人： CURAGEN CORPORATION , ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHILLAKURU, Rajeev, A. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , JEFFERS, Michael, E. , JI, Weizhen , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , MURPHEY, Ryan , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SMITHSON, Glennda , STARLING, Gary , TAUPIER, Raymond, J., Jr. , VOSS, Edward, Z. , ZHONG, Haihong , ZHONG, Mei
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHILLAKURU, Rajeev, A. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , JEFFERS, Michael, E. , JI, Weizhen , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , MURPHEY, Ryan , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SMITHSON, Glennda , STARLING, Gary , TAUPIER, Raymond, J., Jr. , VOSS, Edward, Z. , ZHONG, Haihong , ZHONG, Mei
IPC分类号： C07K14/435
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.

26. 发明申请

WO2003050245A2 THERAPEUTIC POLYPEPTIDES, NUCLEIC ACIDS ENCODING SAME, AND METHODS OF USE 审中-公开
标题翻译：治疗用多肽，编码核酸及使用方法
公开(公告)号：WO2003050245A2
公开(公告)日：2003-06-19
申请号：PCT/US2002/038594
申请日：2002-12-03
申请人： CURAGEN CORPORATION , ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHILLAKURU, Rajeev, A. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , JEFFERS, Michael, E. , JI, Weizhen , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , MURPHEY, Ryan , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SMITHSON, Glennda , STARLING, Gary , TAUPIER, Raymond, J., Jr. , VOSS, Edward, Z. , ZHONG, Haihong , ZHONG, Mei
发明人： ALSOBROOK, John, P., II , ANDERSON, David, W. , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CHILLAKURU, Rajeev, A. , EDINGER, Shlomit, R. , GERLACH, Valerie, L. , GORMAN, Linda , GOULD-ROTHBERG, Bonnie, E. , GUO, Xiaojia , JEFFERS, Michael, E. , JI, Weizhen , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , MURPHEY, Ryan , PATTURAJAN, Meera , PEYMAN, John, A. , RASTELLI, Luca , RIEGER, Daniel, K. , SHENOY, Suresh, G. , SMITHSON, Glennda , STARLING, Gary , TAUPIER, Raymond, J., Jr. , VOSS, Edward, Z. , ZHONG, Haihong , ZHONG, Mei
IPC分类号： C12N
CPC分类号： C07K14/47 , A61K38/00 , C12N9/00
摘要： Disclosed herein are nucleic acid sequences that encode novel polypeptides. Also disclosed are polypeptides encoded by these nucleic acid sequences, and antibodies that immunospecifically bind to the polypeptide, as well as derivatives, variants, mutants, or fragments of the novel polypeptide, polynucleotide, or antibody specific to the polypeptide. Vectors, host cells, antibodies and recombinant methods for producing the polypeptides and polynucleotides, as well as methods for using same are also included. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本文公开了编码新多肽的核酸序列。还公开了由这些核酸序列编码的多肽，以及免疫特异性结合多肽的抗体，以及对多肽特异的新多肽，多核苷酸或抗体的衍生物，变体，突变体或片段。还包括载体，宿主细胞，抗体和用于产生多肽和多核苷酸的重组方法，以及使用它们的方法。本发明进一步公开了诊断，治疗和预防涉及任何一种这些新型人核酸和蛋白质的疾病的治疗，诊断和研究方法。

27. 发明申请

WO2003035893A2 METHOD FOR ANALYZING A NUCLEIC ACID 审中-公开
标题翻译：分析核酸的方法
公开(公告)号：WO2003035893A2
公开(公告)日：2003-05-01
申请号：PCT/US2002/033788
申请日：2002-10-22
申请人： CURAGEN CORPORATION , BOUFFARD, Pascal , HERRMANN, John, L. , HUANG, Chunli , JEFFERS, Michael, E. , JU, Jingfang , RASTELLI, Luca , SHIMKETS, Juliette, B. , SIMONS, Jan, Fredik , TAILLON, Bruce, E.
发明人： BOUFFARD, Pascal , HERRMANN, John, L. , HUANG, Chunli , JEFFERS, Michael, E. , JU, Jingfang , RASTELLI, Luca , SHIMKETS, Juliette, B. , SIMONS, Jan, Fredik , TAILLON, Bruce, E.
IPC分类号： C12Q
CPC分类号： C12Q1/6855 , G06F19/22
摘要： Disclosed is a method in which DNA sequences derived from microsome-associated mRNA sequences in a mixed sample or in an arrayed single sequence clone can be determined and classified without sequencing. The methods make use of information on the presence of carefully chosen target subsequences, typically of length from 4 to 8 base pairs, and preferably the length between target subsequences in a sample DNA sequence together with DNA sequence databases containing lists of sequences likely to be present in the sample to determine a sample sequence. The preferred method uses restriction endonucleases to recognize target subsequences and cut the sample sequence. Then carefully chosen recognition moieties are ligated to the cut fragments, the fragments amplified, and the experimental observation made. Polymerase chain reaction (PCR) is the preferred method of amplification. Another embodiment of the invention uses information on the presence or absence of carefully chosen target subsequences in a single sequence clone together with DNA sequence databases to determine the clone sequence. Computer implemented methods are provided to analyze the experimental results and to determine the sample sequences in question and to carefully choose target subsequences in order that experiments yield a maximum amount of information.
摘要翻译：公开了可以确定和分类来自混合样品或排列单序列克隆中的微粒体相关mRNA序列的DNA序列而不进行测序的方法。这些方法利用关于精确选择的目标子序列的存在的信息，通常长度为4至8个碱基对，优选样品DNA序列中目标子序列之间的长度以及含有可能存在的序列的DNA序列数据库在样品中确定样品序列。优选的方法是使用限制性核酸内切酶识别目标子序列并切割样品序列。然后仔细选择识别部分连接到切割片段，扩增片段，并进行实验观察。聚合酶链反应（PCR）是优选的扩增方法。本发明的另一个实施方案使用关于在单个序列克隆中与DNA序列数据库一起存在或不存在仔细选择的目标子序列的信息来确定克隆序列。提供计算机实现的方法来分析实验结果并确定所讨论的样本序列，并仔细选择目标子序列，以便实验产生最大量的信息。

28. 发明申请

WO2003004687A2 NOVEL PROTEINS AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新蛋白和核酸编码相同
公开(公告)号：WO2003004687A2
公开(公告)日：2003-01-16
申请号：PCT/US2002/021361
申请日：2002-07-03
申请人： CURAGEN CORPORATION , ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , EDINGER, Shlomit , EISEN, Andrew, J. , ELLERMAN, Karen , GERLACH, Valerie , GORMAN, Linda , GUO, Xiaojia , JEFFERS, Michael , KEKUDA, Ramesh , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RASTELLI, Luca , SHENOY, Suresh , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , STONE, David, J. , TAUPIER, Raymond, J., Jr. , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZHONG, Mei
发明人： ANDERSON, David, W. , BERGHS, Constance , BOLDOG, Ferenc, L. , BURGESS, Catherine, E. , CASMAN, Stacie, J. , CATTERTON, Elina , EDINGER, Shlomit , EISEN, Andrew, J. , ELLERMAN, Karen , GERLACH, Valerie , GORMAN, Linda , GUO, Xiaojia , JEFFERS, Michael , KEKUDA, Ramesh , LI, Li , MALYANKAR, Uriel, M. , MILLER, Charles, E. , PADIGARU, Muralidhara , PATTURAJAN, Meera , PENA, Carol, E., A. , RASTELLI, Luca , SHENOY, Suresh , SHIMKETS, Richard, A. , SPADERNA, Steven, K. , SPYTEK, Kimberly, A. , STONE, David, J. , TAUPIER, Raymond, J., Jr. , VERNET, Corine, A., M. , VOSS, Edward, Z. , ZHONG, Mei
IPC分类号： C12Q
CPC分类号： C07K14/47
摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases. The invention further discloses therapeutic small molecules associated with diseases. The invention further discloses therapeutic, diagnostic and research methods for diagnosis, treatment, and prevention of disorders involving any one of these novel human nucleic acids and proteins.
摘要翻译：本发明提供由多核苷酸编码的新型分离的多核苷酸和小分子靶向多肽。公开了免疫特异性结合该多肽，多核苷酸或抗体的新型小分子靶多肽或任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态。更具体地，本发明公开了在各种筛选方法中使用重组表达和/或内源表达的蛋白质用于鉴定与疾病相关的治疗性抗体和治疗性小分子的方法。本发明还公开了与疾病相关的治疗性小分子。本发明还公开了用于诊断，治疗和预防与这些新型人核酸和蛋白质中的任一种相关的病症的治疗，诊断和研究方法。

29. 发明申请

WO2002102990A2 NOVEL FIBROBLAST GROWTH FACTOR AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新型纤维素生长因子和核酸编码相同
公开(公告)号：WO2002102990A2
公开(公告)日：2002-12-27
申请号：PCT/US2002/019400
申请日：2002-06-17
申请人： CURAGEN CORPORATION , SHIMKETS, Richard, A. , JEFFERS, Michael, E. , PRAYAGA, Sudhirdas, K. , BOLDOG, Ferenc, L. , YANG, Meijia , BURGESS, Catherine, E. , FERNANDES, Elma, R. , HERRMANN, John, L. , LAROCHELLE, William, J. , LICHENSTEIN, Henri, S. , GORMAN, Linda , ZHONG, Mei , PADIGARU, Muralidhara , PENA, Carol, E., A. , ALSOBROOK, John, P., II , LEPLEY, Denise, M. , RIEGER, Daniel, K. , GROSSE, William, M.
发明人： SHIMKETS, Richard, A. , JEFFERS, Michael, E. , PRAYAGA, Sudhirdas, K. , BOLDOG, Ferenc, L. , YANG, Meijia , BURGESS, Catherine, E. , FERNANDES, Elma, R. , HERRMANN, John, L. , LAROCHELLE, William, J. , LICHENSTEIN, Henri, S. , GORMAN, Linda , ZHONG, Mei , PADIGARU, Muralidhara , PENA, Carol, E., A. , ALSOBROOK, John, P., II , LEPLEY, Denise, M. , RIEGER, Daniel, K. , GROSSE, William, M.
IPC分类号： C12N
CPC分类号： C07K14/50
摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.
摘要翻译：本发明提供了FGF-CX，一种新的分离的多肽，以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或FGF-CX多肽的任何衍生物，变体，突变体或片段的多核苷酸或抗体。本发明另外提供了FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛的病理状态以及其它用途的方法。

30. 发明申请

WO2002077266A2 NOVEL FIBROBLAST GROWTH FACTOR AND NUCLEIC ACIDS ENCODING SAME 审中-公开
标题翻译：新的成纤维细胞生长因子和编码的核酸
公开(公告)号：WO2002077266A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/009336
申请日：2002-03-26
申请人： CURAGEN CORPORATION , JEFFERS, Michael, E. , SHIMKETS, Richard, A. , PRAYAGA, Sudhirdas, K. , BOLDOG, Ferenc, L. , YANG, Meijia , BURGESS, Catherine, E. , FERNANDES, Elma, R. , HERRMANN, John, L. , LAROCHELLE, William, J. , LICHENSTEIN, Henri, S.
发明人： JEFFERS, Michael, E. , SHIMKETS, Richard, A. , PRAYAGA, Sudhirdas, K. , BOLDOG, Ferenc, L. , YANG, Meijia , BURGESS, Catherine, E. , FERNANDES, Elma, R. , HERRMANN, John, L. , LAROCHELLE, William, J. , LICHENSTEIN, Henri, S.
IPC分类号： C12Q
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , A61K2039/505
摘要： The present invention provides FGF-CX, a novel isolated polypeptide, as well as a polynucleotide encoding FGF-CX and antibodies that immunospecifically bind to FGF-CX or any derivative, variant, mutant, or fragment of the FGF-CX polypeptide, polynucleotide or antibody. The invention additionally provides methods in which the FGF-CX polypeptide, polynucleotide and antibody are used in detection and treatment of a broad range of pathological states, as well as other uses.
摘要翻译：本发明提供了FGF-CX（一种新的分离的多肽）以及编码FGF-CX的多核苷酸和免疫特异性结合FGF-CX或其衍生物，变体，突变体或片段的抗体 FGF-CX多肽，多核苷酸或抗体。本发明另外提供了其中将FGF-CX多肽，多核苷酸和抗体用于检测和治疗广泛范围的病理状态以及其他用途的方法。

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