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21. 发明申请

WO2009070442A2 ENHANCED FC RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY MRNA EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH RHEUMATOID ARTHRITIS 审中-公开
标题翻译：加强FC受体介导的肿瘤坏死因子超家族MRNA在外周血淋巴细胞白血病患者中的表达与RHEUMATOID ARTHRITIS
公开(公告)号：WO2009070442A2
公开(公告)日：2009-06-04
申请号：PCT/US2008083136
申请日：2008-11-11
申请人： HITACHI CHEMICAL CO LTD , HITACHI CHEMICAL RES CT INC , MITSUHASHI MASATO , ENDO KATSUYA , OBARA KAZUHIKO , IZUTSU HIROSHI , OHTA SHUJI
发明人： MITSUHASHI MASATO , ENDO KATSUYA , OBARA KAZUHIKO , IZUTSU HIROSHI , OHTA SHUJI
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158
摘要： A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of tumor necrosis factor superfamily ("TNFSF")-2, TNFSF-8, or TNFSF- 15 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis is disclosed. A method of monitoring the disease state over time in rheumatoid arthritis patients is also disclosed.
摘要翻译：公开了一种预测患者对涉及改变肿瘤坏死因子超家族（“TNFSF”）-2，TNFSF-8或TNFSF-15表达的类风湿关节炎治疗的反应性的方法。还公开了一种用于监测这种疗法的有效性的方法。此外，公开了一种筛选用于治疗类风湿性关节炎的化合物的方法。还公开了一种在类风湿性关节炎患者中监测疾病状态随时间变化的方法。

22. 发明申请

WO2007117589A3 ENHANCED FC RECEPTOR-MEDIATED TUMOR NECROSIS FACTOR SUPERFAMILY AND CHEMOKINE MRNA EXPRESSION IN PERIPHERAL BLOOD LEUKOCYTES IN PATIENTS WITH RHEUMATOID ARTHRITIS 审中-公开
标题翻译：增强FC受体介导的肿瘤坏死因子超家族和CHEMOKINE在外周血淋巴细胞白血病患者中的表达
公开(公告)号：WO2007117589A3
公开(公告)日：2008-11-27
申请号：PCT/US2007008559
申请日：2007-04-05
申请人： HITACHI CHEMICAL CO LTD , HITACHI CHEMICAL RES CT INC , MITSUHASHI MASATO , ENDO KATSUYA
发明人： MITSUHASHI MASATO , ENDO KATSUYA
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6806 , C12Q2600/106 , C12Q2600/158
摘要： A method for predicting patient responsiveness to rheumatoid arthritis treatments involving altering expression of TNFSF-3, TNFSF-4, TNFSF-7, TNFSF-11, or TNFSF-14 is disclosed. A method for monitoring the effectiveness of such therapy is also disclosed. Furthermore, a method of screening compounds for use in the treatment of rheumatoid arthritis is disclosed. A method of monitoring the disease state over time in rheumatoid arthritis patients is also disclosed.
摘要翻译：公开了一种预测患者对涉及改变TNFSF-3，TNFSF-4，TNFSF-7，TNFSF-11或TNFSF-14的表达的类风湿关节炎治疗反应性的方法。还公开了一种用于监测这种疗法的有效性的方法。此外，公开了一种筛选用于治疗类风湿性关节炎的化合物的方法。还公开了一种在类风湿性关节炎患者中监测疾病状态随时间变化的方法。

23. 发明申请

WO2007136772A2 MATERIALS HAVING VARIABLE ELECTRICAL PROPERTIES BASED UPON ENVIRONMENTAL STIMULI 审中-公开
标题翻译：具有基于环境刺激性的可变电气特性的材料
公开(公告)号：WO2007136772A2
公开(公告)日：2007-11-29
申请号：PCT/US2007011944
申请日：2007-05-18
申请人： HITACHI CHEMICAL CO LTD , HITACHI CHEMICAL RES CT INC , LI JIFAN
发明人： LI JIFAN
IPC分类号： C12M3/00
CPC分类号： H01B1/16 , H01B3/004 , H01B3/006 , H01H2029/008 , Y10T428/25
摘要： A composite material switchable between a first state and a second state having different electrical properties, the composite includes a first material responsive to an environmental stimulus, a plurality of nano-deposits formed from a second material disposed on at least a portion of at least one surface of the first material, the second material includes an electrically conductive material, wherein in response to the environmental stimulus, the plurality of nano-deposits are switchable between a first configuration corresponding to the first state, and a second configuration corresponding to the second state. Related devices and methods are also described.
摘要翻译：复合材料可在具有不同电特性的第一状态和第二状态之间切换，所述复合材料包括响应于环境刺激的第一材料，多个纳米沉积物，其由设置在至少一个第一材料的表面，第二材料包括导电材料，其中响应于环境刺激，多个纳米沉积物可在对应于第一状态的第一构型与对应于第二状态的第二构型之间切换。还描述了相关的装置和方法。

24. 发明申请

WO2005115115A2 METHOD OF MEASURING CANCER SUSCEPTIBILITY 审中-公开
标题翻译：测量癌症可疑性的方法
公开(公告)号：WO2005115115A2
公开(公告)日：2005-12-08
申请号：PCT/US2005018289
申请日：2005-05-25
申请人： HITACHI CHEMICAL CO LTD , HITACHI CHEMICAL RES CT INC , MITSUHASHI MASATO
发明人： MITSUHASHI MASATO
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5017 , G01N2800/40 , G01N2800/50
摘要： An individual's susceptibility to cancer is assessed based on the individual's cellular response to mutagenic agents such as radiation. The level of a growth-suppressing marker is measured before and after the individual's cells are exposed to the mutagenic agent. The individual's susceptibility to cancer as a result of the mutagenic agent is correlated with the degree to which the growth-suppressing marker is induced by exposure to the agent. A method is also disclosed for assessing cancer prophylaxis effects of compounds, such as vitamins or food extracts, in individuals. Cells from an individual are incubated with at least one compound in vitro, or the compound is directly administered to the individual, after which some of the incubated cells, as well as non-incubated cells, are exposed to a mutagenic agent such as ionizing radiation. The level of the growth-suppressing marker in the cells incubated with the compound and exposed to the mutagenic agent is then compared with the level in the non-incubated cells exposed to the agent. The cancer prophylaxis effects of the compound are correlated with a higher level of the marker in the incubated cells.
摘要翻译：个体对癌症的敏感性是根据个体对诱变剂如辐射的细胞反应进行评估的。在个体细胞暴露于诱变剂之前和之后测量生长抑制标记的水平。致敏物质对个体的癌症易感性与通过暴露于药剂诱导生长抑制标记的程度相关。还公开了一种用于评估化合物（例如维生素或食物提取物）在个体中的癌症预防效果的方法。来自个体的细胞在体外与至少一种化合物一起温育，或者将化合物直接施用于个体，之后将一些培养的细胞以及未孵育的细胞暴露于诱变剂如电离辐射。然后将与化合物孵育并暴露于诱变剂的细胞中的生长抑制标记物的水平与暴露于该试剂的未孵育细胞中的水平进行比较。该化合物的癌症预防作用与培养细胞中较高水平的标记物相关。

25. 发明申请

WO2005084210A3 MULTIPLEX DETECTION PROBES 审中-公开
标题翻译：多重检测探头
公开(公告)号：WO2005084210A3
公开(公告)日：2005-11-10
申请号：PCT/US2005005955
申请日：2005-02-28
申请人： HITACHI CHEMICAL RES CT INC , HITACHI CHEMICAL CO LTD , MURAKAMI TAKU
发明人： MURAKAMI TAKU
IPC分类号： A61K38/00 , C07H21/02 , C07K1/00 , C12N15/11 , C12Q1/68 , G01N33/53
CPC分类号： C12Q1/6823 , C12Q1/6816 , C12Q1/682 , G01N33/586 , G01N33/6848 , C12Q2537/143 , C12Q2563/161 , C12Q2563/167
摘要： The present invention comprises detection probes utilizing vesicles or soluble bodies to retain multiple mass tag molecules. The detection probes may be used to simultaneously assay a plurality of different biological samples, each comprising a plurality of analytes, by immobilizing the analytes from each of the samples on a surface incubating the surface with a set of the detection probes, each having mass tag molecules with different masses, removing the unbound detection probe, collecting the first and second mass tag molecules from the bound detection probe, and quantifying the first and second mass tag molecules collected.
摘要翻译：本发明包括利用囊泡或可溶性体保留多个质量标签分子的检测探针。检测探针可以用于通过将来自每个样品的分析物固定在表面上孵育表面的一组检测探针来同时分析多个不同的生物样品，每个不同的生物样品包括多个分析物，每个检测探针具有质量标签去除未结合的检测探针，从结合的检测探针收集第一和第二质量标签分子，并量化收集的第一和第二质量标签分子。

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